抗菌肽在肿瘤防治中的作用
摘要
抗菌肽(AMPs)是一类由12~60个氨基酸残基组成的小分子多肽,具有强碱性、热稳定性以及广谱抗菌等特点。既往研究显示,AMPs对细菌、真菌、病毒等具有一定的抗菌作用,AMPs在医药卫生领域具有一定的发展前景。本文就AMPs在肿瘤防治中的应用作一综述。
引文
[1]刘世财,范琳琳,郑珩,等.AMPs作用机制及应用研究进展[J].中国生化药物杂志,2016,4(36):20-28.
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[6]Thakkar V,Korat V,Baldaniya L,et al.Development and characterization of novel hydrogel containing antimicrobial drug for treatment of burns[J].International Journal of Pharmaceutical Investigation,2016,6(3):158-168.
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[8]Octavio RE,Sujhey HB,Alejandro FC,et al.Gene therapy based in antimicrobial peptides and proinflammatory cytokine prevents reactivation of experimental latent tuberculosis[J].Pathogens&Disease,2016,74(7):ftw075.
[9]Gutiérrez Y,Montes R,Scull R,et al.Chemodiversity associated with cytotoxicity and antimicrobial activity of Piper aduncum var.ossanum[J].Chemistry&Biodiversity,2016,13(7):1715.
[10]Lehmann J,Retz M,Sidhu SS,et al.Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines[J].European Urology,2006,50(1):141.
[11]Suttmann H,Retz M,Paulsen F,et al.Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells[J].BMC Urology,2008,8(1):5.
[12]刘奕,费伟,王丽娜,等.十肽对变异链球菌生物膜生长和结构影响的实验研究[J].国际口腔医学杂志,2015,42(4):401-405.
[13]孙倩,李茵,李金陆.人工合成AMPs对白色念珠菌体外抑制作用的初步研究[J].北京口腔医学,2011,19(2):70-73.
[14]冯兴军,李静,赵晓宇,等.牛乳铁蛋白素-马盖宁杂合抗菌肽的设计、合成及抑菌活性[J].东北农业大学学报,2011,42(3):105-109.
[15]Eliassen LT,Berge G,Leknessund A,et al.The antimicrobial peptide,lactoferricin B,is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo[J].International Journal of Cancer,2010,119(3):493-500.
[2]Choi H,Rangarajan N,Weisshaar JC.Lights,Camera,Action!Antimicrobial Peptide Mechanisms Imaged in Space and Time[J].Trends Microbiol,2016,24(2):111-122.
[3]Lakshmaiah NJ,Chen JY.Antimicrobial peptides:Possible anti-infective agents[J].Peptides,2015,72:88-94.
[4]Hu Rothan HA,Bahrani H,Shankar E M,et al.Inhibitory effects of a peptide-fusion protein(Latarcin-PAP1-Thanatin)against chikungunya virus[J].Antiviral Research,2014,108(4):173-180.
[5]胡荣贵,李改瑞,陆家海.AMPs在抗肿瘤方面的研究进展[J].实用肿瘤杂志,2010,25(2):227-230.
[6]Thakkar V,Korat V,Baldaniya L,et al.Development and characterization of novel hydrogel containing antimicrobial drug for treatment of burns[J].International Journal of Pharmaceutical Investigation,2016,6(3):158-168.
[7]Sonibare MA,Aremu OT,Okorie PN.Antioxidant and antimicrobial activities of solvent fractions of Vernonia cinerea(L.)Less leaf extract[J].African Health Sciences,2016,16(2):629.
[8]Octavio RE,Sujhey HB,Alejandro FC,et al.Gene therapy based in antimicrobial peptides and proinflammatory cytokine prevents reactivation of experimental latent tuberculosis[J].Pathogens&Disease,2016,74(7):ftw075.
[9]Gutiérrez Y,Montes R,Scull R,et al.Chemodiversity associated with cytotoxicity and antimicrobial activity of Piper aduncum var.ossanum[J].Chemistry&Biodiversity,2016,13(7):1715.
[10]Lehmann J,Retz M,Sidhu SS,et al.Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines[J].European Urology,2006,50(1):141.
[11]Suttmann H,Retz M,Paulsen F,et al.Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells[J].BMC Urology,2008,8(1):5.
[12]刘奕,费伟,王丽娜,等.十肽对变异链球菌生物膜生长和结构影响的实验研究[J].国际口腔医学杂志,2015,42(4):401-405.
[13]孙倩,李茵,李金陆.人工合成AMPs对白色念珠菌体外抑制作用的初步研究[J].北京口腔医学,2011,19(2):70-73.
[14]冯兴军,李静,赵晓宇,等.牛乳铁蛋白素-马盖宁杂合抗菌肽的设计、合成及抑菌活性[J].东北农业大学学报,2011,42(3):105-109.
[15]Eliassen LT,Berge G,Leknessund A,et al.The antimicrobial peptide,lactoferricin B,is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo[J].International Journal of Cancer,2010,119(3):493-500.