硫化氢在多种生理过程中作用的研究进展
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摘要
硫化氢(hydrogen sulfide,H2S)已被认为是继一氧化氮和一氧化碳之后的第三种气体信号分子,广泛参与机体的生理与病理过程。现总结H2S的合成、代谢、检测、在疾病中的作用及其相关供体,以期为临床研究和治疗提供新思路。
Hydrogen sulfide has been considered as the third gaseous signaling molecule after nitric oxide and carbon monoxide, and is widely involved in the physiological and pathological processes. In this article, we summarize the synthesis, metabolism, and detection of H2 S, the role of H2 S in diseases and its related donors in order to provide new ideas for clinical research and treatment.
Hydrogen sulfide has been considered as the third gaseous signaling molecule after nitric oxide and carbon monoxide, and is widely involved in the physiological and pathological processes. In this article, we summarize the synthesis, metabolism, and detection of H2 S, the role of H2 S in diseases and its related donors in order to provide new ideas for clinical research and treatment.
引文
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[3]Gadalla MM,Snyder SH.Hydrogen sulfide as a gasotransmitter.J Neurochem,2010,113:14-26
[4]Kimura H,Shibuya N,Kimura Y.Hydrogen sulfide is a signaling molecule and a cytoprotectant.Antioxid Redox Sign,2012,17:45-57
[5]Wallace JL,Wang R.Hydrogen sulfide-based therapeutics:exploiting a unique but ubiquitous gasotransmitter.Nat Rev Drug Discov,2015,14:329-45
[6]Hellmich MR,Szabo C.Hydrogen sulfide and cancer.Chemistry,biochemistry and pharmacology of hydrogen sulfide.Springer Int Pub,2015,230:233-41
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[8]Lisjak M,Srivastava N,Teklic T,et al.A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation.Plant Physiol Biochem,2010,48:931-5
[9]Xie L,Feng H,Li S,et al.SIRT3 mediates the antioxidant effect of hydrogen sulfide in endothelial cells.Antioxid Redox Sign,2016,24:329-43
[10]Shibuya N,Tanaka M,Yoshida M,et al.3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain.Antioxid Redox Sign,2009,11:703-14
[11]Wu D,Wang J,Li H,et al.Role of hydrogen sulfide in ischemia-reperfusion injury.Oxid Med Cell Longev,2015,2015:186908
[12]Hosoki R,Matsuki N,Kimura H.The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.Biochem Biophys Res Commun,1997,237:527-31
[13]Zheng Y,Yu B,La Cruz LK,et al.Toward hydrogen sulfide based therapeutics:critical drug delivery and developability issues.Med Res Rev,2017,38:57-100
[14]Shibuya N,Koike S,Tanaka M,et al.A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells.Nat Commun,2013,4:1366
[15]Yang G,Cao K,Wu L,et al.Cystathionineγ-lyase overexpression inhibits cell proliferation via a H2Sdependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1.J Biol Chem,2004,279:49199-205
[16]Insko MA,Deckwerth TL,Hill P,et al.Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide.Br J Pharmacol,2009,157:944-51
[17]Olson KR.A practical look at the chemistry and biology of hydrogen sulfide.Antioxid Redox Sign,2012,17:32-4
[18]Shen X,Peter EA,Bir S,et al.Analytical measurement of discrete hydrogen sulfide pools in biological specimens.Free Rad Biol Med,2012,52:2276-83
[19]Mc Cook O,Radermacher P,Volani C,et al.H2S during circulatory shock:some unresolved questions.Nitric Oxide,2014,41:48-61
[20]Eto K,Asada T,Arima K,et al.Brain hydrogen sulfide is severely decreased in Alzheimer's disease.Biochem Biophys Res Commun,2002,293:1485-8
[21]Tang XQ,Yang CT,Chen J,et al.Effect of hydrogen sulphide onβ-amyloid-induced damage in PC12 cells.Clin Exp Pharmacol Physiol,2008,35:180-6
