疟原虫入侵人类红细胞机制研究进展
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摘要
疟原虫作为一种侵入红细胞的顶复门原虫代表虫种,目前对疟原虫入侵宿主红细胞的机制知之甚少。尽管疟原虫中蛋白质的基本或非基本性质越来越明确,但其功能和蛋白质之间如何相互作用,以及如何有效的抑制疟原虫入侵的机制了解不多。论文讨论裂殖子入侵红细胞的机制,介绍裂殖子入侵宿主红细胞的早期阶段及疟原虫入侵期间与宿主红细胞的平衡和相互作用,阐明当裂殖子入侵红细胞时,由肌动蛋白-肌球蛋白收缩系统提供动力,为研究疟原虫等顶复门原虫的入侵机制奠定了基础,对研究疟原虫具有重要的意义。
Plasmodium falciparumis a species of apicomplexan protozoa that invades red blood cells,we still know little about the mechanisms of Plasmodiuminvading host erythrocytes.While the essential or non-essential natures of different parasite proteins are more and more clear,their actual functions and how proteins interact each other to restrain invasion are not enough to understand.In this review,we discussed the mechanisms of merozoite invading host erythrocytes,introduced the early stage of the invasion of the red blood cells,as well as the balance and interaction between the parasite and the host red blood cells during the invasion.It is demonstrated that when the merozoite invades the red blood cells,it is provided by the actin-myosin constriction system.This article laid the foundation for studying the invasion mechanism of apicomplexan protozoa,such as Plasmodium,and is of great significance for the study of Plasmodium.
Plasmodium falciparumis a species of apicomplexan protozoa that invades red blood cells,we still know little about the mechanisms of Plasmodiuminvading host erythrocytes.While the essential or non-essential natures of different parasite proteins are more and more clear,their actual functions and how proteins interact each other to restrain invasion are not enough to understand.In this review,we discussed the mechanisms of merozoite invading host erythrocytes,introduced the early stage of the invasion of the red blood cells,as well as the balance and interaction between the parasite and the host red blood cells during the invasion.It is demonstrated that when the merozoite invades the red blood cells,it is provided by the actin-myosin constriction system.This article laid the foundation for studying the invasion mechanism of apicomplexan protozoa,such as Plasmodium,and is of great significance for the study of Plasmodium.
引文
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[4]Newsome T P,Marzook N B.Viruses that ride on the coat-tails of actin nucleation[J].Semin Cell Dev Biol,2015,46:155-163.
[5]Heintzelman M B.Gliding motility in apicomplexan parasites[J].Semin Cell Dev Biol,2015,46:135-142.
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[16]Paul G,Deshmukh A,Kumar Chourasia B,et al.Protein-protein interaction studies reveal the Plasmodium falciparum merozoite surface protein-1region involved in a complex formation that binds to human erythrocytes[J].Biochem J,2018,475(6):1197-1209.
[17]Zuccala E S,Gout A M,Dekiwadia C,et al.Subcom partmentalisation of proteins in the rhoptries correlates with ordered events of erythrocyte invasion by the blood stage malaria parasite[J].PLoS One,2012,7:e46160.
[18]Dasgupta S,Auth T,Gov N S,et al.Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte[J].Biophys J,2014b,107:43-54.
[19]Cowman A F,Tonkin C J,Tam W H,et al.The molecular basis of erythrocyte invasion by malaria parasites[J].Cell Host Microbe,2017,22:232-245.
[20]Galaway F,Drought L G,Fala M,et al.P113is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5[J].Nat Commun,2017,8:14333.
[21]Zerka A,Rydzak J,Lass A,et al.Studies on immunogenicity and antigenicity of baculovirus-expressed binding region of Plasmodium falciparum EBA-140merozoite ligand[J].Arch Immunol Ther Exp(Warsz),2016,64(2):149-156.
[22]Zerka A,Rydzak J,Lass A,et al.Erratum to:studies on immunogenicity and antigenicity of baculovirus-expressed binding region of Plasmodium falciparum EBA-140merozoite ligand[J].Arch Immunol Ther Exp(Warsz),2016,64(2):157.
[23]Volz J C,Yap A,Sisquella X,et al.Essential role of the PfRh5/PfRipr/CyRPA complex during Plasmodium falciparuminvasion of erythrocytes[J].Cell Host Microbe,2016,20(1):60-71.
[24]Muramatsu T,Miyauchi T.Basigin(CD147):a multifunctional transmembrane protein involved in reproduction,neural function,inflammation and tumor invasion[J].Histol Histopathol,2003,18:981-987.
[25]Plenderleith L J,Liu W,MacLean O A,et al.Adaptive evolution of RH5in Ape Plasmodiumspecies of the laverania subgenus[J].MBio,2018,9(1).pii:e02237-17.
[26]Ye L,Zhao F,Yang Q,et al.OK/basigin expression on red blood cells varies between blood donors and correlates with binding of recombinant Plasmodium falciparumreticulocytebinding protein homolog 5[J].Transfusion,2018,58(8):2046-2053.
[27]Baum J,Richard D,Healer J,et al.A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites[J].J Biol Chem,2006,281:5197-5208.
[28]Uchime O,Herrera R,Reiter K,et al.Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP[J].Eukaryot Cell,2012,11:615-625.
