扶正类中药抗肿瘤作用的机制及研究进展
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摘要
正气虚弱是恶性肿瘤发生的首要原因,并且与肿瘤的发展和转归有明确关系。临床以补虚扶正为法运用扶正类中药能够取得显著疗效。另外,除了改善患者体质、增强抵御病邪能力的作用,某些扶正类中药还具有直接杀伤肿瘤细胞的作用,如抑制肿瘤细胞增殖、诱导分化、促进凋亡、抑制肿瘤血管生成和逆转肿瘤细胞耐药等。
Deficiency of vital qi is the primary cause of malignant tumor, and it has a clear relationship with the development and prognosis of tumor. In the course of treatment, the clinical use of some strengthening the body resistance Chinese herbs, whose main function is to help vital qi, can achieve significant effect. In addition, besides the effect of improving the patient 's physique and enhancing the ability to resist the disease, those herbs also have the effect of killing the tumor cells directly, such as inhibiting tumor cell proliferation, inducing cell differentiation, promoting cell apoptosis, inhibiting tumor angiogenesis and reversing tumor cell resistance.
Deficiency of vital qi is the primary cause of malignant tumor, and it has a clear relationship with the development and prognosis of tumor. In the course of treatment, the clinical use of some strengthening the body resistance Chinese herbs, whose main function is to help vital qi, can achieve significant effect. In addition, besides the effect of improving the patient 's physique and enhancing the ability to resist the disease, those herbs also have the effect of killing the tumor cells directly, such as inhibiting tumor cell proliferation, inducing cell differentiation, promoting cell apoptosis, inhibiting tumor angiogenesis and reversing tumor cell resistance.
引文
[1]尤杰.刘嘉湘扶正治癌学术思想初探.中华中医药学刊[J].2011,29(8):1830-1832.
[2]朱华宇.周岱翰教授治疗恶性肿瘤学术思想拾萃[J].中医药学刊,2004,22(3):394-395.
[3]韩萍,罗阔,蒋青松,等.人参皂苷Rg3对结肠癌Caco2细胞增殖和迁移的影响[J].免疫学杂志,2014,30(8):722-726.
[4]黄靓,李国庆,毛振江,等.人参多糖注射液对胃癌细胞SGC-7901凋亡的诱导作用及机制[J].世界华人消化杂志,2014,22(33):5114-5117.
[5]王梓,许兴月,李琼,等.人参皂苷Rg1热裂解产物对H22荷瘤小鼠的抗肿瘤作用[J].中国药学杂志,2017,52(15):1319-1324.
[6]靳宝辉,隋华,李琦,等.扶正中药逆转肿瘤多药耐药的研究进展[J].中华中医药杂志,2013,28(8):2367-2370.
[7]罗林明,石雅宁,姜懿纳,等.人参抗肿瘤作用的有效成分及其机制研究进展[J].中草药,2017,48(3):582-596.
[8]李钦,胡继宏,高博,等.黄芪多糖在免疫调节方面的最新研究进展[J].中国实验方剂学杂志,2017,23(2):199-206.
[9]周杰,朱营营,王海丹,等.黄芪多糖对人胃癌细胞MGC-803的生长抑制作用及细胞周期的影响[J].中华中医药学刊,2013,31(5):1116-1119.
[10]吕君君,方诗琪,刘敏,等.黄芪多糖的抗肿瘤作用及其机制的研究进展[J].现代预防医学,2016,43(23):4276-4279.
[11]吴素珍,李加林,陈水亲,等.硫酸酯化当归多糖抗肿瘤实验研究[J].时珍国医国药,2012,23(2):319-320.
[12]程尧,王凯平,李强,等.当归多糖对H22荷瘤小鼠肿瘤生长及体内铁代谢的影响[J].中国医院药学杂志,2015,35(15):1359-1363.
[13]马秀梓,孙润广,李佳媚,等.3种中药多糖抗肿瘤作用的研究[J].陕西师范大学学报,2012,40(6):77-80.
[14]梁曾恩妮.灵芝多糖对结肠癌细胞增殖抑制和凋亡的影响初步研究[D].长沙:湖南农业大学,2014.
[15]邢会军,侯雷,孙勇,等.灵芝多糖对小鼠胃肿瘤活性的体内外抑制作用[J].中国实验方剂学杂志,2017,23(13):116-120.