[22]Zhang LM,Jiang CX,Liu DW.Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in rats.Neurochem Res,2009,34:1984-92
[23]Abeliovich A.Parkinson's disease:pro-survival effects of PINK1.Nature,2007,448:759-60
[24]Hu LF,Lu M,Tiong C X,et al.Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models.Aging Cell,2010,9:135-46
[25]Yin WL,He JQ,Hu B,et al.Hydrogen sulfide inhibits MPP+-induced apoptosis in PC12 cells.Life Sci,2009,85:269-75
[26]Hu LF,Wong PT,Moore PK,et al.Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia.J Neurochem,2007,100:1121-8
[27]Paul BD,Sbodio JI,Xu R,et al.Cystathionineγ-lyase deficiency mediates neurodegeneration in Huntington’s disease.Nature,2014,509:96
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[29]Carbonare LD,Valenti MT,Zanatta M,et al.Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis.Arthritis Rheumatol,2009,60:3356-65
[30]Liu Y,Yang R,Liu X,et al.Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca 2+channel sulfhydration.Cell Stem Cell,2014,15:66-78
[31]Zheng Y,Liao F,Lin X,et al.Cystathionineγ-lyasehydrogen sulfide induces Runt-related transcription factor2 sulfhydration,thereby increasing osteoblast activity to promote bone fracture healing.Antioxid Redox Sign,2017,27:742-53
[32]Yang X,Hao D,Zhang H,et al.Treatment with hydrogen sulfide attenuates sublesional skeletal deterioration following motor complete spinal cord injury in rats.Osteoporosis Int,2017,28:687-95
[33]Burguera EF,Meijide-Failde R,Blanco FJ.Hydrogen sulfide and inflammatory joint diseases.Curr Drug Targets,2017,18:1641-52
[34]Du JT,Li W,Yang JY,et al.Hydrogen sulfide is endogenously generated in rat skeletal muscle and exerts a protective effect against oxidative stress.Chn Med J,2013,126:930-6
[35]Sun NL,Xi Y,Yang SN,et al.Plasma hydrogen sulfide and homocysteine levels in hypertensive patients with different blood pressure levels and complications.Chinese J Cardiol 2007,35:1145-8
[36]Yan H,Du J,Tang C.The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats.Biochem Biophys Res Commun,2004,313:22-7
[37]Zhao X,Zhang L,Zhang C,et al.Regulatory effect of hydrogen sulfide on vascular collagen content in spontaneously hypertensive rats.Hypertens Res,2008,31:1619-30
[38]Shi YX,Chen Y,Zhu YZ,et al.Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles,interstitial fibrosis,and ROS production in spontaneously hypertensive rats.Am J Physiol Heart Circ Physiol,2007,293:H2093-100
[39]Yang G,Wu L,Jiang B,et al.H2S as a physiologic vasorelaxant:hypertension in mice with deletion of cystathionineγ-lyase.Science,2008,322:587-90
[40]Roy A,Khan AH,Islam MT,et al.Interdependency of cystathioneγ-lyase and cystathioneβ-synthase in hydrogen sulfide-induced blood pressure regulation in rats.Am J Hypertens,2012,25:74-81
[41]Wang Y,Zhao X,Jin H,et al.Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice.Arterioscle Thromb Vas Biol,2009,29:173-9
[42]Mani S,Li H,Untereiner A,et al.Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis.Circulation,2013,127:2523-34
[43]Liang M,Jin S,Wu DD,et al.Hydrogen sulfide improves glucose metabolism and prevents hypertrophy in cardiomyocytes.Nitric Oxide,2015,46:114-22
[44]Bazhanov N,Ansar M,Ivanciuc T,et al.Hydrogen sulfide:a novel player in airway development,pathophysiology of respiratory diseases,and antiviral defenses.Am J Resp Cell Mol Biol,2017,57:403-10
[45]Zhang HX,Liu SJ,Tang XL,et al.H2S attenuates LPSinduced acute lung injury by reducing oxidative/nitrative stress and inflammation.Cell Physiol Biochem,2016,40:1603-12