[2]Das S,Hertrich N,Perrin A J,et al.Processing of Plasmodium falciparum merozoite surface protein MSP1activates a spectrin-binding function enabling parasite egress from RBCs[J].Cell Host Microbe,2015,18:433-444.
[3]De Souza Santos M,Orth K.Subversion of the cytoskeleton by intracellular bacteria:lessons from Listeria,Salmonella and Vibrio[J].Cell Microbiol,2015,17:164-173.
[4]Newsome T P,Marzook N B.Viruses that ride on the coat-tails of actin nucleation[J].Semin Cell Dev Biol,2015,46:155-163.
[5]Heintzelman M B.Gliding motility in apicomplexan parasites[J].Semin Cell Dev Biol,2015,46:135-142.
[6]Dobrowolski J M,Sibley L D.Toxoplasmainvasion of mammalian cells is powered by the actin cytoskeleton of the parasite[J].Cell,1996,84:933-939.
[7]Egarter S,Andenmatten N,Jackson A J,et al.The Toxoplasma ActoMyoA motor complex is important but not essential for gliding motility and host cell invasion[J].PLoS One,2014,9:e91819.
[8]Shen B,Sibley L D.Toxoplasma aldolase is required for metabolism but dispensable for host-cell invasion[J].Proc Natl Acad Sci,2014,111:3567-3572.
[9]Gokhin D S,Nowak R B,Khoory J A.Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane[J].Mol Biol Cell,2015,26:1699-1710.
[10]Awandare G A,Nyarko P B,Aniweh Y,et al.Plasmodium falciparum strains spontaneously switch invasion phenotype in suspension culture[J].Sci Rep,2018,8(1):5782.
[11]Lingelbach K,Joiner K A.The parasitophorous vacuole membrane surrounding Plasmodiumand Toxoplasma:an unusual compartment in infected cells[J].J Cell Sci,1998,111(Pt11):1467-1475.
[12]Delgadillo R F,Parker M L,Lebrun M,et al.Stability of the Plasmodium falciparum AMA1-RON2complex is governed by the domainⅡ(DⅡ)loop[J].PLoS One,2016,11(1):e0144764.
[13]Bichet M,Joly C,Henni A,et al.The Toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force[J].BMC Biol,2014,12:773.
[14]Kadekoppala M,Holder A A.Merozoite surface proteins of the malaria parasite:the MSP1complex and the MSP7family[J].Int J Parasitol,2010,40:1155-1161.
[15]Li X,Chen H,Oo T H,et al.A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyte invasion receptor band 3[J].J Biol Chem,2004,279:5765-5771.
[16]Paul G,Deshmukh A,Kumar Chourasia B,et al.Protein-protein interaction studies reveal the Plasmodium falciparum merozoite surface protein-1region involved in a complex formation that binds to human erythrocytes[J].Biochem J,2018,475(6):1197-1209.
[17]Zuccala E S,Gout A M,Dekiwadia C,et al.Subcom partmentalisation of proteins in the rhoptries correlates with ordered events of erythrocyte invasion by the blood stage malaria parasite[J].PLoS One,2012,7:e46160.
[18]Dasgupta S,Auth T,Gov N S,et al.Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte[J].Biophys J,2014b,107:43-54.
[19]Cowman A F,Tonkin C J,Tam W H,et al.The molecular basis of erythrocyte invasion by malaria parasites[J].Cell Host Microbe,2017,22:232-245.
[20]Galaway F,Drought L G,Fala M,et al.P113is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5[J].Nat Commun,2017,8:14333.
[21]Zerka A,Rydzak J,Lass A,et al.Studies on immunogenicity and antigenicity of baculovirus-expressed binding region of Plasmodium falciparum EBA-140merozoite ligand[J].Arch Immunol Ther Exp(Warsz),2016,64(2):149-156.
[22]Zerka A,Rydzak J,Lass A,et al.Erratum to:studies on immunogenicity and antigenicity of baculovirus-expressed binding region of Plasmodium falciparum EBA-140merozoite ligand[J].Arch Immunol Ther Exp(Warsz),2016,64(2):157.
[23]Volz J C,Yap A,Sisquella X,et al.Essential role of the PfRh5/PfRipr/CyRPA complex during Plasmodium falciparuminvasion of erythrocytes[J].Cell Host Microbe,2016,20(1):60-71.
[24]Muramatsu T,Miyauchi T.Basigin(CD147):a multifunctional transmembrane protein involved in reproduction,neural function,inflammation and tumor invasion[J].Histol Histopathol,2003,18:981-987.
[25]Plenderleith L J,Liu W,MacLean O A,et al.Adaptive evolution of RH5in Ape Plasmodiumspecies of the laverania subgenus[J].MBio,2018,9(1).pii:e02237-17.
[26]Ye L,Zhao F,Yang Q,et al.OK/basigin expression on red blood cells varies between blood donors and correlates with binding of recombinant Plasmodium falciparumreticulocytebinding protein homolog 5[J].Transfusion,2018,58(8):2046-2053.
[27]Baum J,Richard D,Healer J,et al.A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites[J].J Biol Chem,2006,281:5197-5208.
[28]Uchime O,Herrera R,Reiter K,et al.Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP[J].Eukaryot Cell,2012,11:615-625.