CGF在上颌窦底提升种植修复中的应用
|
摘要
目的:观察浓缩生长因子在上颌后牙区骨量不足种植修复病例中的临床应用。方法:对20例上颌后牙区严重骨量不足的患者进行上颌窦底提升术,应用浓缩生长因子和Bio-Oss骨粉混合物进行种植骨增量手术,同期植入种植体31颗,记录植入扭矩,分别于术后1周、术后6个月完成上部修复结构后拍摄CBCT以观察骨增量情况。结果:20例患者术前平均剩余骨高度约(3.63±0.49)mm,术后1周上颌窦底平均提升高度为(6.79±0.95)mm,6个月后31颗种植体均实现骨结合,完成上部修复结构后测得上颌窦底平均提升高度为(6.53±0.87)mm。结论:浓缩生长因子和Bio-Oss骨粉混合物用于上颌窦底提升术获得了良好的临床效果。
Objective: To evaluate predictability of new bone formation in the maxillary posterior edentulous with insufficient residual bone height using concentrated growth factor. Methods: A total of 20 patients with severe insufficient residual bone height of maxillary posterior edentulous were consecutively performed using the transcrestal sinus elevation. The concentrated growth factor and Bio-Oss bone granules were mixed and inserted into the sinus. Thirty-one implants were placed simultaneously and the insertion torques were recorded. Cone-beam computed tomography( CBCT) was taken and the residual bone heights were measured 1 week later. The restorations were finished and CBCT was taken again after 6 months. Residual bone heights were measured and the increased bone heights were analyzed. Results: The average residual bone height was( 3. 63 ± 0. 49) mm before sinus augmentation. New bone consolidation in all patients was observed along the implants on cone-beam computed tomograms. The residual bone heights increased( 6. 79 ± 0. 95) mm at 1 week after implant insertion. Six months later,the superstructures were restored,and the residual bone heights increased( 6. 53 ± 0. 87) mm. Conclusion: Good clinical outcomes can be achieved by mixture of concentrated growth factor and Bio-Oss bone granules in maxillary sinus augmentation.
Objective: To evaluate predictability of new bone formation in the maxillary posterior edentulous with insufficient residual bone height using concentrated growth factor. Methods: A total of 20 patients with severe insufficient residual bone height of maxillary posterior edentulous were consecutively performed using the transcrestal sinus elevation. The concentrated growth factor and Bio-Oss bone granules were mixed and inserted into the sinus. Thirty-one implants were placed simultaneously and the insertion torques were recorded. Cone-beam computed tomography( CBCT) was taken and the residual bone heights were measured 1 week later. The restorations were finished and CBCT was taken again after 6 months. Residual bone heights were measured and the increased bone heights were analyzed. Results: The average residual bone height was( 3. 63 ± 0. 49) mm before sinus augmentation. New bone consolidation in all patients was observed along the implants on cone-beam computed tomograms. The residual bone heights increased( 6. 79 ± 0. 95) mm at 1 week after implant insertion. Six months later,the superstructures were restored,and the residual bone heights increased( 6. 53 ± 0. 87) mm. Conclusion: Good clinical outcomes can be achieved by mixture of concentrated growth factor and Bio-Oss bone granules in maxillary sinus augmentation.
引文
[1]Farre-Guasch E,Prins HJ,Overman JR,et al.Human maxillary sinus floor elevation as a model for bone regeneration enabling the application of one-step surgical procedures[J].Tissue Eng Part B Rev,2013,19(1):69-82.
[2]Mangano C,Bartolucci EG,Mazzocco C.A new porous hydroxyapatite for promotion of bone regeneration in maxillary sinus augmentation:clinical and histologic study in humans[J].Int J Oral Maxillofac Implants,2003,18(1):23-30.
[3]Kim TH,Kim SH,Sandor GK,et al.Comparison of platelet-rich plasma(PRP),platelet-rich fibrin(PRF),and concentrated growth factor(CGF)in rabbit-skull defect healing[J].Arch Oral Biol,2014,59(5):550-558.
