CRP和SAA对儿童呼吸道感染鉴别诊断的价值
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摘要
目的:探讨C反应蛋白(CRP)和血清淀粉样蛋白A(SAA)对儿童呼吸道感染鉴别诊断的价值。方法:收集东莞市厚街医院2018年3月-2019年3月收治的急性呼吸道感染患儿120例临床资料,依据血清学、病原体及影像学检查结果,分为细菌组50例和病毒组70例,选取同期健康体检者70例作为对照组。比较CRP与SAA水平及其相关性。结果:细菌组CRP高于病毒组、对照组,对照组SAA低于细菌组、病毒组,细菌组CRP阳性率高于病毒组、对照组,对照组SAA阳性率低于细菌组、病毒组,患儿CRP与SAA具有明显的正相关性,差异均有统计学意义(P<0.05)。结论:CRP与SAA联合检测对于提高儿童呼吸道感染鉴别诊断具有重要的意义。
Objective:To approach the value of differential diagnosis for Children respiratory infections by CRP and SAA.Method:120 cases clinical data of children respiratory infections in Dongguan City Houjie Hospital from March 2018 to March 2019 were analyzed,and according to the results of serology,pathogen and imaging,50 cases were divided into the bacterial group and 70 cases into the viral group,then 70 cases health checkups were selected as the control group.Compared the CRP and SAA levels and their correlation.Result:CRP of the bacterial group was higher than the viral group and the control group,and SAA of the control group was lower than the bacterial group and the viral group.CRP positive rate of the bacterial group was higher than the viral group and the control group,SAA positive rate of the control group was lower than the bacterial group and the virus group.There was a significant positive correlation between CRP and SAA in children.The differences were statistically significant(P<0.05).Conclusion:Joint testing CRP and SAA are important significance for improving the differential diagnosis of respiratory infections in children.
Objective:To approach the value of differential diagnosis for Children respiratory infections by CRP and SAA.Method:120 cases clinical data of children respiratory infections in Dongguan City Houjie Hospital from March 2018 to March 2019 were analyzed,and according to the results of serology,pathogen and imaging,50 cases were divided into the bacterial group and 70 cases into the viral group,then 70 cases health checkups were selected as the control group.Compared the CRP and SAA levels and their correlation.Result:CRP of the bacterial group was higher than the viral group and the control group,and SAA of the control group was lower than the bacterial group and the viral group.CRP positive rate of the bacterial group was higher than the viral group and the control group,SAA positive rate of the control group was lower than the bacterial group and the virus group.There was a significant positive correlation between CRP and SAA in children.The differences were statistically significant(P<0.05).Conclusion:Joint testing CRP and SAA are important significance for improving the differential diagnosis of respiratory infections in children.
引文
[1]刘智,陆少颜,林胜元.联合检测血清淀粉样蛋白A、C反应蛋白和白细胞计数诊断儿童感染性疾病的应用价值[J].中国医学工程,2017,25(11):58-60.
[2]Tartey S,Takeuchi O.Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells[J].International Reviews of Immunology,2017,36(2):57-73.
[3]杨慧敏,海蒂,何玉红.CRP、WBC、PCT检测在儿科感染性疾病早期诊断中的价值[J].延安大学学报:医学科学版,2017,15(4):52-54.
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[5]陈凤华,欧红玲,刘晨,等.SAA检测在感染性疾病诊断中的临床应用价值[J].西北国防医学杂志,2017,38(5):291-294.
[6]Somerville V S,Braakhuis A J,Hopkins W G.Effect of flavonoids on upper respiratory tract infections and immune function:a systematic review and meta-analysis[J].Advances in Nutrition,2016,7(3):488.
[7]张小丹.Hcy、C-反应蛋白、SAA、APN检测评估冠状动脉病变严重程度的价值[J].实验与检验医学,2018,36(1):91-94.
[8]Shakerley N L,Chandrasekaran A,Trebak M,et al.Francisella tularensis catalase restricts immune function by impairing TRPM2 channel activity[J].Journal of Biological Chemistry,2016,291(8):3871.
