雌激素对听力损失影响的研究进展
摘要
雌激素是一种具有多种功能的类固醇类激素。近年来的研究发现,外周血雌激素水平的变化会对听力产生影响,例如,女性在绝经会出现高频听力损失;绝经后给予外源性雌激素补充后,听力损失恢复等。目前研究证明,雌激素对听力损失影响的机制主要有以下几个方面:①雌激素受体在听觉传导通路上表达的分布决定了雌激素对听力的作用,同时,雌激素受体基因异常表达和多态性也会影响雌激素对听力的作用;②雌激素可通过对听觉上皮细胞修复而保护听力;③雌激素浓度可通过改变耳蜗血管纹的代谢和血流速度,进而影响听力水平;④雌激素可通过促进脑源性神经营养因子相关基因表达、抑制细胞凋亡和调节钙离子浓度平衡,进而保护听神经细胞。对雌激素与听力之间的关系及其影响机制的综述和探讨,能够为临床雌激素相关的听力减退的治疗提供理论依据和解决方案。
引文
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[2]Villavisanis DF,Schrode KM,Lauer AM.Sex bias in basic and preclinical age-related hearing loss research[J].Biology of Sex Differences,2018,9(1):1-6.
[3]McFaddeann D,Hsieh MD,Garcia-Sierra A,et al.Differences by sex,ear,and sexual orientation in the time intervals between successive peaks in auditory evoked potentials[J].Hear Res,2010,270(1-2):56-64.
[4]Homans NC,Metselaar RM,Dingemanse JG,et al.Prevalence of age-related hearing loss,including sex differences,in older adults in a large cohort study[J].Laryngoscope,2017,127(3):725-730.
[5]Hederstierna C,Hultcrantz M,Collins A,et al.The menopause triggers hearing decline in healthy women[J].Hear Res,2010,259(1-2):31-35.
[6]Svedbrant J,Bark R,Hultcrantz M,et al.Hearing decline in menopausal women--a 10-year follow-up[J].Acta Otolaryngol,2015,135(8):807-813.
[7]张汀樾,章静菲,余力生,等.绝经前后女性听力变化相关因素分析[J].中国妇产科临床杂志,2017,18(4):324-327.
[8]Zhang J,Zhang T,Yu L,et al.Effects of ovarian reserve and hormone therapy on hearing in premenopausal and postmenopausal women:A cross-sectional study[J].Maturitas,2018,111(5):77-81.
[9]Curhan SG,Eliassen AH,Eavey RD,et al.Menopause and postmenopausal hormone therapy and risk of hearing loss[J].Menopause,2017,24(9):1049-1056.
[10]K??ü?N,K??ü?A,Turhan N?,et al.Hearing levels in menopausal women and the effect of tibolone on audiological functions[J].J Obstet Gynaecol,2012,32(3):294-297.
[11]Rohmann KN,Fergus Daniel J,Bass AH.Plasticity in ion channel expression underlies variation in hearing during reproductive cycles[J].Curr Biol,2013,23(8):678-683.
[12]Diao H,Zhao L,Qin L,et al.Lower expression of prestin and MYO7A correlates with menopause-associated hearing loss[J].Climacteric,2019,21(6):1-9.
[13]Dag EK,Gulumser C,Erbek S.Decrease inmiddle ear resonance frequency during pregnancy[J].Audiol Res,2016,6(1):147.
[14]Spicer SS,Schulte BA.Pathologic changes of presbycusis begin in secondary processes and spread to primary processes of strial marginal cells[J].Hear Res,2005,205(1-2):225.
[15]Hu X,Wang Y,Lau CC.Effects of noise exposure on the auditory function of ovariectomized rats with estrogen deficiency[J].J Int Adv Otol,2016,12(3):261-265.
[16]Motohashi R,Takumida M,Shimizu A,et al.Effects of age and sex on the expression of estrogen receptor alpha and beta in the mouse inner ear[J].Acta Otolaryngol,2010,130(2):204-214.
[17]Maneix L,Antonson P,Humire P,et al.Estrogen receptorβexon3-deleted mouse:The importance of non-ERE pathways in ERβsignaling[J].Proc Natl Acad Sci,2015,112(16):5135-5140.
[18]Baudry M,Bi X,Aguirre C.Progesterone-estrogen interactions in synaptic plasticity and neuroprotection[J].Neuroscience,2013,239(7):280-294.
[19]Kim SY,Lee JK,Sim S,et al.Hearing impairment increases the risk of distal radius,hip,and spine fractures:A longitudinal follow-up study using a national sample cohort[J].PLos One,2018,13(2):e0192820.
[20]Stenberg AE,Wang H,FishⅢJ,et al.Estrogen receptors in the normal adult and developing human inner ear and in Turner’s syndrome[J].Hear Res,2001,157(1):87-92.
[21]Bhatt I,Phillips S,Richter S,et al.A polymorphism in human estrogen-related receptor beta(ESRRβ)predicts audiometric temporary threshold shift[J].Int J Audiol,2016,55(10):571-579.
[22]Schilit SL,Currall BB,Yao R,et al.Estrogen-related receptor gamma implicated in a phenotype including hearing loss and mild developmental delay[J].EJHG,2016,24(11):1622.
[23]Annalisa B,Ingham NJ,Lewis MA,et al.Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing[J].Embo Mol Med,2016,8(3):191-207.
[24]Thatcher SE,Zhang X,Woody S,et al.Exogenous 17-βestradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice[J].Biol Sex Differ,2015,6(1):12.
[25]Williamson TT,Ding B,Zhu X,et al.Hormone replacement therapy attenuates hearing loss:Mechanisms involving estrogen and the IGF-1 pathway[J].Aging Cell,2019,18(3):e12939.
[26]Yang JA,Yasrebi A,Snyder M,et al.The interaction of fasting,caloric restriction,and diet-induced obesity with 17β-estradiol on the expression of KND neuropeptides and their receptors in the female mouse[J].Mol Cell Endocrinol,2016,437(10):35-50.
[27]Willott JF.Effects of sex,gonadal hormones,and augmented acoustic environments on sensorineural hearing loss and the central auditory system:insights from research on C57BL/6Jmice[J].Hear Res,2009,252(6):89-99.
[28]Kow LM,Pfaff DW.Rapid estrogen actions on ion channels:Asurvey in search for mechanisms[J].Steroids,2016,111(7):46-53.
[29]Barald KF,Shen YC,Bianchi LM.Chemokines and cytokines on the neuroimmunoaxis:inner ear neurotrophic cytokines in development and disease.prospects for repair?[J].Exp Neurol,2018,301(3):92-99.
[30]Bean LA,Kumar A,Rani A,et al.Re-opening the critical window for estrogen therapy[J].J Neurosci,2015,35(49):16077-16093.
[31]Hill RA,Pompolo S,Jones ME,et al.Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice[J].Mol Cell Neurosci,2004,27(4):466-476.
[32]Shen H,Matsui JI,Lei D,et al.No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice[J].Mol Neurodegener,2010,5(1):1-7.
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