痛风消颗粒知母水提取工艺优化

详细信息    查看全文 | 推荐本文 |

英文篇名：Optimization of Water Extraction Process for Anemarrhena asphodeloides in TongFengXiao Granule 作者：杨伟兴 ; 刘菊容 ; 肖国辉 ; 李志 ; 王天刚 ; 冯雯 ; 陈辉 ; 蒋亚玲 ; 向未 英文作者：Yang Wei-xing;LIU Ju-rong;XIAO Guo-hui;LI Zhi;WANG Tian-gang;FENG Wen;CHEN Hui;JIANG Ya-ling;XIANG Wei;Affiliated Hospital of Tradtional Chinese Medicine Southwest Medical University; 关键词：痛风消颗粒 ; 正交实验 ; 综合评分 ; 提取工艺 英文关键词：TongFengXiao Granule;;Orthogonal design;;Comprehensive score;;Extraction process 中文刊名：HAIX 英文刊名：Strait Pharmaceutical Journal 机构：西南医科大学附属中医医院; 出版日期：2019-02-15 出版单位：海峡药学 年：2019 期：v.31;No.229 基金：泸州医学院自然科学基金(2017);; 西南医科大学校级课题(2015-YJ106) 语种：中文; 页：HAIX201902015 页数：3 CN：02 ISSN：35-1173/R 分类号：48-50

摘要

目的优选痛风消颗粒中知母的最佳提取工艺。方法以知母皂苷BⅡ、芒果苷含量及浸膏得率为考察指标,以浸泡时间、加水量、提取时间、提取次数为影响因素,采用L_9(3~4)正交实验法优选出最佳提取工艺。结果最佳提取工艺为:提取两次,第一次加6倍量水,煎煮2.0h,第二次加4倍量水煎煮1.5h。结论正交实验优选的提取工艺稳定、简便、可行。
        OBJECTIVE To optimize the extraction process of Anemarrhena asphodeloides in TongFengXiao Granule.METHODS Using the contents of timosaponin BⅡ.,mangiferin and yield of icariin as indexes,the effects of solvent time,solvent usage,extraction time and extraction times were investigated by L_9(3~4) orthogonal experiment design,so as to optimize the best processing technology.RESULTS The optimal parameters were as follows:extracted for two times,the first time added six folds water and heated 2 hours;the second time added four folds water and heated 1.5 hour.CONCLUSION The processing technology was stable and feasible.

引文

[1]郝慧琴.原发性痛风诊治指南[J].中华风湿病学杂志,2005,(9):31-33.
    [2]苏厚恒,赵娜,李霞,等.痛风患者与医师对痛风的认知和诊断现状调查分析[J].中华风湿病学杂志,2013,17(4):257.
    [3]顾玲丽,周唯践.丹溪痛风方治疗痛风的临床观察及中医证侯学研究[J].陕西中医,2016,37(3):300.
    [4]高双荣,马卫国,商学征,等.复方青秦对痛风性肾病大鼠肾组织病理学的影响[J].中国试验方剂学,2012,18(10):183.
    [5][6]卢君蓉,傅超美,陈秋薇,等.二母颗粒中知母水提工艺优化[J].中国实验方剂学,2012,18(2):31-33.