规范化护理对乙肝疫苗低应答及无应答中老年人群疫苗复种后的价值
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摘要
目的探究规范化护理对乙肝疫苗低应答、无应答中老年人群疫苗复种后的护理价值。方法选取2017年1月—2018年1月于绍兴文理学院附属医院(绍兴市立医院)进行乙肝疫苗复种的乙肝疫苗低应答、无应答的中、老年研究对象共160例,将所有研究对象按随机数字表法分为常规护理组和规范化护理组2组各80例。使用重组乙肝表面抗原疫苗(酵母)对2组研究对象上臂三角肌肌肉进行注射接种,对常规护理组研究对象进行常规护理,对规范化护理组研究对象进行规范化护理。免疫透射比浊法检测乙肝病毒标志物,使用特制问卷对所有研究对象家属满意情况进行调查,统计2组研究对象接受疫苗复种后不良反应发生情况以及处理情况,并进行组间比较。结果 2组研究对象分别注射乙肝疫苗并接受护理后,规范化护理组家属总满意度显著高于常规护理组,差异有统计学意义(P<0.05)。2组研究对象分别注射乙肝疫苗后不良反应发生率比较,差异无统计学意义(P>0.05)。经过护理后,规范化护理组出现不良反应全部得到及时处理,显著高于常规护理组的不良反应处理率(36.36%),差异有统计学意义(P<0.05)。结论进行规范化护理干预,能够对疫苗接种后出现的不良反应进行及时处理,使家属更加满意。
Objective To explore the nursing value of standardized nursing for patients with low response and no response to hepatitis b vaccine after reseeding. Methods A total of 160 middle-aged and elderly people who received multiple vaccination of hepatitis B vaccine from January 2017 to January 2018 in Shaoxing Municipal Hospital were selected. All the subjects were randomly divided into two groups: routine nursing group and standardized nursing group, with 80 cases in each group. The recombinant hepatitis B surface antigen vaccine(yeast) was used to inoculate the deltoid muscle of upper arm of two groups of subjects. The subjects in the routine nursing group were given routine nursing, and the subjects in the standardized nursing group were given standardized nursing. Immunotransmission turbidimetry was used to detect hepatitis B virus markers. A special questionnaire was used to investigate the satisfaction of family members of all the subjects. The incidence and treatment of adverse reactions after vaccination were counted and compared between the two groups. Results After two groups of subjects injected with hepatitis B vaccine and received nursing, the total satisfaction of family members in the standardized nursing group was significantly higher than that in the conventional nursing group, with statistical significance(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups after injection of hepatitis B vaccine(P>0.05). After nursing, all the patients in the standardized nursing group who had adverse reactions were treated in time, which was significantly higher than 36.36% in the conventional nursing group(P<0.05). Conclusion The standardized nursing intervention can timely deal with the adverse reactions after vaccination and make the family members more satisfied.
Objective To explore the nursing value of standardized nursing for patients with low response and no response to hepatitis b vaccine after reseeding. Methods A total of 160 middle-aged and elderly people who received multiple vaccination of hepatitis B vaccine from January 2017 to January 2018 in Shaoxing Municipal Hospital were selected. All the subjects were randomly divided into two groups: routine nursing group and standardized nursing group, with 80 cases in each group. The recombinant hepatitis B surface antigen vaccine(yeast) was used to inoculate the deltoid muscle of upper arm of two groups of subjects. The subjects in the routine nursing group were given routine nursing, and the subjects in the standardized nursing group were given standardized nursing. Immunotransmission turbidimetry was used to detect hepatitis B virus markers. A special questionnaire was used to investigate the satisfaction of family members of all the subjects. The incidence and treatment of adverse reactions after vaccination were counted and compared between the two groups. Results After two groups of subjects injected with hepatitis B vaccine and received nursing, the total satisfaction of family members in the standardized nursing group was significantly higher than that in the conventional nursing group, with statistical significance(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups after injection of hepatitis B vaccine(P>0.05). After nursing, all the patients in the standardized nursing group who had adverse reactions were treated in time, which was significantly higher than 36.36% in the conventional nursing group(P<0.05). Conclusion The standardized nursing intervention can timely deal with the adverse reactions after vaccination and make the family members more satisfied.
引文
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[2] 刘会坡,邓素美,李俊颖,等.温阳益气汤联合恩替卡韦治疗老年失代偿期乙肝后肝硬化患者临床疗效研究[J].河北医学,2016,22(4):649-651.
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[7] 陈慧燕,陈建,吕雪丽,等.血清同型半胱氨酸在肝病诊断中的应用价值[J].浙江临床医学,2017,19(7):1333-1334.
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[9] 王碧玉,黄燕妮.乙肝两对半定量、乙肝DNA定量与乙肝前S1抗原联合检测的临床意义[J].海南医学,2016,27(7):1182-1184.
[10] 张丽,吕静静,颜丙玉,等.乙型肝炎疫苗初次免疫成年无应答者再次免疫后24个月免疫持久性观察[J].中华预防医学杂志,2015,49(9):782-787.
[11] 闻玉梅,汪萱怡.乙肝表面抗原与慢性乙肝的功能性治愈[J].复旦学报(医学版),2017,44(6):713-718.
[12] 王晓炜,钟运香,姚雪榕,等.乙肝疫苗无(低)应答者加大不同剂量再免疫效果观察[J].北方药学,2015,12(1):80-81.