[16]王昕妍,陈国杨,苏洁,等.灵芝孢子粉、破壁灵芝孢子粉对Lewis肺癌小鼠肿瘤生长和VEGF表达的比较研究[J].中国药理与临床,2017,33(2):118-122.
[17]梁慧超,唐晖,魏莲等.灵芝三萜对卵巢癌多耐药蛋白表达的影响[J].广东医学,2013,34(12):1829-1831.
[18]章丽霞,王涛,牛彩琴.等红景天苷对小鼠宫颈癌移植瘤中Eag1表达的影响和意义[J].重庆医学.2017,46(25):3470-3476.
[19]黎萍,赵丽晶,张捷,等.红景天对肺癌多药耐药细胞A549/DDP的促凋亡作用研究[J].中国实验诊断学,2014,18(9):1406-1408.
[20]庞晓斌,谢欣梅,赵清辉,等.红景天苷对人肝癌Hep G2细胞增殖及凋亡的影响[J].中国药学杂志,2014,49(3):195-198.
[21]吴剑锋,何晓东,许卫东,等.淫羊藿苷逆转耐甲氨蝶呤肺癌A549细胞转移表型[J].肿瘤,2009,29(12):1124-1128.
[22]Li Q,Huai L,Zhang C,et al.Icaritin induces Aml cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways[J].Int J Hematol,2013,97(5):617-623.
[23]Zhu Jf,Li Zj,Zhang Gs,et al.Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3/AKT signaling[J].PLo S One,2011,6(8):23720-23720.
[24]Sun F,Indran IR,Zhang ZW,et al.A novel prostate cancer therapeutic strategy using icaritin-activated arylhydlocarbon-receptor to co-target androgen receptor and its splice variants[J].Carcinogenesis,2015,36(7):757-768.
[25]Hu J,Zhu W,Wei B,et al.Antitumoral action of icaritin in LNCa P prostate cancer cells by regulating PEA3/HER2/AR signaling[J].Anticancer Drugs,2016,27(10):944-952.
[26]Han H,Xu B,Hou P,et al.Icaritin sensitizes human glioblastoma cells to TRAIL-induced apoptosis[J].Cell Biochem Biophys,2015,72(2):533-542.
[27]Zhao H,Guo Y,Li S,et al.A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway[J].Oncotarget,2015,6(31):31927-31943.
[28]Sun L,Peng Q,Qu L,et al.Anticancer agent icaritin induces apoptosis through caspase-dependent pathways in human hepatocellular carcinoma cells[J].Mol Med Rep,2015,11(4):3094-3100.
[29]赖丽娟,谢佳丽,黄志华,等.淫羊藿素得抗肿瘤作用及机制研究进展[J].中药药理与临床,2016,32(6):235-238.
[30]袁小芬,孙亚梅,张之勇,等.异补骨脂素对HL-60细胞增殖和凋亡影响及其机制探讨[J].中华肿瘤防治杂志,2015,22(21):1675-1679.
[31]陈红莉,冯慧瑾,李援朝,等.补骨脂酚的体外抗肿瘤活性及其关键中间体的合成研究[J].药学学报,2010,45(4):467-470.
[32]王安红,卢国彦,周昆,等.补骨脂乙素诱导Hep G2细胞凋亡及对Bcl-2家族表达的影响[J].中国药理与临床,2012,28(5):23-25.
[33]Wang Y,Hong C,Zhou C,et al.Screening antitumor compounds psoralen andisopsoralenfrompsoraleacorylifolia L.seeds[J].Evid-Based Compl Alt,2011:363052.
[34]Rahman MA,Kim NH,Yang H,et al.Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SSY5Y neuroblastoma cells[J].Mol Cell Biochem,2012,369(12):95-104.
[35]苗琳,马尚伟,樊官伟,等.补骨脂酚拮抗AR转录活性抑制雄激素诱导的前列腺癌细胞LNCa P的增殖[J].天津中医药,2013,30(5):291-293.
[36]史毅,吴伟忠,霍安,等.补骨脂乙素对Tca8113细胞迁移及侵袭的抑制作用及机制[J].中国药理学通报,2015,31(12):1741-1745.
[37]李媛媛,亓翠玲,周芷晴,等.枸杞多糖对自发乳腺癌MMTV-Py MT小鼠肿瘤生长和转移的作用[J].中国实验动物学报,2016,24(6):618-621.
