高脂血症对突发性聋患者椎基底动脉血流动力学影响
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摘要
目的探讨高脂血症对突发性聋患者椎基底动脉血流动力学改变影响。方法以60例突发性聋患者为研究对象,根据血脂异常标准分为高脂血症组(突发性耳聋伴高脂血症)、非高脂血症组(突发性耳聋不伴高脂血症),每组30例,正常对照组30例。所有患者均行经颅多普勒(TCD)检查,比较观察各组椎基底动脉收缩期流速(Vs)、舒张期流速(Vd)、脉冲指数(PI)、阻力指数(RI)之间差异。结果高脂血症组、非高脂血症组、对照组患者的TCD异常率分别是93.33%、66.67%、0%。高脂血症组患者出现异常TCD的比例明显增高,与其他两组比较差异有统计学意义(P <0.05)。高脂血症组患者椎基底动脉的Vs、Vd较非高脂血症组、对照组明显增加,差异有统计学意义(P <0.05)。结论突发性聋伴高脂血症患者椎基底动脉血流动力学异常率明显增加。
Objective To explore the effect of hyperlipidemia on vertebrobasilar hemodynamics of patients with sudden deafness. Methods 60 patients with sudden deafness were selected as research objects and they were divided into the hyperlipidemia group(sudden deafness accompanied by hyperlipidemia) and the non-hyperlipidemia group(sudden deafnesswithouthyperlipidemia) according to dyslipidemia standard, with 30 in each group. In addition, there were 30 cases in the normal control group. All patients were given examination of transcranialdoppler(TCD). Differences in systolic velocity(Vs), diastolic velocity(Vd), pulsitility index(PI) and resistance index(RI) of vertebral basilar artery of all groups were compared. Results Abnormal rate of TCD of patients in the hyperlipidemia group, non-hyperlipidemia group and the normal control group were respectively 93.33%, 66.67% and 0%. The proportion of abnormal TCD in the hyperlipidemia group was significantly increased, which was statistically different compared with that of the other two groups(P < 0.05).Vs, Vd of vertebral basilar artery ofpatients in the hyperlipidemia group were higher than those of the non-hyperlipidemia group and the normal control group. Differences were statistically significant(P < 0.05). Conclusion The abnormal rate of vertebrobasilarhemodynamics in patients with sudden deafness and hyperlipidemia is significantly increased.
Objective To explore the effect of hyperlipidemia on vertebrobasilar hemodynamics of patients with sudden deafness. Methods 60 patients with sudden deafness were selected as research objects and they were divided into the hyperlipidemia group(sudden deafness accompanied by hyperlipidemia) and the non-hyperlipidemia group(sudden deafnesswithouthyperlipidemia) according to dyslipidemia standard, with 30 in each group. In addition, there were 30 cases in the normal control group. All patients were given examination of transcranialdoppler(TCD). Differences in systolic velocity(Vs), diastolic velocity(Vd), pulsitility index(PI) and resistance index(RI) of vertebral basilar artery of all groups were compared. Results Abnormal rate of TCD of patients in the hyperlipidemia group, non-hyperlipidemia group and the normal control group were respectively 93.33%, 66.67% and 0%. The proportion of abnormal TCD in the hyperlipidemia group was significantly increased, which was statistically different compared with that of the other two groups(P < 0.05).Vs, Vd of vertebral basilar artery ofpatients in the hyperlipidemia group were higher than those of the non-hyperlipidemia group and the normal control group. Differences were statistically significant(P < 0.05). Conclusion The abnormal rate of vertebrobasilarhemodynamics in patients with sudden deafness and hyperlipidemia is significantly increased.
引文
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[11]Lu YY,Jin Z,Tong BS,et al.A clinical study of microcirculatory disturbance in Chinesepatients with sudden deafness[J].Acta Otolaryngol,2008,128(11):1168-1172.
[12]顾向阳.柯红林,曹明根.突发性聋患者血液流变学特性及脂代谢研究[J].中国耳鼻咽喉头颈外科,2012,19(9):487-489.
[13]Lu YY,Jin Z,Tong BS,et al.A clinical study of microcirculatory disturbance in Chinesepatients with sudden deafness[J].Acta Otolaryngol,2008,128(11):1168-1172.
[14]张晓彤,许珉,段茂利,等.突发性聋临床流行病学分析[J].中华耳科学杂志,2009,7(2):152-156.
[15]庞玲,肖琴.脑血管多普勒检查对突发性聋治疗的意义[J].听力学及言语疾病杂志,2004,12(3):200.
[16]邢英姿,王东海,侯庆军,等.突发性聋患者椎-基底动脉血流动力学观察[J].听力学及言语疾病杂志,2014,22(3):260-263.
[17]陈祥雷,张念武,赵丹,等.高血糖症对急性特发性感音神经性听力损失预后评估[J].中国医药导报,2018,15(12):114-116.
[2]戴静,彭新,宋丽洁,等.突发性聋患者血液易栓症结果分析[J].中华耳科学杂志,2012,10(3):345-348.
[3]Machida T,Sumino H,Fukushima M,et al.Blood rheology and the low-density lipoprotein cholesterol/highdensity lipoprotein cholesterol ratio in dyslipidaemic and normolipidaemic subjects[J].The Journal of international medical research,2010,38(6):1975-1984.
[4]张红,沈安民.老年性疾病对听力影响分析[J].浙江临床医学,2007,9(8):1055.
[5]Marcucci R,Alessandrello Liotta A,Cellai AP,et al.Cardiovascular and thrombophilic risk factors for idiopathicsuddensensorineural hearing loss[J].J Thromb Haemost,2005,3(5):929-934.
[6]中国成人血脂异常防治指南修订联合委员会.中国成人血脂异常防治指南(2016年修订版)[J].中华心血管病杂志,2016,44(10):833-853.
[7]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.突发性聋诊断和治疗指南(2015)[J].中华耳鼻咽喉头颈外科杂志,2015,50(6):443-447.
[8]顾慎为,经颅多普勒检测与临床(第2版)[M].上海:上海医科大学出版,2001:75-277.
[9]陈银忠,郭清华,俞德顺.突发性聋疗效及预后相关因素分析[J].中国耳鼻咽喉头颈外科,2012,19(11):605-608.
[10]王春花,王小锐,康艳霞,等.单侧低中频下降型突发性聋预后相关因素分析[J].中华耳科学杂志,2014,12(4):603-607.
[11]Lu YY,Jin Z,Tong BS,et al.A clinical study of microcirculatory disturbance in Chinesepatients with sudden deafness[J].Acta Otolaryngol,2008,128(11):1168-1172.
[12]顾向阳.柯红林,曹明根.突发性聋患者血液流变学特性及脂代谢研究[J].中国耳鼻咽喉头颈外科,2012,19(9):487-489.
[13]Lu YY,Jin Z,Tong BS,et al.A clinical study of microcirculatory disturbance in Chinesepatients with sudden deafness[J].Acta Otolaryngol,2008,128(11):1168-1172.
[14]张晓彤,许珉,段茂利,等.突发性聋临床流行病学分析[J].中华耳科学杂志,2009,7(2):152-156.
[15]庞玲,肖琴.脑血管多普勒检查对突发性聋治疗的意义[J].听力学及言语疾病杂志,2004,12(3):200.
[16]邢英姿,王东海,侯庆军,等.突发性聋患者椎-基底动脉血流动力学观察[J].听力学及言语疾病杂志,2014,22(3):260-263.
[17]陈祥雷,张念武,赵丹,等.高血糖症对急性特发性感音神经性听力损失预后评估[J].中国医药导报,2018,15(12):114-116.