基于超分子“印迹模板”理论探讨中药升降浮沉
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摘要
在前期提出超分子化学对中药四性理论特殊影响的基础上,进一步分析中药升降浮沉的历史沿革、研究概况,并运用超分子"印迹模板"理论对中药"升降浮沉"理论进行解析,提出对中药"升降浮沉"的评价方法。人体与中药均是印迹模板印迹作用的聚集体,在印迹模板作用规律下,不同类型的中药成分与人体的靶点通过"锁-钥"关系以非共价键结合,中药客体超分子通过键的作用可纠正人体主体超分子在自识别、自组织、自组装、自复制过程时发生的寒热、气机失调。人体具备抵抗外界病邪侵袭的能力,有赖于其气机"升降出入"的正常;中药具有"升降浮沉"的性能并能祛除病疾,有赖于其能调整人体气机紊乱,或顺应气机、祛邪外出以增强机体免疫的能力。基于此,在分析中药"升降浮沉"药理作用的基础上,探究其物质基础,并建立中药"升降浮沉"的评价方法,通过超分子印迹模板理论对中药升降浮沉进行剖析,揭示其科学内涵,推动中药药性理论不断创新。
Based on the special influence of supramolecular chemistry on the four-character theory of Chinese materia medica(CMM) proposed in the early stage of this laboratory, this paper further analyzes the historical evolution and research situation of CMM lifting and lowering, and uses the supramolecular "imprint template" theory to analyze the "lifting and sinking" of CMM, and proposes evaluation method of CMM floating and sinking. The human body and CMM are "imprinted templates" of the aggregation of imprinting function, under the effect of the "imprinting template", different types of Chinese native medicine ingredient targets with human targets through "lock-and-key" relationship in non covalent bond, the role of CMM object supramolecular by key can correct human body supramolecular in the processes of self-recognition, self-organization, self-assembly, self-replication when the fever, disorder of qi occurs. The human body has the ability to resist the invasion of external diseases and pathogens, which depends on the normal "rise and fall" of human qi; CMM has the property of floating and sinking, and can eliminate diseases. It depends on its adjustment of qi disorder of human body, or compliance with qi and removing pathogens to enhance the ability of immunity. Based on this, on the basis of analyzing the pharmacological effects of the rise and fall of CMM, the material basis of the lifting and lowering of CMM was explored, and the evaluation method of the lifting and lowering of traditional Chinese medicine was established. The supramolecular "imprinting template" theory is used to analyze the lifting and lowering of CMM, revealing its scientific connotation and promoting the continuous innovation of CMM pharmacology theory.
Based on the special influence of supramolecular chemistry on the four-character theory of Chinese materia medica(CMM) proposed in the early stage of this laboratory, this paper further analyzes the historical evolution and research situation of CMM lifting and lowering, and uses the supramolecular "imprint template" theory to analyze the "lifting and sinking" of CMM, and proposes evaluation method of CMM floating and sinking. The human body and CMM are "imprinted templates" of the aggregation of imprinting function, under the effect of the "imprinting template", different types of Chinese native medicine ingredient targets with human targets through "lock-and-key" relationship in non covalent bond, the role of CMM object supramolecular by key can correct human body supramolecular in the processes of self-recognition, self-organization, self-assembly, self-replication when the fever, disorder of qi occurs. The human body has the ability to resist the invasion of external diseases and pathogens, which depends on the normal "rise and fall" of human qi; CMM has the property of floating and sinking, and can eliminate diseases. It depends on its adjustment of qi disorder of human body, or compliance with qi and removing pathogens to enhance the ability of immunity. Based on this, on the basis of analyzing the pharmacological effects of the rise and fall of CMM, the material basis of the lifting and lowering of CMM was explored, and the evaluation method of the lifting and lowering of traditional Chinese medicine was established. The supramolecular "imprinting template" theory is used to analyze the lifting and lowering of CMM, revealing its scientific connotation and promoting the continuous innovation of CMM pharmacology theory.
引文
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[2]郭兆娟,袁一平,孔李婷,等.升降浮沉药性理论溯源及升降浮沉药对配伍研究[J].中国中药杂志,2017,42(16):3225-3228.
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[5]周晋,刘惠,肖美凤,等.基于超分子“印迹模板”的中药成药性及制剂修饰研究策略[J].中草药,2018,49(18):4205-4211.
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[7]周晋,刘惠,刘文龙,等.基于超分子“印迹模板”分析的中药毒与效整合模式探讨[J].药学学报,2018,53(11):1808-1816.
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[11]韩翠翠,俞仲毅.中药升降浮沉理论沿革及应用纂要[J].上海中医药大学学报,2013,27(2):16-22.
[12]仲宗亮,荀丽英,战旗,等.中药升降浮沉的理论研究[J].福建中医药,2012,43(4):61-62.
