黄芪四君子汤治疗妊娠期糖尿病Meta分析
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摘要
目的:系统评价黄芪四君子汤治疗妊娠期糖尿病的有效性、安全性及对妊娠结局的影响。方法:根据Meta分析要求,对CBM、CNKI、VIP、重要会议论文集、PunMed等进行系统检索,纳入以黄芪四君子汤为干预措施治疗妊娠期糖尿病临床试验的研究文献,文献的检索年限均为建库起至2018年4月,由两名研究人员独立进行检索,如果遇到分歧,寻找第三方进行协助解决。采用Review Manager 5.3对有效性进行系统评价。结果:最终纳入14篇RCT,受试者共1566例,11篇文献报道总有效率,8篇文献报道对妊娠结局的影响,6篇文献报道不良反应的相关内容。结论:黄芪四君子汤治疗妊娠期糖尿病效果显著,且能够改善妊娠结局、减少不良反应。
Objective:To systematically evaluate the efficacy and safety of Huangqi Sijunzi Decoction in the treatment of gestational diabetes and its effect on pregnancy outcomes. Methods:According to the requirements of Meta-analysis,systematic search was conducted on CBM,CNKI,VIP,important conference proceedings,PunMed,etc.,and the study literature on treatment of gestational diabetes with Huangqi Sijunzi Decoction as an intervention was included. The search period of the literature is from the establishment of the database to April 2018,which is independently searched by two researchers. If differences are encountered,seek a third party to help solve the problem. Using Review Manager 5.3 for systematic evaluation of effectiveness. Results:The final inclusion of 14 RCTs,a total of 1566 cases of subjects,11 articles reported total efficiency,8 articles reported on the impact of pregnancy outcomes,6 articles reported adverse reactions related content. Conclusion:Huangqi Sijunzi Decoction has a significant effect on gestational diabetes,and can improve pregnancy outcomes and reduce the incidence of adverse reactions.
Objective:To systematically evaluate the efficacy and safety of Huangqi Sijunzi Decoction in the treatment of gestational diabetes and its effect on pregnancy outcomes. Methods:According to the requirements of Meta-analysis,systematic search was conducted on CBM,CNKI,VIP,important conference proceedings,PunMed,etc.,and the study literature on treatment of gestational diabetes with Huangqi Sijunzi Decoction as an intervention was included. The search period of the literature is from the establishment of the database to April 2018,which is independently searched by two researchers. If differences are encountered,seek a third party to help solve the problem. Using Review Manager 5.3 for systematic evaluation of effectiveness. Results:The final inclusion of 14 RCTs,a total of 1566 cases of subjects,11 articles reported total efficiency,8 articles reported on the impact of pregnancy outcomes,6 articles reported adverse reactions related content. Conclusion:Huangqi Sijunzi Decoction has a significant effect on gestational diabetes,and can improve pregnancy outcomes and reduce the incidence of adverse reactions.
引文
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[6]王恒,吴建涛.黄芪四君子汤治疗妊娠糖尿病疗效及对血清C反应蛋白、Mg~(2+)、脂联素水平的影响[J].现代中西医结合杂志,2015,24(26):87-89.
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[9]石玉芬,姚力,王琪.诺和锐特充联合黄芪四君子汤治疗妊娠糖尿病患者的疗效及对妊娠结局的影响[J].内科,2015,10(6):39-41.
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[11]谢玲,赵得雄,李宗英,等.四君子汤合黄芪辅助饮食运动疗法治疗妊娠糖尿病气阴两虚证[J].中国实验方剂学杂志,2015,21(21):189-192.
[12]潘冰雪.黄芪四君子汤为主治疗气阴两虚证妊娠期糖尿病的有效性[J].糖尿病新世界,2017,20(4):93-94.
[13]刘艳.诺和锐特充联合黄芪四君子汤在治疗妊娠合并糖尿病患者中的应用研究[J].糖尿病新世界,2017,20(5):90-91.
[14]吴剑,于四永,王艳会,等.黄芪四君子汤对妊娠期糖尿病的疗效分析[J].国际检验医学杂志,2017,38(13):36-38,41.
[15]谢玲,赵得雄,李宋英.二甲双胍联合黄芪四君子汤对妊娠期糖尿病孕妇妊娠结局的影响研究[J].辽宁中医杂志,2016,43(8):116-118.