[9]赵志鹏,王利君,李润清,等.降钙素原在不同感染部位和类型中的应用价值[J].中国实验诊断学,2017,21(12):2112-2115.
[10]胡亚美,江载芳,申昆玲,等.诸福棠实用儿科学8版[M].北京:人民卫生出版社,2015:1231-1288.
[11]Safer U,Safer V B,Demir S O,et al.Effects of Bisphosphonates and Calcium plus Vitamin-D supplements on cognitive function in postmenopausal osteoporosis[J].Endocrine Metabolic&Immune Disorders Drug Targets,2016,16(1):56.
[12]李林峡,吴亦栋,周杰林,等.血清淀粉样蛋白A在不同类型手足口病急性期中的应用[J].中国现代医生,2017,55(32):43-45.
[13]Martinez-Estevez N S,Alvarez-Guevara A N,Rodriguez-Martinez CE.Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in colombian children:a 12-month randomised controlled trial[J].Allergologia Et Immunopathologia,2016,44(4):368.
[14]闫学平,郝秀丽,孙婷,等.血常规联合hs-CRP、免疫学指标检测在小儿急性上呼吸道感染中的临床价值[J].现代生物医学进展,2018,18(8):1502-1505.
[15]曹建伟,曾永红,常潇丹,等.血清CRP,PCT水平在脓毒血症患者中的早期诊断及预后评估价值[J].现代生物医学进展,2016,16(20):3918-3921.
[2]Tartey S,Takeuchi O.Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells[J].International Reviews of Immunology,2017,36(2):57-73.
[3]杨慧敏,海蒂,何玉红.CRP、WBC、PCT检测在儿科感染性疾病早期诊断中的价值[J].延安大学学报:医学科学版,2017,15(4):52-54.
[4]Barinov A,Galgano A,Krenn G,et al.CD4/CD8/Dendritic cell complexes in the spleen:CD8+T cells can directly bind CD4+T cells and modulate their response[J].Plos One,2017,12(7):e0180644.
[5]陈凤华,欧红玲,刘晨,等.SAA检测在感染性疾病诊断中的临床应用价值[J].西北国防医学杂志,2017,38(5):291-294.
[6]Somerville V S,Braakhuis A J,Hopkins W G.Effect of flavonoids on upper respiratory tract infections and immune function:a systematic review and meta-analysis[J].Advances in Nutrition,2016,7(3):488.
[7]张小丹.Hcy、C-反应蛋白、SAA、APN检测评估冠状动脉病变严重程度的价值[J].实验与检验医学,2018,36(1):91-94.
[8]Shakerley N L,Chandrasekaran A,Trebak M,et al.Francisella tularensis catalase restricts immune function by impairing TRPM2 channel activity[J].Journal of Biological Chemistry,2016,291(8):3871.
[9]赵志鹏,王利君,李润清,等.降钙素原在不同感染部位和类型中的应用价值[J].中国实验诊断学,2017,21(12):2112-2115.
[10]胡亚美,江载芳,申昆玲,等.诸福棠实用儿科学8版[M].北京:人民卫生出版社,2015:1231-1288.
[11]Safer U,Safer V B,Demir S O,et al.Effects of Bisphosphonates and Calcium plus Vitamin-D supplements on cognitive function in postmenopausal osteoporosis[J].Endocrine Metabolic&Immune Disorders Drug Targets,2016,16(1):56.
[12]李林峡,吴亦栋,周杰林,等.血清淀粉样蛋白A在不同类型手足口病急性期中的应用[J].中国现代医生,2017,55(32):43-45.
[13]Martinez-Estevez N S,Alvarez-Guevara A N,Rodriguez-Martinez CE.Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in colombian children:a 12-month randomised controlled trial[J].Allergologia Et Immunopathologia,2016,44(4):368.
[14]闫学平,郝秀丽,孙婷,等.血常规联合hs-CRP、免疫学指标检测在小儿急性上呼吸道感染中的临床价值[J].现代生物医学进展,2018,18(8):1502-1505.
[15]曹建伟,曾永红,常潇丹,等.血清CRP,PCT水平在脓毒血症患者中的早期诊断及预后评估价值[J].现代生物医学进展,2016,16(20):3918-3921.