糖化白蛋白与动脉硬化相关性研究
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摘要
目的:探讨体检人群糖化白蛋白(GA)水平与动脉硬化的相关性。方法:以肱踝脉搏波传导速度(baPWV)≥1 400 cm/s为标准,将参加常规体检的741人,分为动脉硬化组和正常对照组,测定血清GA及其他生化指标,应用动脉硬化诊断仪测量臂踝脉搏波传导速度(baPWV)。采用Spearman相关分析及多重线性回归分析GA和baPWV的相关性。结果:动脉硬化组的年龄、BMI、血压、血脂、尿酸、肌酐、baPWV、空腹血糖及GA均显著高于对照组(P<0.05)。Spearman相关分析显示GA与baPWV呈正相关(P<0.05)。多重线性回归分析显示,调整其他混杂因素后仍与baPWV独立正相关(P<0.05)。结论:体检人群中血清GA水平与动脉硬化正相关,且独立于其他危险因素。健康体检中测定GA对普通人群动脉硬化的预防及早期监测具有意义。
Objective:To explore the correlation between glycated albumin(GA) and arterial stiffness.Methods:Based on brachial-ankle pulse wave velocity(baPWV) ≥ 1 400 cm/s,741 subjects who participated in the routine physical examination were divided into arterial stifness group and control group.Serum GA and baPWV were measured.Spearman correlation and multivariate linear regression analysis were used to evaluate the relationship between GA and baPWV.Results:Age,BMI,blood pressure,blood lipids,uric acid,creatinine,baPWV,fasting blood glucose and GA were significantly higher in arterial stifness group than in control group(P<0.05).GA was positively associated with baPWV(P<0.05).After adjustment for the above confounding factors,GA was still positively associated with baPWV(P<0.05).Conclusion:Serum GA levels were positively correlated with arterial stiffness and were independent of other risk factors.The determination of GA may help detect the development of arterial stiffness in the health screening population.
Objective:To explore the correlation between glycated albumin(GA) and arterial stiffness.Methods:Based on brachial-ankle pulse wave velocity(baPWV) ≥ 1 400 cm/s,741 subjects who participated in the routine physical examination were divided into arterial stifness group and control group.Serum GA and baPWV were measured.Spearman correlation and multivariate linear regression analysis were used to evaluate the relationship between GA and baPWV.Results:Age,BMI,blood pressure,blood lipids,uric acid,creatinine,baPWV,fasting blood glucose and GA were significantly higher in arterial stifness group than in control group(P<0.05).GA was positively associated with baPWV(P<0.05).After adjustment for the above confounding factors,GA was still positively associated with baPWV(P<0.05).Conclusion:Serum GA levels were positively correlated with arterial stiffness and were independent of other risk factors.The determination of GA may help detect the development of arterial stiffness in the health screening population.
引文
[1]LU Y C,LYU P,ZHU H Y,et al.Brachial-ankle pulse wave velocity compared with mean arterial pressure and pulse pressure in risk stratification in a Chinese population[J].Journal of Hypertension,2018,36:1.
[2]夏小琦,杨成明.无创动脉僵硬度检测对早期诊断心血管疾病的意义[J].心血管病学进展,2009,30(30):476-479.
[3]UEDA Y,MATSUMOTO H.Recent topics in chemical and clinical research on glycated albumin[J].J Diabetes Sci Technol,2015,9(2):177-182.
[4]NORIMATSU K,MIURA S,SUEMATSU Y,et al.Associations between glycated albumin or hemoglobin A1c and the presence of coronary artery disease[J].J Cardiol,2015,65(6):487-493.
[5]NAKAGAMI T,TOMINAGA M,NISHIMURA R,et al.Is the measurement of glycated hemoglobin A1c alone an efficient screening test for undiagnosed diabetes?Japan National Diabetes Survey[J].Diabetes Research&Clinical Practice,2007,76(2):251-256.
[6]韩静,李亚伟,刘宏,等.不同空腹血糖与脉搏波传导速度相关性研究[J].白求恩医学杂志,2015,13(2):193-194.
[7]朱旅云,王志强,杨少玲,等.初诊2型糖尿病早期动脉硬化指标检测及其与糖化血红蛋白相关性[J].医学研究杂志,2011,40(10):43-45,97.
[8]董学勤,安艳荣,都伟,等.糖耐量异常与颈动脉血管壁弹性的关系及相关因素分析[J].临床荟萃,2010,25(5):377-379.
[9]周丽华,陈勋.糖尿病糖化血红蛋白水平与颈动脉硬化斑块形成的相关性[J].检验医学与临床,2017,14(21):3186-3188.
[10]李岩,王亚珍,郝志华,等.无糖尿病病史的体检者糖化血红蛋白与颈动脉内-中膜厚度及动脉粥样硬化的相关性研究[J].中国全科医学,2014(21):2440-2444.
