桂枝茯苓方治疗妇科血瘀证类疾病的物质基础研究进展
|
摘要
桂枝茯苓方首见于张仲景《金匮要略》,主治妇人癥病,是目前治疗妇科血瘀证的首选基础方药。从古籍入手,针对桂枝茯苓方及其方中单味药,查阅中外文献对桂枝茯苓方方证、治疗妇科血瘀证物质基础进行归纳整理,为其深入研究提供参考。
Guizhi Fuling Prescription first appeared in "Synopsis of Golden Chamber" by Zhongjing Zhang, which is mainly used to treat the accumulation of the woman's belly. It is the preferred base for the treatment of gynecological blood stasis. The prescription,single herbs and its anti-gynaecological blood stasis material basis of Guizhi Fuling Prescription were summarized in this thesis based on the ancient books and Chinese and foreign literatures mining with view to providing reference for its in-depth study.
Guizhi Fuling Prescription first appeared in "Synopsis of Golden Chamber" by Zhongjing Zhang, which is mainly used to treat the accumulation of the woman's belly. It is the preferred base for the treatment of gynecological blood stasis. The prescription,single herbs and its anti-gynaecological blood stasis material basis of Guizhi Fuling Prescription were summarized in this thesis based on the ancient books and Chinese and foreign literatures mining with view to providing reference for its in-depth study.
引文
[1]孙兰,李家春,周军,等.桂枝茯苓胶囊对肾上腺素诱导大鼠实验性肠系膜微循环障碍的改善研究[J].现代药物与临床,2015,30(1):8-12.
[2]周雪梅,陈姝,徐海榛,等.桂枝茯苓丸新解[J].中国中医基础医学杂志,2018,24(5):673-674.
[3]谭保平,邵乾,邵家德.桂枝茯苓方中桂枝、芍药的本草考证[J].广西中医药,2014,37(6):54-55.
[4]朱政中,邵乾.桂枝茯苓方中芍药品种应用评析[J].辽宁中医学院学报,2006,8(3):19-20.
[5]魏贤坤,邵家德,宛宜文.桂枝茯苓胶囊中芍药品种疑析[J].时珍国医国药,2006,17(5):868.
[6]王付,王林玉.桂枝茯苓丸方证思考与探索[J].中华中医杂志,2016,31(7):2618-2620.
[7]秦泗涟,马利华,贾晓斌,等.桂枝茯苓方物质基础及其制剂质量控制模式研究进展[J].中国实验方剂学杂志,2011,17(13):270-273.
[8]廖正根,平其能,萧伟,等.桂枝茯苓胶囊中有效成分的大鼠在体肠吸收研究[J].中国天然药物,2005,3(5):303-307.
[9]刘新,马成,盛萍,等.茯苓与桂枝配伍对小鼠利尿的实验研究[J].新疆中医药,2009,27(5):45-48.
[10]周蓓.桂枝桃仁及其配伍对抗凝血作用影响的研究[J].云南中医中药杂志,2014,35(1):62-63.
[11]柴丽娜,杜惠兰.关于妇科血瘀证发病机理的研究[J].中医杂志,1997,38(2):102-103.
[12]许丽绵,宋红.《金匮要略》对妇科血瘀证证治述要[J].中医药刊,2003,21(10):1727-1775.
[13]梁文珍.浅析妇科血瘀证[J].安徽中医学院学报,1997,16(4):3-5.
[14]刘玉祁,佘延芬,朱江,等.基于调查的中重度原发性痛经中医病因病机探讨[J].中华中医药杂志,2012,27(1):57-61.
[15]郑玮琳,翁衡,梁雪芳.基于数据挖掘的古代痛经方药运用规律研究[J].时珍国医国药,2017,28(4):1011-1015.
[16]肖新春,刘霞.血水同病乃子宫内膜异位症病机关键[J].陕西中医,2013,34(10):1378.
[17]姜彦,应翩,任辉,等.治疗子宫腺肌症经验[J].辽宁中医药大学学报,2010,12(1):115-116.