[13]杨滨.中药性能配伍的理化本质讨论[J].实用中西医结合杂志,1994,7(7):423-425.
[14]赵正孝.传统中医药理学概论[M].长沙:湖南科学技术出版社,2016.
[15]盛良.论中药矿物药四性与无机化学的结合--二论中药四性与现代化学的统一[J].中国中医基础医学杂志,2004,10(3):24-26.
[16]盛良.论化学元素具有寒热温凉四性--一论中药四性与现代化学的统一[J].中国中医基础医学杂志,2003,9(1):14-15.
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[18]管竞环,李恩宽,薛莎,等.植物类中药四性与无机元素关系的初步研究[J].中国医药学报,1990,5(5):40-43.
[19]陈勇,杨敏,闵志强,等.析中药升降浮沉渊源流变[J].四川中医,2016,34(10):17-20.
[20]仲宗亮,迟秀铭.中药升降浮沉理论浅析[J].河南中医,2015,35(12):2887-2888.
[21]张田.基于AM、IM细胞迁移的麻黄、五味子升降浮沉药性作用特征差异性研究[D].北京:北京中医药大学,2016.
[22]Ariga K,Kunitake T.Supramolecular ChemistryFundamentals and Applications[M].Heidelberg:Springer,2006.
[23]Conn M M,Rebek J J.Self-assembling capsules[J].Chem Rev,1997,97(5):1647-1668.
[24]Lehn J M.Supramolecular chemistry scope and perspectives[J].Angew Chem Int Ed,1988,27(1):89-112.
[25]李文林,李梅兰.超分子化学的现状及进展[J].广东化工,2009,36(9):80-81.
[26]黄英,王娟,郭改英,等.光谱法研究硫鸟嘌呤与七元瓜环及牛血清白蛋白的超分子相互作用[J].高等学校化学学报,2013,34(2):375-380.
[27]杨岩涛,陶叶琴,唐闻汉,等.中药控缓释制剂多成分整体受控的超分子机制探讨[J].中国中药杂志,2016,41(24):4675-4679.
[28]高晓山.中药药性论[M].北京:人民卫生出版社,1992.
[29]张晓乐,吕冠华.石膏药性功效辨析[J].实用中医内科杂志,2018,32(8):1-4.
[30]荀丽英,仲宗亮,邱振刚.中药升降浮沉理论的现代实验研究现状[J].成都中医药大学学报,2013,36(1):122-124.
[31]黄丽萍,杨华永,韦益飞,等.麻杏甘石汤主要有效成分舒张气管环量效关系的研究[J].中药新药与临床药理,2015,26(4):468-471.
[32]贺福元,邓凯文,杨岩涛,等.基于超分子化学的中药药性理论研究方法探讨(1)中药归经[J].中国中药杂志,2015,40(8):1624-1629.
[33]范诗琪,李森,刘金玲.基于分子连接性指数探归肝经中药成分“印迹模板”的特征[J].中国中药杂志,2017,42(2):390-395.
[34]Nicholls I A.Thermodynamic considerations for the design of and ligand recognition by molecular recognition by molecularly imprinted polymers[J].Chem Lett,1995,24(11):1035-1036.
[35]谭天伟.分子印迹技术及应用[M].北京:化学工业出版社,2010.
[36]Liu Y,Li L,Chen Y,et al.Molecular recognition thermo-dynamics of bile salts by cyclodextrin dimers:Factors gover-ning the cooperative binding of cyclodextrin dimers[J].J Phys Chem B,2005,109(9):4129-4134.
[37]邓凯文,陶叶琴,唐闻汉,等.循生物演化轨迹,析经络超分子体属性[J].中国针灸,2017,37(3):325-330.
[38]廖琼,杨岩涛,刘志刚,等.从茜草素的超分子印迹作用探讨中药归经体外研究方法[J].中草药,2015,46(22):3364-3369.
[2]郭兆娟,袁一平,孔李婷,等.升降浮沉药性理论溯源及升降浮沉药对配伍研究[J].中国中药杂志,2017,42(16):3225-3228.
[3]刘惠,刘文龙,唐闻汉,等.基于超分子“印迹模板”理论探讨中药四性[J].中草药,2018,49(19):4473-4479.
[4]贺福元,周逸群,邓凯文,等.超分子化学对中医药理论的特殊影响[J].中国中药杂志,2014,39(8):1534-1543.
[5]周晋,刘惠,肖美凤,等.基于超分子“印迹模板”的中药成药性及制剂修饰研究策略[J].中草药,2018,49(18):4205-4211.
[6]邓凯文,贺福元.中药归经研究的现状及“穴位”法的提出[J].中国中药杂志,2013,38(10):1643-1648.
