嗜酸粒细胞与慢性鼻-鼻窦炎伴鼻息肉相关性的研究进展
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摘要
慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)是耳鼻咽喉头颈外科最常见的疾病之一,其特征是异质性的鼻腔和鼻窦黏膜慢性炎症。多种炎性细胞参与鼻息肉的发生和发展过程,包括嗜酸粒细胞(EOS)、中性粒细胞、肥大细胞、淋巴细胞等。关于CRSwNP炎症相关的细胞,特别是EOS的研究成为研究热点。近年来研究发现,在亚洲国家CRSwNP患者组织EOS浸润的比例呈升高趋势。EOS与鼻息肉的发生、发展、治疗、预后均有密切联系。了解EOS与CRSwNP的关系可使临床工作者对本疾病有更深层的认识,从而更好地服务患者。
Chronic rhinosinusitis with nasal polyps( CRSwNP) is one of the most common diseases in otolaryngology head and neck surgery,characterized by heterogeneous nasal cavity and nasal sinus mucosa chronic inflammation. Many inflammatory cells participate in the progress and development of nasal polyps,including eosinophils( EOS),neutrophils,mast cells and lymphocytes,etc. Research on CRSwNP-related cells,especially EOS,has become a hot topic in the field. In recent years,there has been a gradual increase in the proportion of patients with CRSwNP in Asian countries with significant EOS infiltration. EOS is closely related to the occurrence,development,treatment and prognosis of nasal polyps. To understand the relationship between EOS and CRSwNP allows clinical doctors to have a deeper understanding of the disease and provide better service to the patients.
Chronic rhinosinusitis with nasal polyps( CRSwNP) is one of the most common diseases in otolaryngology head and neck surgery,characterized by heterogeneous nasal cavity and nasal sinus mucosa chronic inflammation. Many inflammatory cells participate in the progress and development of nasal polyps,including eosinophils( EOS),neutrophils,mast cells and lymphocytes,etc. Research on CRSwNP-related cells,especially EOS,has become a hot topic in the field. In recent years,there has been a gradual increase in the proportion of patients with CRSwNP in Asian countries with significant EOS infiltration. EOS is closely related to the occurrence,development,treatment and prognosis of nasal polyps. To understand the relationship between EOS and CRSwNP allows clinical doctors to have a deeper understanding of the disease and provide better service to the patients.
引文
[1]Wang C,Low H,Wang X,et al. Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps[J]. J Allergy Clin Immunol,2015,135(4):922-929.
[2]Wen W,Liu W,Zhang L,et al. Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy[J].J Allergy Clin Immunol,2012,129(6):1522-1528.
[3]Vlaminck S,Vauterin T,Heullings PW,et al. The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis:A 3-year prospective observational study[J]. Am J Rhinol Allergy,2014,28(3):260-264.
[4]Nakayama T,Yoshikawa M,Asaka D,et al. Mucosal eosinophilia and recurrence of nasal polyps-new classification of chronic rhinosinusitis[J]. Rhinology,2011,49(4):392-396.
[5]Ikeda K,Shiozawa A,Ono N,et al. Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil[J]. Laryngoscope,2013,123(11):E1-9.
[6]Matsuwaki Y,Ookushi T,Asaka D,et al. Chronic rhinosinusitis:Risk factors for the recurrence of chronic rhinosinusitis based on5-year follow-up after endoscopic sinus surgery[J]. Int Arch Allergy Immunol,2008,146:77-81.
[7]Fokkens WJ,Lund VJ,Mullol J,et al. European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists[J]. Rhinology,2012,50(1):1-12.
[8]Katotomichelakis M,Tantilipikorn P,Holtappels G,et al. Inflammatory patterns in upper airway disease in the same geographical area may change over time[J]. Am J Rhinol Allergy,2013,27(5):354-360.
[9]Kim SJ,Lee KH,Kim SW,et al. Changes in histological features of nasal polyps in a Korean population over a 17-year period[J].Otolaryngol Head Neck Surg,2013,149(3):431-437.
[10]康健,曲亚荣,陈冬,等.缺氧诱导因子-1α及嗜酸粒细胞趋化因子在鼻息肉组织中的表达及意义[J].中国全科医学,2010,13(27):3043-3045.
[11]Majima Y,Kurono Y,Hirakawa K,et al. Efficacy of combined treatment with S-carboxymethylcysteine(carbocisteine)and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp[J]. Auris Nasus Larynx,2012,39(1):38-47.
[12]Giuseppe B,Umberto B,Claudia Z,et al. Blood eosinophil-tobasophil ratio in patients with sinonasal polyps:Does it have a clinical role?[J]. Ann Allergy Asthma Immunol,2017,119(3):223-226.
[13]张罗,韩德民,张波. IL-5在鼻息肉发病机制中的作用[J].国外医学(耳鼻咽喉科学分册),2000,24(4):223-226.