[18]张军会,王永辉,周文静,等.中医辨治慢性盆腔炎经验[J].河北中医,2015,37(3):429-430.
[19]王敏杰,王丽莉,张铁军.治疗慢性盆腔炎中药的研究进展[J].药物评价研究,2010,33(6):461-466.
[20]司银套,申贝贝,常宁甫.乳腺增生病中医发病机制与防治思路浅探[J].江苏中医药,2011,43(8):3-5.
[21]樊凤英.浅谈乳腺增生病的治疗[J].江苏中医药,2009,41(11):20-21.
[22]尉万春,李成卫,沈绍功.子宫肌瘤虚瘀同治整体治疗方案设计[J].时珍国医国药,2016,27(1):173-175.
[23]戚益铭,沈敏鹤,阮善明,等.乳腺癌病因病机及中医证治的研究进展[J].黑龙江中医药,2014,43(5):81-83.
[24]朴胜华,罗朵生.中药物质基础研究方法评述[J].中国药房,2012,23(23):2194-2196.
[25]仲云熙,孙建国,王广基.桂枝茯苓胶囊药理作用与临床应用研究进展[J].中草药,2016,47(17):3115-3120.
[26]Sun L,Liu L,Zong S,et al.Traditional Chinese medicine Guizhi Fuling capsule used for therapy of dysmenorrhea via attenuating uterus contraction[J].J Ethnopharmacol,2016,191:273-279.
[27]王振中,范麒如,窦霞,等.桂枝茯苓胶囊抑制小鼠离体子宫收缩效应及其物质基础评价[J].中草药,2009,40(4):609-611.
[28]曹泽彧,丁玥,苏真真,等.分子烙印-活性筛选结合评价桂枝茯苓胶囊主要成分活性贡献度研究[J].中国中药杂志,2015,40(12):2420-2427.
[29]仲云熙,金孝亮,谷世寅,等.基于抗炎活性的桂枝茯苓胶囊抗痛经作用机制研究[J].中国临床药理学与治疗学,2016,21(10):1095-1102.
[30]陶晓倩,李娜,曹亮,等.桂枝茯苓胶囊中主要成分对人子宫肌瘤细胞增殖及小鼠离体子宫收缩活动的影响[J].中国实验方剂学杂志,2016,22(2):91-96.
[31]萧伟,曹亮,范麒如,等.基于生物网络的桂枝茯苓胶囊作用机理研究[J].计算机与应用化学,2012,29(12):1455-1459.
[32]Terawaki K,Noguchi M,Yuzurihara M,et al.Keishibukuryogan,a traditional Japanese medicine,inhibits platelet aggregation in guinea pig whole blood[J].Evid Based Compl Alternat Med,2015,2015:295706.
[33]孙兰,林楠,吕耀中,等.桂枝茯苓胶囊对大鼠慢性盆腔炎的影响[J].中药药理与临床,2013,29(4):21-24.
[34]唐兴梅,李芳,刘莉娜,等.桂枝茯苓胶囊及其成分对LPS诱导RAW264.7细胞产生炎症介质的影响[J].临床医学研究与实践,2017,2(20):6-8.
[35]张珍珍,张新庄,李娜,等.桂枝茯苓胶囊及其活性成分组合物抗炎作用与机制研究[J].中国中药杂志,2015,40(6):993-998.
[36]王俨如,李娜,曹亮,等.应用高内涵技术研究桂枝茯苓胶囊抗炎及免疫调节活性成分[J].中国中药杂志,2015,40(6):1005-1011.
[37]范麒如,王振中,马宏跃,等.分子对接法虚拟筛选桂枝茯苓胶囊抗子宫肌瘤的潜在活性成分[J].世界科学技术-中医药现代化,2016,18(2):307-312.
[38]邓淑蓉,潘宇政.肉桂主要化学成分及药理作用研究概况[J].现代中西医结合杂志,2018,27(4):448-451.
[39]徐硕,姜文清,邝咏梅,等.茯苓的化学成分及生物活性研究进展[J].西北药学杂志,2016,31(3):327-330.
