头孢他啶联合氨茶碱治疗慢性阻塞性肺气肿的疗效及对血清IGF-1、α1-AT、PDGF-B水平的影响
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摘要
目的:探讨头孢他啶联合氨茶碱治疗慢性阻塞性肺气肿(COPD)的临床疗效及对患者血清胰岛素样生长因子-1(IGF-1)、血清α1-抗胰蛋白酶(α1-AT)、血小板衍生生长因子-B(PDGF-B)水平的影响。方法:选择我院2015年4月至2018年4月收治的154例慢性阻塞性肺气肿作为研究对象,采用随机数字表法将其分为观察组与对照组。对照组采用头孢他啶治疗,观察组在对照组基础上加用氨茶碱联合治疗。对比两组患者的临床疗效、治疗前后血清IGF-1、α1-AT、PDGF-B水平的变化及不良反应的发生情况。结果:治疗后,观察组与对照组临床疗效总有效率分别为94.80%和71.43%,观察组显著高于对照组(P<0.05);观察组血清IGF-1、PDGF-B水平均显著低于对照组[(110.67±13.58) vs.(143.17±15.74)ng/ml、(128.67±15.33) vs.(247.69±30.17)ng/L],而血清α1-AT水平明显高于对照组[(2.79±0.43) vs.(1.77±0.46)g/L](P<0.05);观察组与对照组不良反应率分别为5.19%和50.64%,观察组明显低于对照组(P<0.05)。结论:综上所述,头孢他啶联合氨茶碱治疗COPD的临床疗效和安全性均显著优于单用头孢他啶治疗,可能与其有效降低COPD患者血清PDGF-B、IGF-1,明显提高血清α1-AT水平有关。
Objective: To investigate the clinical efficacy of ceftazidime combined with aminophylline in the treatment of chronic obstructive emphysema and the effect on the serum insulin-like growth factor-1, serum 1-antitrypsin and platelet-derived growth factor-b levels. Methods: 154 cases of patients with chronic obstructive emphysema admitted to our hospital from April 2015 to April 2018 were selected and were divided into the observation group and the control group by random number table method. The control group was treated with ceftazidime, and the observation group was treated with aminophylline on the basis of control group. The clinical efficacy, changes of serum IGF-1, α1-AT and PDGF-B levels before and after treatment and the occurrence of adverse reactions were compared between the two groups. Results: After treatment, the total effective rates of observation group and the control group were 94.80% and 71.43% respectively, and which was significantly higher in the the observation group than that of the control group(P<0.05). The serum IGF-1 and PDGF-B levels in the observation group were significantly lower than those in the control group [(110.67 13.58) vs.(143.17 15.74)ng/mL,(128.67 15.33) vs.(247.69 30.17)ng/L], while serum α1-AT level was significantly higher than that in the control group [(2.79 0.43) vs.(1.77 0.46)g/L](P<0.05). The incidence of adverse reactions in the observation group and the control group were 5.19% and 50.64% respectively, which were significantly lower in the observation group than that of the control group(P<0.05). Conclusion: The clinical efficacy and safety of ceftazidime combined with aminophylline in the treatment of COPD are significantly better than that of ceftazidime alone, which may be related to the effective reduction of serum PDGF-B and IGF-1 levels and the significant increase of serum α1-AT level.
Objective: To investigate the clinical efficacy of ceftazidime combined with aminophylline in the treatment of chronic obstructive emphysema and the effect on the serum insulin-like growth factor-1, serum 1-antitrypsin and platelet-derived growth factor-b levels. Methods: 154 cases of patients with chronic obstructive emphysema admitted to our hospital from April 2015 to April 2018 were selected and were divided into the observation group and the control group by random number table method. The control group was treated with ceftazidime, and the observation group was treated with aminophylline on the basis of control group. The clinical efficacy, changes of serum IGF-1, α1-AT and PDGF-B levels before and after treatment and the occurrence of adverse reactions were compared between the two groups. Results: After treatment, the total effective rates of observation group and the control group were 94.80% and 71.43% respectively, and which was significantly higher in the the observation group than that of the control group(P<0.05). The serum IGF-1 and PDGF-B levels in the observation group were significantly lower than those in the control group [(110.67 13.58) vs.(143.17 15.74)ng/mL,(128.67 15.33) vs.(247.69 30.17)ng/L], while serum α1-AT level was significantly higher than that in the control group [(2.79 0.43) vs.(1.77 0.46)g/L](P<0.05). The incidence of adverse reactions in the observation group and the control group were 5.19% and 50.64% respectively, which were significantly lower in the observation group than that of the control group(P<0.05). Conclusion: The clinical efficacy and safety of ceftazidime combined with aminophylline in the treatment of COPD are significantly better than that of ceftazidime alone, which may be related to the effective reduction of serum PDGF-B and IGF-1 levels and the significant increase of serum α1-AT level.
