骨化相关基因在椎间盘退行性变中的作用机制研究进展
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摘要
<正>椎间盘退行性变(IDD)是脊柱外科常见病和多发病,会引起一系列临床症状,是下腰痛及颈肩痛的主要原因,严重影响患者生活质量。IDD是一个多因素过程,包括基因因素、代谢和生物力学损伤等。发生退行性变的椎间盘会通过应力失衡、血供障碍、免疫反应、炎性因子介导等相关因素进一步导致相应症状及疾病的发生,而这些过程都
引文
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[8]Wuertz K,Haglund L.Inflammatory mediators in intervertebral disk degeneration and discogenic pain[J].Global Spine J,2013,3(3):175-184.
[9]Hao Z,Duncan GS,Seagal J,et al.Fas receptor expression in germinal-center B cells is essential for Tand B lymphocyte homeostasis[J].Immunity,2008,29(4):615-627.
[10]Hu B,Xu C,Cao P,et al.TGF-βstimulates expression of chondroitin polymerizing factor in nucleus pulposus cells through the Smad3,RhoA/ROCK1,and MAPKsignaling pathways[J].J Cell Biochem,2018,119(1):566-579.
[11]Tian Y,Yuan W,Fujita N,et al.Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1(ADAMTS-4)expression in nucleus pulposus cells through MAPK and NF-κB[J].Am J Pathol,2013,182(6):2310-2321.
[12]Ye W,Zhou J,Markova DZ,et al.Xylosyltransferase-1expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factorαand IL-1βin nucleus pulposus cells:novel regulation by AP-1,Sp1,and Sp3[J].Am J Pathol,2015,185(2):485-495.
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[15]Choi H,Tessier S,Silagi ES,et al.A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis[J].Matrix Biol,2018,70:102-122.
[16]Huang RL,Sun Y,Ho CK,et al.IL-6 potentiates BMP-2-induced osteogenesis and adipogenesis via two different BMPR1A-mediated pathways[J].Cell Death Dis,2018,9(2):144.
[17]马宗艳,蔡宏斌,葛朝明.晚期糖基化终末产物与阿尔茨海默病的关系[J].解放军医学杂志,2018,43(1):79-84.
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[19]Zieba J,Forlenza KN,Khatra JS,et al.TGFβand BMP dependent cell fate changes due to loss of filamin b produces disc degeneration and progressive vertebral fusions[J].PLoS Genet,2016,12(3):e1005936.
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[22]Komori T.Runx2,an inducer of osteoblast and chondrocyte differentiation[J].Histochem Cell Biol,2018,149(4):313-323.
[23]Genchi GG,Sinibaldi E,Ceseracciu L,et al.Ultrasoundactivated piezoelectric P(VDF-TrFE)/boron nitride nanotube composite films promote differentiation of human SaOS-2 osteoblast-like cells[J].Nanomedicine,2018,14(7):2421-2432.
[24]Sato S,Kimura A,Ozdemir J,et al.The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration:findings in murine models and in human disease[J].Arthritis Rheum,2008,58(9):2764-2775.
[25]Torkki M,Majuri ML,Wolff H,et al.Osteoclast activators are elevated in intervertebral disks with modic changes among patients operated for herniated nucleus pulposus[J].Eur Spine J,2016,25(1):207-216.
[26]Menini S,Iacobini C,Ricci C,et al.The galectin-3/RAGEdyad modulates vascular osteogenesis in atherosclerosis[J].Cardiovasc Res,2013,100(3):472-480.
[27]Wauquier A,van Sweden B,Lagaay AM,et al.Ambulatory monitoring of sleep-wakefulness patterns in healthy elderly males and females(greater than 88years):the“Senieur”protocol[J].J Am Geriatr Soc,1992,40(2):109-114.
[28]Minogue BM,Richardson SM,Zeef LA,et al.Transcriptional profiling of bovine intervertebral disc cells:implications for identification of normal and degenerate human intervertebral disc cell phenotypes[J].Arthritis Res Ther,2010,12(1):R22.
[29]Minogue BM,Richardson SM,Zeef LA,et al.Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation[J].Arthritis Rheum,2010,62(12):3695-705.
[30]Tomaszewski KA,Adamek D,Pasternak A,et al.Degeneration and calcification of the cervical endplate is connected with decreased expression of ANK,ENPP-1,OPN and TGF-β1 in the intervertebral disc[J].Pol JPathol,2014,65(3):210-217.