[40]王仁芳,范令刚,高文远,等.桃仁化学成分与药理活性研究进展[J].现代药物与临床,2010,25(6):426-429.
[41]赵强,李莹,孔令升,等.桃仁化学成分及药理作用研究进展[J].天水师范学院学报,2008,28(2):56-59.
[42]杨骅,马继琴,韩志云,等.丹皮酚对急性微循环障碍大鼠血管内皮细胞分泌的ET-1和NO的调控[J].海峡药学,2008,20(6):47-49.
[43]章丽,赵冰洁,袁嘉瑞,等.牡丹皮、赤芍与白芍对急性血瘀模型大鼠活血功效的比较研究[J].中草药,2016,47(15):2676-2683.
[44]尹权微,李家春,秦建平,等.UPLC/Q-TOF-MS快速分析桂枝茯苓胶囊的入血成分[J].中国实验方剂学杂志,2016,22(21):83-86.
[45]李莉,易醒,肖小年.肉桂油药理研究进展[J].江西食品工业,2010(4):43-46.
[46]史青.肉桂和肉桂醛对氧自由基诱导的自发性高血压大鼠离体主动脉收缩的抑制作用[J].国外医学:中医中药分册,2003,25(2):95-96.
[47]周本杰,李亚冰.退热止痛散解热镇痛活性部位气相色谱-质谱分析[J].时珍国医国药,2011,22(10):2457-2458.
[48]鲍邢杰,宿树兰,段金廒.肉桂挥发油及其抑制血小板聚集的效应成分分析[J].时珍国医国药,2010,21(11):2860-2861.
[49]黄敬群,王四旺,罗晓星.肉桂油β-环糊精包合物体内抗血栓作用实验研究[J].中国药理学通报,2006,22(1):126-127.
[50]马悦颖,李沧海,李兰芳,等.桂皮醛解热镇痛抗炎作用的实验研究[J].中国临床药理学与治疗学,2006,11(12):1336-1339.
[51]陈立平,张慧萍,陈光,等.肉桂油成分分析及肉桂醛体外抗肿瘤活性研究[J].中国微生态学杂志,2012,24(4):327-330.
[52]金戈,张婷,王涛,等.α-干扰素与肉桂酸对人肺癌细胞增殖的抑制作用[J].癌症,2002,21(8):860-862.
[53]周宏超,高立云,范光丽,等.茯苓酸对SLT-IIe诱导大鼠肠黏膜微血管内皮细胞分泌细胞因子的影响[J].中国兽医科学,2008,38(10):884-888.
[54]周宏超,索占伟,范光丽,等.茯苓酸对SLT-IIe诱导的大鼠肠黏膜微血管内皮细胞分泌P-选凝素、s ICAM-1及TNF-α的影响[J].中国兽医学报,2009,29(5):628-631.
[55]邓刚民,许津.茯苓素:一种潜在的醛固酮拮抗剂[J].中国抗生素杂志,1992,17(1):34-37.
[56]田婷,陈华,殷璐,等.茯苓和茯苓皮水和乙醇提取物的利尿作用及其活性成分的分离鉴定[J].中国药理学与毒理学杂志,2014,28(1):57-62.
[57]王玉,韩志武.齐墩果酸对氧化损伤人脐静脉内皮细胞线粒体中一氧化氮合酶的调控作用[J].中国药房,2015,26(19):2617-2620.
[58]吴青青,王娟,崔树娜,等.齐墩果酸抑制脂多糖诱导RAW264.7细胞炎症反应[J].扬州大学学报:农业与生命科学版,2017,38(3):27-31.
[59]连俊江,程彬峰,高尧鑫,等.齐墩果酸对IL-1β诱导的SW982细胞炎症反应的抑制作用[J].药学学报,2016,51(11):1711-1716.
[60]刘玉兰,王慧姝.齐墩果酸对血小板功能的影响[J].沈阳药学院学报,1993,10(4):275-278.
