乳酸菌作为基因工程菌的研究进展
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摘要
随着基因工程技术的发展,乳酸菌作为基因工程宿主菌的应用越来越多。本文对乳酸菌作为宿主菌的生物学功能,乳酸菌种中主要用于宿主菌的菌种,以及其表达外源基因的情况进行了简要概括,并对基因工程乳酸菌的应用进行了阐述。
With the development of genetic engineering technology,there are more and more applications of Lactic acid bacteria as genetic engineering host bacteria. This article briefly summarized the biological functions of Lactic acid bacteria as host bacteria, the species of Lactic acid bacteria mainly used for host bacteria, the expression of their foreign genes and the application of genetically engineered Lactic acid bacteria.
With the development of genetic engineering technology,there are more and more applications of Lactic acid bacteria as genetic engineering host bacteria. This article briefly summarized the biological functions of Lactic acid bacteria as host bacteria, the species of Lactic acid bacteria mainly used for host bacteria, the expression of their foreign genes and the application of genetically engineered Lactic acid bacteria.
引文
[1]陈瑞玲,钟颖,邓颖琦,等.表达H9N2亚型禽流感病毒HA蛋白重组乳酸杆菌的构建[J].中国兽医学报,2015,35(12):1917~1920.
[2]高云航,张喜宏,王巍,等.蜡样芽胞杆菌纤维素酶基因的克隆与其在乳酸菌中的表达[J].上海交通大学学报(农业科学版),2015,2:34~38.
[3]黄海楠,黄海鸥,杨金生,等.表达TGEV S基因AD片段的重组乳酸杆菌的构建及免疫研究[J].养殖与饲料,2015,11:9~13.
[4]姜咏昊,李倩,葛俊伟,等.表达F4~+ETEC的靶向性乳酸杆菌活菌载体的构建[J].畜牧与兽医,2015,47(2):70~74.
[5]郦萍,王嘉雯,徐栋,等.双肽细菌素Plantaricin EF在乳酸乳球菌中的异源表达及其抑菌活性[J].中国食品学报,2018,1:34~41.
[6]刘大伟,孙忠科,郭燕红,等.长双歧杆菌NCC2705高效转化系统的建立及GFP表达[J].生物技术通讯,2010,21(6):80~811.
[7]倪能能,王新珂,赖强,等.猪圆环病毒2型ORF2基因重组植物乳杆菌的构建及其免疫原性分析[J].中国畜牧兽医,2017,8:2408~2416.
[8]苏凤艳,李哲,李艳芝,等.重组犬瘟热病毒F-H融合基因乳酸菌的构建及表达[J].中国兽药杂志,2016,50(9):15~21.
[9]孙艳影,金晓秋,秦丽丽,等.EV71-VP1抗原在双歧杆菌中表达的免疫效果检测[J].医学研究杂志,2018,47(3):82~84.
[10]王小康,吴铁松,刘江红,等.抗菌肽LL-37在长双歧杆菌中的表达及活性鉴定[J].中国医药工业杂志,2018,1:68~73.
[11]王艳.多粘类芽胞杆菌纤维素酶基因在大肠杆菌和乳酸菌中的表达[D].兰州:甘肃农业大学,2017.
[12]尹清强,冯华,左瑞雨.淀粉酶基因在猪消化道乳酸杆菌中的表达[A].全国饲料营养学术研讨会[C].2006.
[13]岳璐,李昆鹏,侯喜林,等.重组PEDV-S干酪乳杆菌的构建及其表达[J].黑龙江八一农垦大学学报,2016,28(2):76~79.
[14]张秋香,侯慧丽,芦颖,等.猪链球菌口服疫苗的制备及小鼠血清免疫效果的评价[J].中国生物工程杂志,2013,33(7):25~30.
[15]张旺,刘琳琳,祁小乐,等.表达鸡传染性法氏囊病毒VP2蛋白重组乳酸乳球菌的构建及其表达的优化[J].中国预防兽医学报,2015,37(11):825~828.
