铝镁加联合兰索拉唑治疗重型颅脑损伤应激性溃疡的临床分析
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摘要
目的:研究铝镁加联合兰索拉唑治疗重型颅脑损伤应激性溃疡的机制和临床疗效。方法:选择2012~2016年来我院治疗的重型颅脑损伤应激性溃疡患者100例为研究对象,按1∶1随机分为2组,每组50例。2组患者均给予开颅手术、营养支持等积极治疗,实验组在此基础上加兰索拉唑和铝镁加各15mg,3/d;对照组给予铝镁加15mg,3/d。2组疗程均为7d。观察2组患者在给药期间的临床疗效、胃酸分泌变化以及不良反应。结果:实验组的总有效率为88%,明显高于对照组的78%。治疗中患者的胃酸水平有显著改善,并且实验组的胃酸pH值也高于对照组。两组患者在用药中未见明显异常。结论:铝镁加联合兰索拉唑疗效好、起效快,对于重型颅脑损伤应激性溃疡患者有很高的临床医疗价值,可帮助患者迅速提升胃酸pH值,帮助修复愈合胃黏膜,疗效确切,未见明显不良反应。
Objective:To investigate the mechanism and clinical effect of almagate combined with lansoprazole in the treatment of stress ulcer severe traumatic brain injury.Methods:A total of 100 cases stress ulcer severe brain injury patients in our hospital 2012-2016 were randomly divided into two groups,50 patients in each group.All patients were treated with craniotomy,nutritional support.The experimental group was given lansoprazole 15 mg and almagate 15 mg,three times a day for 7days;the control group was given almagate 15 mg,three times a day for7 days.Clinical efficacy,the gastric acid secretion changes,and untoward effect were observed during administration.Results:The total effective rate of the experimental group was 88%,significantly higher than that of control group 78%.Gastric acid levels in patients showed significant improvement,and gastric acid pH in experimental group was also higher than that of the control group.There was no significant difference in two groups in treatment.Conclusion:Almagate combined with lansoprazole has a high clinical value and can rise the gastric acid pH level,repair gastric mucosal,has a good clinical efficacy in treatment of stress ulcer after severe craniocerebral injury.
Objective:To investigate the mechanism and clinical effect of almagate combined with lansoprazole in the treatment of stress ulcer severe traumatic brain injury.Methods:A total of 100 cases stress ulcer severe brain injury patients in our hospital 2012-2016 were randomly divided into two groups,50 patients in each group.All patients were treated with craniotomy,nutritional support.The experimental group was given lansoprazole 15 mg and almagate 15 mg,three times a day for 7days;the control group was given almagate 15 mg,three times a day for7 days.Clinical efficacy,the gastric acid secretion changes,and untoward effect were observed during administration.Results:The total effective rate of the experimental group was 88%,significantly higher than that of control group 78%.Gastric acid levels in patients showed significant improvement,and gastric acid pH in experimental group was also higher than that of the control group.There was no significant difference in two groups in treatment.Conclusion:Almagate combined with lansoprazole has a high clinical value and can rise the gastric acid pH level,repair gastric mucosal,has a good clinical efficacy in treatment of stress ulcer after severe craniocerebral injury.
引文
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[11]李建平.重度颅脑损伤患者应激性溃疡预防及治疗体会[J].亚太传统医药,2011,7(12):158-159.
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[2]中华医学会消化内镜学分会.反流性食管炎诊断及治疗指南(2003年)[J].中华消化内镜杂志,2004,21(4):221-222.
[3]崔欣,付芳敏,朱槿,等.奥美拉唑、兰索拉唑对映体及相关物质在不同手性柱的分离比较[J].分析化学,2012,30(12):1494-1496.
[4]魏敏吉,赵彩芸,齐慧敏,等.兰索拉唑肠溶胶囊在健康人体的生物等效性[J].中国临床药理学杂志,2011,27(1):24-28.
[5]钟文洲,陈正义,黄晓曦,等.兰索拉唑对糜烂性胃炎患者血清白细胞介素-4、干扰素-γ水平的变化影响研究[J].中国生化药物杂志,2014,34(6):145-147.
[6]陈文林,郑小波.奥曲肽联合兰索拉唑治疗急性上消化道出血的疗效观察[J].中国急救医学,2014,34(7):59-60.
[7]陈杰,王彬.铝镁加联合艾普拉唑治疗反流性食管炎的疗效观察[J].中国基层医药,2013,20(21):3316-3318.
[8]武联军.埃索美拉唑和莫沙比利联合铝镁加治疗胃食管反流病[J].当代医学,2013,19(30):90-91.
[9]田祖成.兰索拉唑联合铝镁加治疗贲门癌术后胃食管反流病41例[J].交通医学,2013,27(6):652-654.
[10]董新.循证护理在预防老年重度颅脑损伤应激性溃疡中的应用及效果观察[J].山西医药杂志,2013,42(17):1085-1086.
[11]李建平.重度颅脑损伤患者应激性溃疡预防及治疗体会[J].亚太传统医药,2011,7(12):158-159.
[12]闫喜功.重度颅脑损伤并发应激性溃疡的诊治体会[J].中外健康文摘,2009,6(12):99-100.