柴胡桂枝干姜汤加味辅助治疗原发性高血压寒热错杂证临床观察
|
摘要
目的观察柴胡桂枝干姜汤加味治疗原发性高血压寒热错杂证的临床疗效。方法将62例患者分为治疗组31例、对照组31例。对照组给予口服缬沙坦氨氯地平片治疗,治疗组在对照组治疗的基础上,予柴胡桂枝干姜汤加味口服。观察2组降压疗效、中医证候疗效、中医症状评分、焦虑评分。结果 2组降压疗效比较差异无统计学意义(P>0.05)。2组中医证候疗效比较:治疗组30例中,显效19例,有效10例,无效1例,总有效29例,总有效率为96.7%;对照组30例中,显效9例,有效13例,无效8例,总有效22例,总有效率为73.3%。经秩和检验,Z=-4.404,P<0.001,说明治疗组中医证候疗效优于对照组。2组治疗后眩晕、头痛、口干、口苦、畏寒肢冷、心烦急躁评分较本组治疗前均降低(P<0.05)。治疗组腹中冷评分较本组治疗前降低。对照组腹中冷评分与本组治疗前比较差异无统计学意义(P>0.05)。治疗组头痛、口干、口苦、腹中冷评分较对照组降低明显,治疗前后评分差值比较,差异均有统计学意义(P<0.05),治疗组优于对照组。2组眩晕、畏寒肢冷、心烦急躁治疗前后评分差值比较,差异无统计学意义(P>0.05)。2组治疗后焦虑评分较本组治疗前均降低(P<0.05),治疗组评分较对照组降低明显,治疗前后评分差值比较,差异有统计学意义(P<0.05),治疗组优于对照组。结论柴胡桂枝干姜汤加味联合缬沙坦氨氯地平片治疗原发性高血压寒热错杂证具有较好的临床疗效。
Objective To observe the clinical efficacy of Chaihu Guizhi Ganjiang Decoction in treating primary hypertension with intermingled heat and cold syndrome. Methods 62 patients with primary hypertension( intermingled heat and cold syndrome) were randomly divided into 2 groups,with 31 patients in each. Valsartan amlodipine tablets were given to control group,while Chaihu Guizhi Ganjiang Decoction subtraction was given to the patients in the treatment group besides Valsartan amlodipine. The antihypertensive efficacy,TCM syndrome efficacy,TCM symptom score,and anxiety score in both groups were observed before and after the treatment. Results The difference of antihypertensive effect in both group was not significant( P > 0. 05). In treatment group,there were 19 cases with obvious effects,10 showed effective,1 showed ineffective,and the total effective rate was 96. 7%. In control group,there were 9 cases with obvious effects,13 showed effective,8 showed ineffective,and the total effective rate was73. 3%. Rank sum test analysis showed Z =-4. 404,P < 0. 001,which indicated the treatment group was superior to the control group. The scores of dizziness,headache,dry mouth,bitterness,aversion to coldness,upsetness of both groups were all decreased than those before treatment( P < 0. 05). The abdominal cold score of the treatment group was lower than before the treatment. The abdominal cold score before and after treatment in the control group had no significant difference( P > 0. 05). The scores of headache,dry mouth,bitter taste,and abdominal cold in the treatment group were significantly lower than those in the control group. The differentials was statistically significant( P < 0. 05),and the treatment group was superior to the control group. In both groups,the differentials was no significant difference in dizziness,aversion to coldness,and upsetness before-after treatment( P > 0. 05). After treatment,the anxiety score of both groups were lower than those before treatment( P < 0. 05). The score in the treatment group were significantly lower than those in the control group. The difference before and after treatment was statistically significant( P < 0. 05),and the score of treatment group decreased significantly than control group,the differentials before-after treatment was significantly different( P < 0. 05),which indicated the treatment group was superior to control group. Conclusion Chaihu Guizhi Ganjiang Decoction combines Valsartan amlodipine tablets has good curative effect on hypertension patients with intermingled heat and cold syndrome.
