多酚类化合物与其他活性物质协同作用研究进展
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摘要
多酚类化合物是一类广泛存在于可食性植物中的次生代谢产物,因其具有抗氧化、抗病毒、抗肿瘤、抗衰老等功能,引起医药、食品等多领域的关注。近年来与多酚类化合物协同作用有关的研究逐渐增加。本文总结了近期相关多酚物质协同作用的国内外研究报道,对多酚类化合物与其他物质如VC、多糖之间在工业、食品生产以及医药三个方面协同抗氧化、抑菌、保鲜、抗辐射、抗癌、降血糖、抗炎七个方面的作用及其机制进行综述。
Polyphenolic compounds are a class of secondary metabolites widely found in edible plants. Because of its good antioxidant,anti-viral,anti-tumor,anti-aging and other functions,it has attracted attention in many fields such as medicine and food. In recent years,research related to the synergy of polyphenolic compounds had gradually increased. This article reviewed the synergistic effect and mechanism of polyphenols and other substances such as VCand polysaccharides in industry,food production and medicine from seven aspects: Antioxidation,bacteriostasis,preservation,antiradiation,anti-inflammatory,hypoglycemic and anticancer.
Polyphenolic compounds are a class of secondary metabolites widely found in edible plants. Because of its good antioxidant,anti-viral,anti-tumor,anti-aging and other functions,it has attracted attention in many fields such as medicine and food. In recent years,research related to the synergy of polyphenolic compounds had gradually increased. This article reviewed the synergistic effect and mechanism of polyphenols and other substances such as VCand polysaccharides in industry,food production and medicine from seven aspects: Antioxidation,bacteriostasis,preservation,antiradiation,anti-inflammatory,hypoglycemic and anticancer.
引文
[1]姜楠,王蒙,韦迪哲,等.植物多酚类物质研究进展[J].食品安全质量检测学报,2016,7(2):439-444.
[2]蒋晨凤.水解对槟榔多酚抗氧化活性的影响及多酚协同抗氧化特性研究[D].长沙:湖南农业大学,2016.
[3]姚莉,蒋爱民,杨承鸿,等.乌龙茶多糖和多酚对肝癌细胞Hep G2的协同抑制作用[J].动物医学进展,2018,39(7):55-58.
[4]李蕊.茶多酚与维生素协同作用对食用油脂抗氧化活性的影响[D].西安:西北农林科技大学,2014.
[5]姚远,董庆利,叶维,等.乳酸钠、茶多酚与壳聚糖协同抑制铜绿假单胞菌的效果[J].生物加工过程,2014,12(4):60-65.
[6]孟旭,刘学波.茶多酚协同荷叶碱的抗氧化活性及其对结肠癌细胞的抑制作用[J].食品科学,2014,35(19):119-124.
[7]吕旭聪.菌草灵芝多糖的分离纯化及其与茶多酚抗氧化协同作用研究[A].中国食品科学技术学会第十一届年会论文摘要集[C].中国食品科学技术学会,2014:2.
[8]孙世利,刘淑媚,赵超艺,等.茶多酚与维生素C/E的协同抗氧化作用研究[J].广东农业科学,2013,40(1):96-98.
[9]Fang Dai,Wei-Feng Chen,Bo Zhou.Antioxidant synergism of green tea polyphenols withα-tocopherol and l-ascorbic acid in SDS micelles[J].Biochimie,2008,90(10):1499-1505.
[10]王绪英,王婉婷,茶多酚与类胡萝卜素的协同抗氧化作用[J].食品研究与开发,2015,36(17):44-47.
[11]林美容,刘晓艳,杜劲松,等.茶多酚与竹荪、海带提取物的抗氧化协同效应[J].食品工业,2015,36(4):181-185.
[12]刘晓娟,何凤林,赵力超,等.番薯提取液与茶多酚、葛根黄酮对PC12细胞的协同抗氧化研究[J].现代食品科技,2015,31(12):14-18.
