组织常驻记忆性T细胞参与银屑病复发的研究进展
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摘要
皮损反复发作是银屑病重要的临床特点和治疗难点之一,且复发常可位于原皮损消退区域,提示银屑病的复发与"免疫记忆"有关。皮肤组织常驻记忆性T细胞(tissue resident memory T cells,T_(RM))是记忆性T细胞中的重要亚群,具有在皮肤中长期存活(long-lived)和低迁移(lowmigration)的显著特点。研究提示,T_(RM)细胞在银屑病复发中发挥重要作用,本文就T_(RM)细胞的生物学特性及其参与银屑病复发的研究进展进行综述。
Recurrence is one of the important clinical features and treatment obstacles of psoriasis.Its recurrence often occurs in the remission area of the primary lesions,suggesting that the recurrence of psoriasis is related to the "immune memory".Tissue resident memory T cells(T_(RM)) are the important members of memory T cells.The permanent characteristics of T_(RM) cells have the features of long-lived survival and lowmigration in the skin.It has been suggested that the T_(RM) cells play an important role in the recurrence of psoriasis.This article reviews the research progress of biological characteristics of T_(RM) cells and their participation in the recurrence of psoriasis.
Recurrence is one of the important clinical features and treatment obstacles of psoriasis.Its recurrence often occurs in the remission area of the primary lesions,suggesting that the recurrence of psoriasis is related to the "immune memory".Tissue resident memory T cells(T_(RM)) are the important members of memory T cells.The permanent characteristics of T_(RM) cells have the features of long-lived survival and lowmigration in the skin.It has been suggested that the T_(RM) cells play an important role in the recurrence of psoriasis.This article reviews the research progress of biological characteristics of T_(RM) cells and their participation in the recurrence of psoriasis.
引文
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[9] Mizukawa Y,Shiohara T.Fixed drug eruption:a prototypic disorder mediated by effector memory T cells[J].Curr Allergy Asthma Rep,2009,9(1):71-77.
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[14] Sch?n M,Denzer D,Kubitza RC,et al.Critical role of neutrophils for the generation of psoriasiform skin lesions in flaky skin mice[J].J Invest Dermatol,2000,114(5):976-983.
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[19] Li Y,Hofmann M,Wang Q,et al.Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missingself recognition[J].Immunity,2009,31(1):35-46.
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[24] Ansel J,Perry P,Brown J,et al.Cytokine modulation of keratinocyte cytokines[J].J Invest Dermatol,1990,94(6 Suppl):101S-107S.
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[26] Riou C,Yassine-Diab B,Van grevenynghe J,et al.Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells[J].J Exp Med,2007,204(1):79-91.
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[28] Chetoui N,Boisvert M,Gendron S,et al.Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway[J].Immunology,2010,130(3):418-426.
[29] Hand TW,Cui W,Jung YW,et al.Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival[J].Proc Natl Acad Sci USA,2010,107(38):16601-16606.
[30] Quigley M,Huang X,Yang Y.Extent of stimulation controls the formation of memory CD8 T cells[J].J Immunol,2007,179(9):5768-5777.
[31] Li Y,Shen C,Zhu B,et al.Persistent antigen and prolonged AKT-mTORC1 activation underlie memory CD8 T cell impairment in the absence of CD4 T cells[J].J Immunol,2015,195(4):1591-1598.
[32] Kim EH,Sullivan JA,Plisch EH,et al.Signal integration by Akt regulates CD8 T cell effector and memory differentiation[J].J Immunol,2012,188(9):4305-4314.
[33] Maekawa Y,Ishifune C,Tsukumo S,et al.Notch controls the survival of memory CD4+ T cells by regulating glucose uptake[J].Nat Med,2015,21(1):55-61.
[34] Hombrink P,Helbig C,Backer RA,et al.Programs for the persistence,vigilance and control of human CD8+ lung-resident memory T cells[J].Nat Immunol,2016,17(12):1467-1478.
[35] Wijeyesinghe S,Masopust D.Resident memory T cells are a Notch above the rest[J].Nat Immunol,2016,17(12):1337-1338.
[36] Clark RA.Skin-resident T Cells:the ups and downs of on site immunity[J].J Invest Dermatol,2009,130(2):362-370.
[37] Cai Y,Shen X,Ding C,et al.Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation[J].Immunity,2011,35(4):596-610.
