摘要
目的:探讨固冲止崩汤联合地屈孕酮治疗围绝经期异常子宫出血对患者临床效果、子宫内膜厚度、症状恢复、激素水平和炎性因子的影响。方法:选取新疆维吾尔自治区中医医院异常子宫出血的围绝经期患者124例,按入院时间分为治疗组与对照组,每组62例,治疗组予固冲止崩汤联合地屈孕酮,对照组予地屈孕酮,比较两组治疗后临床效果、子宫内膜厚度、控制出血和完全止血时间、中医证候积分、血红蛋白、激素水平以及炎性因子。结果:治疗组治愈率、显效率和总有效率分别为35.5%、33.9%和95.2%,均高于对照组,差异均有统计学意义(P<0.05);治疗组治疗后子宫内膜厚度小于对照组,控制出血时间和完全止血时间均少于对照组,差异具有统计学意义(P<0.05);治疗组治疗后月经色淡有块、小腹疼痛、气短神疲和面色萎黄等症状积分均低于对照组,差异均有统计学意义(P<0.05);治疗组治疗后FSH和LH值均低于对照组,E2值高于对照组,差异均有统计学意义(P<0.05);治疗组治疗后血红蛋白值高于对照组,炎性因子IL-2和TNF-α值均低于对照组,差异均有统计学意义(P<0.05)。结论:固冲止崩汤联合地屈孕酮治疗围绝经期异常子宫出血临床效果较好,子宫内膜厚度降低明显,可缩短止血时间,改善激素水平,缓解炎性反应,症状恢复更快。
Object: To investigate the clinical effect, endometrial thickness, symptom recovery, hormone levels and inflammatory factors of Guchong Zhipeng Decoction combined with dydrogesterone in the treatment of abnormal uterine bleeding in perimenopausal period. Method: A total of 124 perimenopausal patients with abnormal uterine bleeding in TCM Hospital of Xinjiang Uygur Autonomous Region were divided into observation group and control group according to admission time, 62 cases in each group.The observation group was treated with Guchong Zhipeng Decoction and dydrogesterone, while the control group was given dydrogesterone. The clinical effect, endometrial thickness, control bleeding and complete hemostasis time, TCM syndrome score,hemoglobin, hormone levels and inflammatory factors were compared between the two groups after treatment.Result: The cure rate, marked effective rate and total effective rate of the observation group were 35.5%, 33.9%and 95.2% respectively, which were higher than those of the control group, the difference were statistically significant(P<0.05). The endometrial thickness of the observation group was less than that of the control group,and t he control bleeding time and complete hemostasis time were less than those of the control group, the difference was statistically significant(P<0.05). The scores of symptoms such as pale menstrual lump, abdominal pain, shortness of breath and mental fatigue, and yellowness of complexion in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). FSH and LH values of the observation group were lower than those of the control group, the E2 values were higher than those of the control group, the difference were statistically significant(P<0.05). The hemoglobin level of the observation group was higher than that of the control group, and the inflammatory factors IL-2 and TNF-alpha levels were lower than those of the control group, the difference were statistically significant(P<0.05). Conclusion: The application of Guchong Zhipeng Decoction combined with dydrogesterone in the treatment of abnormal uterine bleeding in peri-menopausal period has a better clinical effect, which can reduce the endometrial thickness more obviously,shorten hemostasis time, improve the hormone level, alleviate the inflammatory response and fasten the symptoms recover time.
引文
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