钙传感器基质交感分子1与心血管疾病的研究进展
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摘要
<正>冠心病和心力衰竭等心血管疾病的发病机制多样、病理生理过程复杂多变,虽目前从多个方面研究,但仍未能完全明确。钙离子主要位于细胞外或储存在内质网等细胞器中,是常见的第二信使,在细胞生存进程中有着十分重要的作用。近些年研究发现细胞内钙稳态失调是诱发心血管疾病的重要因素[1-2]。钙离子耗竭引起的翻译后蛋白修饰异常会导致蛋白运输错误、内质网应激、生长抑制和细胞凋
Stromal interaction molecule 1(STIM1)is a transmembrane protein of the endoplasmic reticulum(ER),a Ca~(2+) transducer in ER that activates the store-operated calcium channel.Through Orai1 protein,STIM1 adjusts the intracellular and extracellular calcium concentration.This way is called a store-operated Ca~(2+) entry.STIM1 plays a key role in phenotypic transformation of vascular smooth muscle cells,proliferation of endothelial cells,myocardial hypertrophy and myocardial fibrosis to regulate lots of cardiovascular diseases,such as atherosclerosis,congestive heart failure and systemic hypertension.STIM1 is closely related to cardiovascular diseases through calcium signal.The research progress of STIM1 in cardiovascular diseases is mainly discussed in this article.
Stromal interaction molecule 1(STIM1)is a transmembrane protein of the endoplasmic reticulum(ER),a Ca~(2+) transducer in ER that activates the store-operated calcium channel.Through Orai1 protein,STIM1 adjusts the intracellular and extracellular calcium concentration.This way is called a store-operated Ca~(2+) entry.STIM1 plays a key role in phenotypic transformation of vascular smooth muscle cells,proliferation of endothelial cells,myocardial hypertrophy and myocardial fibrosis to regulate lots of cardiovascular diseases,such as atherosclerosis,congestive heart failure and systemic hypertension.STIM1 is closely related to cardiovascular diseases through calcium signal.The research progress of STIM1 in cardiovascular diseases is mainly discussed in this article.
引文
[1]Fischer TH,Maier LS,Sossalla S.The ryanodine receptor leak:how a tattered receptor plunges the failing heart into crisis[J].Heart Fail Rev,2013,18(4):475-483.
[2]Kalogeris T,Baines CP,Krenz M,et al.Cell biology of ischemia/reperfusion injury[J].Int Rev Cell Mol Biol,2012,298:229-317.
[3]Wray S,Burdyga T.Sarcoplasmic reticulum function in smooth muscle[J].Physiol Rev,2010,90(1):113-178.
[4]Edwards JM,Neeb ZP,Alloosh MA,et al.Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosis[J].Cardiovasc Res,2010,85(3):631-640.
[5]Jardin I,Dionisio N,Frischauf I,et al.The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium[J].Cell Signal,2013,25(5):1328-1337.
[6]Collins HE,Zhu-Mauldin X,Marchase RB,et al.STIM1/Orai1-mediated SOCE:current perspectives and potential roles in cardiac function and pathology[J].Am JPhysiol Heart Circ Physiol,2013,305(4):H446-H458.
[7]Putney JJ.A model for receptor-regulated calcium entry[J].Cell Calcium,1986,7(1):1-12.
[8]Lewis RS.Store-operated calcium channels:new perspectives on mechanism and function[J].Cold Spring Harb Perspect Biol,2011,3(12):1-24.
[9]Lewis RS.The molecular choreography of a store-operated calcium channel[J].Nature,2007,446(7133):284-287.
[10]Stathopulos PB,Li GY,Plevin MJ,et al.Stored Ca2+depletion-induced oligomerization of stromal interaction molecule 1(STIM1)via the EF-SAM region:an initiation mechanism for capacitive Ca2+entry[J].J Biol Chem,2006,281(47):35855-35862.
[11]Luik RM,Wang B,Prakriya M,et al.Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation[J].Nature,2008,454(7203):538-542.
[12]Shinya K,Nakayama T,Nakayama T,et al.A case-control study between the STIM1 gene and hypertensive disorders of pregnancy[J].Hypertens Res,2018,41(1):39-44.
[13]Nishimoto M,Mizuno R,Fujita T,et al.Stromal interaction molecule 1 modulates blood pressure via NO production in vascular endothelial cells[J].Hypertens Res,2018,41(7):506-514.