[14]Payne SC,Han JK,Huyett P,et al. Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polyps[J]. AM J Rhinol,2008,22(6):568-581.
[15]胡志红,张海军,李健,王晶华.嗜酸性粒细胞和IL-5在鼻息肉中的表达及在发病中的作用[J].临床和实验医学杂志,2014,13(19):1605-1608.
[16]王建玲,马瑞琴,杨海忆,等.白细胞介素-5与嗜酸性粒细胞阳离子蛋白在鼻息肉发病中的意义及相互关系[J].临床耳鼻咽喉科杂志,2003,17(5):272-274.
[17]Ba L,Zhang N,Meng J,et al. The association between bacterial colonization and inflammatory pattern in Chinese chronic rhinosinusitis patients with nasal polyps[J]. Allergy,2011,66(10):1296-1303.
[18]张罗,韩德民,周兵,等.鼻息肉中嗜酸性粒细胞浸润和活化与白细胞介素5表达[J].中国耳鼻咽喉头颈外科杂志,2005,12(3):171-174.
[19]Cao P,Zhang Y,Liao B,et al. Increased local Ig E production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic,but not non-eosinophilic,chronic rhinosinusitis with nasal polyps[J]. Clin Exp Allergy,2014,44(5):690-700.
[20]Polzehl D,Moeller P,Riechelmann H,et al. Distinct features of chronic rhinosinusitis with and without nasal polyps[J]. Allergy,2006,61(11):1275-1279.
[21]Bachert C,Zhang N,Holtappels G,et al. Presence of IL-5 protein and Ig E antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma[J]. J Allergy Clin Immunol,2010,126(5):962-968.
[22]黄思海,夏文彤,李华斌. B细胞活化因子在鼻息肉组织中的表达及与合并哮喘的关联性[J].中国耳鼻咽喉头颈外科杂志,2013,20(8):419-422.
[23]王明婕,周兵,李云川,等.外周血嗜酸粒细胞比例在慢性鼻-鼻窦炎伴鼻息肉分类中的作用[J].中华耳鼻咽喉头颈外科杂志,2013,48(8):650-653.
[24]Ishitoya J,Sakuma Y,Tsukuda M. Eosinophilic chronic rhinosinusitis in Japan[J]. Allergol Int,2010,59(3):239-245.
[25]George L,Brightling CE. Eosinophilic airway inflammation:Role in asthma and chronic obstructive pulmonary disease[J]. Ther Adv Chronic Dis,2016,7(1):34-51.
[26]Palmer JN,Conley DB,Dong RG,et al. Efficacy of endoscopic sinus surgery in the management of patients with asthma and chronic sinusitis[J]. Am J Rhinol,2001,15(1):49-53.
[27]Mori E,Matsawaki Y,Mitsuyama C,et al. Risk factors for olfactory dysfunction in chronic rhrinosinusitis[J]. Auris Nasus Larynx,2013,40(5):465-469.
[28]Pearlman AN,chandra RK,challg D,et al. Relationships between severity chronic rhinosinusitis and nasal poplyposis,asthma,and atopy[J]. Am J Rhino1 Allergy,2009,23(2):145-148.
[29]Barbi E,Longo G. Chronic and recurrent cough,sinusitis and asthma. Much ado about nothing[J]. Pediatr Allergy Immunol,2007,18(1):22-24.
[30]Lin DC,Chandra RK,Tan BK,et al. Association between severity of asthma and degree of chronic rhinosinusitis[J]. Am J Rhinol Allergy,2011,25(4):205-208.
[31]张敏,王建亭,武大伟,等.慢性鼻-鼻窦炎伴鼻息肉的炎性亚型与其共患病哮喘黏膜炎性表型的相关性研究[J].临床耳鼻咽喉头颈外科杂志,2018,32(1):48-52.
[32]武大伟,王建亭.变应性联合气道疾病[J].国际耳鼻咽喉头颈外科杂志,2014,38(5):304-308.
[33]Kim SY,Park JH,Rhee CS,et al. Does eosinophilic inflammation affect the outcome of endoscopic sinus surgery in chronic rhinosinusitis in Koreans?[J]. Am J Rhinol Allergy,2013,27(6):e166-169.
[34]Sakuma Y,Ishitoya J,Komatsu M,et al. New clinical diagnostic criteria for eosinophilic chronic rhinosinusitis[J]. Auris Nasus Larynx,2011,38(5):583-588.
[35]Steinke JW,Payne SC,Tessier ME,et al. Pilot study of budesonide inhalant suspention irrigations of chronic eosinophilic sinusitis[J].J Allergy Clin Immunol,2009,124(6):1352-1354.