[61]Martínez-González J,Rodríguez-Rodríguez R,González-Díez M,et al.Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism[J].J Nutr,2008,138(3):443-448.
[62]Yang H Y,Chang H K,Lee J W,et al.Amygdalin suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells[J].Neurol Res,2007,29(Suppl 1):59-64.
[63]Hwang H J,Kim P,Kim C J,et al.Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats[J].Biol Pharm Bull,2008,31(8):1559-1564.
[64]张艳玲.王不留行、桃仁和郁金中抑制FXa活性成分研究[D].南京:南京中医药大学,2015.
[65]Cheng Y,Zhao J,Tse H F,et al.Plant natural products calycosin and gallic acid synergistically attenuate neutrophil infiltration and subsequent injury in isoproterenol-induced myocardial infarction:A possible role for leukotriene B4 12-hydroxydehydrogenase?[J].Oxidat Med Cell Longev,2015,2015:434052.
[66]Matsubara Y,Matsumoto T,Sekiguchi K,et al.Oral administration of the Japanese traditional medicine Keishibukuryogan-ka-yokuinin decreases reactive oxygen metabolites in rat plasma:Identification of chemical constituents contributing to antioxidant activity[J].Molecules,2017,22(2):256.
[67]Park J H,Kho M C,Oh H C,et al.1,6-Penta-O-galloyl-β-D-glucose from Galla rhois ameliorates renal tubular injury and microvascular inflammation in acute kidney injury rats[J].Am J Chin Med,2018,46(4):785-800.
[68]Anantharaju P G,Reddy B D,Padukudru M A,et al.Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases(HDAC)[J].Cancer Biol Therapy,2017,18(7):492-504.
[69]Zhu X.New monoterpene glycosides from the root cortex of Paeonia suffruticosa and their potential anti-inflammatory activity[J].Nat Prod Res,2014,28(5):301-305.
[70]吴丽,王丽丽,费文婷,等.芍药苷和芍药内酯苷对小鼠疼痛模型的镇痛作用及对β-EP、PGE2的影响[J].中华中医药杂志,2018,33(3):915-918.
[71]郝霁萍,高宇勤,贺少辉,等.芍药苷预处理激活PPARα对在体大鼠心肌缺血再灌注损伤保护的作用研究[J].中国中医急症,2015,24(11):1888-1890.
[72]Qiu H,Zhang L,Zhu M,et al.Capture of anti-coagulant active ingredients from Moutan Cortex by platelet immobilized chromatography and evaluation of anticoagulant activity in rats[J].Biomed Pharmacother,2017,95:235-244.
[73]王桐生,王艳华,吴德玲,等.丹皮不同提取物对子宫内膜异位症模型大鼠血液流变学及细胞因子的影响[J].中药材,2012,35(10):1649-1652.
[74]Wu H,Song A,Hu W.The anti-atherosclerotic effect of paeonol against vascular smooth muscle cell proliferation by up-regulation of autophagy via the AMPK/mTORsignaling pathway[J].Frontiers Pharmacol,2017,8:948.
[75]Choy K W,Lau Y S,Murugan D,et al.Paeonol attenuates LPS-induced endothelial dysfunction and apoptosis by inhibiting BMP4 and TLR4 signaling simultaneously but independently[J].J Pharmacol Experim Therap,2018,364(3):420-432.
[76]Yuan X,Chen J.Paeonol promotes micro RNA-126expression to inhibit monocyte adhesion to ox-LDL-injured vascular endothelial cells and block the activation of the PI3K/Akt/NF-κB pathway[J].Int J Mol Med,2016,38(6):1871-1878.
[77]安福丽,张仲,康兰芳,等.肉桂挥发性成分抑制小鼠离体子宫收缩的研究[J].河北医药,2009,31(13):1544-1545.
[78]Sun L,Liu L N,Li J C,et al.The essential oil from the twigs of Cinnamomum cassia Presl inhibits oxytocin-induced uterine contraction in vitro and in vivo[J].J Ethnopharmacol,2017,206:107-114.
