Q开关激光联合强脉冲光治疗黄褐斑疗效的观察
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摘要
目的探讨Q开关激光联合强脉冲光治疗黄褐斑的临床疗效。方法选择我院医学整形美容科2017年1月至2018年1月共90例黄褐斑患者为研究对象,以随机数字表法分为观察组与对照组各45例,对照组接受Q开关1064nm激光治疗,观察组接受Q开关1064nm激光联合强脉冲光治疗,对两组患者治疗后黄褐斑皮损面积及严重指数(MASI)进行观察。结果观察组基本治愈34例,显效5例,有效3例,无效3例,总有效率93.33%;对照组基本治愈28例,显效4例,有效3例,无效10例,总有效率77.77%。观察组总有效率高于对照组,差异具有统计学意义(P <0.05)。结论 Q开关1064nm激光联合强脉冲光治疗黄褐斑有明显临床疗效,值得临床推广。
Objective To investigate the clinical effect of Q-switched laser combined IPL the treatment of melasma. Methods 90 patients with melasma from January 2017 to January 2018 in the department of plastic and reconstructive of our hospital were selected as the research objects.They were divided into observation group and control group by random number table methed,45 cases in each group.The control group was treated by Q-switch 1064 nm laser,while the observation group was treated by Q-switch 1064 nm laser combined with IPL.After treatment, the area and severity index of melasma skin lesion(MASI) of the two groups were analyzed.Results In the observation group,34 cases were basically cured,5 cases were markedly effective, 3 cases were effective,3 cases were ineffective,and the total effective rate was 93.33%.In the control group,28 cases were basically crued, 4 cases were markedly effective,3 cases were effective,10 cases were ineffective,and the total effective rate was 77.77%. The total effective rate of the observation group was higher than that of the control group(P < 0.05).Conclusions Q-switched 1064 nm laser combined with IPL has obvious clinical efficacy in the treatment of melasma,which is worthy of clinical promotion.
Objective To investigate the clinical effect of Q-switched laser combined IPL the treatment of melasma. Methods 90 patients with melasma from January 2017 to January 2018 in the department of plastic and reconstructive of our hospital were selected as the research objects.They were divided into observation group and control group by random number table methed,45 cases in each group.The control group was treated by Q-switch 1064 nm laser,while the observation group was treated by Q-switch 1064 nm laser combined with IPL.After treatment, the area and severity index of melasma skin lesion(MASI) of the two groups were analyzed.Results In the observation group,34 cases were basically cured,5 cases were markedly effective, 3 cases were effective,3 cases were ineffective,and the total effective rate was 93.33%.In the control group,28 cases were basically crued, 4 cases were markedly effective,3 cases were effective,10 cases were ineffective,and the total effective rate was 77.77%. The total effective rate of the observation group was higher than that of the control group(P < 0.05).Conclusions Q-switched 1064 nm laser combined with IPL has obvious clinical efficacy in the treatment of melasma,which is worthy of clinical promotion.
引文
[1]邱志强,刘冬梅.内外合治黄褐斑30例临床观察.时珍国医国药,2007,18(12):3100.doi:10.3969/j.issn.1008-0805.2007.12.119.
[2]余慧,梁虹,鞠小玲,等.激光联合氨甲环酸、谷胱甘肽及维生素C治疗黄褐斑的临床观察[J].现代生物医学进展,2015,15(27)2598-5298.doi:10.13241/j.cnki.pmb.2015.27.025.
[3]李勤,吴溯帆.激光整形美容外科学[M].第1版,浙江:浙江科学技术出版社,2013:293-303.
[4]谷恋秋,李任,金岚.Star Lux G强脉冲光与Q-开关倍频Nd:YAG激光治疗雀斑的疗效对比研究[J].重庆医科大学学报,2015,40(8):1164-1166.doi:10.13406/j.cnki.cyxb.000627.
[5]沈明康.调Q1064激光联合参棘软膏治疗黄褐斑的效果观察[J].现代中西医结合杂志,2015,24(12):1332-1333.doi:10.3969/j.issn.1008-8849.2015.12.030.
[6]中国中西医结合皮肤性病专业委员会色素病学组.黄褐斑的临床诊断和疗效判定标准[J].中华皮肤科杂志,2004,37(07):440.doi:10.3760/j.issn:0412-4030.2004.07.027.
[7]王敏,晏洪波,杨凌云,等.Q开关1064nm激光联合微针导人治疗黄褐斑的临床效果[J].中华医学美学美容杂志,2015,21(6):347-349.doi:10.3760/cma.j.issn.1671-0290.2015.06.009.
[8]Sivayathorn A.Melasma in Orientals[J].Clin Drug Invest,1995,10(l2):34-40.doi:10.2165/00044011-199500102-00006.
[9]凌磊,王晓霞,梁少飞,等.Q开关Nd:YAG激光联合化瘀祛斑胶囊治疗黄褐斑疗效观察[J].中国中西医结合皮肤性病学杂志,2016,15(4):233-235.doi:10.3969/j.issn.1672-0709.2016.04.012
[10]栾琪,刘玲,高天文,等.激光和强脉冲光治疗黄褐斑的进展中华皮肤科杂志,2015,48(2):142-143.doi:10.3760/cma.j.issn.0412-4030.2015.02.023.