[13]唐煜括,左聪聪,李佳笑,等.汉中仙毫茶多酚与维生素C抗氧化及抑菌活性的协同作用[J].食品科学技术学报,2017,35(3):55-60.
[14]刘晓慧,孟庆,李伟,等.茶多酚类化合物与维生素协同抗氧化机理研究进展[J].热带作物学报,2012,33(12):2305-2310.
[15]樊梓鸾,林秀芳,王振宇.黑木耳多糖与浆果多酚的协同抗氧化研究[J].现代食品科技,2015,31(12):166-171,55.
[16]付慧,杨萍,汪秋宽.茶多酚的制备及其抑菌活性的研究[J].食品科技,2012,37(6):273-276.
[17]黄诗琪,冯卫华,于立梅,等.香椿多酚抑菌特性研究[J].食品科技,2013,38(11):212-216.
[18]李建慧,马会勤,陈尚武.葡萄多酚抑菌效果的研究[J].中国食品学报,2008(2):100-107.
[19]黄和,林晓霞,邝高波,等.番石榴多酚成分分析及抑菌活性研究[J].热带作物学报,2014,35(12):2482-2487.
[20]孙红男,孙爱东,苏雅静,等.苹果多酚抑菌效果的研究[J].北京林业大学学报,2010,32(4):280-283.
[21]Sudano Roccaro A,Blanco A R,Giuliano F,et al.Epigallocatechin-gallate enhances the activity of tetracycline in staphylococci by inhibiting its efflux from bacterial cells[J].Antimicrobial Agents and Chemotherapy,2004,48(6):1968-1973.
[22]Haghjoo B,Lee L H,Habiba U,et al.The synergistic effects of green tea polyphenols and antibiotics against potential pathogens[J].Advances in Bioscience and Biotechnology,2013,4:959-967.
[23]Fanaki N H,Kassem M A,Fawzi M A,et al.Influence of aqueous green tea extract on the antimicrobial activity of some antibiotics against multiresistant clinical isolates[J].Egyptian Journal of Medical Microbiology,2008,17:449-460.
[24]Cui Y,Kim S H,Kim H,et al.AFM probing the mechanism of synergistic effects of the green tea polyphenol(-)-epigallocatechin-3-gallate(EGCG)with cefotaxime against extended-spectrum beta-lactamase(ESBL)-producing Escherichia coli[J].Plos One,2012,7(11):e48880.
[25]Passat D N.Interactions of black and green tea water extracts with antibiotics activity in local urinary isolated Escherichia coli[J].Journal of Al Nahrain University,2012,15:134-142.
[26]Tsao R.13-synergistic interactions between antioxidants used in food preservation[J].Handbook of Antioxidants for Food Preservation,2015:335-347.
[27]彭乃才.茶多酚对肉品保鲜的机理及其应用研究[J].肉类工业,2015(5):47-50.
[28]骆扬,鲁才秀.香蕉皮多糖与茶多酚复配对卤牛肉的保鲜研究[J].肉类工业,2015(8):41-45.
[29]张立彦,贾艳花,芮汉明.壳聚糖和茶多酚对鸡肉的保鲜效果及复合保鲜条件的优选[J].食品与发酵工业,2011,37(12):177-182.
[30]庞克华.枸杞多糖对体外培养脊髓神经细胞辐射损伤所诱导自噬的影响[D].银川:宁夏医科大学,2018.
[31]郭娜,孙云朝,张艳景,等.山楂水提取物对辐射损伤小鼠遗传生殖系统影响[J].中华肿瘤防治杂志,2017,24(22):1563-1567.
[32]陈萃,孙可,耿珊,等.人参皂苷Rg1对辐射致造血干/祖细胞衰老的影响及其机制[J].中国生物制品学杂志,2013,26(11):1604-1609,1616.
[33]张雪岩,彭瑞云,高亚兵,等.黄芪总苷对微波辐射致大鼠心脏损伤的保护作用研究[J].中国体视学与图像分析,2018,23(2):189-197.