[16]赵艳丽,柏亚铎,陈中秋,等.猪传染性胃肠炎病毒S1基因在食品级乳酸菌中的表达[J].中国兽医学报,2015,35(6):868~872.
[17]周必英,刘美辰,贺莉芳.猪带绦虫双歧杆菌表达系统pGEX-TSOL18/B.longum的构建及鉴定[J].中国寄生虫学与寄生虫病杂志,2014,32(3):239~241.
[18]周建波,胡莉萍,黄河,等.重组羊奇异变形杆菌ompA乳酸乳球菌的构建及其在小鼠体内的定植规律检测[J].中国兽医学报,2018,1:142~147.
[19]Ai C,Zhang Q X,Ding J R,et al.Suppression of dust mite allergy by mucosal delivery of a hypoallergenic derivative in a mouse model[J].Applied Microbiology&Biotechnology,2015,99(10):4309.
[20]Altermann E,Russell W M,Peril M A A,et al.Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM[J].Proc Natl Acad Sci U S A,2005,102(11):3906~3912.
[21]Bhuyan A A,Memon A M,Bhuiyan A A,et al.The construction of recombinant,Lactobacillus casei,expressing BVDV E2 protein and its immune response in mice[J].Journal of Biotechnology,2018,270:51~60.
[22]Bolotin A,Wincker P,Stéphane Mauger,et al.The Complete Genome Sequence of the Lactic Acid Bacterium[J].Genome Research,2001,11(5):731~753.
[23]Chassy B M.A gentle method for the lysis of oral streptococci[J].Biochemical&Biophysical Research Communications,1976,68(2):603~608.
[24]De Vos W M.Gene expression systems for lactic acid bacteria[J].Current Opinion in Microbiology,1999,2(3):289~295.
[25]Gálvez A,López R L,Pulido R P,et al.Natural Antimicrobials for Food Biopreservation[M].Food Biopreservation.2014.
[26]Haan A D,Haijema B J,Voorn P,et al.Bacterium-like particles supplemented with inactivated influenza antigen induce cross-protective influenza-specific antibody responses through intranasal administration[J].Vaccine,2012,30(32):4884~4891.
[27]Kobierecka P A,Olech B,M Ksi,a觃zek,et al.Cell Wall Anchoring of the Campylobacter Antigens to Lactococcus lactis[J].Frontiers in Microbiology,2016,7(e40409):165.
[28]Lin J,Zou Y,Ma C,et al.Heterologous Expression of Mannanase and Developing a New Reporter Gene System in Lactobacillus casei and Escherichia coli[J].PLOS ONE,2015,10(11):e0142886.
[29]Lu W W,Wang T,Wang Y,et al.A food-grade fimbrial adhesin FaeG expression system in Lactococcus lactis and Lactobacillus casei[J].Canadian Journal of Microbiology,2015,62(3):1.
[30]Ren C,Jelleke D F,Lozano S F,et al.Lactic Acid Bacteria may Impact Intestinal Barrier Function by Modulating Goblet Cells[J].Molecular Nutrition&Food Research,2018,62(6):1700572.
[31]Ren C,Zhang Q,Wang G,et al.Modulation of peanut-induced allergic immune responses by oral lactic acid bacteria-based vaccines in mice.[J].Applied Microbiology&Biotechnology,2014,98(14):6353~6364.
[32]Schell M A,Karmirantzou M,Snel B,et al.The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract[J].Proceedings of the National Academy of Sciences,2002,99(22):14422~14427.
[33]Wang Z H,Wang Y L,Zeng X Y.Construction and expression of a heterologous protein in Lactococcus lactis by using the nisincontrolled gene expression system:The case of the PRRSV ORF6[J].Genet mol kes,2014,13(1):1088~1096.