[38] Suárez-Fariňas M,Fuentes-Duculan J,Lowes MA,et al.Resolved psoriasis lesions retain expression of a subset of disease-related genes[J].J Invest Dermatol,2011,131(2):391-400.
[39] Gebhardt T,Wakim LM,Eidsmo L,et al.Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus[J].Nat Immunol,2009,10(5):524-530.
[40] Cheuk S,Schlums H,Gallais Sérézal I,et al.CD49a expression defines tissue-resident CD8+ T cells poised for cytotoxic function in human skin[J].Immunity,2017,46(2):287-300.
[41] Tekin NS,Tekin IO,Barut F,et al.Accumulation of oxidized low-density lipoprotein in psoriatic skin and changes of plasma lipid levels in psoriatic patients[J].Mediators Inflamm,2007,2007:78454.
[42] Fischer N,Haug M,Kwok WW,et al.Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells[J].Eur J Immunol,2010,40(4):986-997.
[43] Yao Y,Wang Y,Zhang Y,et al.Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOSpathways[J].Lipids Health Dis,2017,16(1):77.
[44] Cibrian D,Saiz ML,de la Fuente H,et al.CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis[J].Nat Immunol,2016,17(8):985-996.
[45] Yamauchi K,Kasuya Y,Kuroda F,et al.Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratrachealbleomycin[J].Respir Res,2011,12:131.
[46] Cibrian D,Saiz ML,de la Fuente H,et al.CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis[J],Nat Immunol,2016,17(8):985-996.
[2] Diani M,Altomare G,Reali E.T cell responses in psoriasis and psoriatic arthritis[J].Autoimmun Rev,2015,14(4):286-292.
[3] Clark RA.Resident memory T cells in human health and disease[J].Sci Transl Med,2015,7(269):269rv1.
[4] Turner DL,Gordon CL,Farber DL.Tissue-resident T cells,in situ immunity and transplantation[J].Immunol Rev,2014,258(1):150-166.
[5] Cheuk S,Wikén M,Blomqvist L,et al.Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis[J].J Immunol,2014,192(7):3111-3120.
[6] Topham DJ,Reilly EC.Tissue-resident memory CD8+ T cells:from phenotype to function[J].Front Immunol,2018,9:515.
[7] Park CO,Kupper TS.The emerging role of resident memory T cells in protective immunity and inflammatory disease[J].Nat Med,2015,21(7):688-697.
[8] Schenkel JM,Fraser KA,Vezys V,et al.Sensing and alarm function of resident memory CD8+ T cells[J].Nat Immunol,2013,14(5):509-513.
[9] Mizukawa Y,Shiohara T.Fixed drug eruption:a prototypic disorder mediated by effector memory T cells[J].Curr Allergy Asthma Rep,2009,9(1):71-77.
[10] Pan Y,Tian T,Park CO,et al.Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism[J].Nature,2017,543(7644):252-256.
[11] Homey B,Alenius H,Müller A,et al.CCL27-CCR10 interactions regulate T cell-mediated skin inflammation[J].Nat Med,2002,8(2):157-165.
[12] Xia M,Hu S,Fu Y,et al.CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin[J].J Allergy Clin Immunol,2014,134(3):634-644.
[13] Lim K,Hyun YM,Lambert-Emo K,et al.Neutrophil trails guide influenza-specific CD8+ T cells in the airways[J].Science,2015,349(6252):aaa4352.
[14] Sch?n M,Denzer D,Kubitza RC,et al.Critical role of neutrophils for the generation of psoriasiform skin lesions in flaky skin mice[J].J Invest Dermatol,2000,114(5):976-983.
[15] Jiang X,Clark RA,Liu L,et al.Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity[J].Nature,2012,483(7388):227-231.
[16] Mackay LK,Braun A,Macleod BL,et al.Cutting edge:CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention[J].J Immunol,2015,194(5):2059-2063.
[17] Skon CN,Lee JY,Anderson KG,et al.Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells[J].Nat Immunol,2013,14(12):1285-1293.
[18] Zhang N,Bevan MJ.Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention[J].Immunity,2013,39(4):687-696.
[19] Li Y,Hofmann M,Wang Q,et al.Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missingself recognition[J].Immunity,2009,31(1):35-46.
[20] Comerford I,Harata-Lee Y,Bunting MD,et al.A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system[J].Cytokine Growth Factor Rev,2013,24(3):269-283.