[11]YAMASHINA A,TOMIYAMA H,ARAI T,et al.Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk[J].Hypertension Research,2003,26(8):615-622.
[12]FURUSYO N,KOGA T,AI M,et al.Plasma glycated albumin level and atherosclerosis:results from the Kyushu and Okinawa Population Study[J].Int J Cardiol,2013,167(5):2066-2072.
[13]祁瑞芳.糖化白蛋白、超敏C-反应蛋白在2型糖尿病合并冠心病中的检测意义[J].西部中医药,2015,28(6):154-155.
[14]ARASTEH A,FARAHI S,HABIBI-RAZAEI M,et al.Glycated albumin:an overview of the In Vitro models of an In Vivo potential disease marker[J].J Diabetes Metab Disord,2014,13:49.
[15]FURUSYN N,HAYASHI J,et al.Glycated albumin and diabetes mellitus[J].Biochim Biophys Acta,2013,1830(12):5509-5514.
[16]KUMEDA Y,INABA M,SHOJI S,et al.Significant correlation of glycated albumin,but not glycated haemoglobin,with arterial stiffening in haemodialysis patients with type 2 diabetes[J].Clinical Endocrinology,2010,69(4):556-561.
[17]KOGA M,OTSUKI M,MATSUMOTO S,et al.Negative association of obesity and its related chronic inflammation with serum glycated albumin but not glycated hemoglobin levels[J].Clinica Chimica Acta,2007,378(1):48-52.
[2]夏小琦,杨成明.无创动脉僵硬度检测对早期诊断心血管疾病的意义[J].心血管病学进展,2009,30(30):476-479.
[3]UEDA Y,MATSUMOTO H.Recent topics in chemical and clinical research on glycated albumin[J].J Diabetes Sci Technol,2015,9(2):177-182.
[4]NORIMATSU K,MIURA S,SUEMATSU Y,et al.Associations between glycated albumin or hemoglobin A1c and the presence of coronary artery disease[J].J Cardiol,2015,65(6):487-493.
[5]NAKAGAMI T,TOMINAGA M,NISHIMURA R,et al.Is the measurement of glycated hemoglobin A1c alone an efficient screening test for undiagnosed diabetes?Japan National Diabetes Survey[J].Diabetes Research&Clinical Practice,2007,76(2):251-256.
[6]韩静,李亚伟,刘宏,等.不同空腹血糖与脉搏波传导速度相关性研究[J].白求恩医学杂志,2015,13(2):193-194.
[7]朱旅云,王志强,杨少玲,等.初诊2型糖尿病早期动脉硬化指标检测及其与糖化血红蛋白相关性[J].医学研究杂志,2011,40(10):43-45,97.
[8]董学勤,安艳荣,都伟,等.糖耐量异常与颈动脉血管壁弹性的关系及相关因素分析[J].临床荟萃,2010,25(5):377-379.
[9]周丽华,陈勋.糖尿病糖化血红蛋白水平与颈动脉硬化斑块形成的相关性[J].检验医学与临床,2017,14(21):3186-3188.
[10]李岩,王亚珍,郝志华,等.无糖尿病病史的体检者糖化血红蛋白与颈动脉内-中膜厚度及动脉粥样硬化的相关性研究[J].中国全科医学,2014(21):2440-2444.
[11]YAMASHINA A,TOMIYAMA H,ARAI T,et al.Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk[J].Hypertension Research,2003,26(8):615-622.
[12]FURUSYO N,KOGA T,AI M,et al.Plasma glycated albumin level and atherosclerosis:results from the Kyushu and Okinawa Population Study[J].Int J Cardiol,2013,167(5):2066-2072.
[13]祁瑞芳.糖化白蛋白、超敏C-反应蛋白在2型糖尿病合并冠心病中的检测意义[J].西部中医药,2015,28(6):154-155.
[14]ARASTEH A,FARAHI S,HABIBI-RAZAEI M,et al.Glycated albumin:an overview of the In Vitro models of an In Vivo potential disease marker[J].J Diabetes Metab Disord,2014,13:49.
[15]FURUSYN N,HAYASHI J,et al.Glycated albumin and diabetes mellitus[J].Biochim Biophys Acta,2013,1830(12):5509-5514.
[16]KUMEDA Y,INABA M,SHOJI S,et al.Significant correlation of glycated albumin,but not glycated haemoglobin,with arterial stiffening in haemodialysis patients with type 2 diabetes[J].Clinical Endocrinology,2010,69(4):556-561.
[17]KOGA M,OTSUKI M,MATSUMOTO S,et al.Negative association of obesity and its related chronic inflammation with serum glycated albumin but not glycated hemoglobin levels[J].Clinica Chimica Acta,2007,378(1):48-52.