单硝酸异山梨酯联合丹参多酚酸盐治疗冠心病心绞痛的临床观察
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摘要
目的探讨单硝酸异山梨酯联合丹参多酚酸盐治疗冠心病心绞痛的临床价值。方法选取2015年5月—2018年1月于我院就诊的106例冠心病心绞痛患者为研究对象,按治疗方法不同分为对照组50例和观察组56例,对照组给予单硝酸异山梨酯治疗,观察组在对照组基础上联合丹参多酚酸盐治疗,治疗结束后比较2组疾病情况、药物用量、临床疗效、心电图检查结和不良反应。结果治疗后2组硝酸甘油用量、心绞痛发作次数和持续时间均较治疗前减少,且观察组减少程度显著优于对照组(P<0.05);观察组临床治疗总有效率和心电图总有效率高于对照组(P<0.05);2组均未出现不良反应。结论单硝酸异山梨酯联合丹参多酚酸盐治疗可进一步改善冠心病心绞痛患者临床症状和提高其临床有效率,且具有一定的安全性,值得作为临床上治疗冠心病心绞痛的适用方案之一。
Objective To investigate clinical value of Isosorbide Mononitrate combined with Polyphenol Acid Salt of Salvia Miltiorrhiza in treatment of coronary heart disease patients with angina pectoris. Methods A total of coronary heart disease 106 patients with angina pectoris during May 2015 and January 2018 were divided into control group(n=50) and observation group(n=56) according to therapeutic methods. Control group was treated with Isosorbide Mononitrate, while observation group was treated with Isosorbide Mononitrate combined with Polyphenol Acid Salt of Salvia Miltiorrhiza. After treatment, disease condition, drug dosage, clinical efficacy, results of electrocardiogram examination and incidence rate of adverse reactions were compared between two groups. Results After treatment, values of Nitroglycerin dosage, number and duration of angina pectoris attacks were significantly decreased compared with those before treatment in two groups, while decreased degrees in observation group were significantly better than those in control group(P<0.05). The total effective rates of clinical treatment and electrocardiogram in observation group were significantly higher than those in control group(P<0.05). There were no adverse reactions in two groups. Conclusion Isosorbide Mononitrate combined with Polyphenol Acid Salt of Salvia Miltiorrhiza may further improve clinical symptoms and efficiency with a certain safety, and it can be used as one of applicable method in treatment of coronary heart disease patients with angina pectoris
Objective To investigate clinical value of Isosorbide Mononitrate combined with Polyphenol Acid Salt of Salvia Miltiorrhiza in treatment of coronary heart disease patients with angina pectoris. Methods A total of coronary heart disease 106 patients with angina pectoris during May 2015 and January 2018 were divided into control group(n=50) and observation group(n=56) according to therapeutic methods. Control group was treated with Isosorbide Mononitrate, while observation group was treated with Isosorbide Mononitrate combined with Polyphenol Acid Salt of Salvia Miltiorrhiza. After treatment, disease condition, drug dosage, clinical efficacy, results of electrocardiogram examination and incidence rate of adverse reactions were compared between two groups. Results After treatment, values of Nitroglycerin dosage, number and duration of angina pectoris attacks were significantly decreased compared with those before treatment in two groups, while decreased degrees in observation group were significantly better than those in control group(P<0.05). The total effective rates of clinical treatment and electrocardiogram in observation group were significantly higher than those in control group(P<0.05). There were no adverse reactions in two groups. Conclusion Isosorbide Mononitrate combined with Polyphenol Acid Salt of Salvia Miltiorrhiza may further improve clinical symptoms and efficiency with a certain safety, and it can be used as one of applicable method in treatment of coronary heart disease patients with angina pectoris
引文
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[10] 潘兴飞,张绍全,黄小萍,等.白细胞介素32γ通过活化核转录因子κB通路诱导LX-2细胞表达基质金属蛋白酶9[J].医学分子生物学杂志,2016,13(3):149-152.