Objective To observe the clinical efficacy of Chaihu Guizhi Ganjiang Decoction in treating primary hypertension with intermingled heat and cold syndrome. Methods 62 patients with primary hypertension( intermingled heat and cold syndrome) were randomly divided into 2 groups,with 31 patients in each. Valsartan amlodipine tablets were given to control group,while Chaihu Guizhi Ganjiang Decoction subtraction was given to the patients in the treatment group besides Valsartan amlodipine. The antihypertensive efficacy,TCM syndrome efficacy,TCM symptom score,and anxiety score in both groups were observed before and after the treatment. Results The difference of antihypertensive effect in both group was not significant( P > 0. 05). In treatment group,there were 19 cases with obvious effects,10 showed effective,1 showed ineffective,and the total effective rate was 96. 7%. In control group,there were 9 cases with obvious effects,13 showed effective,8 showed ineffective,and the total effective rate was73. 3%. Rank sum test analysis showed Z =-4. 404,P < 0. 001,which indicated the treatment group was superior to the control group. The scores of dizziness,headache,dry mouth,bitterness,aversion to coldness,upsetness of both groups were all decreased than those before treatment( P < 0. 05). The abdominal cold score of the treatment group was lower than before the treatment. The abdominal cold score before and after treatment in the control group had no significant difference( P > 0. 05). The scores of headache,dry mouth,bitter taste,and abdominal cold in the treatment group were significantly lower than those in the control group. The differentials was statistically significant( P < 0. 05),and the treatment group was superior to the control group. In both groups,the differentials was no significant difference in dizziness,aversion to coldness,and upsetness before-after treatment( P > 0. 05). After treatment,the anxiety score of both groups were lower than those before treatment( P < 0. 05). The score in the treatment group were significantly lower than those in the control group. The difference before and after treatment was statistically significant( P < 0. 05),and the score of treatment group decreased significantly than control group,the differentials before-after treatment was significantly different( P < 0. 05),which indicated the treatment group was superior to control group. Conclusion Chaihu Guizhi Ganjiang Decoction combines Valsartan amlodipine tablets has good curative effect on hypertension patients with intermingled heat and cold syndrome.
引文
[1]林晓斐.《中国居民营养与慢性病状况报告(2015年)》发布[J].中医药管理杂志,2015,23(13):89.
[2]陈伟伟,高润霖,刘力生,等.《中国心血管病报告2016》概要[J].中国循环杂志,2017,32(6):521-530.
[3]隋辉,陈伟伟,王文.《中国心血管病报告2015》要点解读[J].中国心血管杂志,2016,21(4):259-261.
[4]中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):701-708.
[5]吕冰清,王琼,葛玉红,等.高血压的中医药研究进展[J].内蒙古中医药,2016,35(4):127-128.
[6]屈晨,冯辉.中医药治疗原发性高血压伴焦虑的研究进展[J].天津中医药,2016,33(3):185-188.
[7]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:73-77.
[8]曲姗,胜利.广泛性焦虑量表在综合医院心理科门诊筛查广泛性焦虑障碍的诊断试验[J].中国心理卫生杂志,2015,29(12):939-944.
[9]中华中医药学会.高血压中医诊疗指南[J].中国中医药现代远程教育,2011,9(23):108-109.
[10]莫政.柴胡桂枝干姜汤文献与应用研究[D].南京:南京中医药大学,2011.
[11]张仲景.伤寒论[M].钱超尘,郝万山,整理.北京:人民卫生出版社,2005:59.
[12]王庆国,刘燕华.伤寒论通俗讲话[M].北京:人民卫生出版社,2013:137.
[13]冯世纶,石应轩.柴胡桂枝干姜汤面面观[N].中国中医药报,2005-08-01(6).
[14]张田仓.加味柴胡桂枝干姜汤治疗失眠42例疗效观察[J].光明中医,2015,30(2):298-299.
[15]何锟鹏.柴胡桂枝干姜汤对溃疡性结肠炎的疗效分析[J].世界中医药,2013,8(9):1051-1052,1057.
[2]陈伟伟,高润霖,刘力生,等.《中国心血管病报告2016》概要[J].中国循环杂志,2017,32(6):521-530.
[3]隋辉,陈伟伟,王文.《中国心血管病报告2015》要点解读[J].中国心血管杂志,2016,21(4):259-261.
[4]中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):701-708.
[5]吕冰清,王琼,葛玉红,等.高血压的中医药研究进展[J].内蒙古中医药,2016,35(4):127-128.
[6]屈晨,冯辉.中医药治疗原发性高血压伴焦虑的研究进展[J].天津中医药,2016,33(3):185-188.
[7]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:73-77.
[8]曲姗,胜利.广泛性焦虑量表在综合医院心理科门诊筛查广泛性焦虑障碍的诊断试验[J].中国心理卫生杂志,2015,29(12):939-944.
[9]中华中医药学会.高血压中医诊疗指南[J].中国中医药现代远程教育,2011,9(23):108-109.
[10]莫政.柴胡桂枝干姜汤文献与应用研究[D].南京:南京中医药大学,2011.
[11]张仲景.伤寒论[M].钱超尘,郝万山,整理.北京:人民卫生出版社,2005:59.
[12]王庆国,刘燕华.伤寒论通俗讲话[M].北京:人民卫生出版社,2013:137.
[13]冯世纶,石应轩.柴胡桂枝干姜汤面面观[N].中国中医药报,2005-08-01(6).
[14]张田仓.加味柴胡桂枝干姜汤治疗失眠42例疗效观察[J].光明中医,2015,30(2):298-299.
[15]何锟鹏.柴胡桂枝干姜汤对溃疡性结肠炎的疗效分析[J].世界中医药,2013,8(9):1051-1052,1057.