[34]Wells J.Mucosal Vaccination and Therapy with Genetically Modified Lactic Acid Bacteria[J].Annual Review of Food Science&Technology,2011,2(1):423.
[35]Zeng W S,Zhang S X,Shao C W,et al.Intragastric administration of interferon-α-transformed Bifidobacterium promotes lymphocyte proliferation and maturation in mice][J].Nan fang yi ke da xue xue bao Journal of Southern Medical University,2015,35(3):326~332.
[36]Zhang Q,Liu M,Li S.Oral Bifidobacterium longum expressing GLP-2 improves nutrient assimilation and nutritional homeostasis in mice.[J].Journal of Microbiological Methods,2018,145:87.
[2]高云航,张喜宏,王巍,等.蜡样芽胞杆菌纤维素酶基因的克隆与其在乳酸菌中的表达[J].上海交通大学学报(农业科学版),2015,2:34~38.
[3]黄海楠,黄海鸥,杨金生,等.表达TGEV S基因AD片段的重组乳酸杆菌的构建及免疫研究[J].养殖与饲料,2015,11:9~13.
[4]姜咏昊,李倩,葛俊伟,等.表达F4~+ETEC的靶向性乳酸杆菌活菌载体的构建[J].畜牧与兽医,2015,47(2):70~74.
[5]郦萍,王嘉雯,徐栋,等.双肽细菌素Plantaricin EF在乳酸乳球菌中的异源表达及其抑菌活性[J].中国食品学报,2018,1:34~41.
[6]刘大伟,孙忠科,郭燕红,等.长双歧杆菌NCC2705高效转化系统的建立及GFP表达[J].生物技术通讯,2010,21(6):80~811.
[7]倪能能,王新珂,赖强,等.猪圆环病毒2型ORF2基因重组植物乳杆菌的构建及其免疫原性分析[J].中国畜牧兽医,2017,8:2408~2416.
[8]苏凤艳,李哲,李艳芝,等.重组犬瘟热病毒F-H融合基因乳酸菌的构建及表达[J].中国兽药杂志,2016,50(9):15~21.
[9]孙艳影,金晓秋,秦丽丽,等.EV71-VP1抗原在双歧杆菌中表达的免疫效果检测[J].医学研究杂志,2018,47(3):82~84.
[10]王小康,吴铁松,刘江红,等.抗菌肽LL-37在长双歧杆菌中的表达及活性鉴定[J].中国医药工业杂志,2018,1:68~73.
[11]王艳.多粘类芽胞杆菌纤维素酶基因在大肠杆菌和乳酸菌中的表达[D].兰州:甘肃农业大学,2017.
[12]尹清强,冯华,左瑞雨.淀粉酶基因在猪消化道乳酸杆菌中的表达[A].全国饲料营养学术研讨会[C].2006.
[13]岳璐,李昆鹏,侯喜林,等.重组PEDV-S干酪乳杆菌的构建及其表达[J].黑龙江八一农垦大学学报,2016,28(2):76~79.
[14]张秋香,侯慧丽,芦颖,等.猪链球菌口服疫苗的制备及小鼠血清免疫效果的评价[J].中国生物工程杂志,2013,33(7):25~30.
[15]张旺,刘琳琳,祁小乐,等.表达鸡传染性法氏囊病毒VP2蛋白重组乳酸乳球菌的构建及其表达的优化[J].中国预防兽医学报,2015,37(11):825~828.
[16]赵艳丽,柏亚铎,陈中秋,等.猪传染性胃肠炎病毒S1基因在食品级乳酸菌中的表达[J].中国兽医学报,2015,35(6):868~872.
[17]周必英,刘美辰,贺莉芳.猪带绦虫双歧杆菌表达系统pGEX-TSOL18/B.longum的构建及鉴定[J].中国寄生虫学与寄生虫病杂志,2014,32(3):239~241.
