中药对PM2.5致机体损伤的干预研究进展
摘要
<正>细颗粒物(PM2.5)作为大气污染的主要成分,对人体具有毒性强、危害大的特点。流行病学、毒理学资料研究证实,PM2.5与死亡率和发病率增加有关~([1]),能引发哮喘,造成肺功能下降、呼吸系统炎症甚至导致心血管系统疾病、神经系统疾病、免疫系统疾病,诱发肺癌、肝癌等~([2])。由于PM2.5的组成复杂,其致病机理是由多种因素导致
引文
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[8]邹天森,吴虎兵,黄万玉,等.2013年北京灰霾事件对医院成人门急诊量影响的定量研究[J].环境与健康杂志,2014,31(10):860-863.3
[9]刘萍,唐富山,朱艳,等.槲皮素对PM 2.5导致支气管上皮细胞炎症的保护作用[J].中药药理与临床,2017,33(1):22-26.
[10]YANG G,WANG Y,ZENG Y,et al.Rapid health transition in China,1990-2010:findings from the Global Burden of Disease Study 2010[J].Lancet,2013,381(9882):1987-2015.
[11]DICK CA,SINGH P,DANIELS M,et al.Murine pulmonary inflammatory responses following instillation of size-fractionated ambient particulate matter[J].JToxicol Environ Health A,2003,66(23):2193-2207.
[12]杨拉维,王亚红,杨腾,等.OGG1对PM2.5造成人肺上皮细胞DNA损伤的修复作用[J].现代医院,2015,15(8):4-6.
[13]JIN X,XUE B,ZHOU Q,et al.Mitochondria damage mediated by ROS incurs bronchial epithelial cel apoptosis upon ambient PM2.5 exposure[J].J Toxico Sci,2018,43(2):101-111.
[14]DENG X,ZHANG F,RUI W,et al.PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells[J].Toxicol in Vitro,2013,27(6):1762-1770.
[15]DENG X,RUI W,ZHANG F,et al.PM2.5induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells[J].Cell Bio Toxicol,2013,29(3):143-157.
[16]FUENTES-MATTEI E,RIVERA E,GIODA A,et al.Use of human bronchial epithelial cells(BEAS-2B)to study immunological markers resulting from exposure to PM2.5,organic extract from Puerto Rico[J].Toxicol App Pharmacol,2010,243(3):381-389.
[17]秦玉英,刘颖,敬岳,等.PM2.5对呼吸系统的病理影响及中医药防治[J].中华中医药杂志,2015,30(10):3477-3482.
[18]刘婷,魏海英,杨文妍,等.太原市冬季灰霾天气大气PM2.5对肺泡巨噬细胞的氧化损伤作用[J].环境科学学报,2015,35(3):890-896.
[19]王菲菲,王先良,刘芳盈,等.燃煤PM2.5不同组分对血管内皮细胞的氧化损伤效应[J].中国环境科学,2014,34(3):780-785.
[20]ZHAO J,GAO Z,TIAN Z,et al.The biologica effects of individual-level PM2.5 exposure on systemic immunity and inflammatory response in traffic policemen[J].Occup Environ Med,2013,70(6):426-431.
[21]?VREVIK J,REFSNES M,L?G M,et al.Activation of proinflammatory responses in cells o the airway mucosa by particulate matter:oxidant and non-oxidant-mediated triggering mechanisms.[J]Biomole,2015,5(3):1399-1440.
[22]李文娟,潘庆杰,李美玉.p53基因及其功能研究进展[J].生物技术通讯,2014,25(2):282-285.
[23]刘颖,敬岳,郭丽丽,等.固本止咳中药对COPD小鼠肺组织γδT细胞及IL-17的影响[J].中华中医药杂志,2014,29(12):3981-3984.
[24]闫庆倩,赵学彬,杨莉,等.不同地区大气PM2.5致大鼠肺损伤的比较实验研究[J].环境与健康杂志,2012,29(1):7-11.
[25]贾玉巧,赵晓红,郭新彪.大气颗粒物PM10和PM2.5对人肺成纤维细胞及其炎性因子分泌的影响[J].环境与健康杂志,2011,28(3):206-208.
[26]邓元荣,李泳宁,黄晓敏,等.大气细颗粒物吸入动物模型建立及适用性评价[J].中国比较医学杂志,2016,26(9):42-49.
[27]F I R M I N S,V E R D I N A,C O U R C O TD.Proinflammatory effects and oxidative stress within human bronchial epithelial cells exposed to atmospheric particulate matter(PM(2.5)and PM(>2.5))collected from Cotonou,Benin.[J].Environ Pollut,2014,185:340-351.
[28]焦周光,付绪磊,温占波,等.北京大气PM2.5对A549细胞炎性因子及DNA损伤的毒性[J].中国环境科学,2016,36(5):1579-1588.
[29]颜森波,于国伟,谌慧.PM2.5对DNA的损伤作用概述[J].职业与健康,2015,31(6):847-850.
[30]何俊,赵增明,赵君,等.汉阳PM2.5对人胚胎干细胞来源的成纤维细胞的遗传毒性研究[J].毒理学杂志,2015,29(6):436-439.
[31]GUALTIERI M,OVREVIK J,MOLLERUP S,et al.Airborne urban particles(Milan winter-PM2.5)cause mitotic arrest and cell death:Effects on DNA,mitochondria,AhR binding and spindle organization[J].Mutat Res-Fund Mol M,2011,713(1):18-31.
[32]毕婷婷,陈世杰,赵晓红,等.PM2.5对线粒体损伤作用机制的研究进展[J].生命科学,2016,28(3):409-414.
[33]汪军兵,龚正,董军,等.姜黄素对放线菌素D/TNF-α协同诱导PC12细胞凋亡的保护作用及机制研究[J].细胞与分子免疫学杂志,2012,28(5):484-487.
[34]SURYUN JUNG,KIJIN KIM.Exercise-induced PGC-1αtranscriptional factors in skeletal muscle[J]Integr Med Res,2014,3(4):155-160.
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