SLIT2和TRPV1在子宫内膜异位症组织中的表达及意义
摘要
目的:探讨SLIT2和TRPV1在子宫内膜异位症组织中的表达及意义。方法:通过腹腔镜和宫腔镜手术,选取45例子宫内膜异位症患者的在位及同源异位内膜(实验样本)和45例正常子宫内膜(对照组)。采用免疫组化方法对上述子宫内膜组织中SLIT2和TRPV1的表达情况进行检测。结果:SLIT2在异位内膜的表达率(68.9%)>在位内膜(46.7%)>正常内膜(26.7%),组间比较,差异具有统计学意义(P<0.05);TRPV1在异位内膜的表达率(71.1%)>在位内膜(51.1%)>正常内膜(28.9%),组间比较,差异具有统计学意义(P<0.05);子宫内膜异位症患者疼痛程度越重,SLIT2和TRPV1表达水平也越高,两组比较,差异具有统计学意义(P<0.05);SLIT2与TRPVl在子宫内膜异位症异位内膜组织中表达呈正相关。结论:SLIT2和TRPV1在子宫内膜异位症组织中的表达显著增高,且其表达强度与痛经程度相关,二者在子宫内膜异位症的发生、发展中可能起到协同促进作用。
引文
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[9] 张正琼.促性腺激素释放激素激动剂联合腹腔镜手术治疗EMT疗效及对TRPV1、NGF、BK/BKB1R、PGF2α水平的影响[J].标记免疫分析与临床,2018,25(4):509.
[10] Lian Y L,Cheng M J,Zhang X X,et al.Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis:[J].Molecular Medicine Reports,2017,16(2):1920.
[11] 何海美,潘晔.子宫内膜异位症患者异位及在位内膜组织中BCAR1的表达及其意义[J].中国妇幼健康研究,2017,28(11):19.
[2] 郑昕,朱莉.SLIT/ROBO信号通路在女性生殖系统的研究进展[J].中国优生与遗传杂志,2015,23(3):4.
[3] 王水英,黄荷凤.子宫内膜异位症不孕与盆腔内环境及表观遗传学的关系[J].中国实用妇科与产科杂志,2013,29(7):545.
[4] 陈景伟,仝瑞晓,杨剑,等.补肾温阳化瘀方对实验性子宫内膜异位症TRPV1及其致敏因子NGF的影响[J].中国中西医结合杂志,2015,35(6):717.
[5] De C K,Held K,Van B R,et al.Functional expression of transient receptor potential channels in human endometrial stromal cells during the luteal phase of the menstrual cycle[J].Human Reproduction,2015,30(6):1421.
[6] Wang B,Xiao Y,Dmg BB,et al. Induction of tumor angiogensis by SLIT/ROBO signaling and inhibition of cancer growth by blocking Robo activity[J].Cancer Cell,2003,4(1):19.
[7] Macias H,Moran A,Samara Y,et al.SLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell number[J].Developmental Cell,2011,20(6):827.
[8] Giovannone D,Reyes M,Reyes R,et al.Slits Affect the Timely Migration of Neural Crest Cells via Robo Receptor[J].Developmental Dynamics,2012,241(8):1274.
[9] 张正琼.促性腺激素释放激素激动剂联合腹腔镜手术治疗EMT疗效及对TRPV1、NGF、BK/BKB1R、PGF2α水平的影响[J].标记免疫分析与临床,2018,25(4):509.
[10] Lian Y L,Cheng M J,Zhang X X,et al.Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis:[J].Molecular Medicine Reports,2017,16(2):1920.
[11] 何海美,潘晔.子宫内膜异位症患者异位及在位内膜组织中BCAR1的表达及其意义[J].中国妇幼健康研究,2017,28(11):19.