[36]贺红斌,潘松林,刘涛,等.手术治疗慢性鼻窦炎对控制支气管哮喘发作疗效的初步观察[J].中国耳鼻咽喉颅底外科杂志,2012,18(1):47-50.
[37]Varvyanskaya A,Lopatin A. Efficacy of long-term low-dose macrolide therapy in preventing early recurrence of nasal polyps after endoscopic sinus surgery[J]. Int Forum Allergy Rhinol,2014,4(7):533-541.
[38]Bachert C,Mannent L,Naclerio RM,et al. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis:A randomized clinical trial[J]. JAMA,2016,315(5):469-479.
[39]Gevaert P,Calus L,Van Zele T,et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma[J].J Allergy Clin Immunol,2013,131(1):110-116.
[40]Tokunaga T,Sakashita M,Haruna T,et al. Novel scoring system and algorithm for classifying chronic rhinosinusitis:the JESREC Study[J]. Allergy,2015,70(8):995-1003.
[41]Lou H,Meng Y,Piao Y,et al. Predictive significance of tissue eosinophilia for nasal polyps recurrence in the Chinese population[J]. Am J Rhinol Allergy,2015,29(5):350-356.
[42]Saiton T,Kusunoki T,Yao T,et al. Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis[J]. Rhinology,2009,47(3):275-279.
[2]Wen W,Liu W,Zhang L,et al. Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy[J].J Allergy Clin Immunol,2012,129(6):1522-1528.
[3]Vlaminck S,Vauterin T,Heullings PW,et al. The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis:A 3-year prospective observational study[J]. Am J Rhinol Allergy,2014,28(3):260-264.
[4]Nakayama T,Yoshikawa M,Asaka D,et al. Mucosal eosinophilia and recurrence of nasal polyps-new classification of chronic rhinosinusitis[J]. Rhinology,2011,49(4):392-396.
[5]Ikeda K,Shiozawa A,Ono N,et al. Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil[J]. Laryngoscope,2013,123(11):E1-9.
[6]Matsuwaki Y,Ookushi T,Asaka D,et al. Chronic rhinosinusitis:Risk factors for the recurrence of chronic rhinosinusitis based on5-year follow-up after endoscopic sinus surgery[J]. Int Arch Allergy Immunol,2008,146:77-81.
[7]Fokkens WJ,Lund VJ,Mullol J,et al. European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists[J]. Rhinology,2012,50(1):1-12.
[8]Katotomichelakis M,Tantilipikorn P,Holtappels G,et al. Inflammatory patterns in upper airway disease in the same geographical area may change over time[J]. Am J Rhinol Allergy,2013,27(5):354-360.
[9]Kim SJ,Lee KH,Kim SW,et al. Changes in histological features of nasal polyps in a Korean population over a 17-year period[J].Otolaryngol Head Neck Surg,2013,149(3):431-437.
[10]康健,曲亚荣,陈冬,等.缺氧诱导因子-1α及嗜酸粒细胞趋化因子在鼻息肉组织中的表达及意义[J].中国全科医学,2010,13(27):3043-3045.
[11]Majima Y,Kurono Y,Hirakawa K,et al. Efficacy of combined treatment with S-carboxymethylcysteine(carbocisteine)and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp[J]. Auris Nasus Larynx,2012,39(1):38-47.
[12]Giuseppe B,Umberto B,Claudia Z,et al. Blood eosinophil-tobasophil ratio in patients with sinonasal polyps:Does it have a clinical role?[J]. Ann Allergy Asthma Immunol,2017,119(3):223-226.
[13]张罗,韩德民,张波. IL-5在鼻息肉发病机制中的作用[J].国外医学(耳鼻咽喉科学分册),2000,24(4):223-226.
[14]Payne SC,Han JK,Huyett P,et al. Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polyps[J]. AM J Rhinol,2008,22(6):568-581.
[15]胡志红,张海军,李健,王晶华.嗜酸性粒细胞和IL-5在鼻息肉中的表达及在发病中的作用[J].临床和实验医学杂志,2014,13(19):1605-1608.
[16]王建玲,马瑞琴,杨海忆,等.白细胞介素-5与嗜酸性粒细胞阳离子蛋白在鼻息肉发病中的意义及相互关系[J].临床耳鼻咽喉科杂志,2003,17(5):272-274.
[17]Ba L,Zhang N,Meng J,et al. The association between bacterial colonization and inflammatory pattern in Chinese chronic rhinosinusitis patients with nasal polyps[J]. Allergy,2011,66(10):1296-1303.
[18]张罗,韩德民,周兵,等.鼻息肉中嗜酸性粒细胞浸润和活化与白细胞介素5表达[J].中国耳鼻咽喉头颈外科杂志,2005,12(3):171-174.
[19]Cao P,Zhang Y,Liao B,et al. Increased local Ig E production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic,but not non-eosinophilic,chronic rhinosinusitis with nasal polyps[J]. Clin Exp Allergy,2014,44(5):690-700.