[79]曾俊芬,鲁建武,宋金春.肉桂活性部位对大鼠凝血功能及血液流变学的影响[J].中国医院药学杂志,2015,35(21):1937-1940.
[80]王波,龚伟,陈国宝,等.肉桂挥发性成分的气相色谱/质谱分析[J].世界中西医结合杂志,2014,9(9):941-943.
[81]赵宇辉,唐丹丹,陈丹倩,等.利尿药茯苓、茯苓皮、猪苓和泽泻的化学成分及其利尿作用机制研究进展[J].中国药理学与毒理学杂志,2014,28(4):594-599.
[82]Wilson R.Chain separation of monounsaturated fatty acid methyl esters by argentation thin-layer chromatography[J].J Chromatogr A,2001,905(1/2):251-257.
[2]周雪梅,陈姝,徐海榛,等.桂枝茯苓丸新解[J].中国中医基础医学杂志,2018,24(5):673-674.
[3]谭保平,邵乾,邵家德.桂枝茯苓方中桂枝、芍药的本草考证[J].广西中医药,2014,37(6):54-55.
[4]朱政中,邵乾.桂枝茯苓方中芍药品种应用评析[J].辽宁中医学院学报,2006,8(3):19-20.
[5]魏贤坤,邵家德,宛宜文.桂枝茯苓胶囊中芍药品种疑析[J].时珍国医国药,2006,17(5):868.
[6]王付,王林玉.桂枝茯苓丸方证思考与探索[J].中华中医杂志,2016,31(7):2618-2620.
[7]秦泗涟,马利华,贾晓斌,等.桂枝茯苓方物质基础及其制剂质量控制模式研究进展[J].中国实验方剂学杂志,2011,17(13):270-273.
[8]廖正根,平其能,萧伟,等.桂枝茯苓胶囊中有效成分的大鼠在体肠吸收研究[J].中国天然药物,2005,3(5):303-307.
[9]刘新,马成,盛萍,等.茯苓与桂枝配伍对小鼠利尿的实验研究[J].新疆中医药,2009,27(5):45-48.
[10]周蓓.桂枝桃仁及其配伍对抗凝血作用影响的研究[J].云南中医中药杂志,2014,35(1):62-63.
[11]柴丽娜,杜惠兰.关于妇科血瘀证发病机理的研究[J].中医杂志,1997,38(2):102-103.
[12]许丽绵,宋红.《金匮要略》对妇科血瘀证证治述要[J].中医药刊,2003,21(10):1727-1775.
[13]梁文珍.浅析妇科血瘀证[J].安徽中医学院学报,1997,16(4):3-5.
[14]刘玉祁,佘延芬,朱江,等.基于调查的中重度原发性痛经中医病因病机探讨[J].中华中医药杂志,2012,27(1):57-61.
[15]郑玮琳,翁衡,梁雪芳.基于数据挖掘的古代痛经方药运用规律研究[J].时珍国医国药,2017,28(4):1011-1015.
[16]肖新春,刘霞.血水同病乃子宫内膜异位症病机关键[J].陕西中医,2013,34(10):1378.
[17]姜彦,应翩,任辉,等.治疗子宫腺肌症经验[J].辽宁中医药大学学报,2010,12(1):115-116.
[18]张军会,王永辉,周文静,等.中医辨治慢性盆腔炎经验[J].河北中医,2015,37(3):429-430.
[19]王敏杰,王丽莉,张铁军.治疗慢性盆腔炎中药的研究进展[J].药物评价研究,2010,33(6):461-466.
[20]司银套,申贝贝,常宁甫.乳腺增生病中医发病机制与防治思路浅探[J].江苏中医药,2011,43(8):3-5.
[21]樊凤英.浅谈乳腺增生病的治疗[J].江苏中医药,2009,41(11):20-21.
[22]尉万春,李成卫,沈绍功.子宫肌瘤虚瘀同治整体治疗方案设计[J].时珍国医国药,2016,27(1):173-175.
