糖尿病性骨质疏松症中医病因病机理论框架研究
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摘要
糖尿病性骨质疏松(Diabetic Osteoporosis,DOP)是一种常见的糖尿病慢性并发症,该病不仅仅降低患者的生命质量,还给社会和家庭带来了沉重的经济负担,尤其是老年患者,而临床上目前尚无能够治愈及完全预防的药物。本研究基于中医经典、官修和各医家著作及现代进展与成果,深入研究和具体阐明糖尿病性骨质疏松症中医病因病机理论框架,将其总结为脾失健运、生化乏源,肾脏虚惫、髓海不足等因机理论,并结合现代DOP辨证论治的研究进展,充分发挥其对临床的指导作用。
Diabetic osteoporosis(DOP)is a common chronic complication of diabetes,which not only reduces the quality of life of patients,but also imposes a heavy economic burden on society and families,especially elderly patients. However,there is currently no clinically preventable and completely preventive drugs. Based on traditional Chinese medicine classics,official revisions and various medical books and modern progress and achievements,this study thoroughly studies and clarifies the theoretical framework of the pathogenesis of diabetic osteoporosis,and summarizes it as spleen dysfunction, biochemical deficiency,kidney fatigue and insufficiency of medullary sea,combined with the research progress of modern DOP syndrome differentiation,give full play to its guiding role in clinical.
Diabetic osteoporosis(DOP)is a common chronic complication of diabetes,which not only reduces the quality of life of patients,but also imposes a heavy economic burden on society and families,especially elderly patients. However,there is currently no clinically preventable and completely preventive drugs. Based on traditional Chinese medicine classics,official revisions and various medical books and modern progress and achievements,this study thoroughly studies and clarifies the theoretical framework of the pathogenesis of diabetic osteoporosis,and summarizes it as spleen dysfunction, biochemical deficiency,kidney fatigue and insufficiency of medullary sea,combined with the research progress of modern DOP syndrome differentiation,give full play to its guiding role in clinical.
引文
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[26]张发荣.中西医结合糖尿病治疗学[M].北京:中国中医药出版社,1998:309.
[2]Schwartz AV.Efficacy of Osteoporosis Therapies in Diabetic Patients[J].Calcif Tissue Int,2017,100(2):165-173.
[3]Liu J,Ho S C,Su Y X,et al.Effect of long-term intervention of soy isoflavones on bone mineral density in women:A metaanalysis of randomized controlled trials[J].Bone,2009,44(5):948-953.
[4]Li C,Li Q,Liu R,et al.Medicinal herbs in the prevention and treatment of osteoporosis[J].Am J Chin Med,2014,42(1):1-22.
[5]《中医大辞典》编辑委员会.中医大辞典·内科分册(试用本)[M].北京:人民卫生出版社,1987:302.
[6]佚名.黄帝内经[M].北京:中国医药科学技术出版社,2013:63,223-224.
[7]王怀隐.太平圣惠方[M].北京:人民卫生出版社,2016:175.
[8]郑洪新,师双斌,李佳.“肾藏精”藏象理论概念体系[J].世界中医药,2014,9(6):699-703.
[9]严用和.严氏济生方[M].北京:中国医药科技出版社,2012:50.
[10]张新渝,马烈光.黄帝内经·素问[M].成都:四川科学技术出版社,2008:89,272,442.
[11]孙广仁.中医基础理论[M].北京:中国中医药出版社,2002:89-91.
[12]马莳.黄帝内经灵枢注证发微[M].北京:人民卫生出版社,1994:258.
[13]刘完素.三消论[M].南京:江苏广陵古籍刻印出版社,1984:67.
[14]杨宇峰,田晓君,石岩.2型糖尿病中医病因病机理论框架结构研究[J].时珍国医国药,2016,27(5):1173.
[15]陶乐维.糖尿病性骨质疏松症中医研究现状[J].四川中医,2013,31(2):129-131.
[16]王儒平,陈雪梅.“脾为生痰之源,肺为贮痰之器”的机理[J].河南中医,2013,33(9):1396-1397.
[17]王敬.脏腑功能失调与“痰”的产生[J].天津中医学院学报,1999(1):6-7.
[18]尚德阳.瘀血与骨质疏松症关系研究[J].辽宁中医药大学学报,2008(9):40-41.
[19]中华中医药学会糖尿病分会.糖尿病合并骨质疏松中医诊疗标准[J].糖尿病天地(临床),2016,10(12):554-559.
[20]方朝晖,李家云,舒仪琼,等.消渴病合并骨病(糖尿病合并骨质疏松症)中医诊疗方案[J].中医药临床杂志,2013,25(9):838-840.
[21]冯维斌,唐彩平,薛冬梅,等.2型糖尿病并骨质疏松的辨证分型及中医治疗[J].现代中西医结合杂志,2001(2):149-151.
[22]苏友新,郭进建,郑良朴,等.糖尿病性骨质疏松症的中医证候研究[J].福建中医学院学报,2002(1):26-29.
[23]曲震,曾伟坤,庞瑞明,等.糖尿病性骨质疏松症中医证候特点及体质分布的临床研究[J].中医临床研究,2018,10(11):96-97.
[24]夏士宇.糖尿病性骨质疏松中医证型临床分析[J].糖尿病新世界,2017,20(5):47-48.
[25]雷枭.糖尿病性骨质疏松中医证型研究[D].成都:成都中医药大学,2013.
[26]张发荣.中西医结合糖尿病治疗学[M].北京:中国中医药出版社,1998:309.