摘要
目的探讨正电子发射型计算机断层显像(PET)在帕金森病(PD)患者早期诊断中的影像学特征。方法选取25例原发性早期PD患者作为研究组,另选取除外神经系统相关疾病的同期检查者25例作为对照组,两组均采用PET检查进行扫描诊断,观察比较两组双侧尾状核和前后壳核~(11)C-CFT摄取值。结果研究组双侧尾状核~(11)C-CFT摄取值与对照组比较差异无统计学意义(t=1.387,P>0.05);前壳核和后壳核~(11)C-CFT摄取值明显低于对照组,差异具有统计学意义(t=18.007、32.998,P<0.05)。研究组发病同侧与对照组、研究组发病对侧与对照组、研究组发病同侧与研究组发病对侧双侧尾状核~(11)C-CFT摄取值比较差异均无统计学意义(t=1.359、1.359、0,P>0.05);研究组发病同侧与对照组、研究组发病对侧与对照组、研究组发病同侧与研究组发病对侧前壳核~(11)C-CFT摄取值比较差异具有统计学意义(t=20.525、26.226、5.528,P<0.05);研究组发病同侧与对照组、研究组发病对侧与对照组、研究组发病同侧与研究组发病对侧后壳核~(11)C-CFT摄取值比较差异具有统计学意义(t=33.122、38.422、6.633,P<0.05)。结论 PET显像技术能够早期分辨出双侧尾状核和前后壳核中多巴胺(DA)转运体的不同分布,可帮助提高早期PD患者诊断的准确性。
Objective To discuss the imaging features of positron emission tomography(PET) in the early diagnosis of Parkinson's disease(PD).Methods There were 25 primary early PD patients as research group,and concurrent 25 examiner without nervous system-related diseases as control group.Both groups were scanned by PET to observe and compare the ~(11)C-CFT uptake value of the bilateral caudate nucleus and the anterior and posterior putamen.Results The research group had no statistically significant difference in bilateral caudate nucleus ~(11)C-CFT uptake value(t=1.387,P>0.05),and obviously lower uptake value of anterior and posterior putamen ~(11)C-CFT than the control group.Their difference was statistically significant(t=18.007,32.998,P<0.05).There was no significant difference in the incidence of bilateral caudate nucleus ~(11)C-CFT uptake value between ipsilateral of research group and control group,contralateral of research group and control group,and ipsilateral and contralateral of research group(t=1.359,1.359,0,P>0.05).There was significant difference in uptake value of anterior putamen between ipsilateral of research group and control group,contralateral of research group and control group,and ipsilateral and contralateral of research group(t=20.525,26.226,5.528,P<0.05).There was significant difference in ~(11)C-CFT uptake value of posterior putamen between ipsilateral of research group and control group,contralateral of research group and control group,and ipsilateral and contralateral of research group(t=33.122,38.422,6.633,P<0.05).Conclusion PET imaging technique can identify the different distribution of dopamine(DA) transporters in bilateral caudate nucleus and the anterior and posterior putamen,and help to improve the accuracy of early diagnosis of PD patients.
引文
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