[23]戚益铭,沈敏鹤,阮善明,等.乳腺癌病因病机及中医证治的研究进展[J].黑龙江中医药,2014,43(5):81-83.
[24]朴胜华,罗朵生.中药物质基础研究方法评述[J].中国药房,2012,23(23):2194-2196.
[25]仲云熙,孙建国,王广基.桂枝茯苓胶囊药理作用与临床应用研究进展[J].中草药,2016,47(17):3115-3120.
[26]Sun L,Liu L,Zong S,et al.Traditional Chinese medicine Guizhi Fuling capsule used for therapy of dysmenorrhea via attenuating uterus contraction[J].J Ethnopharmacol,2016,191:273-279.
[27]王振中,范麒如,窦霞,等.桂枝茯苓胶囊抑制小鼠离体子宫收缩效应及其物质基础评价[J].中草药,2009,40(4):609-611.
[28]曹泽彧,丁玥,苏真真,等.分子烙印-活性筛选结合评价桂枝茯苓胶囊主要成分活性贡献度研究[J].中国中药杂志,2015,40(12):2420-2427.
[29]仲云熙,金孝亮,谷世寅,等.基于抗炎活性的桂枝茯苓胶囊抗痛经作用机制研究[J].中国临床药理学与治疗学,2016,21(10):1095-1102.
[30]陶晓倩,李娜,曹亮,等.桂枝茯苓胶囊中主要成分对人子宫肌瘤细胞增殖及小鼠离体子宫收缩活动的影响[J].中国实验方剂学杂志,2016,22(2):91-96.
[31]萧伟,曹亮,范麒如,等.基于生物网络的桂枝茯苓胶囊作用机理研究[J].计算机与应用化学,2012,29(12):1455-1459.
[32]Terawaki K,Noguchi M,Yuzurihara M,et al.Keishibukuryogan,a traditional Japanese medicine,inhibits platelet aggregation in guinea pig whole blood[J].Evid Based Compl Alternat Med,2015,2015:295706.
[33]孙兰,林楠,吕耀中,等.桂枝茯苓胶囊对大鼠慢性盆腔炎的影响[J].中药药理与临床,2013,29(4):21-24.
[34]唐兴梅,李芳,刘莉娜,等.桂枝茯苓胶囊及其成分对LPS诱导RAW264.7细胞产生炎症介质的影响[J].临床医学研究与实践,2017,2(20):6-8.
[35]张珍珍,张新庄,李娜,等.桂枝茯苓胶囊及其活性成分组合物抗炎作用与机制研究[J].中国中药杂志,2015,40(6):993-998.
[36]王俨如,李娜,曹亮,等.应用高内涵技术研究桂枝茯苓胶囊抗炎及免疫调节活性成分[J].中国中药杂志,2015,40(6):1005-1011.
[37]范麒如,王振中,马宏跃,等.分子对接法虚拟筛选桂枝茯苓胶囊抗子宫肌瘤的潜在活性成分[J].世界科学技术-中医药现代化,2016,18(2):307-312.
[38]邓淑蓉,潘宇政.肉桂主要化学成分及药理作用研究概况[J].现代中西医结合杂志,2018,27(4):448-451.
[39]徐硕,姜文清,邝咏梅,等.茯苓的化学成分及生物活性研究进展[J].西北药学杂志,2016,31(3):327-330.
[40]王仁芳,范令刚,高文远,等.桃仁化学成分与药理活性研究进展[J].现代药物与临床,2010,25(6):426-429.
[41]赵强,李莹,孔令升,等.桃仁化学成分及药理作用研究进展[J].天水师范学院学报,2008,28(2):56-59.
[42]杨骅,马继琴,韩志云,等.丹皮酚对急性微循环障碍大鼠血管内皮细胞分泌的ET-1和NO的调控[J].海峡药学,2008,20(6):47-49.
[43]章丽,赵冰洁,袁嘉瑞,等.牡丹皮、赤芍与白芍对急性血瘀模型大鼠活血功效的比较研究[J].中草药,2016,47(15):2676-2683.