[31]Marfia G,Navone SE,Di Vito C,et al.Gene expression profile analysis of human mesenchymal stem cells from herniated and degenerated intervertebral discs reveals different expression of osteopontin[J].Stem Cells Dev,2015,24(3):320-328.
[32]Noponen-Hietala N,Kyll?nen E,M?nnikk?M,et al.Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis[J].Ann Rheum Dis,2003,62(12):1208-1214.
[33]白波,黄弘轩,黄芳立,等.人骨形态蛋白-2可调控系统在大鼠骨髓间充质干细胞的表达[J].中华关节外科杂志(电子版),2017,11(6):622-628.
[34]Pan Y,Chen J,Yu Y,et al.Enhancement of BMP-2-mediated angiogenesis and osteogenesis by 2-N,6-O-sulfated chitosan in bone regeneration[J].Biomater Sci,2018,6(2):431-439.
[35]Trost Z,Trebse R,Prezelj J,et al.A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts[J].Bone,2010,46(1):72-80.
[36]潘欣,梁兴伦,曾思良,等.补肾方含药血清干预大鼠椎间盘软骨细胞miRNA的差异表达[J].上海中医药杂志,2016,50(1):65-69.
[37]孙传海,吕刚.基质金属蛋白酶及其抑制剂与椎间盘退变、突出及吸收的关系[J].中华骨科杂志,2001(10):50-52.
[2]顾韬,王新伟,袁文,等.颈椎间盘与后纵韧带上交感神经的解剖学观察及在颈椎间盘源性疼痛中作用的探讨[J].脊柱外科杂志,2008,6(1):36-39.
[3]Iwata M,Aikawa T,Hakozaki T,et al.Enhancement of Runx2 expression is potentially linked toβ-catenin accumulation in canine intervertebral disc degeneration[J].J Cell Physiol,2015,230(1):180-190.
[4]Wang Y,Jiang L,Dai G,et al.Bioinformatics analysis reveals different gene expression patterns in the annulus fibrosis and nucleus pulpous during intervertebral disc degeneration[J].Exp Ther Med,2018,16(6):5031-5040.
[5]Markova DZ,Kepler CK,Addya S,et al.An organ culture system to model early degenerative changes of the intervertebral discⅡ:profiling global gene expression changes[J].Arthritis Res Ther,2013,15(5):R121.
[6]Hoyland JA,Le Maitre C,Freemont AJ.Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc[J].Rheumatology(Oxford),2008,47(6):809-814.
[7]Deng X,Zhao F,Kang B,et al.Elevated interleukin-6expression levels are associated with intervertebral disc degeneration[J].Exp Ther Med,2016,11(4):1425-1432.
[8]Wuertz K,Haglund L.Inflammatory mediators in intervertebral disk degeneration and discogenic pain[J].Global Spine J,2013,3(3):175-184.
[9]Hao Z,Duncan GS,Seagal J,et al.Fas receptor expression in germinal-center B cells is essential for Tand B lymphocyte homeostasis[J].Immunity,2008,29(4):615-627.
[10]Hu B,Xu C,Cao P,et al.TGF-βstimulates expression of chondroitin polymerizing factor in nucleus pulposus cells through the Smad3,RhoA/ROCK1,and MAPKsignaling pathways[J].J Cell Biochem,2018,119(1):566-579.
[11]Tian Y,Yuan W,Fujita N,et al.Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1(ADAMTS-4)expression in nucleus pulposus cells through MAPK and NF-κB[J].Am J Pathol,2013,182(6):2310-2321.
[12]Ye W,Zhou J,Markova DZ,et al.Xylosyltransferase-1expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factorαand IL-1βin nucleus pulposus cells:novel regulation by AP-1,Sp1,and Sp3[J].Am J Pathol,2015,185(2):485-495.
[13]Imai Y,Okuma M,An HS,et al.Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC[J].Spine(Phila Pa 1976),2007,32(11):1197-1205.
[14]Illien-Jünger S,Torre OM,Kindschuh WF,et al.AGEs induce ectopic endochondral ossification in intervertebral discs[J].Eur Cell Mater,2016,32:257-270.
[15]Choi H,Tessier S,Silagi ES,et al.A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis[J].Matrix Biol,2018,70:102-122.
[16]Huang RL,Sun Y,Ho CK,et al.IL-6 potentiates BMP-2-induced osteogenesis and adipogenesis via two different BMPR1A-mediated pathways[J].Cell Death Dis,2018,9(2):144.