[46]Spassov SG,Donus R,Ihle PM,et al.Hydrogen sulfide prevents formation of reactive oxygen species through PI3K/Akt signaling and limits ventilator-induced lung injury.Oxid Med Cell Longev 2017,2017:3715037
[47]Wallace JL,Blackler RW,Chan MV,et al.Antiinflammatory and cytoprotective actions of hydrogen sulfide:translation to therapeutics.Antioxid Redox Sign,2015,22:398-410
[48]Wu D,Zheng N,Qi K,et al.Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential.Med Gas Res,2015,5:1-8
[49]Jain SK,Micinski D,Lieblong BJ,et al.Relationship between hydrogen sulfide levels and HDL-cholesterol,adiponectin,and potassium levels in the blood of healthy subjects.Atherosclerosis,2012,225:242-5
[50]Okamoto M,Ishizaki T,Kimura T.Protective effect of hydrogen sulfide on pancreaticβ-cells.Nitric Oxide,2015,46:32-6
[51]Wang CN,Liu YJ,Duan GL,et al.CBS and CSE are critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.Antioxid Redox Sign,2014,21:2192-207
[52]Wang K,Zhu D,Yu X,et al.Differences in the H2Sinduced quantal release of catecholamine in adrenal chromaffin cells of neonatal and adult rats.Toxicology,2013,312:12-7
[53]Sen U,Munjal C,Qipshidze N,et al.Hydrogen sulfide regulates homocysteine-mediated glomerulosclerosis.A J Nephrol,2010,31:442-55
[54]Wu D,Luo N,Wang L,et al.Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.Sci Rep,2017,7:455
[55]Wu D,Gao B,Li M,et al.Hydrogen sulfide mitigates kidney injury in high fat diet-induced obese mice.Oxid Med Cell Longev,2016,2016:2715718
[56]Ge SN,Zhao MM,Wu DD,et al.Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na+/K+-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats.Antioxid Redox Sign,2014,21:2061-82
[57]Wang J,Wang W,Li S,et al.Hydrogen sulfide as a potential target in preventing spermatogenic failure and testicular dysfunction.Antioxid Redox Sign,2018,28:1447-62
[58]d'Emmanuele di Villa Bianca R,Fusco F,Mirone V,et al.The role of the hydrogen sulfide pathway in male and female urogenital system in health and disease.Antioxid Redox Sign,2017,27:654-68
[59]Zeng J,Lin X,Fan H,et al.Hydrogen sulfide attenuates the inflammatory response in a mouse burn injury model.Molecular medicine reports,2013,8:1204-8
[60]未培轩,李毅,王洪瑾,等.硫化氢对大鼠烧伤后炎症反应的影响.中华损伤与修复杂志(电子版),2012,7:40-3
[61]吴晓伟,李毅,王洪瑾.硫化氢对烧伤大鼠肠道SIg A和T淋巴细胞亚群的影响.中华损伤与修复杂志(电子版),2013,8:22-5
[62]Zhang J,Sio SW,Moochhala S,et al.Role of hydrogen sulfide in severe burn injury-induced inflammation in mice.Mol Med,2010,16:417-24
[63]Chen YH,Wu R,Geng B,et al.Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma.Cytokine,2009,45:117-23
[64]Wu WJ,Jia WW,Liu XH,et al.S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway.Redox Biol,2016,10:157-67
[65]Li L,Salto-Tellez M,Tan CH,et al.GYY4137,a novel hydrogen sulfide-releasing molecule,protects against endotoxic shock in the rat.Free Radic Biol Med,2009,47:103-13
[66]Chen YH,Wu R,Geng B,et al.Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma.Cytokine,2009,45:117-23
[67]Li L,Hsu A,Moore PK.Actions and interactions of nitric oxide,carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases!Pharmacol Ther,2009,123:386-400
[68]Baskar R,Bian J.Hydrogen sulfide gas has cell growth regulatory role.Eur J Pharmacol,2011,656:5-9
[69]Li L,Whiteman M,Guan YY,et al.Characterization of a novel,water-soluble hydrogen sulfide-releasing molecule(GYY4137).Circulation,2008,117:2351-60