[34]刘冰.白藜芦醇二聚体Vam3和褪黑素衍生物ZZW1对免疫系统辐射损伤防护作用研究[D].北京:北京协和医学院,2016.
[35]薛晓蕾.抗氧化剂对辐射诱导小鼠造血系统损伤的防护作用及机制研究[D].北京:北京协和医学院,2017.
[36]白海娜.黑木耳多糖AAP-4与原花青素对辐射诱导氧化损伤协同防护作用[D].哈尔滨:哈尔滨工业大学,2016.
[37]张乃珣,王振宇,尹红力,等.红松多酚和黑木耳多糖对辐射诱导小鼠氧化损伤的防护作用[J].营养学报,2016,38(3):278-284.
[38]王清吉,王友绍,何磊,等.茶多酚和银杏叶有效成分的抗辐射作用研究[J].核技术,2004(2):148-150.
[39]Marion Man-Ying Chan,John A Mattiacci,Hyon S Hwang,et al.Synergy between ethanol and grape polyphenols,quercetin,and resveratrol,in the inhibition of the inducible nitric oxide synthase pathway[J].Biochemical Pharmacology,2000,60(10):1539-1548.
[40]谈宁芝.灵芝提取物Reishi Max对S180瘤小鼠的抗肿瘤作用和Reishi Max与绿茶多酚Tegreen抗肿瘤的协同作用研究[A].全国药用真菌学术研讨会论文集[C].中国菌物学会药用真菌专业委员会,2008:7.
[41]Yang Jun,Liu Rui Hai.Synergistic effect of apple extracts and quercetin 3-β-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells in vitro[J].Agric Food Chem,2009,57(18):8581-8586.
[42]仇菊,朱宏,卢林纲.葡萄籽多酚对糖尿病大鼠的降血糖作用及其机制[J].食品科学,2018,39(1):226-231.
[43]Martha Estrella García-Pérez,Pierre Betu Kasangana,Tatjana Stevanovic.Bioactive polyphenols for diabetes and inflammation in psoriasis disease[J].Studies in Natural Products Chemistry,2017,52:231-268.
[44]李星亚,汪东风,王林戈,等.茶多糖和茶多酚对糖尿病的协同防治作用[J].食品研究与开发,2013,34(11):72-76.
[45]王林戈.绿茶茶多糖与茶多酚对胰岛细胞的协同保护作用研究[D].青岛:中国海洋大学,2011.
[46]韦芳媚,陈春,李超,等.桑叶提取物、茶多酚及其复配物的抗氧化和降血糖活性[J].食品工业科技,2018,39(21):299-305.
[47]祖元刚,胡艳,姜守刚.红松多酚物质的提取工艺及其抗炎活性初步研究[J].植物研究,2016,36(4):634-640.
[48]张波.苹果中含有的几种多酚类化合物抗氧化及抗炎症活性研究[D].泰安:山东农业大学,2015.
[2]蒋晨凤.水解对槟榔多酚抗氧化活性的影响及多酚协同抗氧化特性研究[D].长沙:湖南农业大学,2016.
[3]姚莉,蒋爱民,杨承鸿,等.乌龙茶多糖和多酚对肝癌细胞Hep G2的协同抑制作用[J].动物医学进展,2018,39(7):55-58.
[4]李蕊.茶多酚与维生素协同作用对食用油脂抗氧化活性的影响[D].西安:西北农林科技大学,2014.
[5]姚远,董庆利,叶维,等.乳酸钠、茶多酚与壳聚糖协同抑制铜绿假单胞菌的效果[J].生物加工过程,2014,12(4):60-65.
[6]孟旭,刘学波.茶多酚协同荷叶碱的抗氧化活性及其对结肠癌细胞的抑制作用[J].食品科学,2014,35(19):119-124.
[7]吕旭聪.菌草灵芝多糖的分离纯化及其与茶多酚抗氧化协同作用研究[A].中国食品科学技术学会第十一届年会论文摘要集[C].中国食品科学技术学会,2014:2.
