冬凌草中1个新的黄烷类化合物
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摘要
目的研究冬凌草(碎米桠Rabdosia rubescens地上部分)的化学成分。方法采用硅胶柱、十八烷基硅烷键合硅胶开放柱、小孔树脂凝胶柱以及反相高效液相色谱法进行分离纯化,通过理化性质及波谱数据对化合物进行结构鉴定。结果从冬凌草中分离得到1个黄烷类化合物,鉴定为3′-羟基-2′,4′-二甲氧基-3-烯-黄烷(1)。结论化合物1为新的黄烷类化合物,命名为冬凌烷A。
Objective To study the chemical constituents of Rabdosia rubescens. Methods The chemical constituent of R. rubescens was separated and purified by using of various column chromatographic technologies(silica gel, MCI, and ODS column chromatography) as well as HPLC. Structures were elucidated by physicochemical characteristics and spectral data. Results One new flavanoiel compound was isolated from supercritical fluid extract of R. rubescens, and it was elucidated as 3′-hydroxy-2′,4′-dimethoxy-flav-3-ene(1). Conclusion Compound 1 is a new flavanoid, named as rubescenane A.
Objective To study the chemical constituents of Rabdosia rubescens. Methods The chemical constituent of R. rubescens was separated and purified by using of various column chromatographic technologies(silica gel, MCI, and ODS column chromatography) as well as HPLC. Structures were elucidated by physicochemical characteristics and spectral data. Results One new flavanoiel compound was isolated from supercritical fluid extract of R. rubescens, and it was elucidated as 3′-hydroxy-2′,4′-dimethoxy-flav-3-ene(1). Conclusion Compound 1 is a new flavanoid, named as rubescenane A.
引文
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[14]Liu H,Qian C L,Shen Z Y.Anti-tumor activity of oridonin on SNU-5 subcutaneous xenograft model via regulation of c-Met pathway[J].Tumor Biol,2014,35(9):9139-9146.
[15]Wu J,Ding Y,Chen C H Z,et al.A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5[J].Cancer Lett,2016,380(2):393-402.
[16]Zhang Y Y,Jiang H Y,Liu M,et al.Bioactive ent-kaurane diterpenoids from Isodon rubescens[J].Phytochemistry,2017,143:199-207.
[17]李春雨,王琪,申珅,等.冬凌草甲素对人黑色素瘤A375细胞侵袭和转移的影响及机制研究[J].中草药,2018,49(3):658-662.
[2]中国药典[S].一部.2015.
[3]Han Q B,Lu Y,Zhang L L,et al.Novel ent-kaurane dimers from Isodon rubescens var.rubescens[J].Tetrahedron Lett,2004,45(13):2833-2837.
[4]Huang S X,Xiao W L,Li L M,et al.Bisrubescensins A-C:Three new dimeric ent-kauranoids isolated from Isodon rubescens[J].Org Lett,2006,8(6):1157-1160.
[5]Bai N S,He K,Zhu Z,et al.Ent-kaurane diterpenoids from Rabdosia rubescens and their cytotoxic effects on human cancer cell lines[J].Planta Med,2010,76(2):140-145.
[6]Zhang H B,Du X,Pu J X,et al.Two novel diterpenoids from Isodon rubescens var.lushanensis[J].Tetrahedron Lett,2010,51(32):4225-4228.
[7]Zhou J,Pan L T,Li Q J,et al.Rubesanolides C-E:Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity[J].Org Biomol Chem,2012,10(26):5039-5044.
[8]Xie R J,Yan F L,Hai G F,et al.Two new diterpenoids and other constituents from Isodon rubescens[J].Fitoterapia,2011,82(4):726-730.
[9]段浩清,李绵洋,高丽,等.冬凌草甲素对多发性骨髓瘤抗肿瘤的机制研究[J].中国实验血液学杂志,2014,22(2):364-369.
[10]王健,周雯,宋秀宇,等.冬凌草甲素对人肺癌A549和PC-9细胞侵袭的抑制作用和机制研究[J].天津医药,2015,43(9):965-969.
[11]高成伟,李文强.冬凌草甲素通过抑制COX-2表达及PGE2合成降低人胃癌HGC-27细胞侵袭能力的研究[J].临床急诊杂志,2016,17(8):625-627.
[12]Gao F,Tang Q,Yang P,et al.Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and-resistant acute promyelocytic leukemia cells[J].Int J Lab Hem,2010,32:e114-e122.
[13]Jin H Y,Tan X Z,Liu X F,et al.Down regulation of AP-1gene expression is an initial event in the oridoninmediated inhibition of colorectal cancer:Studies in vitro and in vivo[J].J Gastroen Hepatol,2011,26(4):706-715.
[14]Liu H,Qian C L,Shen Z Y.Anti-tumor activity of oridonin on SNU-5 subcutaneous xenograft model via regulation of c-Met pathway[J].Tumor Biol,2014,35(9):9139-9146.
[15]Wu J,Ding Y,Chen C H Z,et al.A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5[J].Cancer Lett,2016,380(2):393-402.
[16]Zhang Y Y,Jiang H Y,Liu M,et al.Bioactive ent-kaurane diterpenoids from Isodon rubescens[J].Phytochemistry,2017,143:199-207.
[17]李春雨,王琪,申珅,等.冬凌草甲素对人黑色素瘤A375细胞侵袭和转移的影响及机制研究[J].中草药,2018,49(3):658-662.