[38]单铁英,赵如同,杨书良,等.枸杞多糖对人肝癌细胞Bel-7402的抑制作用及凋亡的研究[J].时珍国医国药,2010,21(8):1928-1929.
[39]王君敏,薛敬礼,葛蓓蕾,等.枸杞多糖及其硫酸酯化体外免疫及抗肿瘤活性[J].郑州大学学报,2015,50(6):809-813.
[40]李卓能,张靖,周敦金,等.枸杞多糖对人前列腺癌DU-145细胞株体外抗肿瘤作用[J].公共卫生与预防医学,2013,24(5):3-6.
[41]朱彩平,张声华,肖军霞,等.枸杞多糖诱导人宫颈癌Hela细胞凋亡的形态学研究[J].食品科学,2010,31(19):329-334.
[2]朱华宇.周岱翰教授治疗恶性肿瘤学术思想拾萃[J].中医药学刊,2004,22(3):394-395.
[3]韩萍,罗阔,蒋青松,等.人参皂苷Rg3对结肠癌Caco2细胞增殖和迁移的影响[J].免疫学杂志,2014,30(8):722-726.
[4]黄靓,李国庆,毛振江,等.人参多糖注射液对胃癌细胞SGC-7901凋亡的诱导作用及机制[J].世界华人消化杂志,2014,22(33):5114-5117.
[5]王梓,许兴月,李琼,等.人参皂苷Rg1热裂解产物对H22荷瘤小鼠的抗肿瘤作用[J].中国药学杂志,2017,52(15):1319-1324.
[6]靳宝辉,隋华,李琦,等.扶正中药逆转肿瘤多药耐药的研究进展[J].中华中医药杂志,2013,28(8):2367-2370.
[7]罗林明,石雅宁,姜懿纳,等.人参抗肿瘤作用的有效成分及其机制研究进展[J].中草药,2017,48(3):582-596.
[8]李钦,胡继宏,高博,等.黄芪多糖在免疫调节方面的最新研究进展[J].中国实验方剂学杂志,2017,23(2):199-206.
[9]周杰,朱营营,王海丹,等.黄芪多糖对人胃癌细胞MGC-803的生长抑制作用及细胞周期的影响[J].中华中医药学刊,2013,31(5):1116-1119.
[10]吕君君,方诗琪,刘敏,等.黄芪多糖的抗肿瘤作用及其机制的研究进展[J].现代预防医学,2016,43(23):4276-4279.
[11]吴素珍,李加林,陈水亲,等.硫酸酯化当归多糖抗肿瘤实验研究[J].时珍国医国药,2012,23(2):319-320.
[12]程尧,王凯平,李强,等.当归多糖对H22荷瘤小鼠肿瘤生长及体内铁代谢的影响[J].中国医院药学杂志,2015,35(15):1359-1363.
[13]马秀梓,孙润广,李佳媚,等.3种中药多糖抗肿瘤作用的研究[J].陕西师范大学学报,2012,40(6):77-80.
[14]梁曾恩妮.灵芝多糖对结肠癌细胞增殖抑制和凋亡的影响初步研究[D].长沙:湖南农业大学,2014.
[15]邢会军,侯雷,孙勇,等.灵芝多糖对小鼠胃肿瘤活性的体内外抑制作用[J].中国实验方剂学杂志,2017,23(13):116-120.
[16]王昕妍,陈国杨,苏洁,等.灵芝孢子粉、破壁灵芝孢子粉对Lewis肺癌小鼠肿瘤生长和VEGF表达的比较研究[J].中国药理与临床,2017,33(2):118-122.
[17]梁慧超,唐晖,魏莲等.灵芝三萜对卵巢癌多耐药蛋白表达的影响[J].广东医学,2013,34(12):1829-1831.
[18]章丽霞,王涛,牛彩琴.等红景天苷对小鼠宫颈癌移植瘤中Eag1表达的影响和意义[J].重庆医学.2017,46(25):3470-3476.
[19]黎萍,赵丽晶,张捷,等.红景天对肺癌多药耐药细胞A549/DDP的促凋亡作用研究[J].中国实验诊断学,2014,18(9):1406-1408.