[8]孙世利,刘淑媚,赵超艺,等.茶多酚与维生素C/E的协同抗氧化作用研究[J].广东农业科学,2013,40(1):96-98.
[9]Fang Dai,Wei-Feng Chen,Bo Zhou.Antioxidant synergism of green tea polyphenols withα-tocopherol and l-ascorbic acid in SDS micelles[J].Biochimie,2008,90(10):1499-1505.
[10]王绪英,王婉婷,茶多酚与类胡萝卜素的协同抗氧化作用[J].食品研究与开发,2015,36(17):44-47.
[11]林美容,刘晓艳,杜劲松,等.茶多酚与竹荪、海带提取物的抗氧化协同效应[J].食品工业,2015,36(4):181-185.
[12]刘晓娟,何凤林,赵力超,等.番薯提取液与茶多酚、葛根黄酮对PC12细胞的协同抗氧化研究[J].现代食品科技,2015,31(12):14-18.
[13]唐煜括,左聪聪,李佳笑,等.汉中仙毫茶多酚与维生素C抗氧化及抑菌活性的协同作用[J].食品科学技术学报,2017,35(3):55-60.
[14]刘晓慧,孟庆,李伟,等.茶多酚类化合物与维生素协同抗氧化机理研究进展[J].热带作物学报,2012,33(12):2305-2310.
[15]樊梓鸾,林秀芳,王振宇.黑木耳多糖与浆果多酚的协同抗氧化研究[J].现代食品科技,2015,31(12):166-171,55.
[16]付慧,杨萍,汪秋宽.茶多酚的制备及其抑菌活性的研究[J].食品科技,2012,37(6):273-276.
[17]黄诗琪,冯卫华,于立梅,等.香椿多酚抑菌特性研究[J].食品科技,2013,38(11):212-216.
[18]李建慧,马会勤,陈尚武.葡萄多酚抑菌效果的研究[J].中国食品学报,2008(2):100-107.
[19]黄和,林晓霞,邝高波,等.番石榴多酚成分分析及抑菌活性研究[J].热带作物学报,2014,35(12):2482-2487.
[20]孙红男,孙爱东,苏雅静,等.苹果多酚抑菌效果的研究[J].北京林业大学学报,2010,32(4):280-283.
[21]Sudano Roccaro A,Blanco A R,Giuliano F,et al.Epigallocatechin-gallate enhances the activity of tetracycline in staphylococci by inhibiting its efflux from bacterial cells[J].Antimicrobial Agents and Chemotherapy,2004,48(6):1968-1973.
[22]Haghjoo B,Lee L H,Habiba U,et al.The synergistic effects of green tea polyphenols and antibiotics against potential pathogens[J].Advances in Bioscience and Biotechnology,2013,4:959-967.
[23]Fanaki N H,Kassem M A,Fawzi M A,et al.Influence of aqueous green tea extract on the antimicrobial activity of some antibiotics against multiresistant clinical isolates[J].Egyptian Journal of Medical Microbiology,2008,17:449-460.
[24]Cui Y,Kim S H,Kim H,et al.AFM probing the mechanism of synergistic effects of the green tea polyphenol(-)-epigallocatechin-3-gallate(EGCG)with cefotaxime against extended-spectrum beta-lactamase(ESBL)-producing Escherichia coli[J].Plos One,2012,7(11):e48880.
[25]Passat D N.Interactions of black and green tea water extracts with antibiotics activity in local urinary isolated Escherichia coli[J].Journal of Al Nahrain University,2012,15:134-142.
[26]Tsao R.13-synergistic interactions between antioxidants used in food preservation[J].Handbook of Antioxidants for Food Preservation,2015:335-347.
[27]彭乃才.茶多酚对肉品保鲜的机理及其应用研究[J].肉类工业,2015(5):47-50.
[28]骆扬,鲁才秀.香蕉皮多糖与茶多酚复配对卤牛肉的保鲜研究[J].肉类工业,2015(8):41-45.