引文
[1]Lee H,Hong Y,Lim MN,et al.Inflammatory biomarkers and radiologic measurements in never-smokers with COPD:A cross-sectional study from the CODA cohort[J].Chronic respiratory disease,2018,15(2):138-145
[2]Bon J,Zhang Y,Leader JK,et al.Radiographic Emphysema,Circulating Bone Biomarkers,and Progressive Bone Mineral Density Loss in Smokers[J].Annals of the American Thoracic Society,2018,15(5):615-621
[3]Tong L,Qi G.Crocin prevents platelet derived growth factor BB induced vascular smooth muscle cells proliferation and phenotypic switch[J].Molecular medicine reports,2018,17(6):7595-7602
[4]Bhatt SP,Kim YI,Harrington KF,et al.Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years[J].Thorax,2018,73(5):414-421
[5]Singh P,Kim YJ,Nguyen NL,et al.Cupriavidus yeoncheonense sp nov.,isolated from soil of ginseng[J].Antonie van Leeuwenhoek2015,107(3):749-758
[6]Wen X,Su J,Cui L,et al.Distribution and drug resistance of the pathogenic bacteria from sputum specimens of 1 125 children with tracheo bronchial foreign bodies[J].Zh onghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2015,50(2):155-157
[7]Voskrebenzev A,Gutberlet M,Klime觢F,et al.Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung(PREFUL)MRI in healthy volunteers and COPD,CTEPH,and CF patients[J].Magnetic resonance in medicine,2018,79(4):2306-2314
[8]Takamochi K,Nojiri S,Oh S,et al.Comparison of digital and traditional thoracic drainage systems for postoperative chest tube management after pulmonary resection:A prospective randomized trial[J].The Journal of thoracic and cardiovascular surgery,2018,155(4):1834-1840
[9]Copeland CR,Nath H,Terry NLJ,et al.Paratracheal Paraseptal Emphysema and Expiratory Central Airway Collapse in Smokers[J].Annals of the American Thoracic Society,2018,15(4):479-484
[10]Park SK.Trajectories of change in cognitive function in people with chronic obstructive pulmonary disease[J].Journal of clinical nursing,2018,27(7-8):1529-1542
[11]Kyung SY,Kim YJ,Son ES,et al.The Phosphodiesterase 4 Inhibitor Roflumilast Protects against Cigarette Smoke Extract-Induced Mitophagy-Dependent Cell Death in Epithelial Cells[J].Tuberculosis and respiratory diseases,2018,81(2):138-147
[12]Windisch W,Criée CP.OPD-Importance of Lung Function Testing for Diagnosis and Treatment[J].Deutsche medizinische Wochenschrift(1946),2018,143(8):593-596
[13]Bodduluri S,Reinhardt JM,Hoffman EA,et al.Recent Advances in Computed Tomography Imaging in Chronic Obstructive Pulmonary Disease[J].Annals of the American Thoracic Society,2018,15(3):281-289
[14]Louren觭o JD,Ito JT.The tick-derived r Bm TI-A protease inhibitor attenuates the histological and functional changes induced by cigarette smoke exposure[J].Histology and histopathology,2018,33(3):289-298
[15]Welling JBA,Hartman JE,van Rikxoort EM,et al.Minimal important difference of target lobar volume reduction after endobronchial valve treatment for emphysema[J].Respirology(Carlton,Vic.),2018,23(3):306-310
[16]Sears CR,Zhou H,Justice MJ,et al.Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development[J].American journal of respiratory cell and molecular biology,2018,58(3):402-411
[17]Melzer AC,Clothier BA,Japuntich SJ,et al.Comparative Effectiveness of Proactive Tobacco Treatment among Smokers with and without Chronic Lower Respiratory Disease[J].Annals of the American Thoracic Society,2018,15(3):341-347
[18]Biswas A,Mehta HJ,Folch EE.Chronic obstructive pulmonary disease and lung cancer:inter-relationships[J].Current opinion in pulmonary medicine,2018,24(2):152-160
[19]Sergio LPS,Lucinda LMF,Reboredo MM,et al.Emphysema induced by elastase alters the m RNA relative levels from DNA repair genes in acute lung injury in response to sepsis induced by lipopolysaccharide administration in Wistar rats[J].Experimental lung research,2018,44(2):79-88
[20]Sakamoto N,Tsuchiya K,Hikone M.Community-acquired necrotizing pneumonia with bacteremia caused by Pseudomonas aeruginosa in a patient with emphysema:An autopsy case report[J].Respiratory investigation,2018,56(2):189-194