[14]Kassan M,Ait-Aissa K,Radwan E,et al.Essential role of smooth muscle STIM1 in hypertension and cardiovascular dysfunction[J].Arterioscler Thromb Vasc Biol,2016,36(9):1900-1909.
[15]Kassan M,Zhang W,Aissa KA,et al.Differential role for stromal interacting molecule 1 in the regulation of vascular function[J].Pflugers Arch,2015,467(6):1195-1202.
[16]Hirano K,Hirano M,Hanada A.Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+influx in vascular endothelial cells[J].J Cell Biochem,2009,108(2):499-507.
[17]Abdullaev IF,Bisaillon JM,Potier M,et al.Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation[J].Circ Res,2008,103(11):1289-1299.
[18]Shi Y,Song M,Guo R,et al.Knockdown of stromal interaction molecule 1 attenuates hepatocyte growth factor-induced endothelial progenitor cell proliferation[J].Exp Biol Med(Maywood),2010,235(3):317-325.
[19]Elvers M,Herrmann A,Seizer P,et al.Intracellular cyclophilin A is an important Ca2+regulator in platelets and critically involved in arterial thrombus formation[J].Blood,2012,120(6):1317-1326.
[20]Lang F,Munzer P,Gawaz M,et al.Regulation of STIM1/Orai1-dependent Ca2+signalling in platelets[J].Thromb Haemost,2013,110(5):925-930.
[21]Borst O,Schmidt EM,Munzer P,et al.The serum-and glucocorticoid-inducible kinase 1(SGK1)influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes[J].Blood,2012,119(1):251-261.
[22]Dolan AT,Diamond SL.Systems modeling of Ca2+homeostasis and mobilization in platelets mediated by IP3and store-operated Ca2+entry[J].Biophys J,2014,106(9):2049-2060.
[23]Yang Y,Sun Y,Chen Y.STIM1 deficiency in vascular smooth muscle cells promotes vascular calcification in atherosclerosis[J].Arterioscler Thromb Vasc Biol,2016,36(Suppl 1):A383.
[24]Aubart FC,Sassi Y,Coulombe A,et al.RNA interference targeting STIM1 suppresses vascular smooth muscle cell proliferation and neointima formation in the rat[J].Mol Ther,2009,17(3):455-462.
[25]Bisaillon JM,Motiani RK,Gonzalez-Cobos JC,et al.Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration[J].Am J Physiol Cell Physiol,2010,298(5):C993-C1005.
[26]Simo-Cheyou ER,Tan JJ,Grygorczyk R,et al.STIM-1and ORAI-1 channel mediate angiotensin-II-induced expression of Egr-1 in vascular smooth muscle cells[J].JCell Physiol,2017,232(12):3496-3509.
[27]Yang J,Yu J,Li D,et al.Store-operated calcium entryactivated autophagy protects EPC proliferation via the CAMKK2-MTOR pathway in ox-LDL exposure[J].Autophagy,2017,13(1):82-98.
[28]Mali V,Haddox S,Belmadani S,et al.Essential role for smooth muscle cell stromal interaction molecule-1 in myocardial infarction[J].J Hypertens,2018,36(2):377-386.
[29]Varga-Szabo D,Braun A,Kleinschnitz C,et al.The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction[J].J Exp Med,2008,205(7):1583-1591.
[30]Braun A,Varga-Szabo D,Kleinschnitz C,et al.Orai1(CRACM1)is the platelet SOC channel and essential for pathological thrombus formation[J].Blood,2009,113(9):2056-2063.
[31]Grosse J,Braun A,Varga-Szabo D,et al.An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice[J].J Clin Invest,2007,117(11):3540-3550.
[32]Kazmierczak E,Grajek S,Kowal J,et al.Prognostic usefulness of IL-6 and VEGF for the occurrence of changes in coronary arteries of patients with stable angina and implanted stents[J].Eur Rev Med Pharmacol Sci,2014,18(15):2169-2175.
[33]Chen YF,Chiu WT,Chen YT,et al.Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth,migration,and angiogenesis[J].Proc Natl Acad Sci U S A,2011,108(37):15225-15230.
[34]Hou J,Liu L,Zhu Q,et al.MicroRNA-185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1[J].Cell Biol Int,2016,40(3):318-328.