[11] 卢炜,王鸿超,杜超,等.血浆同型半胱氨酸水平与冠心病患者中心动脉压及颈动脉狭窄程度的相关性研究[J].解放军医药杂志,2016,28(11):69-72.
[12] 邱丹,王凡,赵涛.丹参多酚酸盐治疗冠心病心绞痛的疗效及其对血液流变学、氧化应激的影响[J].安徽医药,2018,22(1):147-151.
[13] 郝瑞军.丹参注射液与丹参多酚酸盐治疗冠心病心绞痛的疗效比较[J].西南国防医药,2017,27(4):385-387.
[14] 周云,吴弘,张超,等.瑞舒伐他汀在冠心病合并高脂血症治疗中的应用及对血清hs-CRP MFG-E8和Klotho的影响[J].西部医学,2017,29(3):339-342.
[15] 吴皓,李旭红.T细胞免疫球蛋白粘蛋白分子-4在免疫应答中的作用以及与相关疾病的关系[J].医学分子生物学杂志,2016,13(2):120-124.
[16] 刘春阳,王莒生,刘志勇.针药联合治疗带状疱疹急性期肝经郁热证52例疗效观察[J].中医杂志,2017,58(21):1842-1845.
[17] 王春玲.注射用丹参多酚酸盐治疗老年不稳定心绞痛的临床观察[J].实用老年医学,2016,30(6):507-509.
[18] 冯双,胡明.丹参川芎嗪注射液对比丹参多酚酸盐注射液治疗冠心病心绞痛的药物经济学评价[J].药学实践杂志,2018,36(2):147-155.
[19] 宋硕,王建春,杨国平.单硝酸异山梨酯联合多巴胺治疗心力衰竭的疗效及安全性分析[J].中国循证心血管医学杂志,2017,9(7):837-839.
[20] 张颖,王媛,邓争荣.大株红景天注射液联合丹参多酚酸盐治疗不稳定型心绞痛的疗效观察[J].临床和实验医学杂志,2018,17(9):961-964.
[21] 王信凡,卢桂兰,史丽,等.丹参多酚酸盐联合左卡尼汀治疗稳定型心绞痛的疗效观察[J].中华中医药学刊,2017,35(9):2404-2406.
[22] 杨丽萍,赵谷天,陈宗宁,等.冠心病合并房颤患者的甲状腺激素水平变化及其机制探讨[J].西部医学,2016,28(10):1386-1388,1392.
[23] 胡丹,邓鹏,焦琳,等.热敏灸加腹针疗法联合盆底肌训练法治疗女性压力性尿失禁28例临床观察[J].中医杂志,2017,58(19):1662-1665.
[24] 李园,王连心,谢雁鸣.注射用丹参多酚酸盐联合常规西药治疗稳定型心绞痛研究的疗效及安全性探讨[J].中国中药杂志,2016,41(24):4488-4493.
[25] 陈杨,徐万宇,范建生,等.丹参多酚酸盐治疗冠心病、心绞痛患者临床疗效观察[J].中国煤炭工业医学杂志,2014,17(11):1756-1758.
[2] 刁克,逯艺,郭德刚.磷酸肌酸钠联合丹参多酚酸盐治疗冠心病心绞痛的疗效观察[J].现代药物与临床,2017,32(3):419-422.
[3] 温亮,孙涛,王瑞峰,等.美托洛尔联合丹参多酚酸盐治疗老年冠心病心绞痛患者的临床效果[J].中国医药导报,2016,13(13):129-132.
[4] 范艳平,赵铁梅,卢经君,等.脂蛋白相关磷脂A2与稳定型冠心病主要心血管事件的相关性[J].临床误诊误治,2018,31(1):86-89.
[5] 马国强,李春晓,张勇涛,等.依折麦布联合瑞舒伐他汀对冠心病血脂、颈动脉粥样硬化斑块和超敏C反应蛋白的影响[J].解放军医药杂志,2017,29(10):91-94.
[6] 鱼跃进,鱼津铭.丹参多酚酸盐联合左旋氨氯地平治疗冠心病心绞痛的疗效观察[J].现代药物与临床,2016,31(9):1374-1377.