[21] Moed H,Boorsma DM,Tensen CP,et al.Increased CCL27-CCR10 expression in allergic contact dermatitis:implications for local skin memory[J].J Pathol,2004,204(1):39-46.
[22] Xia M,Hu S,Fu Y,et al.CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin[J].J Allergy Clin Immunol,2014,134(3):634-644.
[23] Schluns KS,Kieper WC,Jameson SC,et al.Interleukin-7 mediates the homeostasis of na?ve and memory CD8 T cells in vivo[J].Nat Immunol,2000,1(5):426-432.
[24] Ansel J,Perry P,Brown J,et al.Cytokine modulation of keratinocyte cytokines[J].J Invest Dermatol,1990,94(6 Suppl):101S-107S.
[25] Quan C,Cho MK,Shao Y,et al.Dermal fibroblast expression of stromal cell-derived factor-1 (SDF-1) promotes epidermal keratinocyte proliferation in normal and diseased skin[J].Protein Cell,2015,6(12):890-903.
[26] Riou C,Yassine-Diab B,Van grevenynghe J,et al.Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells[J].J Exp Med,2007,204(1):79-91.
[27] Grange M,Giordano M,Mas A,et al.Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B[J].Immunology,2015,145(4):543-557.
[28] Chetoui N,Boisvert M,Gendron S,et al.Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway[J].Immunology,2010,130(3):418-426.
[29] Hand TW,Cui W,Jung YW,et al.Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival[J].Proc Natl Acad Sci USA,2010,107(38):16601-16606.
[30] Quigley M,Huang X,Yang Y.Extent of stimulation controls the formation of memory CD8 T cells[J].J Immunol,2007,179(9):5768-5777.
[31] Li Y,Shen C,Zhu B,et al.Persistent antigen and prolonged AKT-mTORC1 activation underlie memory CD8 T cell impairment in the absence of CD4 T cells[J].J Immunol,2015,195(4):1591-1598.
[32] Kim EH,Sullivan JA,Plisch EH,et al.Signal integration by Akt regulates CD8 T cell effector and memory differentiation[J].J Immunol,2012,188(9):4305-4314.
[33] Maekawa Y,Ishifune C,Tsukumo S,et al.Notch controls the survival of memory CD4+ T cells by regulating glucose uptake[J].Nat Med,2015,21(1):55-61.
[34] Hombrink P,Helbig C,Backer RA,et al.Programs for the persistence,vigilance and control of human CD8+ lung-resident memory T cells[J].Nat Immunol,2016,17(12):1467-1478.
[35] Wijeyesinghe S,Masopust D.Resident memory T cells are a Notch above the rest[J].Nat Immunol,2016,17(12):1337-1338.
[36] Clark RA.Skin-resident T Cells:the ups and downs of on site immunity[J].J Invest Dermatol,2009,130(2):362-370.
[37] Cai Y,Shen X,Ding C,et al.Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation[J].Immunity,2011,35(4):596-610.
[38] Suárez-Fariňas M,Fuentes-Duculan J,Lowes MA,et al.Resolved psoriasis lesions retain expression of a subset of disease-related genes[J].J Invest Dermatol,2011,131(2):391-400.
[39] Gebhardt T,Wakim LM,Eidsmo L,et al.Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus[J].Nat Immunol,2009,10(5):524-530.
[40] Cheuk S,Schlums H,Gallais Sérézal I,et al.CD49a expression defines tissue-resident CD8+ T cells poised for cytotoxic function in human skin[J].Immunity,2017,46(2):287-300.
[41] Tekin NS,Tekin IO,Barut F,et al.Accumulation of oxidized low-density lipoprotein in psoriatic skin and changes of plasma lipid levels in psoriatic patients[J].Mediators Inflamm,2007,2007:78454.
[42] Fischer N,Haug M,Kwok WW,et al.Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells[J].Eur J Immunol,2010,40(4):986-997.
[43] Yao Y,Wang Y,Zhang Y,et al.Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOSpathways[J].Lipids Health Dis,2017,16(1):77.
[44] Cibrian D,Saiz ML,de la Fuente H,et al.CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis[J].Nat Immunol,2016,17(8):985-996.
[45] Yamauchi K,Kasuya Y,Kuroda F,et al.Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratrachealbleomycin[J].Respir Res,2011,12:131.
[46] Cibrian D,Saiz ML,de la Fuente H,et al.CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis[J],Nat Immunol,2016,17(8):985-996.