[35]王芳,丁小云,吕果,等.PCI术后血清S1P和STIM1含量对支架内再狭窄的预测价值及其与血管新生、炎症反应的相关性[J].海南医学院学报,2017,23(13):1798-1800.
[36]Ohba T,Watanabe H,Murakami M,et al.Essential role of STIM1 in the development of cardiomyocyte hypertrophy[J].Biochem Biophys Res Commun,2009,389(1):172-176.
[37]Abramowitz J,Birnbaumer L.Physiology and pathophysiology of canonical transient receptor potential channels[J].FASEB J,2009,23(2):297-328.
[38]Dai F,Zhang Y,Wang Q,et al.Overexpression of SARAF ameliorates pressure overload-induced cardiac hypertrophy through suppressing STIM1-Orai1 in mice[J].Cell Physiol Biochem,2018,47(2):817-826.
[39]Voelkers M,Salz M,Herzog N,et al.Orai1 and Stim1regulate normal and hypertrophic growth in cardiomyocytes[J].J Mol Cell Cardiol,2010,48(6):1329-1334.
[40]Benard L,Oh JG,Cacheux M,et al.Cardiac Stim1 silencing impairs adaptive hypertrophy and promotes heart failure through inactivation of m TORC2/Akt signaling[J].Circulation,2016,133(15):1458-1471.
[41]Zhang B,Jiang J,Yue Z,et al.Store-operated Ca2+entry(SOCE)contributes to angiotensin II-induced cardiac fibrosis in cardiac fibroblasts[J].J Pharmacol Sci,2016,132(3):171-180.
[42]Ross GR,Bajwa TJ,Edwards S,et al.Enhanced storeoperated Ca2+influx and ORAI1 expression in ventricular fibroblasts from human failing heart[J].Biol Open,2017,6(3):326-332.
[43]Correll RN,Goonasekera SA,van Berlo JH,et al.STIM1elevation in the heart results in aberrant Ca2+handling and cardiomyopathy[J].J Mol Cell Cardiol,2015,87:38-47.
[44]Zheng C,Lo CY,Meng Z,et al.Gastrodin inhibits storeoperated Ca2+entry and alleviates cardiac hypertrophy[J].Front Pharmacol,2017,8:222.
[45]Lu Y,Zhao M,Liu JJ,et al.Long-term administration of pyridostigmine attenuates pressure overload-induced cardiac hypertrophy by inhibiting calcineurin signalling[J].JCell Mol Med,2017,21(9):2106-2116.
[46]Jing XD,Wei XM,Deng SB,et al.The relationship between the high-density lipoprotein(HDL)-associated sphingosine-1-phosphate(S1P)and coronary in-stent restenosis[J].Clin Chim Acta,2015,446:248-252.
[47]Isaaz K,Gerbay A,Terreaux J,et al.Restenosis after percutaneous coronary intervention for coronary chronic total occlusion.The central role of an optimized immediate post-procedural angiographic result[J].Int J Cardiol,2016,224:343-347.
[48]Li H,Jiang Z,Liu X,et al.Higher plasma level of STIM1,OPG are correlated with stent restenosis after PCI[J].Int J Clin Exp Med,2015,8(11):21089-21097.
[49]Estrada IA,Donthamsetty R,Debski P,et al.STIM1 restores coronary endothelial function in type 1 diabetic mice[J].Circ Res,2012,111(9):1166-1175.
[2]Kalogeris T,Baines CP,Krenz M,et al.Cell biology of ischemia/reperfusion injury[J].Int Rev Cell Mol Biol,2012,298:229-317.
[3]Wray S,Burdyga T.Sarcoplasmic reticulum function in smooth muscle[J].Physiol Rev,2010,90(1):113-178.
[4]Edwards JM,Neeb ZP,Alloosh MA,et al.Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosis[J].Cardiovasc Res,2010,85(3):631-640.
[5]Jardin I,Dionisio N,Frischauf I,et al.The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium[J].Cell Signal,2013,25(5):1328-1337.
[6]Collins HE,Zhu-Mauldin X,Marchase RB,et al.STIM1/Orai1-mediated SOCE:current perspectives and potential roles in cardiac function and pathology[J].Am JPhysiol Heart Circ Physiol,2013,305(4):H446-H458.
[7]Putney JJ.A model for receptor-regulated calcium entry[J].Cell Calcium,1986,7(1):1-12.