[13] 刘甲野,吕静静,颜丙玉,等.乙型肝炎病毒核心抗体单项阳性及健康的成年人乙肝疫苗免疫效果配对比较研究[J].中华流行病学杂志,2014,35(10):1091-1094.
[14] 唐广心,叶发忠,刘晓军,等.低/无应答者接种60μg乙肝疫苗后抗体水平衰减及其影响因素研究[J].疾病监测与控制,2015,9(5):307-308,306.
[15] 陈胜玉,余运贤,王学才,等.成人乙肝疫苗免疫无应答影响因素及60μg重组疫苗复种效果评价[J].预防医学,2016,28(8):762-765.
[16] 张健波,骆文博,黄顺英,等.成人接种乙肝疫苗后无、弱免疫应答的相关因素[J].国际检验医学杂志,2015,36(15):2172-2174.
[17] 杨丽萍,刘彬辉.60 μg乙肝疫苗用于323例成人无应答者接种效果的观察[J].疾病监测,2014,29(4):298-299.
[18] 宋红潮,熊传庆,梁绍莲,等.两种大剂量乙肝疫苗对低/无应答成人再免疫效果分析[J].中国热带医学,2016,16(1):60-62.
[19] 贺玉芬,梁培芳.新生儿接种乙肝疫苗低、无应答调查及再免疫效果分析[J].实用预防医学,2015,22(9):1079-1081.
[20] 方继红,武凤芹,唐艳华.规范化护理流程在产瘫患儿围手术期中的应用效果[J].安徽医学,2017,38(06):793-795.
[21] 杨海红,高娟,马跃武,等.规范化护理管理在0～6岁儿童预防接种中的应用[J].大家健康(上旬版),2017,11(7):31-32.
[2] 刘会坡,邓素美,李俊颖,等.温阳益气汤联合恩替卡韦治疗老年失代偿期乙肝后肝硬化患者临床疗效研究[J].河北医学,2016,22(4):649-651.
[3] 马建新,肖敏,张卫,等.我国新生儿乙肝疫苗不同免疫策略成本效益分析[J].北京医学,2015,37(6):547-550.
[4] 宋红潮,熊传庆,郭艳秋,等.成人乙型肝炎疫苗无应答者大剂量再免疫效果评价[J].现代预防医学,2015,42(20):3783-3785.
[5] 赵云,朱培福.恩替卡韦联合微生态制剂对乙肝肝硬化患者肝功能、HBV-DNA和肝纤维化指标的影响[J].河北医药,2018,40(5):759-761.
[6] 侯成功.不同血清标志物检测方法诊断乙型病毒性肝炎的一致性[J].中华实用诊断与治疗杂志,2015,29(12):1247-1248.
[7] 陈慧燕,陈建,吕雪丽,等.血清同型半胱氨酸在肝病诊断中的应用价值[J].浙江临床医学,2017,19(7):1333-1334.
[8] 沈华江,王志炜,孙芳,等.国产恩替卡韦治疗慢性乙型肝炎的临床疗效及影响因素[J].中国医药,2015,10(2):209-213.
[9] 王碧玉,黄燕妮.乙肝两对半定量、乙肝DNA定量与乙肝前S1抗原联合检测的临床意义[J].海南医学,2016,27(7):1182-1184.
[10] 张丽,吕静静,颜丙玉,等.乙型肝炎疫苗初次免疫成年无应答者再次免疫后24个月免疫持久性观察[J].中华预防医学杂志,2015,49(9):782-787.
[11] 闻玉梅,汪萱怡.乙肝表面抗原与慢性乙肝的功能性治愈[J].复旦学报(医学版),2017,44(6):713-718.
[12] 王晓炜,钟运香,姚雪榕,等.乙肝疫苗无(低)应答者加大不同剂量再免疫效果观察[J].北方药学,2015,12(1):80-81.
[13] 刘甲野,吕静静,颜丙玉,等.乙型肝炎病毒核心抗体单项阳性及健康的成年人乙肝疫苗免疫效果配对比较研究[J].中华流行病学杂志,2014,35(10):1091-1094.
[14] 唐广心,叶发忠,刘晓军,等.低/无应答者接种60μg乙肝疫苗后抗体水平衰减及其影响因素研究[J].疾病监测与控制,2015,9(5):307-308,306.
[15] 陈胜玉,余运贤,王学才,等.成人乙肝疫苗免疫无应答影响因素及60μg重组疫苗复种效果评价[J].预防医学,2016,28(8):762-765.
[16] 张健波,骆文博,黄顺英,等.成人接种乙肝疫苗后无、弱免疫应答的相关因素[J].国际检验医学杂志,2015,36(15):2172-2174.
[17] 杨丽萍,刘彬辉.60 μg乙肝疫苗用于323例成人无应答者接种效果的观察[J].疾病监测,2014,29(4):298-299.
[18] 宋红潮,熊传庆,梁绍莲,等.两种大剂量乙肝疫苗对低/无应答成人再免疫效果分析[J].中国热带医学,2016,16(1):60-62.
[19] 贺玉芬,梁培芳.新生儿接种乙肝疫苗低、无应答调查及再免疫效果分析[J].实用预防医学,2015,22(9):1079-1081.
[20] 方继红,武凤芹,唐艳华.规范化护理流程在产瘫患儿围手术期中的应用效果[J].安徽医学,2017,38(06):793-795.
[21] 杨海红,高娟,马跃武,等.规范化护理管理在0～6岁儿童预防接种中的应用[J].大家健康(上旬版),2017,11(7):31-32.