[44]尹权微,李家春,秦建平,等.UPLC/Q-TOF-MS快速分析桂枝茯苓胶囊的入血成分[J].中国实验方剂学杂志,2016,22(21):83-86.
[45]李莉,易醒,肖小年.肉桂油药理研究进展[J].江西食品工业,2010(4):43-46.
[46]史青.肉桂和肉桂醛对氧自由基诱导的自发性高血压大鼠离体主动脉收缩的抑制作用[J].国外医学:中医中药分册,2003,25(2):95-96.
[47]周本杰,李亚冰.退热止痛散解热镇痛活性部位气相色谱-质谱分析[J].时珍国医国药,2011,22(10):2457-2458.
[48]鲍邢杰,宿树兰,段金廒.肉桂挥发油及其抑制血小板聚集的效应成分分析[J].时珍国医国药,2010,21(11):2860-2861.
[49]黄敬群,王四旺,罗晓星.肉桂油β-环糊精包合物体内抗血栓作用实验研究[J].中国药理学通报,2006,22(1):126-127.
[50]马悦颖,李沧海,李兰芳,等.桂皮醛解热镇痛抗炎作用的实验研究[J].中国临床药理学与治疗学,2006,11(12):1336-1339.
[51]陈立平,张慧萍,陈光,等.肉桂油成分分析及肉桂醛体外抗肿瘤活性研究[J].中国微生态学杂志,2012,24(4):327-330.
[52]金戈,张婷,王涛,等.α-干扰素与肉桂酸对人肺癌细胞增殖的抑制作用[J].癌症,2002,21(8):860-862.
[53]周宏超,高立云,范光丽,等.茯苓酸对SLT-IIe诱导大鼠肠黏膜微血管内皮细胞分泌细胞因子的影响[J].中国兽医科学,2008,38(10):884-888.
[54]周宏超,索占伟,范光丽,等.茯苓酸对SLT-IIe诱导的大鼠肠黏膜微血管内皮细胞分泌P-选凝素、s ICAM-1及TNF-α的影响[J].中国兽医学报,2009,29(5):628-631.
[55]邓刚民,许津.茯苓素:一种潜在的醛固酮拮抗剂[J].中国抗生素杂志,1992,17(1):34-37.
[56]田婷,陈华,殷璐,等.茯苓和茯苓皮水和乙醇提取物的利尿作用及其活性成分的分离鉴定[J].中国药理学与毒理学杂志,2014,28(1):57-62.
[57]王玉,韩志武.齐墩果酸对氧化损伤人脐静脉内皮细胞线粒体中一氧化氮合酶的调控作用[J].中国药房,2015,26(19):2617-2620.
[58]吴青青,王娟,崔树娜,等.齐墩果酸抑制脂多糖诱导RAW264.7细胞炎症反应[J].扬州大学学报:农业与生命科学版,2017,38(3):27-31.
[59]连俊江,程彬峰,高尧鑫,等.齐墩果酸对IL-1β诱导的SW982细胞炎症反应的抑制作用[J].药学学报,2016,51(11):1711-1716.
[60]刘玉兰,王慧姝.齐墩果酸对血小板功能的影响[J].沈阳药学院学报,1993,10(4):275-278.
[61]Martínez-González J,Rodríguez-Rodríguez R,González-Díez M,et al.Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism[J].J Nutr,2008,138(3):443-448.
[62]Yang H Y,Chang H K,Lee J W,et al.Amygdalin suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells[J].Neurol Res,2007,29(Suppl 1):59-64.
[63]Hwang H J,Kim P,Kim C J,et al.Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats[J].Biol Pharm Bull,2008,31(8):1559-1564.
[64]张艳玲.王不留行、桃仁和郁金中抑制FXa活性成分研究[D].南京:南京中医药大学,2015.
[65]Cheng Y,Zhao J,Tse H F,et al.Plant natural products calycosin and gallic acid synergistically attenuate neutrophil infiltration and subsequent injury in isoproterenol-induced myocardial infarction:A possible role for leukotriene B4 12-hydroxydehydrogenase?[J].Oxidat Med Cell Longev,2015,2015:434052.