[8]Lewis RS.Store-operated calcium channels:new perspectives on mechanism and function[J].Cold Spring Harb Perspect Biol,2011,3(12):1-24.
[9]Lewis RS.The molecular choreography of a store-operated calcium channel[J].Nature,2007,446(7133):284-287.
[10]Stathopulos PB,Li GY,Plevin MJ,et al.Stored Ca2+depletion-induced oligomerization of stromal interaction molecule 1(STIM1)via the EF-SAM region:an initiation mechanism for capacitive Ca2+entry[J].J Biol Chem,2006,281(47):35855-35862.
[11]Luik RM,Wang B,Prakriya M,et al.Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation[J].Nature,2008,454(7203):538-542.
[12]Shinya K,Nakayama T,Nakayama T,et al.A case-control study between the STIM1 gene and hypertensive disorders of pregnancy[J].Hypertens Res,2018,41(1):39-44.
[13]Nishimoto M,Mizuno R,Fujita T,et al.Stromal interaction molecule 1 modulates blood pressure via NO production in vascular endothelial cells[J].Hypertens Res,2018,41(7):506-514.
[14]Kassan M,Ait-Aissa K,Radwan E,et al.Essential role of smooth muscle STIM1 in hypertension and cardiovascular dysfunction[J].Arterioscler Thromb Vasc Biol,2016,36(9):1900-1909.
[15]Kassan M,Zhang W,Aissa KA,et al.Differential role for stromal interacting molecule 1 in the regulation of vascular function[J].Pflugers Arch,2015,467(6):1195-1202.
[16]Hirano K,Hirano M,Hanada A.Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+influx in vascular endothelial cells[J].J Cell Biochem,2009,108(2):499-507.
[17]Abdullaev IF,Bisaillon JM,Potier M,et al.Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation[J].Circ Res,2008,103(11):1289-1299.
[18]Shi Y,Song M,Guo R,et al.Knockdown of stromal interaction molecule 1 attenuates hepatocyte growth factor-induced endothelial progenitor cell proliferation[J].Exp Biol Med(Maywood),2010,235(3):317-325.
[19]Elvers M,Herrmann A,Seizer P,et al.Intracellular cyclophilin A is an important Ca2+regulator in platelets and critically involved in arterial thrombus formation[J].Blood,2012,120(6):1317-1326.
[20]Lang F,Munzer P,Gawaz M,et al.Regulation of STIM1/Orai1-dependent Ca2+signalling in platelets[J].Thromb Haemost,2013,110(5):925-930.
[21]Borst O,Schmidt EM,Munzer P,et al.The serum-and glucocorticoid-inducible kinase 1(SGK1)influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes[J].Blood,2012,119(1):251-261.
[22]Dolan AT,Diamond SL.Systems modeling of Ca2+homeostasis and mobilization in platelets mediated by IP3and store-operated Ca2+entry[J].Biophys J,2014,106(9):2049-2060.
[23]Yang Y,Sun Y,Chen Y.STIM1 deficiency in vascular smooth muscle cells promotes vascular calcification in atherosclerosis[J].Arterioscler Thromb Vasc Biol,2016,36(Suppl 1):A383.
[24]Aubart FC,Sassi Y,Coulombe A,et al.RNA interference targeting STIM1 suppresses vascular smooth muscle cell proliferation and neointima formation in the rat[J].Mol Ther,2009,17(3):455-462.
[25]Bisaillon JM,Motiani RK,Gonzalez-Cobos JC,et al.Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration[J].Am J Physiol Cell Physiol,2010,298(5):C993-C1005.
[26]Simo-Cheyou ER,Tan JJ,Grygorczyk R,et al.STIM-1and ORAI-1 channel mediate angiotensin-II-induced expression of Egr-1 in vascular smooth muscle cells[J].JCell Physiol,2017,232(12):3496-3509.
[27]Yang J,Yu J,Li D,et al.Store-operated calcium entryactivated autophagy protects EPC proliferation via the CAMKK2-MTOR pathway in ox-LDL exposure[J].Autophagy,2017,13(1):82-98.
[28]Mali V,Haddox S,Belmadani S,et al.Essential role for smooth muscle cell stromal interaction molecule-1 in myocardial infarction[J].J Hypertens,2018,36(2):377-386.
[29]Varga-Szabo D,Braun A,Kleinschnitz C,et al.The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction[J].J Exp Med,2008,205(7):1583-1591.