[16]孟红娟,贺漪,高雪梅.黄芪四君子汤为主治疗气阴两虚证妊娠期糖尿病的有效性研究[J].陕西中医,2016,37(8):89-90.
[17]程慧敏,梅彬.个体化营养干预联合黄芪四君子汤对妊娠期糖尿病患者妊娠结局的影响[J].中国妇幼保健,2016,31(6):200-202.
[18]郭丽.黄芪四君子汤治疗妊娠糖尿病的临床疗效评价[J].内蒙古中医药,2016,35(13):17.
[19]李楠,范颖,贾旭鸣,等.黄芪不同有效部位对糖尿病模型大鼠血清胰岛素、脂联素的影响[J].中国实验方剂学杂志,2011,17(5):144-146.
[2]关怀,尚丽新.妊娠期糖尿病流行现状[J].中国实用妇科与产科杂志,2015,31(1):91-94.
[3]Mclachlan KA,'Neal D,enkins A,et al.Do adiponectin,TNF-αleptin and CRP relate to insulin resistance in pregnancy?Studies in women with and without gestational diabetes,uring and after pregnancy[J].Diabetes Metab Res Rev,2006,2(2):131-138.
[4]翟凤霞,刘蔚霞,李焱,等.中医体质类型与妊娠期糖尿病相关性分析[J].中医学报,2017,32(1):113-116.
[5]刘梅,秦莹,邢建红.诺和锐特充联合黄芪四君子汤治疗妊娠糖尿病的效果及对妊娠结局的影响[J].中国妇幼健康研究,2017,28(7):134-136.
[6]王恒,吴建涛.黄芪四君子汤治疗妊娠糖尿病疗效及对血清C反应蛋白、Mg~(2+)、脂联素水平的影响[J].现代中西医结合杂志,2015,24(26):87-89.
[7]冷丽丽.黄芪四君子汤联合诺和锐特充对妊娠糖尿病患者妊娠结局影响及临床疗效分析[J].糖尿病新世界,2016,19(23):35-36.
[8]龚文婧,郑春青,张颖,等.黄芪四君子汤加减治疗气阴两虚型妊娠糖尿病30例临床观察[J].中医药导报,2012,18(11):37-39.
[9]石玉芬,姚力,王琪.诺和锐特充联合黄芪四君子汤治疗妊娠糖尿病患者的疗效及对妊娠结局的影响[J].内科,2015,10(6):39-41.
[10]沙琦,夏亲华.黄芪四君子汤治疗气阴两虚型妊娠糖尿病的临床观察[J].临床医药文献电子杂志,2018,5(8):155,157.
[11]谢玲,赵得雄,李宗英,等.四君子汤合黄芪辅助饮食运动疗法治疗妊娠糖尿病气阴两虚证[J].中国实验方剂学杂志,2015,21(21):189-192.
[12]潘冰雪.黄芪四君子汤为主治疗气阴两虚证妊娠期糖尿病的有效性[J].糖尿病新世界,2017,20(4):93-94.
[13]刘艳.诺和锐特充联合黄芪四君子汤在治疗妊娠合并糖尿病患者中的应用研究[J].糖尿病新世界,2017,20(5):90-91.
[14]吴剑,于四永,王艳会,等.黄芪四君子汤对妊娠期糖尿病的疗效分析[J].国际检验医学杂志,2017,38(13):36-38,41.
[15]谢玲,赵得雄,李宋英.二甲双胍联合黄芪四君子汤对妊娠期糖尿病孕妇妊娠结局的影响研究[J].辽宁中医杂志,2016,43(8):116-118.
[16]孟红娟,贺漪,高雪梅.黄芪四君子汤为主治疗气阴两虚证妊娠期糖尿病的有效性研究[J].陕西中医,2016,37(8):89-90.
[17]程慧敏,梅彬.个体化营养干预联合黄芪四君子汤对妊娠期糖尿病患者妊娠结局的影响[J].中国妇幼保健,2016,31(6):200-202.
[18]郭丽.黄芪四君子汤治疗妊娠糖尿病的临床疗效评价[J].内蒙古中医药,2016,35(13):17.
[19]李楠,范颖,贾旭鸣,等.黄芪不同有效部位对糖尿病模型大鼠血清胰岛素、脂联素的影响[J].中国实验方剂学杂志,2011,17(5):144-146.