[7]周晋,刘惠,刘文龙,等.基于超分子“印迹模板”分析的中药毒与效整合模式探讨[J].药学学报,2018,53(11):1808-1816.
[8]邓先瑜.中药升降浮沉源流钩玄[J].时珍国药研究,1998,2(9):8.
[9]张恒,杨锐.中医升降学说疏要[M].北京:学苑出版社,2012.
[10]陈勇,杨敏,闵志强,等.析中药升降浮沉渊源流变[J].四川中医,2016,34(10):17-20.
[11]韩翠翠,俞仲毅.中药升降浮沉理论沿革及应用纂要[J].上海中医药大学学报,2013,27(2):16-22.
[12]仲宗亮,荀丽英,战旗,等.中药升降浮沉的理论研究[J].福建中医药,2012,43(4):61-62.
[13]杨滨.中药性能配伍的理化本质讨论[J].实用中西医结合杂志,1994,7(7):423-425.
[14]赵正孝.传统中医药理学概论[M].长沙:湖南科学技术出版社,2016.
[15]盛良.论中药矿物药四性与无机化学的结合--二论中药四性与现代化学的统一[J].中国中医基础医学杂志,2004,10(3):24-26.
[16]盛良.论化学元素具有寒热温凉四性--一论中药四性与现代化学的统一[J].中国中医基础医学杂志,2003,9(1):14-15.
[17]管竞环,李恩宽,汤学军,等.药性阴阳消长、转化与稀土元素的关系[J].中草药,1995,26(6):321-325.
[18]管竞环,李恩宽,薛莎,等.植物类中药四性与无机元素关系的初步研究[J].中国医药学报,1990,5(5):40-43.
[19]陈勇,杨敏,闵志强,等.析中药升降浮沉渊源流变[J].四川中医,2016,34(10):17-20.
[20]仲宗亮,迟秀铭.中药升降浮沉理论浅析[J].河南中医,2015,35(12):2887-2888.
[21]张田.基于AM、IM细胞迁移的麻黄、五味子升降浮沉药性作用特征差异性研究[D].北京:北京中医药大学,2016.
[22]Ariga K,Kunitake T.Supramolecular ChemistryFundamentals and Applications[M].Heidelberg:Springer,2006.
[23]Conn M M,Rebek J J.Self-assembling capsules[J].Chem Rev,1997,97(5):1647-1668.
[24]Lehn J M.Supramolecular chemistry scope and perspectives[J].Angew Chem Int Ed,1988,27(1):89-112.
[25]李文林,李梅兰.超分子化学的现状及进展[J].广东化工,2009,36(9):80-81.
[26]黄英,王娟,郭改英,等.光谱法研究硫鸟嘌呤与七元瓜环及牛血清白蛋白的超分子相互作用[J].高等学校化学学报,2013,34(2):375-380.
[27]杨岩涛,陶叶琴,唐闻汉,等.中药控缓释制剂多成分整体受控的超分子机制探讨[J].中国中药杂志,2016,41(24):4675-4679.
[28]高晓山.中药药性论[M].北京:人民卫生出版社,1992.
[29]张晓乐,吕冠华.石膏药性功效辨析[J].实用中医内科杂志,2018,32(8):1-4.
[30]荀丽英,仲宗亮,邱振刚.中药升降浮沉理论的现代实验研究现状[J].成都中医药大学学报,2013,36(1):122-124.
[31]黄丽萍,杨华永,韦益飞,等.麻杏甘石汤主要有效成分舒张气管环量效关系的研究[J].中药新药与临床药理,2015,26(4):468-471.
[32]贺福元,邓凯文,杨岩涛,等.基于超分子化学的中药药性理论研究方法探讨(1)中药归经[J].中国中药杂志,2015,40(8):1624-1629.
[33]范诗琪,李森,刘金玲.基于分子连接性指数探归肝经中药成分“印迹模板”的特征[J].中国中药杂志,2017,42(2):390-395.
[34]Nicholls I A.Thermodynamic considerations for the design of and ligand recognition by molecular recognition by molecularly imprinted polymers[J].Chem Lett,1995,24(11):1035-1036.
[35]谭天伟.分子印迹技术及应用[M].北京:化学工业出版社,2010.
[36]Liu Y,Li L,Chen Y,et al.Molecular recognition thermo-dynamics of bile salts by cyclodextrin dimers:Factors gover-ning the cooperative binding of cyclodextrin dimers[J].J Phys Chem B,2005,109(9):4129-4134.
[37]邓凯文,陶叶琴,唐闻汉,等.循生物演化轨迹,析经络超分子体属性[J].中国针灸,2017,37(3):325-330.
[38]廖琼,杨岩涛,刘志刚,等.从茜草素的超分子印迹作用探讨中药归经体外研究方法[J].中草药,2015,46(22):3364-3369.