[11]Hofbauer Parra CA,Careta MF,Valente NY,et al.Clinical and histopathologic assessment of facial melasma after low-fluence QS Nd:YAG laser[J].Dermatol Surg,2016,42(4):507-512.doi:10.1097/DSS.0000000000000653.
[12]Gokalp H,Akkaya AD,Oram Y.Long-term results in low-fluence 1064-nm Q-Switched Nd:YAG laser for melasma:Is it effective?[J].J Cosmet Dermatol,2016,15(4):420-426.doi:10.1111/jocd.12253.
[13]Choi CP,Yim SM,Seo SH,et al.Retrospective analysis of melasma treatment using a dual mode of low-fl uence Q-switched and longpulse Nd:YAG laser vs.low-fl uence Q-switched Nd:YAG laser monotherapy[J].J Cosmet Laser Ther,2015,17(1):2-8.doi:10.3109/14764172.2014.957217.
[14]Cunha PR,Pinto CA,Mattos CB,et al.New insight in the treatment of refractory melasma:Laser Q-switched Nd:YAG non-ablative fractionated followed by intense pulsed light[J].ermatol Ther,2015,28(5):296-299.doi:10.1111/dth.12250.
[15]曾丽,胡晗菲,谢红矩,等.口服氨甲环酸片联合Q开关1064 nm Nd:YAG激光治疗黄褐斑临床疗效观察[J].中南医学科学杂志,2016,44(3):328-331.doi:10.15972/j.cnki.43-1509/r.2016.03.024.
[2]余慧,梁虹,鞠小玲,等.激光联合氨甲环酸、谷胱甘肽及维生素C治疗黄褐斑的临床观察[J].现代生物医学进展,2015,15(27)2598-5298.doi:10.13241/j.cnki.pmb.2015.27.025.
[3]李勤,吴溯帆.激光整形美容外科学[M].第1版,浙江:浙江科学技术出版社,2013:293-303.
[4]谷恋秋,李任,金岚.Star Lux G强脉冲光与Q-开关倍频Nd:YAG激光治疗雀斑的疗效对比研究[J].重庆医科大学学报,2015,40(8):1164-1166.doi:10.13406/j.cnki.cyxb.000627.
[5]沈明康.调Q1064激光联合参棘软膏治疗黄褐斑的效果观察[J].现代中西医结合杂志,2015,24(12):1332-1333.doi:10.3969/j.issn.1008-8849.2015.12.030.
[6]中国中西医结合皮肤性病专业委员会色素病学组.黄褐斑的临床诊断和疗效判定标准[J].中华皮肤科杂志,2004,37(07):440.doi:10.3760/j.issn:0412-4030.2004.07.027.
[7]王敏,晏洪波,杨凌云,等.Q开关1064nm激光联合微针导人治疗黄褐斑的临床效果[J].中华医学美学美容杂志,2015,21(6):347-349.doi:10.3760/cma.j.issn.1671-0290.2015.06.009.
[8]Sivayathorn A.Melasma in Orientals[J].Clin Drug Invest,1995,10(l2):34-40.doi:10.2165/00044011-199500102-00006.
[9]凌磊,王晓霞,梁少飞,等.Q开关Nd:YAG激光联合化瘀祛斑胶囊治疗黄褐斑疗效观察[J].中国中西医结合皮肤性病学杂志,2016,15(4):233-235.doi:10.3969/j.issn.1672-0709.2016.04.012
[10]栾琪,刘玲,高天文,等.激光和强脉冲光治疗黄褐斑的进展中华皮肤科杂志,2015,48(2):142-143.doi:10.3760/cma.j.issn.0412-4030.2015.02.023.
[11]Hofbauer Parra CA,Careta MF,Valente NY,et al.Clinical and histopathologic assessment of facial melasma after low-fluence QS Nd:YAG laser[J].Dermatol Surg,2016,42(4):507-512.doi:10.1097/DSS.0000000000000653.
[12]Gokalp H,Akkaya AD,Oram Y.Long-term results in low-fluence 1064-nm Q-Switched Nd:YAG laser for melasma:Is it effective?[J].J Cosmet Dermatol,2016,15(4):420-426.doi:10.1111/jocd.12253.
[13]Choi CP,Yim SM,Seo SH,et al.Retrospective analysis of melasma treatment using a dual mode of low-fl uence Q-switched and longpulse Nd:YAG laser vs.low-fl uence Q-switched Nd:YAG laser monotherapy[J].J Cosmet Laser Ther,2015,17(1):2-8.doi:10.3109/14764172.2014.957217.
[14]Cunha PR,Pinto CA,Mattos CB,et al.New insight in the treatment of refractory melasma:Laser Q-switched Nd:YAG non-ablative fractionated followed by intense pulsed light[J].ermatol Ther,2015,28(5):296-299.doi:10.1111/dth.12250.
[15]曾丽,胡晗菲,谢红矩,等.口服氨甲环酸片联合Q开关1064 nm Nd:YAG激光治疗黄褐斑临床疗效观察[J].中南医学科学杂志,2016,44(3):328-331.doi:10.15972/j.cnki.43-1509/r.2016.03.024.