[70]Lin S,Visram F,Liu W,et al.GYY4137,a slow-releasing hydrogen sulfide donor,ameliorates renal damage associated with chronic obstructive uropathy.J Urol,2016,196:1778-87
[71]Karwi QG,Whiteman M,Wood ME,et al.Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor,GYY4137.Pharmacol Res,2016,111:442-51
[72]Feng W,Teo XY,Novera W,et al.Discovery of new H2S releasing phosphordithioates and 2,3-dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with improved antiproliferative activity.J Med Chem,2015,58:6456-80
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[74]Kaium MA,Liu Y,Zhu Q,et al.H2S donor,S-propargylcysteine,increases CSE in SGC-7901 and cancer-induced mice:evidence for a novel anti-cancer effect of endogenous H2S?PLo S One,2011,6:e20525
[75]Wang M,Tang W,Xin H,et al.S-propargyl-cysteine,a novel hydrogen sulfide donor,inhibits inflammatory hepcidin and relieves anemia of inflammation by inhibiting IL-6/STAT3 pathway.PLo S One,2016,11:e0163289
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[2]Abe K,Kimura H.The possible role of hydrogen sulfid as an endogenous neuromodulator.J Neurosci,1996,16:1066-71
[3]Gadalla MM,Snyder SH.Hydrogen sulfide as a gasotransmitter.J Neurochem,2010,113:14-26
[4]Kimura H,Shibuya N,Kimura Y.Hydrogen sulfide is a signaling molecule and a cytoprotectant.Antioxid Redox Sign,2012,17:45-57
[5]Wallace JL,Wang R.Hydrogen sulfide-based therapeutics:exploiting a unique but ubiquitous gasotransmitter.Nat Rev Drug Discov,2015,14:329-45
[6]Hellmich MR,Szabo C.Hydrogen sulfide and cancer.Chemistry,biochemistry and pharmacology of hydrogen sulfide.Springer Int Pub,2015,230:233-41
[7]Zhao W,Zhang J,Lu Y,et al.The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener.EMBO J,2001,20:6008-16
[8]Lisjak M,Srivastava N,Teklic T,et al.A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation.Plant Physiol Biochem,2010,48:931-5
[9]Xie L,Feng H,Li S,et al.SIRT3 mediates the antioxidant effect of hydrogen sulfide in endothelial cells.Antioxid Redox Sign,2016,24:329-43
[10]Shibuya N,Tanaka M,Yoshida M,et al.3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain.Antioxid Redox Sign,2009,11:703-14
[11]Wu D,Wang J,Li H,et al.Role of hydrogen sulfide in ischemia-reperfusion injury.Oxid Med Cell Longev,2015,2015:186908
[12]Hosoki R,Matsuki N,Kimura H.The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.Biochem Biophys Res Commun,1997,237:527-31
[13]Zheng Y,Yu B,La Cruz LK,et al.Toward hydrogen sulfide based therapeutics:critical drug delivery and developability issues.Med Res Rev,2017,38:57-100
[14]Shibuya N,Koike S,Tanaka M,et al.A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells.Nat Commun,2013,4:1366
[15]Yang G,Cao K,Wu L,et al.Cystathionineγ-lyase overexpression inhibits cell proliferation via a H2Sdependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1.J Biol Chem,2004,279:49199-205
[16]Insko MA,Deckwerth TL,Hill P,et al.Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide.Br J Pharmacol,2009,157:944-51
[17]Olson KR.A practical look at the chemistry and biology of hydrogen sulfide.Antioxid Redox Sign,2012,17:32-4
[18]Shen X,Peter EA,Bir S,et al.Analytical measurement of discrete hydrogen sulfide pools in biological specimens.Free Rad Biol Med,2012,52:2276-83
[19]Mc Cook O,Radermacher P,Volani C,et al.H2S during circulatory shock:some unresolved questions.Nitric Oxide,2014,41:48-61
[20]Eto K,Asada T,Arima K,et al.Brain hydrogen sulfide is severely decreased in Alzheimer's disease.Biochem Biophys Res Commun,2002,293:1485-8
