正电子发射型计算机断层显像在帕金森病患者早期诊断中的应用
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摘要
目的探讨正电子发射型计算机断层显像(PET)在帕金森病(PD)患者早期诊断中的影像学特征。方法选取25例原发性早期PD患者作为研究组,另选取除外神经系统相关疾病的同期检查者25例作为对照组,两组均采用PET检查进行扫描诊断,观察比较两组双侧尾状核和前后壳核~(11)C-CFT摄取值。结果研究组双侧尾状核~(11)C-CFT摄取值与对照组比较差异无统计学意义(t=1.387,P>0.05);前壳核和后壳核~(11)C-CFT摄取值明显低于对照组,差异具有统计学意义(t=18.007、32.998,P<0.05)。研究组发病同侧与对照组、研究组发病对侧与对照组、研究组发病同侧与研究组发病对侧双侧尾状核~(11)C-CFT摄取值比较差异均无统计学意义(t=1.359、1.359、0,P>0.05);研究组发病同侧与对照组、研究组发病对侧与对照组、研究组发病同侧与研究组发病对侧前壳核~(11)C-CFT摄取值比较差异具有统计学意义(t=20.525、26.226、5.528,P<0.05);研究组发病同侧与对照组、研究组发病对侧与对照组、研究组发病同侧与研究组发病对侧后壳核~(11)C-CFT摄取值比较差异具有统计学意义(t=33.122、38.422、6.633,P<0.05)。结论 PET显像技术能够早期分辨出双侧尾状核和前后壳核中多巴胺(DA)转运体的不同分布,可帮助提高早期PD患者诊断的准确性。
Objective To discuss the imaging features of positron emission tomography(PET) in the early diagnosis of Parkinson's disease(PD).Methods There were 25 primary early PD patients as research group,and concurrent 25 examiner without nervous system-related diseases as control group.Both groups were scanned by PET to observe and compare the ~(11)C-CFT uptake value of the bilateral caudate nucleus and the anterior and posterior putamen.Results The research group had no statistically significant difference in bilateral caudate nucleus ~(11)C-CFT uptake value(t=1.387,P>0.05),and obviously lower uptake value of anterior and posterior putamen ~(11)C-CFT than the control group.Their difference was statistically significant(t=18.007,32.998,P<0.05).There was no significant difference in the incidence of bilateral caudate nucleus ~(11)C-CFT uptake value between ipsilateral of research group and control group,contralateral of research group and control group,and ipsilateral and contralateral of research group(t=1.359,1.359,0,P>0.05).There was significant difference in uptake value of anterior putamen between ipsilateral of research group and control group,contralateral of research group and control group,and ipsilateral and contralateral of research group(t=20.525,26.226,5.528,P<0.05).There was significant difference in ~(11)C-CFT uptake value of posterior putamen between ipsilateral of research group and control group,contralateral of research group and control group,and ipsilateral and contralateral of research group(t=33.122,38.422,6.633,P<0.05).Conclusion PET imaging technique can identify the different distribution of dopamine(DA) transporters in bilateral caudate nucleus and the anterior and posterior putamen,and help to improve the accuracy of early diagnosis of PD patients.
Objective To discuss the imaging features of positron emission tomography(PET) in the early diagnosis of Parkinson's disease(PD).Methods There were 25 primary early PD patients as research group,and concurrent 25 examiner without nervous system-related diseases as control group.Both groups were scanned by PET to observe and compare the ~(11)C-CFT uptake value of the bilateral caudate nucleus and the anterior and posterior putamen.Results The research group had no statistically significant difference in bilateral caudate nucleus ~(11)C-CFT uptake value(t=1.387,P>0.05),and obviously lower uptake value of anterior and posterior putamen ~(11)C-CFT than the control group.Their difference was statistically significant(t=18.007,32.998,P<0.05).There was no significant difference in the incidence of bilateral caudate nucleus ~(11)C-CFT uptake value between ipsilateral of research group and control group,contralateral of research group and control group,and ipsilateral and contralateral of research group(t=1.359,1.359,0,P>0.05).There was significant difference in uptake value of anterior putamen between ipsilateral of research group and control group,contralateral of research group and control group,and ipsilateral and contralateral of research group(t=20.525,26.226,5.528,P<0.05).There was significant difference in ~(11)C-CFT uptake value of posterior putamen between ipsilateral of research group and control group,contralateral of research group and control group,and ipsilateral and contralateral of research group(t=33.122,38.422,6.633,P<0.05).Conclusion PET imaging technique can identify the different distribution of dopamine(DA) transporters in bilateral caudate nucleus and the anterior and posterior putamen,and help to improve the accuracy of early diagnosis of PD patients.
引文
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[10]蒋雨平,王坚,丁正同,等.18F-FP-CIT PET和99Tcm-TRODAT-1SPECT纹状体DAT显像在早期诊断帕金森病中的敏感性比较.中国临床神经科学,2006,14(2):128-133.
[2]邢一兰,陈俊抛,苏欢欢.磁共振弥散张量成像在帕金森病早期诊断以及定量分析中的临床应用价值.中国现代医学杂志,2015,25(8):43-46.
[3]杨晖,沈智辉,徐白萱.11C-CFT PET/CT显像鉴别多系统萎缩与帕金森病的价值.中国医学影像学杂志,2017,25(5):349-353.
[4]米涛免,顾朱勤,陈彪.经颅超声检查在帕金森病诊断及鉴别诊断中的应用.中华神经科杂志,2016,49(12):983-986.
[5]黄喆慜,左传涛,武猛.症状前期帕金森病的PET/SPECT功能影像学研究.中国临床神经科学,2015,23(3):355-358.
[6]郑朋楼,杨斌,刘玲.帕金森病早期诊断的影像技术应用.中国中西医结合影像学杂志,2016,14(3):363-366.
[7]王瑞民,郭喆,杨晖,等.帕金森病与多系统萎缩患者多模态正电子成像统计参数图对比分析.中华神经科杂志,2017,50(7):501-505.
[8]许靖,张奇洲,秦永德,等.11C-CFT脑多巴胺转运体PET显像在不同类型帕金森病患者病情评估中的应用价值.新疆医科大学学报,2017,40(6):738-742.
[9]李梦婷,兰晓莉,唐军.18F FP—CIT PET用于特发性帕金森病患者和正常人脑纹状体功能容量分析.中华核医学与分子影像杂志,2017,37(3):191.
[10]蒋雨平,王坚,丁正同,等.18F-FP-CIT PET和99Tcm-TRODAT-1SPECT纹状体DAT显像在早期诊断帕金森病中的敏感性比较.中国临床神经科学,2006,14(2):128-133.