[7] 王夏云,陈民,全守霞,等.麝香保心丸联合丹参多酚酸盐对冠心病心绞痛患者心功能及血清CRP与Hcy水平的影响[J].现代生物医学进展,2017,17(10):1907-1910.
[8] 周广朋,张景岚,陈树,等.冠心病合并Ⅱ型糖尿病患者脂联素与胰岛素受体的表达水平及临床意义[J].西部医学,2015,27(10):1494-1496.
[9] 夏静雯,李岩松,奚茵华.丹参多酚酸盐联合西药治疗冠心病不稳定型心绞痛的临床疗效及对血清 NO、ET -1的影响[J].现代中西医结合杂志,2016,25(4):375-378.
[10] 潘兴飞,张绍全,黄小萍,等.白细胞介素32γ通过活化核转录因子κB通路诱导LX-2细胞表达基质金属蛋白酶9[J].医学分子生物学杂志,2016,13(3):149-152.
[11] 卢炜,王鸿超,杜超,等.血浆同型半胱氨酸水平与冠心病患者中心动脉压及颈动脉狭窄程度的相关性研究[J].解放军医药杂志,2016,28(11):69-72.
[12] 邱丹,王凡,赵涛.丹参多酚酸盐治疗冠心病心绞痛的疗效及其对血液流变学、氧化应激的影响[J].安徽医药,2018,22(1):147-151.
[13] 郝瑞军.丹参注射液与丹参多酚酸盐治疗冠心病心绞痛的疗效比较[J].西南国防医药,2017,27(4):385-387.
[14] 周云,吴弘,张超,等.瑞舒伐他汀在冠心病合并高脂血症治疗中的应用及对血清hs-CRP MFG-E8和Klotho的影响[J].西部医学,2017,29(3):339-342.
[15] 吴皓,李旭红.T细胞免疫球蛋白粘蛋白分子-4在免疫应答中的作用以及与相关疾病的关系[J].医学分子生物学杂志,2016,13(2):120-124.
[16] 刘春阳,王莒生,刘志勇.针药联合治疗带状疱疹急性期肝经郁热证52例疗效观察[J].中医杂志,2017,58(21):1842-1845.
[17] 王春玲.注射用丹参多酚酸盐治疗老年不稳定心绞痛的临床观察[J].实用老年医学,2016,30(6):507-509.
[18] 冯双,胡明.丹参川芎嗪注射液对比丹参多酚酸盐注射液治疗冠心病心绞痛的药物经济学评价[J].药学实践杂志,2018,36(2):147-155.
[19] 宋硕,王建春,杨国平.单硝酸异山梨酯联合多巴胺治疗心力衰竭的疗效及安全性分析[J].中国循证心血管医学杂志,2017,9(7):837-839.
[20] 张颖,王媛,邓争荣.大株红景天注射液联合丹参多酚酸盐治疗不稳定型心绞痛的疗效观察[J].临床和实验医学杂志,2018,17(9):961-964.
[21] 王信凡,卢桂兰,史丽,等.丹参多酚酸盐联合左卡尼汀治疗稳定型心绞痛的疗效观察[J].中华中医药学刊,2017,35(9):2404-2406.
[22] 杨丽萍,赵谷天,陈宗宁,等.冠心病合并房颤患者的甲状腺激素水平变化及其机制探讨[J].西部医学,2016,28(10):1386-1388,1392.
[23] 胡丹,邓鹏,焦琳,等.热敏灸加腹针疗法联合盆底肌训练法治疗女性压力性尿失禁28例临床观察[J].中医杂志,2017,58(19):1662-1665.
[24] 李园,王连心,谢雁鸣.注射用丹参多酚酸盐联合常规西药治疗稳定型心绞痛研究的疗效及安全性探讨[J].中国中药杂志,2016,41(24):4488-4493.
[25] 陈杨,徐万宇,范建生,等.丹参多酚酸盐治疗冠心病、心绞痛患者临床疗效观察[J].中国煤炭工业医学杂志,2014,17(11):1756-1758.