降钙素原对脑出血脑室外引流术后颅内感染的早期诊断价值
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摘要
目的:评价血清降钙素原(PCT)检测对于脑出血脑室外引流(External ventricular drainageEVD)术后颅内感染早期诊断的应用价值,为脑室外引流相关感染早期诊断提供参考依据。方法:选取高血压脑出血行脑室外引流的患者44例,确诊颅内感染的14例患者作为观察组,未发生术后颅内感染的30例患者为对照组,检测两组患者在特定时期血清降钙素原(PCT)、C-反应蛋白(CRP)、白细胞计数(WBC)水平进行比较分析。数据采用SPASS19.0软件进行统计分析。结果:观察组及对照组血清PCT、CRP、WBC、中性粒细胞比例水平比较,差异无统计学意义(P>0.05)。结论:血清PCT检测对于脑出血脑室外引流术后颅内感染早期诊断价值有限,需要结合脑脊液检查综合进行判定。
Objective To evaluate the application value of serum procalcitonin for the early diagnosis of intracranial infections after external ventricular drainage,for external ventricular drainage related infections provided a reference.Method 44 cases of patients of hypertension cerebral hemorrhage after external ventricular drainage were collected,they were divided into two groups:intracranial infection 14 patients as observation group,intracranial non-infection 30 patients as control group,detection of two groups of patients in a specific period of serum calcitonin(PCT),C-reactive protein(CRP) and white blood cell count(WBC) and comparative analysis.SPASS19.0 software was used for statistical analysis of the data.Results There was no significant difference in serum PCT,CRP,WBC,or neutrophil proportion between the observation group and the control group(P>0.05).Conclusion PCT detection of serum is of limited value in the early diagnosis of intracranial infection after intracranial drainage for intracranial hemorrhage,which needs to be determined by combining with cerebrospinal fluid examination.
Objective To evaluate the application value of serum procalcitonin for the early diagnosis of intracranial infections after external ventricular drainage,for external ventricular drainage related infections provided a reference.Method 44 cases of patients of hypertension cerebral hemorrhage after external ventricular drainage were collected,they were divided into two groups:intracranial infection 14 patients as observation group,intracranial non-infection 30 patients as control group,detection of two groups of patients in a specific period of serum calcitonin(PCT),C-reactive protein(CRP) and white blood cell count(WBC) and comparative analysis.SPASS19.0 software was used for statistical analysis of the data.Results There was no significant difference in serum PCT,CRP,WBC,or neutrophil proportion between the observation group and the control group(P>0.05).Conclusion PCT detection of serum is of limited value in the early diagnosis of intracranial infection after intracranial drainage for intracranial hemorrhage,which needs to be determined by combining with cerebrospinal fluid examination.
引文
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[9] 降钙素原急诊临床应用专家共识组.降钙素原(PCT)急诊临床应用的专家共识降钙素原(PCT)急诊临床应用的专家共识[J].中华急诊医学杂志,2012,21(9):944.
[10] 吴先华,汪勇军.血清降钙素原在开颅手术后颅内感染诊断及预后中的诊断价值[J].中国微生态学杂志,2014,44(2):178.
[11] Hoffmann O,Reuter U,Masuhr F,et al.Low sensitivity of serum procalcitonin in bacterial meningitis in adults[J].Scand J Infect Dis,2001,33(3):215.
[12] Martínez R,Gaul C,Buchfelder M,et al.Serum procalcitonin monitoring for differential diagnosis of ventriculitis in adult intensive care patients[J].Intensive Care Med,2002,28(2):208.
[13] Tomio R,Akiyama T,Shibao S,et al.Procalcitonin as an early diagnostic marker for ventriculoperitoneal shunt infections [J].Surgical Infections,2013,14(5):433.
[14] 郝京京,武元星,王强.神经外科术后颅内感染的危险因素及降钙素原等炎性标志物的诊断价值[J].临床神经外科杂志,2016,13(5):348.
[2] 周振军,孙新林,文平,等.探讨降钙素原在颅脑手术术后颅内感染的诊断价值[J].中华神经医学杂志,2013,6(12):621.
[3] 杨树源,张建宁.神经外科学[M].北京:人民卫生出版社,2015:1046-1047.
[4] 向昊,陈伟明.脑脊液降钙素原在颅内感染中的表达和意义[J].海南医学,2015,17(6):699.
[5] Kourbeti IS,Jacobs AV,Koslow M,et al.Risk factors associated with postcraniotomy meningitis[J].Neurosurgery,2007,60(2):317.
[6] 沈云龙,刘加令,漆松涛,等.脑室出血外引流术后继发颅内感染危险因素分析[J].中国神经精神疾病杂志,2015,41(12):705.
[7] 丛玉隆,王丁.当代检验分析技术与临床[M].北京:中国科学技术出版社,2002:273-274.
[8] 黄文锋.动态监测降钙素原对脑出血患者感染及预后判断的意义[J].吉林医学,2015,36(7):1344.
[9] 降钙素原急诊临床应用专家共识组.降钙素原(PCT)急诊临床应用的专家共识降钙素原(PCT)急诊临床应用的专家共识[J].中华急诊医学杂志,2012,21(9):944.
[10] 吴先华,汪勇军.血清降钙素原在开颅手术后颅内感染诊断及预后中的诊断价值[J].中国微生态学杂志,2014,44(2):178.
[11] Hoffmann O,Reuter U,Masuhr F,et al.Low sensitivity of serum procalcitonin in bacterial meningitis in adults[J].Scand J Infect Dis,2001,33(3):215.
[12] Martínez R,Gaul C,Buchfelder M,et al.Serum procalcitonin monitoring for differential diagnosis of ventriculitis in adult intensive care patients[J].Intensive Care Med,2002,28(2):208.
[13] Tomio R,Akiyama T,Shibao S,et al.Procalcitonin as an early diagnostic marker for ventriculoperitoneal shunt infections [J].Surgical Infections,2013,14(5):433.
[14] 郝京京,武元星,王强.神经外科术后颅内感染的危险因素及降钙素原等炎性标志物的诊断价值[J].临床神经外科杂志,2016,13(5):348.