[21]Tang XQ,Yang CT,Chen J,et al.Effect of hydrogen sulphide onβ-amyloid-induced damage in PC12 cells.Clin Exp Pharmacol Physiol,2008,35:180-6
[22]Zhang LM,Jiang CX,Liu DW.Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in rats.Neurochem Res,2009,34:1984-92
[23]Abeliovich A.Parkinson's disease:pro-survival effects of PINK1.Nature,2007,448:759-60
[24]Hu LF,Lu M,Tiong C X,et al.Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models.Aging Cell,2010,9:135-46
[25]Yin WL,He JQ,Hu B,et al.Hydrogen sulfide inhibits MPP+-induced apoptosis in PC12 cells.Life Sci,2009,85:269-75
[26]Hu LF,Wong PT,Moore PK,et al.Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia.J Neurochem,2007,100:1121-8
[27]Paul BD,Sbodio JI,Xu R,et al.Cystathionineγ-lyase deficiency mediates neurodegeneration in Huntington’s disease.Nature,2014,509:96
[28]Paul BD,Snyder SH.Neurodegeneration in Huntington's disease involves loss of cystathionineγ-lyase.Cell Cycle,2014,13:2491-3
[29]Carbonare LD,Valenti MT,Zanatta M,et al.Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis.Arthritis Rheumatol,2009,60:3356-65
[30]Liu Y,Yang R,Liu X,et al.Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca 2+channel sulfhydration.Cell Stem Cell,2014,15:66-78
[31]Zheng Y,Liao F,Lin X,et al.Cystathionineγ-lyasehydrogen sulfide induces Runt-related transcription factor2 sulfhydration,thereby increasing osteoblast activity to promote bone fracture healing.Antioxid Redox Sign,2017,27:742-53
[32]Yang X,Hao D,Zhang H,et al.Treatment with hydrogen sulfide attenuates sublesional skeletal deterioration following motor complete spinal cord injury in rats.Osteoporosis Int,2017,28:687-95
[33]Burguera EF,Meijide-Failde R,Blanco FJ.Hydrogen sulfide and inflammatory joint diseases.Curr Drug Targets,2017,18:1641-52
[34]Du JT,Li W,Yang JY,et al.Hydrogen sulfide is endogenously generated in rat skeletal muscle and exerts a protective effect against oxidative stress.Chn Med J,2013,126:930-6
[35]Sun NL,Xi Y,Yang SN,et al.Plasma hydrogen sulfide and homocysteine levels in hypertensive patients with different blood pressure levels and complications.Chinese J Cardiol 2007,35:1145-8
[36]Yan H,Du J,Tang C.The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats.Biochem Biophys Res Commun,2004,313:22-7
[37]Zhao X,Zhang L,Zhang C,et al.Regulatory effect of hydrogen sulfide on vascular collagen content in spontaneously hypertensive rats.Hypertens Res,2008,31:1619-30
[38]Shi YX,Chen Y,Zhu YZ,et al.Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles,interstitial fibrosis,and ROS production in spontaneously hypertensive rats.Am J Physiol Heart Circ Physiol,2007,293:H2093-100
[39]Yang G,Wu L,Jiang B,et al.H2S as a physiologic vasorelaxant:hypertension in mice with deletion of cystathionineγ-lyase.Science,2008,322:587-90
[40]Roy A,Khan AH,Islam MT,et al.Interdependency of cystathioneγ-lyase and cystathioneβ-synthase in hydrogen sulfide-induced blood pressure regulation in rats.Am J Hypertens,2012,25:74-81
[41]Wang Y,Zhao X,Jin H,et al.Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice.Arterioscle Thromb Vas Biol,2009,29:173-9
[42]Mani S,Li H,Untereiner A,et al.Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis.Circulation,2013,127:2523-34
[43]Liang M,Jin S,Wu DD,et al.Hydrogen sulfide improves glucose metabolism and prevents hypertrophy in cardiomyocytes.Nitric Oxide,2015,46:114-22
[44]Bazhanov N,Ansar M,Ivanciuc T,et al.Hydrogen sulfide:a novel player in airway development,pathophysiology of respiratory diseases,and antiviral defenses.Am J Resp Cell Mol Biol,2017,57:403-10