[66]Matsubara Y,Matsumoto T,Sekiguchi K,et al.Oral administration of the Japanese traditional medicine Keishibukuryogan-ka-yokuinin decreases reactive oxygen metabolites in rat plasma:Identification of chemical constituents contributing to antioxidant activity[J].Molecules,2017,22(2):256.
[67]Park J H,Kho M C,Oh H C,et al.1,6-Penta-O-galloyl-β-D-glucose from Galla rhois ameliorates renal tubular injury and microvascular inflammation in acute kidney injury rats[J].Am J Chin Med,2018,46(4):785-800.
[68]Anantharaju P G,Reddy B D,Padukudru M A,et al.Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases(HDAC)[J].Cancer Biol Therapy,2017,18(7):492-504.
[69]Zhu X.New monoterpene glycosides from the root cortex of Paeonia suffruticosa and their potential anti-inflammatory activity[J].Nat Prod Res,2014,28(5):301-305.
[70]吴丽,王丽丽,费文婷,等.芍药苷和芍药内酯苷对小鼠疼痛模型的镇痛作用及对β-EP、PGE2的影响[J].中华中医药杂志,2018,33(3):915-918.
[71]郝霁萍,高宇勤,贺少辉,等.芍药苷预处理激活PPARα对在体大鼠心肌缺血再灌注损伤保护的作用研究[J].中国中医急症,2015,24(11):1888-1890.
[72]Qiu H,Zhang L,Zhu M,et al.Capture of anti-coagulant active ingredients from Moutan Cortex by platelet immobilized chromatography and evaluation of anticoagulant activity in rats[J].Biomed Pharmacother,2017,95:235-244.
[73]王桐生,王艳华,吴德玲,等.丹皮不同提取物对子宫内膜异位症模型大鼠血液流变学及细胞因子的影响[J].中药材,2012,35(10):1649-1652.
[74]Wu H,Song A,Hu W.The anti-atherosclerotic effect of paeonol against vascular smooth muscle cell proliferation by up-regulation of autophagy via the AMPK/mTORsignaling pathway[J].Frontiers Pharmacol,2017,8:948.
[75]Choy K W,Lau Y S,Murugan D,et al.Paeonol attenuates LPS-induced endothelial dysfunction and apoptosis by inhibiting BMP4 and TLR4 signaling simultaneously but independently[J].J Pharmacol Experim Therap,2018,364(3):420-432.
[76]Yuan X,Chen J.Paeonol promotes micro RNA-126expression to inhibit monocyte adhesion to ox-LDL-injured vascular endothelial cells and block the activation of the PI3K/Akt/NF-κB pathway[J].Int J Mol Med,2016,38(6):1871-1878.
[77]安福丽,张仲,康兰芳,等.肉桂挥发性成分抑制小鼠离体子宫收缩的研究[J].河北医药,2009,31(13):1544-1545.
[78]Sun L,Liu L N,Li J C,et al.The essential oil from the twigs of Cinnamomum cassia Presl inhibits oxytocin-induced uterine contraction in vitro and in vivo[J].J Ethnopharmacol,2017,206:107-114.
[79]曾俊芬,鲁建武,宋金春.肉桂活性部位对大鼠凝血功能及血液流变学的影响[J].中国医院药学杂志,2015,35(21):1937-1940.
[80]王波,龚伟,陈国宝,等.肉桂挥发性成分的气相色谱/质谱分析[J].世界中西医结合杂志,2014,9(9):941-943.
[81]赵宇辉,唐丹丹,陈丹倩,等.利尿药茯苓、茯苓皮、猪苓和泽泻的化学成分及其利尿作用机制研究进展[J].中国药理学与毒理学杂志,2014,28(4):594-599.
[82]Wilson R.Chain separation of monounsaturated fatty acid methyl esters by argentation thin-layer chromatography[J].J Chromatogr A,2001,905(1/2):251-257.