[18]周建波,胡莉萍,黄河,等.重组羊奇异变形杆菌ompA乳酸乳球菌的构建及其在小鼠体内的定植规律检测[J].中国兽医学报,2018,1:142~147.
[19]Ai C,Zhang Q X,Ding J R,et al.Suppression of dust mite allergy by mucosal delivery of a hypoallergenic derivative in a mouse model[J].Applied Microbiology&Biotechnology,2015,99(10):4309.
[20]Altermann E,Russell W M,Peril M A A,et al.Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM[J].Proc Natl Acad Sci U S A,2005,102(11):3906~3912.
[21]Bhuyan A A,Memon A M,Bhuiyan A A,et al.The construction of recombinant,Lactobacillus casei,expressing BVDV E2 protein and its immune response in mice[J].Journal of Biotechnology,2018,270:51~60.
[22]Bolotin A,Wincker P,Stéphane Mauger,et al.The Complete Genome Sequence of the Lactic Acid Bacterium[J].Genome Research,2001,11(5):731~753.
[23]Chassy B M.A gentle method for the lysis of oral streptococci[J].Biochemical&Biophysical Research Communications,1976,68(2):603~608.
[24]De Vos W M.Gene expression systems for lactic acid bacteria[J].Current Opinion in Microbiology,1999,2(3):289~295.
[25]Gálvez A,López R L,Pulido R P,et al.Natural Antimicrobials for Food Biopreservation[M].Food Biopreservation.2014.
[26]Haan A D,Haijema B J,Voorn P,et al.Bacterium-like particles supplemented with inactivated influenza antigen induce cross-protective influenza-specific antibody responses through intranasal administration[J].Vaccine,2012,30(32):4884~4891.
[27]Kobierecka P A,Olech B,M Ksi,a觃zek,et al.Cell Wall Anchoring of the Campylobacter Antigens to Lactococcus lactis[J].Frontiers in Microbiology,2016,7(e40409):165.
[28]Lin J,Zou Y,Ma C,et al.Heterologous Expression of Mannanase and Developing a New Reporter Gene System in Lactobacillus casei and Escherichia coli[J].PLOS ONE,2015,10(11):e0142886.
[29]Lu W W,Wang T,Wang Y,et al.A food-grade fimbrial adhesin FaeG expression system in Lactococcus lactis and Lactobacillus casei[J].Canadian Journal of Microbiology,2015,62(3):1.
[30]Ren C,Jelleke D F,Lozano S F,et al.Lactic Acid Bacteria may Impact Intestinal Barrier Function by Modulating Goblet Cells[J].Molecular Nutrition&Food Research,2018,62(6):1700572.
[31]Ren C,Zhang Q,Wang G,et al.Modulation of peanut-induced allergic immune responses by oral lactic acid bacteria-based vaccines in mice.[J].Applied Microbiology&Biotechnology,2014,98(14):6353~6364.
[32]Schell M A,Karmirantzou M,Snel B,et al.The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract[J].Proceedings of the National Academy of Sciences,2002,99(22):14422~14427.
[33]Wang Z H,Wang Y L,Zeng X Y.Construction and expression of a heterologous protein in Lactococcus lactis by using the nisincontrolled gene expression system:The case of the PRRSV ORF6[J].Genet mol kes,2014,13(1):1088~1096.
[34]Wells J.Mucosal Vaccination and Therapy with Genetically Modified Lactic Acid Bacteria[J].Annual Review of Food Science&Technology,2011,2(1):423.
[35]Zeng W S,Zhang S X,Shao C W,et al.Intragastric administration of interferon-α-transformed Bifidobacterium promotes lymphocyte proliferation and maturation in mice][J].Nan fang yi ke da xue xue bao Journal of Southern Medical University,2015,35(3):326~332.
[36]Zhang Q,Liu M,Li S.Oral Bifidobacterium longum expressing GLP-2 improves nutrient assimilation and nutritional homeostasis in mice.[J].Journal of Microbiological Methods,2018,145:87.