[29]张立彦,贾艳花,芮汉明.壳聚糖和茶多酚对鸡肉的保鲜效果及复合保鲜条件的优选[J].食品与发酵工业,2011,37(12):177-182.
[30]庞克华.枸杞多糖对体外培养脊髓神经细胞辐射损伤所诱导自噬的影响[D].银川:宁夏医科大学,2018.
[31]郭娜,孙云朝,张艳景,等.山楂水提取物对辐射损伤小鼠遗传生殖系统影响[J].中华肿瘤防治杂志,2017,24(22):1563-1567.
[32]陈萃,孙可,耿珊,等.人参皂苷Rg1对辐射致造血干/祖细胞衰老的影响及其机制[J].中国生物制品学杂志,2013,26(11):1604-1609,1616.
[33]张雪岩,彭瑞云,高亚兵,等.黄芪总苷对微波辐射致大鼠心脏损伤的保护作用研究[J].中国体视学与图像分析,2018,23(2):189-197.
[34]刘冰.白藜芦醇二聚体Vam3和褪黑素衍生物ZZW1对免疫系统辐射损伤防护作用研究[D].北京:北京协和医学院,2016.
[35]薛晓蕾.抗氧化剂对辐射诱导小鼠造血系统损伤的防护作用及机制研究[D].北京:北京协和医学院,2017.
[36]白海娜.黑木耳多糖AAP-4与原花青素对辐射诱导氧化损伤协同防护作用[D].哈尔滨:哈尔滨工业大学,2016.
[37]张乃珣,王振宇,尹红力,等.红松多酚和黑木耳多糖对辐射诱导小鼠氧化损伤的防护作用[J].营养学报,2016,38(3):278-284.
[38]王清吉,王友绍,何磊,等.茶多酚和银杏叶有效成分的抗辐射作用研究[J].核技术,2004(2):148-150.
[39]Marion Man-Ying Chan,John A Mattiacci,Hyon S Hwang,et al.Synergy between ethanol and grape polyphenols,quercetin,and resveratrol,in the inhibition of the inducible nitric oxide synthase pathway[J].Biochemical Pharmacology,2000,60(10):1539-1548.
[40]谈宁芝.灵芝提取物Reishi Max对S180瘤小鼠的抗肿瘤作用和Reishi Max与绿茶多酚Tegreen抗肿瘤的协同作用研究[A].全国药用真菌学术研讨会论文集[C].中国菌物学会药用真菌专业委员会,2008:7.
[41]Yang Jun,Liu Rui Hai.Synergistic effect of apple extracts and quercetin 3-β-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells in vitro[J].Agric Food Chem,2009,57(18):8581-8586.
[42]仇菊,朱宏,卢林纲.葡萄籽多酚对糖尿病大鼠的降血糖作用及其机制[J].食品科学,2018,39(1):226-231.
[43]Martha Estrella García-Pérez,Pierre Betu Kasangana,Tatjana Stevanovic.Bioactive polyphenols for diabetes and inflammation in psoriasis disease[J].Studies in Natural Products Chemistry,2017,52:231-268.
[44]李星亚,汪东风,王林戈,等.茶多糖和茶多酚对糖尿病的协同防治作用[J].食品研究与开发,2013,34(11):72-76.
[45]王林戈.绿茶茶多糖与茶多酚对胰岛细胞的协同保护作用研究[D].青岛:中国海洋大学,2011.
[46]韦芳媚,陈春,李超,等.桑叶提取物、茶多酚及其复配物的抗氧化和降血糖活性[J].食品工业科技,2018,39(21):299-305.
[47]祖元刚,胡艳,姜守刚.红松多酚物质的提取工艺及其抗炎活性初步研究[J].植物研究,2016,36(4):634-640.
[48]张波.苹果中含有的几种多酚类化合物抗氧化及抗炎症活性研究[D].泰安:山东农业大学,2015.