[21]Onishi M,Kobayashi T,D'Alessandro-Gabazza CN,et al.Mice overexpressing latent matrix metalloproteinase-2 develop lung emphysema after short-term exposure to cigarette smoke extract[J].Biochemical and biophysical research communications,2018,497(1):332-338
[22]Saint GL,Semple MG,Sinha I,et al.Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children[J].Paediatric drugs,2018,20(3):209-214
[23]Megaly M,Sandoval Y,Lillyblad MP,et al.Aminophylline for Preventing Bradyarrhythmias During Orbital or Rotational Atherectomy of the Right Coronary Artery[J].The Journal of invasive cardiology,2018,30(5):186-189
[24]Leow EH,Chan YH,Ng YH,et al.Prevention of Acute Kidney Injury in Children Undergoing Cardiac Surgery:A Narrative Review[J].World journal for pediatric&congenital heart surgery,2018,9(1):79-90
[25]Chiloiro S,Mazziotti G,Giampietro A,et al.Effects of pegvisomant and somatostatin receptor ligands on incidence of vertebral fractures in patients with acromegaly[J].Pituitary,2018,21(3):302-308
[26]Zelazowska-Rutkowska B,Trusiak M,Bossowski A,et al.Diagnostic Usefulness of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor Binding Protein 3 in Children with Suspected Pituitary Dwarfism[J].Clinical laboratory,2018,64(5):759-765
[27]Prandina A,Herfindal L,Radix S,et al.Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles[J].Journal of enzyme inhibition and medicinal chemistry,2018,33(1):370-375
[28]Wang B,Liu T,Wu Z,Zhang L,et al.Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents[J].Journal of enzyme inhibition and medicinal chemistry,2018,33(1):416-423
[29]Kadivar A,Ibrahim Noordin M,Aditya A,et al.Antiproliferative effects of imatinib mesylate on ZR-75-1 and MDA-MB-231 cell lines via PDGFRβ,PDGF BB,c Kit and SCF expression[J].International journal of molecular medicine,2018,42(1):414-424
[30]Jansson S,Aaltonen K,Bendahl PO,et al.The PDGF pathway in breast cancer is linked to tumour aggressiveness,triple-negative subtype and early recurrence[J].Breast cancer research and treatment,2018,169(2):231-241
[2]Bon J,Zhang Y,Leader JK,et al.Radiographic Emphysema,Circulating Bone Biomarkers,and Progressive Bone Mineral Density Loss in Smokers[J].Annals of the American Thoracic Society,2018,15(5):615-621
[3]Tong L,Qi G.Crocin prevents platelet derived growth factor BB induced vascular smooth muscle cells proliferation and phenotypic switch[J].Molecular medicine reports,2018,17(6):7595-7602
[4]Bhatt SP,Kim YI,Harrington KF,et al.Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years[J].Thorax,2018,73(5):414-421
[5]Singh P,Kim YJ,Nguyen NL,et al.Cupriavidus yeoncheonense sp nov.,isolated from soil of ginseng[J].Antonie van Leeuwenhoek2015,107(3):749-758
[6]Wen X,Su J,Cui L,et al.Distribution and drug resistance of the pathogenic bacteria from sputum specimens of 1 125 children with tracheo bronchial foreign bodies[J].Zh onghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2015,50(2):155-157
[7]Voskrebenzev A,Gutberlet M,Klime觢F,et al.Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung(PREFUL)MRI in healthy volunteers and COPD,CTEPH,and CF patients[J].Magnetic resonance in medicine,2018,79(4):2306-2314
[8]Takamochi K,Nojiri S,Oh S,et al.Comparison of digital and traditional thoracic drainage systems for postoperative chest tube management after pulmonary resection:A prospective randomized trial[J].The Journal of thoracic and cardiovascular surgery,2018,155(4):1834-1840
[9]Copeland CR,Nath H,Terry NLJ,et al.Paratracheal Paraseptal Emphysema and Expiratory Central Airway Collapse in Smokers[J].Annals of the American Thoracic Society,2018,15(4):479-484
[10]Park SK.Trajectories of change in cognitive function in people with chronic obstructive pulmonary disease[J].Journal of clinical nursing,2018,27(7-8):1529-1542
[11]Kyung SY,Kim YJ,Son ES,et al.The Phosphodiesterase 4 Inhibitor Roflumilast Protects against Cigarette Smoke Extract-Induced Mitophagy-Dependent Cell Death in Epithelial Cells[J].Tuberculosis and respiratory diseases,2018,81(2):138-147