[20]Polzehl D,Moeller P,Riechelmann H,et al. Distinct features of chronic rhinosinusitis with and without nasal polyps[J]. Allergy,2006,61(11):1275-1279.
[21]Bachert C,Zhang N,Holtappels G,et al. Presence of IL-5 protein and Ig E antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma[J]. J Allergy Clin Immunol,2010,126(5):962-968.
[22]黄思海,夏文彤,李华斌. B细胞活化因子在鼻息肉组织中的表达及与合并哮喘的关联性[J].中国耳鼻咽喉头颈外科杂志,2013,20(8):419-422.
[23]王明婕,周兵,李云川,等.外周血嗜酸粒细胞比例在慢性鼻-鼻窦炎伴鼻息肉分类中的作用[J].中华耳鼻咽喉头颈外科杂志,2013,48(8):650-653.
[24]Ishitoya J,Sakuma Y,Tsukuda M. Eosinophilic chronic rhinosinusitis in Japan[J]. Allergol Int,2010,59(3):239-245.
[25]George L,Brightling CE. Eosinophilic airway inflammation:Role in asthma and chronic obstructive pulmonary disease[J]. Ther Adv Chronic Dis,2016,7(1):34-51.
[26]Palmer JN,Conley DB,Dong RG,et al. Efficacy of endoscopic sinus surgery in the management of patients with asthma and chronic sinusitis[J]. Am J Rhinol,2001,15(1):49-53.
[27]Mori E,Matsawaki Y,Mitsuyama C,et al. Risk factors for olfactory dysfunction in chronic rhrinosinusitis[J]. Auris Nasus Larynx,2013,40(5):465-469.
[28]Pearlman AN,chandra RK,challg D,et al. Relationships between severity chronic rhinosinusitis and nasal poplyposis,asthma,and atopy[J]. Am J Rhino1 Allergy,2009,23(2):145-148.
[29]Barbi E,Longo G. Chronic and recurrent cough,sinusitis and asthma. Much ado about nothing[J]. Pediatr Allergy Immunol,2007,18(1):22-24.
[30]Lin DC,Chandra RK,Tan BK,et al. Association between severity of asthma and degree of chronic rhinosinusitis[J]. Am J Rhinol Allergy,2011,25(4):205-208.
[31]张敏,王建亭,武大伟,等.慢性鼻-鼻窦炎伴鼻息肉的炎性亚型与其共患病哮喘黏膜炎性表型的相关性研究[J].临床耳鼻咽喉头颈外科杂志,2018,32(1):48-52.
[32]武大伟,王建亭.变应性联合气道疾病[J].国际耳鼻咽喉头颈外科杂志,2014,38(5):304-308.
[33]Kim SY,Park JH,Rhee CS,et al. Does eosinophilic inflammation affect the outcome of endoscopic sinus surgery in chronic rhinosinusitis in Koreans?[J]. Am J Rhinol Allergy,2013,27(6):e166-169.
[34]Sakuma Y,Ishitoya J,Komatsu M,et al. New clinical diagnostic criteria for eosinophilic chronic rhinosinusitis[J]. Auris Nasus Larynx,2011,38(5):583-588.
[35]Steinke JW,Payne SC,Tessier ME,et al. Pilot study of budesonide inhalant suspention irrigations of chronic eosinophilic sinusitis[J].J Allergy Clin Immunol,2009,124(6):1352-1354.
[36]贺红斌,潘松林,刘涛,等.手术治疗慢性鼻窦炎对控制支气管哮喘发作疗效的初步观察[J].中国耳鼻咽喉颅底外科杂志,2012,18(1):47-50.
[37]Varvyanskaya A,Lopatin A. Efficacy of long-term low-dose macrolide therapy in preventing early recurrence of nasal polyps after endoscopic sinus surgery[J]. Int Forum Allergy Rhinol,2014,4(7):533-541.
[38]Bachert C,Mannent L,Naclerio RM,et al. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis:A randomized clinical trial[J]. JAMA,2016,315(5):469-479.
[39]Gevaert P,Calus L,Van Zele T,et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma[J].J Allergy Clin Immunol,2013,131(1):110-116.
[40]Tokunaga T,Sakashita M,Haruna T,et al. Novel scoring system and algorithm for classifying chronic rhinosinusitis:the JESREC Study[J]. Allergy,2015,70(8):995-1003.
[41]Lou H,Meng Y,Piao Y,et al. Predictive significance of tissue eosinophilia for nasal polyps recurrence in the Chinese population[J]. Am J Rhinol Allergy,2015,29(5):350-356.
[42]Saiton T,Kusunoki T,Yao T,et al. Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis[J]. Rhinology,2009,47(3):275-279.