[20]庞晓斌,谢欣梅,赵清辉,等.红景天苷对人肝癌Hep G2细胞增殖及凋亡的影响[J].中国药学杂志,2014,49(3):195-198.
[21]吴剑锋,何晓东,许卫东,等.淫羊藿苷逆转耐甲氨蝶呤肺癌A549细胞转移表型[J].肿瘤,2009,29(12):1124-1128.
[22]Li Q,Huai L,Zhang C,et al.Icaritin induces Aml cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways[J].Int J Hematol,2013,97(5):617-623.
[23]Zhu Jf,Li Zj,Zhang Gs,et al.Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3/AKT signaling[J].PLo S One,2011,6(8):23720-23720.
[24]Sun F,Indran IR,Zhang ZW,et al.A novel prostate cancer therapeutic strategy using icaritin-activated arylhydlocarbon-receptor to co-target androgen receptor and its splice variants[J].Carcinogenesis,2015,36(7):757-768.
[25]Hu J,Zhu W,Wei B,et al.Antitumoral action of icaritin in LNCa P prostate cancer cells by regulating PEA3/HER2/AR signaling[J].Anticancer Drugs,2016,27(10):944-952.
[26]Han H,Xu B,Hou P,et al.Icaritin sensitizes human glioblastoma cells to TRAIL-induced apoptosis[J].Cell Biochem Biophys,2015,72(2):533-542.
[27]Zhao H,Guo Y,Li S,et al.A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway[J].Oncotarget,2015,6(31):31927-31943.
[28]Sun L,Peng Q,Qu L,et al.Anticancer agent icaritin induces apoptosis through caspase-dependent pathways in human hepatocellular carcinoma cells[J].Mol Med Rep,2015,11(4):3094-3100.
[29]赖丽娟,谢佳丽,黄志华,等.淫羊藿素得抗肿瘤作用及机制研究进展[J].中药药理与临床,2016,32(6):235-238.
[30]袁小芬,孙亚梅,张之勇,等.异补骨脂素对HL-60细胞增殖和凋亡影响及其机制探讨[J].中华肿瘤防治杂志,2015,22(21):1675-1679.
[31]陈红莉,冯慧瑾,李援朝,等.补骨脂酚的体外抗肿瘤活性及其关键中间体的合成研究[J].药学学报,2010,45(4):467-470.
[32]王安红,卢国彦,周昆,等.补骨脂乙素诱导Hep G2细胞凋亡及对Bcl-2家族表达的影响[J].中国药理与临床,2012,28(5):23-25.
[33]Wang Y,Hong C,Zhou C,et al.Screening antitumor compounds psoralen andisopsoralenfrompsoraleacorylifolia L.seeds[J].Evid-Based Compl Alt,2011:363052.
[34]Rahman MA,Kim NH,Yang H,et al.Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SSY5Y neuroblastoma cells[J].Mol Cell Biochem,2012,369(12):95-104.
[35]苗琳,马尚伟,樊官伟,等.补骨脂酚拮抗AR转录活性抑制雄激素诱导的前列腺癌细胞LNCa P的增殖[J].天津中医药,2013,30(5):291-293.
[36]史毅,吴伟忠,霍安,等.补骨脂乙素对Tca8113细胞迁移及侵袭的抑制作用及机制[J].中国药理学通报,2015,31(12):1741-1745.
[37]李媛媛,亓翠玲,周芷晴,等.枸杞多糖对自发乳腺癌MMTV-Py MT小鼠肿瘤生长和转移的作用[J].中国实验动物学报,2016,24(6):618-621.
[38]单铁英,赵如同,杨书良,等.枸杞多糖对人肝癌细胞Bel-7402的抑制作用及凋亡的研究[J].时珍国医国药,2010,21(8):1928-1929.
[39]王君敏,薛敬礼,葛蓓蕾,等.枸杞多糖及其硫酸酯化体外免疫及抗肿瘤活性[J].郑州大学学报,2015,50(6):809-813.
[40]李卓能,张靖,周敦金,等.枸杞多糖对人前列腺癌DU-145细胞株体外抗肿瘤作用[J].公共卫生与预防医学,2013,24(5):3-6.
[41]朱彩平,张声华,肖军霞,等.枸杞多糖诱导人宫颈癌Hela细胞凋亡的形态学研究[J].食品科学,2010,31(19):329-334.