[4]Barboni B,Mangano C,Valbonetti L,et al.Synthetic bone substitute engineered with amniotic epithelial cells enhances bone regeneration after maxillary sinus augmentation[J].Plo S one,2013,8(5):e63256.
[5]Dursun CK,Dursun E,Eratalay K,et al.Effect ofporous titanium granules on bone regeneration and primary stability in maxillary sinus:A human clinical,histomorphometric,and microcomputed tomography analyses[J].J Craniofac Surg,2016,27(2):391-397.
[6]高巍,李良玉,张峰.经牙槽嵴顶入路两种微创上颌窦提升方法的应用及3-5年的临床观察[J].口腔医学研究,2016,32(6):643-647.
[7]Honda H,Tamai N,Naka N,et al.Bone tissue engineering with bone marrow-derived stromal cells integrated with concentrated growth factor in Rattus norvegicus calvaria defect model[J].J Artif Organs,2013,16(3):305-315.
[8]Sohn DS,Heo JU,Kwak DH,et al.Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone[J].Implant Dent,2011,20(5):389-395.
[9]Yu B,Wang Z.Effect of concentrated growth factors on beagle periodontal ligament stem cells in vitro[J].Mol Med Rep,2014,9(1):235-242.
[10]柳宏志,邹高峰,王天祥,等.浓缩生长因子促进犬软组织损伤修复的实验研究[J].口腔颌面外科杂志,2013,23(1):28-31.
[11]王天祥,李超,邹高峰,等.浓缩生长因子促进犬种植体周围骨缺损修复的实验研究[J].中国口腔颌面外科杂志,2013,11(3):199-203.
[2]Mangano C,Bartolucci EG,Mazzocco C.A new porous hydroxyapatite for promotion of bone regeneration in maxillary sinus augmentation:clinical and histologic study in humans[J].Int J Oral Maxillofac Implants,2003,18(1):23-30.
[3]Kim TH,Kim SH,Sandor GK,et al.Comparison of platelet-rich plasma(PRP),platelet-rich fibrin(PRF),and concentrated growth factor(CGF)in rabbit-skull defect healing[J].Arch Oral Biol,2014,59(5):550-558.
[4]Barboni B,Mangano C,Valbonetti L,et al.Synthetic bone substitute engineered with amniotic epithelial cells enhances bone regeneration after maxillary sinus augmentation[J].Plo S one,2013,8(5):e63256.
[5]Dursun CK,Dursun E,Eratalay K,et al.Effect ofporous titanium granules on bone regeneration and primary stability in maxillary sinus:A human clinical,histomorphometric,and microcomputed tomography analyses[J].J Craniofac Surg,2016,27(2):391-397.
[6]高巍,李良玉,张峰.经牙槽嵴顶入路两种微创上颌窦提升方法的应用及3-5年的临床观察[J].口腔医学研究,2016,32(6):643-647.
[7]Honda H,Tamai N,Naka N,et al.Bone tissue engineering with bone marrow-derived stromal cells integrated with concentrated growth factor in Rattus norvegicus calvaria defect model[J].J Artif Organs,2013,16(3):305-315.
[8]Sohn DS,Heo JU,Kwak DH,et al.Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone[J].Implant Dent,2011,20(5):389-395.
[9]Yu B,Wang Z.Effect of concentrated growth factors on beagle periodontal ligament stem cells in vitro[J].Mol Med Rep,2014,9(1):235-242.
[10]柳宏志,邹高峰,王天祥,等.浓缩生长因子促进犬软组织损伤修复的实验研究[J].口腔颌面外科杂志,2013,23(1):28-31.
[11]王天祥,李超,邹高峰,等.浓缩生长因子促进犬种植体周围骨缺损修复的实验研究[J].中国口腔颌面外科杂志,2013,11(3):199-203.