益气宣窍方辅助电子鼻咽喉镜治疗儿童中耳炎及听力功能的影响
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摘要
目的:探讨益气宣窍方辅助电子鼻咽喉镜治疗儿童中耳炎疗效及对听力功能的影响。方法:136例中耳炎患儿随机分组,对照组患儿应用常规治疗,试验组患儿实施益气宣窍方辅助电子鼻咽喉镜治疗,观察比较两组患儿听力水平、血清炎症因子和免疫水平的差异。结果:试验组患者0.5 kHz(21.73±2.58)dB、1 kHz(16.67±3.09)dB、2 kHz(12.31±1.09)dB较对照组患者明显提高(P<0.05);治疗后试验组患者IL-2(7.39±1.82)ng/L、IL-6(16.99±4.25)ng/L、TNF-α(0.17±0.03)μg/L和IgE(152.34±21.94)μg/L明显优于对照组(P<0.05);治疗后试验组患者CD~+_3(60.36±6.71)%、CD~+_4(45.63±4.25)%、CD~+_8(37.01±1.56)%和CD~+_4/CD~+_8(1.12±0.11)%同对照组比较明显改善(P<0.05)。结论:针对中耳炎患儿应用益气宣窍方辅助电子鼻咽喉镜可提高治疗效果,降低炎症因子水平,改善免疫细胞功能,提高听力水平,值得推广应用。
Objective:To explore the effect of Yiqi Xuanqiao Prescription assisted electronic nasolaryngoscope in the treatment of otitis media and its effect on the immune function of children. Methods:136 cases of otitis media in children were radomly divided into two groups. The control group were treated by routine treatment and the test group with the implementation of Yiqi Xuanqiao Prescription assisted electronic nasolaryngoscope. We compared two groups' hearing, serum inflammatory factors and immune level differences. Results:Test group's 0.5 kHz(21.73±2.58) dB, 1 kHz(16.67±3.09) dB, 2 kHz(12.31±1.09) dB increased significantly compared with those of the control group(P<0.05). The test group's IL-2(7.39±1.82)ng/L, IL-6(16.99±4.25)ng/L, TNF-alpha(0.17±0.03)g/L and IgE(152.34±21.94)g/L after treatment were significantly better than those of the control group(P<0.05). The test group's CD~+_3(60.36±6.71)%, CD~+_4(45.63±4.25)%, CD~+_8(37.01±1.56)% and CD~+_4/CD~+_8(1.12±0.11)% after treatment improved significantly compared with those of the control group(P<0.05). Conclusion:For children with otitis media, the application of Yiqi Xuanqiao Prescription to assist electronic nasolaryngoscope treatment can improve the therapeutic effect, inflammatory factors and immune cell function and hearing, which is worthy of popularization and application.
Objective:To explore the effect of Yiqi Xuanqiao Prescription assisted electronic nasolaryngoscope in the treatment of otitis media and its effect on the immune function of children. Methods:136 cases of otitis media in children were radomly divided into two groups. The control group were treated by routine treatment and the test group with the implementation of Yiqi Xuanqiao Prescription assisted electronic nasolaryngoscope. We compared two groups' hearing, serum inflammatory factors and immune level differences. Results:Test group's 0.5 kHz(21.73±2.58) dB, 1 kHz(16.67±3.09) dB, 2 kHz(12.31±1.09) dB increased significantly compared with those of the control group(P<0.05). The test group's IL-2(7.39±1.82)ng/L, IL-6(16.99±4.25)ng/L, TNF-alpha(0.17±0.03)g/L and IgE(152.34±21.94)g/L after treatment were significantly better than those of the control group(P<0.05). The test group's CD~+_3(60.36±6.71)%, CD~+_4(45.63±4.25)%, CD~+_8(37.01±1.56)% and CD~+_4/CD~+_8(1.12±0.11)% after treatment improved significantly compared with those of the control group(P<0.05). Conclusion:For children with otitis media, the application of Yiqi Xuanqiao Prescription to assist electronic nasolaryngoscope treatment can improve the therapeutic effect, inflammatory factors and immune cell function and hearing, which is worthy of popularization and application.
引文
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[4] 陶佳,罗仁忠,刘碧霞,等.改良咽鼓管吹张治疗儿童分泌性中耳炎的短期疗效评估[J].中华耳科学杂志,2016,14(5):605-609.
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[15] Neulen ML,Viertlboeck BC,Straub C,et al.Identification of novel chicken CD4(+) CD3(-) blood population with NK cell like features[J].Developmental and Comparative Immunology: Ontogeny, Phylogeny, Aging: The Official Journal of the International Society of Developmental and Comparative Immunology,2015,49(1):72-78.