[17]马宗艳,蔡宏斌,葛朝明.晚期糖基化终末产物与阿尔茨海默病的关系[J].解放军医学杂志,2018,43(1):79-84.
[18]Ye S,Ju B,Wang H,et al.Bone morphogenetic protein-2 provokes interleukin-18-induced human intervertebral disc degeneration[J].Bone Joint Res,2016,5(9):412-418.
[19]Zieba J,Forlenza KN,Khatra JS,et al.TGFβand BMP dependent cell fate changes due to loss of filamin b produces disc degeneration and progressive vertebral fusions[J].PLoS Genet,2016,12(3):e1005936.
[20]Yeh CH,Jin L,Shen F,et al.miR-221 attenuates the osteogenic differentiation of human annulus fibrosus cells[J].Spine J,2016,16(7):896-904.
[21]Bach FC,Miranda-Bedate A,van Heel FW,et al.Bone morphogenetic protein-2,but not mesenchymal stromal cells,exert regenerative effects on canine and human nucleus pulposus cells[J].Tissue Eng Part A,2017,23(5-6):233-242.
[22]Komori T.Runx2,an inducer of osteoblast and chondrocyte differentiation[J].Histochem Cell Biol,2018,149(4):313-323.
[23]Genchi GG,Sinibaldi E,Ceseracciu L,et al.Ultrasoundactivated piezoelectric P(VDF-TrFE)/boron nitride nanotube composite films promote differentiation of human SaOS-2 osteoblast-like cells[J].Nanomedicine,2018,14(7):2421-2432.
[24]Sato S,Kimura A,Ozdemir J,et al.The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration:findings in murine models and in human disease[J].Arthritis Rheum,2008,58(9):2764-2775.
[25]Torkki M,Majuri ML,Wolff H,et al.Osteoclast activators are elevated in intervertebral disks with modic changes among patients operated for herniated nucleus pulposus[J].Eur Spine J,2016,25(1):207-216.
[26]Menini S,Iacobini C,Ricci C,et al.The galectin-3/RAGEdyad modulates vascular osteogenesis in atherosclerosis[J].Cardiovasc Res,2013,100(3):472-480.
[27]Wauquier A,van Sweden B,Lagaay AM,et al.Ambulatory monitoring of sleep-wakefulness patterns in healthy elderly males and females(greater than 88years):the“Senieur”protocol[J].J Am Geriatr Soc,1992,40(2):109-114.
[28]Minogue BM,Richardson SM,Zeef LA,et al.Transcriptional profiling of bovine intervertebral disc cells:implications for identification of normal and degenerate human intervertebral disc cell phenotypes[J].Arthritis Res Ther,2010,12(1):R22.
[29]Minogue BM,Richardson SM,Zeef LA,et al.Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation[J].Arthritis Rheum,2010,62(12):3695-705.
[30]Tomaszewski KA,Adamek D,Pasternak A,et al.Degeneration and calcification of the cervical endplate is connected with decreased expression of ANK,ENPP-1,OPN and TGF-β1 in the intervertebral disc[J].Pol JPathol,2014,65(3):210-217.
[31]Marfia G,Navone SE,Di Vito C,et al.Gene expression profile analysis of human mesenchymal stem cells from herniated and degenerated intervertebral discs reveals different expression of osteopontin[J].Stem Cells Dev,2015,24(3):320-328.
[32]Noponen-Hietala N,Kyll?nen E,M?nnikk?M,et al.Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis[J].Ann Rheum Dis,2003,62(12):1208-1214.
[33]白波,黄弘轩,黄芳立,等.人骨形态蛋白-2可调控系统在大鼠骨髓间充质干细胞的表达[J].中华关节外科杂志(电子版),2017,11(6):622-628.
[34]Pan Y,Chen J,Yu Y,et al.Enhancement of BMP-2-mediated angiogenesis and osteogenesis by 2-N,6-O-sulfated chitosan in bone regeneration[J].Biomater Sci,2018,6(2):431-439.
[35]Trost Z,Trebse R,Prezelj J,et al.A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts[J].Bone,2010,46(1):72-80.
[36]潘欣,梁兴伦,曾思良,等.补肾方含药血清干预大鼠椎间盘软骨细胞miRNA的差异表达[J].上海中医药杂志,2016,50(1):65-69.
[37]孙传海,吕刚.基质金属蛋白酶及其抑制剂与椎间盘退变、突出及吸收的关系[J].中华骨科杂志,2001(10):50-52.