[30]Braun A,Varga-Szabo D,Kleinschnitz C,et al.Orai1(CRACM1)is the platelet SOC channel and essential for pathological thrombus formation[J].Blood,2009,113(9):2056-2063.
[31]Grosse J,Braun A,Varga-Szabo D,et al.An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice[J].J Clin Invest,2007,117(11):3540-3550.
[32]Kazmierczak E,Grajek S,Kowal J,et al.Prognostic usefulness of IL-6 and VEGF for the occurrence of changes in coronary arteries of patients with stable angina and implanted stents[J].Eur Rev Med Pharmacol Sci,2014,18(15):2169-2175.
[33]Chen YF,Chiu WT,Chen YT,et al.Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth,migration,and angiogenesis[J].Proc Natl Acad Sci U S A,2011,108(37):15225-15230.
[34]Hou J,Liu L,Zhu Q,et al.MicroRNA-185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1[J].Cell Biol Int,2016,40(3):318-328.
[35]王芳,丁小云,吕果,等.PCI术后血清S1P和STIM1含量对支架内再狭窄的预测价值及其与血管新生、炎症反应的相关性[J].海南医学院学报,2017,23(13):1798-1800.
[36]Ohba T,Watanabe H,Murakami M,et al.Essential role of STIM1 in the development of cardiomyocyte hypertrophy[J].Biochem Biophys Res Commun,2009,389(1):172-176.
[37]Abramowitz J,Birnbaumer L.Physiology and pathophysiology of canonical transient receptor potential channels[J].FASEB J,2009,23(2):297-328.
[38]Dai F,Zhang Y,Wang Q,et al.Overexpression of SARAF ameliorates pressure overload-induced cardiac hypertrophy through suppressing STIM1-Orai1 in mice[J].Cell Physiol Biochem,2018,47(2):817-826.
[39]Voelkers M,Salz M,Herzog N,et al.Orai1 and Stim1regulate normal and hypertrophic growth in cardiomyocytes[J].J Mol Cell Cardiol,2010,48(6):1329-1334.
[40]Benard L,Oh JG,Cacheux M,et al.Cardiac Stim1 silencing impairs adaptive hypertrophy and promotes heart failure through inactivation of m TORC2/Akt signaling[J].Circulation,2016,133(15):1458-1471.
[41]Zhang B,Jiang J,Yue Z,et al.Store-operated Ca2+entry(SOCE)contributes to angiotensin II-induced cardiac fibrosis in cardiac fibroblasts[J].J Pharmacol Sci,2016,132(3):171-180.
[42]Ross GR,Bajwa TJ,Edwards S,et al.Enhanced storeoperated Ca2+influx and ORAI1 expression in ventricular fibroblasts from human failing heart[J].Biol Open,2017,6(3):326-332.
[43]Correll RN,Goonasekera SA,van Berlo JH,et al.STIM1elevation in the heart results in aberrant Ca2+handling and cardiomyopathy[J].J Mol Cell Cardiol,2015,87:38-47.
[44]Zheng C,Lo CY,Meng Z,et al.Gastrodin inhibits storeoperated Ca2+entry and alleviates cardiac hypertrophy[J].Front Pharmacol,2017,8:222.
[45]Lu Y,Zhao M,Liu JJ,et al.Long-term administration of pyridostigmine attenuates pressure overload-induced cardiac hypertrophy by inhibiting calcineurin signalling[J].JCell Mol Med,2017,21(9):2106-2116.
[46]Jing XD,Wei XM,Deng SB,et al.The relationship between the high-density lipoprotein(HDL)-associated sphingosine-1-phosphate(S1P)and coronary in-stent restenosis[J].Clin Chim Acta,2015,446:248-252.
[47]Isaaz K,Gerbay A,Terreaux J,et al.Restenosis after percutaneous coronary intervention for coronary chronic total occlusion.The central role of an optimized immediate post-procedural angiographic result[J].Int J Cardiol,2016,224:343-347.
[48]Li H,Jiang Z,Liu X,et al.Higher plasma level of STIM1,OPG are correlated with stent restenosis after PCI[J].Int J Clin Exp Med,2015,8(11):21089-21097.
[49]Estrada IA,Donthamsetty R,Debski P,et al.STIM1 restores coronary endothelial function in type 1 diabetic mice[J].Circ Res,2012,111(9):1166-1175.