[16] 陆颖霞,梁洁琼,谷庆隆,等.北京地区儿童急性中耳炎发病特点及其与气象因素的相关性研究[J].中华耳鼻咽喉头颈外科杂志,2017,52(10):724-728.
[17] 杨拾梅,徐兰飞.儿童肺炎支原体感染合并急性中耳炎的临床分析[J].中国妇幼健康研究,2017,28(3):340-342.
[18] 张烁,熊辉.以发热角膜炎中耳炎为首发表现的ANCA相关小血管炎1例[J].中国急救医学,2017,37(7):679-681.
[19] 朱珠,郑国玺,李琦,等.鼓膜置管或鼓膜穿刺对腺样体切除治疗儿童分泌性中耳炎的影响[J].重庆医学,2017,46(15):2041-2044.
[20] 张玉忠,陈耔辰,徐勇,等.嗜酸粒细胞性中耳炎一例[J].中华耳鼻咽喉头颈外科杂志,2017,52(9):707-709.
[2] 李莉,樊兆民,韩月臣,等.中耳乳突再手术相关因素分析[J].中华耳鼻咽喉头颈外科杂志,2016,51(5):333-337.
[3] 张华.疏风解毒胶囊治疗小儿急性中耳炎的临床观察[J].中国中医急症,2017,26(2):288-291.
[4] 陶佳,罗仁忠,刘碧霞,等.改良咽鼓管吹张治疗儿童分泌性中耳炎的短期疗效评估[J].中华耳科学杂志,2016,14(5):605-609.
[5] 刘斌,苏亚,冯晓辉,等.嗜酸性中耳炎的研究现状[J].中华耳科学杂志,2017,15(3):372-375.
[6] 任妍妍,何双八,于振坤,等.分泌性中耳炎病因研究及治疗进展[J].国际耳鼻咽喉头颈外科杂志,2017,41(3):132-135.
[7] 吕宇,陈朝辉,胡章威,等.氧氟沙星联合地塞米松治疗中耳炎临床疗效观察[J].海南医学,2017,28(4):586-588.
[8] 吴佳丽.鼓膜穿刺联合地塞米松鼓室注射治疗分泌性中耳炎临床疗效[J].中国卫生标准管理,2016,7(8):103-105.
[9] 张东晓.宣窍化湿汤治疗分泌性中耳炎43例[J].河南中医,2016,36(12):2193-2195.
[10] 张浩然.宣肺通窍汤联合微波治疗急性分泌性中耳炎的疗效观察[J].中西医结合心血管病电子杂志,2016,4(7):75-76.
[11] 申琪,王秉权.从肺论治分泌性中耳炎文献的中药分布规律[J].中医研究,2016,29(6):55-57.
[12] Witkowska-BanaszczakE.The Genus Trollius-Review of Pharmacological and Chemical Research[J].Phytotherapy research: PTR,2015,29(4):475-500.
[13] 迟作华,刘振,肖平,等.Tregs及IL-6、 IL-10、 TNF在急性分泌性中耳炎患者中的变化及意义[J].实用医学杂志,2016,32(2):255-257.
[14] 刘霞,钟凤如,马和平,等.氨溴索辅助治疗分泌性中耳炎对患者局部和全身炎症介质水平的影响[J].现代医院,2017,17(10):1504-1506.
[15] Neulen ML,Viertlboeck BC,Straub C,et al.Identification of novel chicken CD4(+) CD3(-) blood population with NK cell like features[J].Developmental and Comparative Immunology: Ontogeny, Phylogeny, Aging: The Official Journal of the International Society of Developmental and Comparative Immunology,2015,49(1):72-78.
[16] 陆颖霞,梁洁琼,谷庆隆,等.北京地区儿童急性中耳炎发病特点及其与气象因素的相关性研究[J].中华耳鼻咽喉头颈外科杂志,2017,52(10):724-728.
[17] 杨拾梅,徐兰飞.儿童肺炎支原体感染合并急性中耳炎的临床分析[J].中国妇幼健康研究,2017,28(3):340-342.
[18] 张烁,熊辉.以发热角膜炎中耳炎为首发表现的ANCA相关小血管炎1例[J].中国急救医学,2017,37(7):679-681.
[19] 朱珠,郑国玺,李琦,等.鼓膜置管或鼓膜穿刺对腺样体切除治疗儿童分泌性中耳炎的影响[J].重庆医学,2017,46(15):2041-2044.
[20] 张玉忠,陈耔辰,徐勇,等.嗜酸粒细胞性中耳炎一例[J].中华耳鼻咽喉头颈外科杂志,2017,52(9):707-709.