吉西他滨联合奥沙利铂治疗晚期胆管癌的疗效评价
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摘要
目的本研究旨在对吉西他滨联合奥沙利铂治疗晚期胆管癌患者的疗效及安全性进行评价分析。方法纳入2013年8月～2018年8月在安徽省立医院就诊的晚期胆管癌患者,分为吉西他滨联合奥沙利铂方案化疗组24例,吉西他滨单药化疗组22例,比较分析联合用药及单药化疗之间的疗效和毒副反应。结果联合化疗组能有效提高KPS评分(P=0. 489);疾病控制率高于单药组(P=0. 019),差异有统计学意义;两组患者毒副反应均可耐受,无明显统计学差异。结论吉西他滨联合奥沙利铂可作为晚期胆管癌患者较佳的综合治疗方案。
Objective The aim of this study was to evaluate the efficacy and safety of patients with advanced cholangiocarcinoma in the treatment of chemotherapy with gemcitabine and oxaliplatin(GEMOX). Methods The patients with advanced cholangiocarcinoma in Anhui Provincial Hospital from August 2013 to August 2018 were divided into two groups. One group including 24 cases received chemotherapy with gemcitabine and oxaliplatin and another group including 22 cases received chemotherapy with gemcitabine only. The efficacy and toxicity of combination therapy and single drug chemotherapy were compared and analyzed. Results The GEMOX regimen could effectively improve the KPS score(P = 0. 489) and disease control rate(P = 0. 019). The toxicity and side effects of two groups were tolerable and there was no statistic difference between two groups. Conclusion Gemcitabine combined with oxaliplatin can be used as a better comprehensive treatment for patients with advanced cholangiocarcinoma.
Objective The aim of this study was to evaluate the efficacy and safety of patients with advanced cholangiocarcinoma in the treatment of chemotherapy with gemcitabine and oxaliplatin(GEMOX). Methods The patients with advanced cholangiocarcinoma in Anhui Provincial Hospital from August 2013 to August 2018 were divided into two groups. One group including 24 cases received chemotherapy with gemcitabine and oxaliplatin and another group including 22 cases received chemotherapy with gemcitabine only. The efficacy and toxicity of combination therapy and single drug chemotherapy were compared and analyzed. Results The GEMOX regimen could effectively improve the KPS score(P = 0. 489) and disease control rate(P = 0. 019). The toxicity and side effects of two groups were tolerable and there was no statistic difference between two groups. Conclusion Gemcitabine combined with oxaliplatin can be used as a better comprehensive treatment for patients with advanced cholangiocarcinoma.
引文
1刘子沛,郑燕华,白洁,等.多种肿瘤标志物检测在胆管癌诊断中的临床意义.中华肝胆外科杂志,2013,19(9):657-660.
2 GU Wei-guang,XIE Zhong,LIAO Si-hai,et al.Therapeutic effect of gemcitabine combined with oxaliplatin in advanced Cholangiocarcinoma.Mod Oncol,2009,17(8):1520-1521.
3 Nishino M,Jagannathan JP,Ramaiya NH.Revised RECIST guideline version 11:What oncologists want to know and what radiologists need to know.AJR.American journal of roentgenology,2010,195(2):281-289.
4 Fan Y,Lin NM,Ma SL,et al.Phase II trial of gemcitabine plus cisplatin in patients with advanced non-small cell lung cancer.Acta pharmacologica Sinica,2010,31(6):746-752.
5 Raymond E,ChaneyS,Taamma A,et al.Oxalipatin:A review of preclinical and clinical studies.Ann Oncol,1998,9(7):1053-1057.
6 Ghiringhelli F,Lorgis V,Vincent J,et al.Hepatic arterial infusion of gemcitabine plus oxaliplatin as second-line treatment for locally advanced intrahepatic cholangiocarcinoma:preliminary experience.Chemotherapy,2013,59(5):354-360.
7 Thongprasert S,Napapan S,Charoentum C.Phase II study of gemcitabine and cisplatin as first-line chemotherapy in inoperable biliary tract carcinoma.Annals of oncology:official journal of the European Society for Medical Oncology/ESMO,2005,16(2):279-281.
8 Jang JS,Lim HY,Hwang IG,et al.Gemcitabine and oxaliplatin in patients with unresectable biliary cancer including gall bladder cancer:a Korean Cancer Study Group phase II trial.Cancer chemotherapy and pharmacology,2010,65(4):641-647.
9 Kim HJ,Lee NS,Lee SC,et al.A phase II study of gemcitabine in combination with oxaliplatin as first-line chemotherapy in patients with inoperable biliary tract cancer.Cancer chemotherapy and pharmacology,2009,64(2):371-377.
10 Manzione L,Romano R.Chemotherapy with gemcitabine and oxaliplatin in patients with advanced biliary tract cancer:a single-institution experience.Oncology,2007,73(5-6):311-315.
2 GU Wei-guang,XIE Zhong,LIAO Si-hai,et al.Therapeutic effect of gemcitabine combined with oxaliplatin in advanced Cholangiocarcinoma.Mod Oncol,2009,17(8):1520-1521.
3 Nishino M,Jagannathan JP,Ramaiya NH.Revised RECIST guideline version 11:What oncologists want to know and what radiologists need to know.AJR.American journal of roentgenology,2010,195(2):281-289.
4 Fan Y,Lin NM,Ma SL,et al.Phase II trial of gemcitabine plus cisplatin in patients with advanced non-small cell lung cancer.Acta pharmacologica Sinica,2010,31(6):746-752.
5 Raymond E,ChaneyS,Taamma A,et al.Oxalipatin:A review of preclinical and clinical studies.Ann Oncol,1998,9(7):1053-1057.
6 Ghiringhelli F,Lorgis V,Vincent J,et al.Hepatic arterial infusion of gemcitabine plus oxaliplatin as second-line treatment for locally advanced intrahepatic cholangiocarcinoma:preliminary experience.Chemotherapy,2013,59(5):354-360.
7 Thongprasert S,Napapan S,Charoentum C.Phase II study of gemcitabine and cisplatin as first-line chemotherapy in inoperable biliary tract carcinoma.Annals of oncology:official journal of the European Society for Medical Oncology/ESMO,2005,16(2):279-281.
8 Jang JS,Lim HY,Hwang IG,et al.Gemcitabine and oxaliplatin in patients with unresectable biliary cancer including gall bladder cancer:a Korean Cancer Study Group phase II trial.Cancer chemotherapy and pharmacology,2010,65(4):641-647.
9 Kim HJ,Lee NS,Lee SC,et al.A phase II study of gemcitabine in combination with oxaliplatin as first-line chemotherapy in patients with inoperable biliary tract cancer.Cancer chemotherapy and pharmacology,2009,64(2):371-377.
10 Manzione L,Romano R.Chemotherapy with gemcitabine and oxaliplatin in patients with advanced biliary tract cancer:a single-institution experience.Oncology,2007,73(5-6):311-315.