[45]Zhang HX,Liu SJ,Tang XL,et al.H2S attenuates LPSinduced acute lung injury by reducing oxidative/nitrative stress and inflammation.Cell Physiol Biochem,2016,40:1603-12
[46]Spassov SG,Donus R,Ihle PM,et al.Hydrogen sulfide prevents formation of reactive oxygen species through PI3K/Akt signaling and limits ventilator-induced lung injury.Oxid Med Cell Longev 2017,2017:3715037
[47]Wallace JL,Blackler RW,Chan MV,et al.Antiinflammatory and cytoprotective actions of hydrogen sulfide:translation to therapeutics.Antioxid Redox Sign,2015,22:398-410
[48]Wu D,Zheng N,Qi K,et al.Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential.Med Gas Res,2015,5:1-8
[49]Jain SK,Micinski D,Lieblong BJ,et al.Relationship between hydrogen sulfide levels and HDL-cholesterol,adiponectin,and potassium levels in the blood of healthy subjects.Atherosclerosis,2012,225:242-5
[50]Okamoto M,Ishizaki T,Kimura T.Protective effect of hydrogen sulfide on pancreaticβ-cells.Nitric Oxide,2015,46:32-6
[51]Wang CN,Liu YJ,Duan GL,et al.CBS and CSE are critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.Antioxid Redox Sign,2014,21:2192-207
[52]Wang K,Zhu D,Yu X,et al.Differences in the H2Sinduced quantal release of catecholamine in adrenal chromaffin cells of neonatal and adult rats.Toxicology,2013,312:12-7
[53]Sen U,Munjal C,Qipshidze N,et al.Hydrogen sulfide regulates homocysteine-mediated glomerulosclerosis.A J Nephrol,2010,31:442-55
[54]Wu D,Luo N,Wang L,et al.Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.Sci Rep,2017,7:455
[55]Wu D,Gao B,Li M,et al.Hydrogen sulfide mitigates kidney injury in high fat diet-induced obese mice.Oxid Med Cell Longev,2016,2016:2715718
[56]Ge SN,Zhao MM,Wu DD,et al.Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na+/K+-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats.Antioxid Redox Sign,2014,21:2061-82
[57]Wang J,Wang W,Li S,et al.Hydrogen sulfide as a potential target in preventing spermatogenic failure and testicular dysfunction.Antioxid Redox Sign,2018,28:1447-62
[58]d'Emmanuele di Villa Bianca R,Fusco F,Mirone V,et al.The role of the hydrogen sulfide pathway in male and female urogenital system in health and disease.Antioxid Redox Sign,2017,27:654-68
[59]Zeng J,Lin X,Fan H,et al.Hydrogen sulfide attenuates the inflammatory response in a mouse burn injury model.Molecular medicine reports,2013,8:1204-8
[60]未培轩,李毅,王洪瑾,等.硫化氢对大鼠烧伤后炎症反应的影响.中华损伤与修复杂志(电子版),2012,7:40-3
[61]吴晓伟,李毅,王洪瑾.硫化氢对烧伤大鼠肠道SIg A和T淋巴细胞亚群的影响.中华损伤与修复杂志(电子版),2013,8:22-5
[62]Zhang J,Sio SW,Moochhala S,et al.Role of hydrogen sulfide in severe burn injury-induced inflammation in mice.Mol Med,2010,16:417-24
[63]Chen YH,Wu R,Geng B,et al.Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma.Cytokine,2009,45:117-23
[64]Wu WJ,Jia WW,Liu XH,et al.S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway.Redox Biol,2016,10:157-67
[65]Li L,Salto-Tellez M,Tan CH,et al.GYY4137,a novel hydrogen sulfide-releasing molecule,protects against endotoxic shock in the rat.Free Radic Biol Med,2009,47:103-13
[66]Chen YH,Wu R,Geng B,et al.Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma.Cytokine,2009,45:117-23
[67]Li L,Hsu A,Moore PK.Actions and interactions of nitric oxide,carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases!Pharmacol Ther,2009,123:386-400
[68]Baskar R,Bian J.Hydrogen sulfide gas has cell growth regulatory role.Eur J Pharmacol,2011,656:5-9
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