基于纳米材料比色传感器的构建及其应用
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摘要
比色检测可将目标物识别事件转变为颜色变化,具有操作简单、肉眼可见和不需要昂贵或复杂的仪器等优势,已被广泛应用于环境污染监控、食品安全监测、生化分析以及疾病诊断等领域。随着纳米科技的发展,纳米材料因其优异的光学性质、良好的生物相容性、高的催化活性和易于表面功能化等优点,已被广泛用于构建比色传感器,极大提升了比色传感平台或比色传感器件的检测灵敏度和稳定性,为比色传感器的发展注入了新的活力。文中系统总结了纳米材料在构建比色传感器中的作用机制,并综述了自2010年以来基于纳米材料的比色传感器对重金属离子、有机磷化合物、食品添加剂、生物小分子、药物小分子、肿瘤标志物以及肿瘤细胞等分析物检测的研究进展。
Colorimetric detection can transform target molecules recognition events into color changes,and has advantages of simple operation,visible to the naked eyes and no need for expensive or complicated equipment. At present,colorimetric sensors have been widely used in environmental pollution monitoring,food safety monitoring,biochemical analysis,disease diagnosis,and other fields. With the development of the nanotechnology,nanomaterials have been successfully introduced into the construction of colorimetric sensors due to their excellent optical properties,good biocompatibility,high catalytic activity,and easy surface functionalization,improving the detection sensitivity and the stability of colorimetric sensors. Therefore,the introduction of nanomaterials brings new vitality to the development of colorimetric sensors. The mechanism of nanomaterials in the construction of colorimetric sensors is systematically summarized. This paper reviews the advances of colorimetric sensors in the detection of heavy metal ions,organophosphorus compounds,food additives,small biological molecules,small drug molecules,tumor markers,and cancer cells since 2010.
Colorimetric detection can transform target molecules recognition events into color changes,and has advantages of simple operation,visible to the naked eyes and no need for expensive or complicated equipment. At present,colorimetric sensors have been widely used in environmental pollution monitoring,food safety monitoring,biochemical analysis,disease diagnosis,and other fields. With the development of the nanotechnology,nanomaterials have been successfully introduced into the construction of colorimetric sensors due to their excellent optical properties,good biocompatibility,high catalytic activity,and easy surface functionalization,improving the detection sensitivity and the stability of colorimetric sensors. Therefore,the introduction of nanomaterials brings new vitality to the development of colorimetric sensors. The mechanism of nanomaterials in the construction of colorimetric sensors is systematically summarized. This paper reviews the advances of colorimetric sensors in the detection of heavy metal ions,organophosphorus compounds,food additives,small biological molecules,small drug molecules,tumor markers,and cancer cells since 2010.
引文
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[21]HOWES P D,RANA S,STEVENS M M.Plasmonic nanomaterials for biodiagnostics[J].Chemical Society Reviews,2014,43(11):3835-3853.
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[24]ZHENG W S,JIANG X Y.Integration of nanomaterials for colorimetric immunoassays with improved performance:a functional perspective[J].Analyst,2016,141(4):1196-1208.
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