[12]Windisch W,Criée CP.OPD-Importance of Lung Function Testing for Diagnosis and Treatment[J].Deutsche medizinische Wochenschrift(1946),2018,143(8):593-596
[13]Bodduluri S,Reinhardt JM,Hoffman EA,et al.Recent Advances in Computed Tomography Imaging in Chronic Obstructive Pulmonary Disease[J].Annals of the American Thoracic Society,2018,15(3):281-289
[14]Louren觭o JD,Ito JT.The tick-derived r Bm TI-A protease inhibitor attenuates the histological and functional changes induced by cigarette smoke exposure[J].Histology and histopathology,2018,33(3):289-298
[15]Welling JBA,Hartman JE,van Rikxoort EM,et al.Minimal important difference of target lobar volume reduction after endobronchial valve treatment for emphysema[J].Respirology(Carlton,Vic.),2018,23(3):306-310
[16]Sears CR,Zhou H,Justice MJ,et al.Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development[J].American journal of respiratory cell and molecular biology,2018,58(3):402-411
[17]Melzer AC,Clothier BA,Japuntich SJ,et al.Comparative Effectiveness of Proactive Tobacco Treatment among Smokers with and without Chronic Lower Respiratory Disease[J].Annals of the American Thoracic Society,2018,15(3):341-347
[18]Biswas A,Mehta HJ,Folch EE.Chronic obstructive pulmonary disease and lung cancer:inter-relationships[J].Current opinion in pulmonary medicine,2018,24(2):152-160
[19]Sergio LPS,Lucinda LMF,Reboredo MM,et al.Emphysema induced by elastase alters the m RNA relative levels from DNA repair genes in acute lung injury in response to sepsis induced by lipopolysaccharide administration in Wistar rats[J].Experimental lung research,2018,44(2):79-88
[20]Sakamoto N,Tsuchiya K,Hikone M.Community-acquired necrotizing pneumonia with bacteremia caused by Pseudomonas aeruginosa in a patient with emphysema:An autopsy case report[J].Respiratory investigation,2018,56(2):189-194
[21]Onishi M,Kobayashi T,D'Alessandro-Gabazza CN,et al.Mice overexpressing latent matrix metalloproteinase-2 develop lung emphysema after short-term exposure to cigarette smoke extract[J].Biochemical and biophysical research communications,2018,497(1):332-338
[22]Saint GL,Semple MG,Sinha I,et al.Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children[J].Paediatric drugs,2018,20(3):209-214
[23]Megaly M,Sandoval Y,Lillyblad MP,et al.Aminophylline for Preventing Bradyarrhythmias During Orbital or Rotational Atherectomy of the Right Coronary Artery[J].The Journal of invasive cardiology,2018,30(5):186-189
[24]Leow EH,Chan YH,Ng YH,et al.Prevention of Acute Kidney Injury in Children Undergoing Cardiac Surgery:A Narrative Review[J].World journal for pediatric&congenital heart surgery,2018,9(1):79-90
[25]Chiloiro S,Mazziotti G,Giampietro A,et al.Effects of pegvisomant and somatostatin receptor ligands on incidence of vertebral fractures in patients with acromegaly[J].Pituitary,2018,21(3):302-308
[26]Zelazowska-Rutkowska B,Trusiak M,Bossowski A,et al.Diagnostic Usefulness of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor Binding Protein 3 in Children with Suspected Pituitary Dwarfism[J].Clinical laboratory,2018,64(5):759-765
[27]Prandina A,Herfindal L,Radix S,et al.Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles[J].Journal of enzyme inhibition and medicinal chemistry,2018,33(1):370-375
[28]Wang B,Liu T,Wu Z,Zhang L,et al.Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents[J].Journal of enzyme inhibition and medicinal chemistry,2018,33(1):416-423
[29]Kadivar A,Ibrahim Noordin M,Aditya A,et al.Antiproliferative effects of imatinib mesylate on ZR-75-1 and MDA-MB-231 cell lines via PDGFRβ,PDGF BB,c Kit and SCF expression[J].International journal of molecular medicine,2018,42(1):414-424
[30]Jansson S,Aaltonen K,Bendahl PO,et al.The PDGF pathway in breast cancer is linked to tumour aggressiveness,triple-negative subtype and early recurrence[J].Breast cancer research and treatment,2018,169(2):231-241