胎儿纤维连接蛋白及C-反应蛋白检测羊膜腔感染诊断与预后临床评价
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摘要
目的探讨胎儿纤维连接蛋白(FFN)与C-反应蛋白(CRP)联合检测和胎膜早破并发羊膜腔感染的关系,从而为诊断羊膜腔感染以及预测早产儿的预后提供依据。方法选择医院2010年6月-2012年6月的胎膜早破(PROM)孕妇70例为研究组,正常孕妇50名为对照组,分别行FFN定性检测、CRP检测和胎盘胎膜病理检查,采用SPSS 16.0软件对数据进行统计分析。结果 CRP>10mg/L、FFN及联合检测阳性率,对照组分别为2.00%、4.00%、0,研究组分别为60.00%、71.43%、47.14%,研究组CRP>10mg/L、FFN阳性和联合检测阳性率均高于对照组,差异有统计学意义(P<0.05);70例PROM患者中绒毛膜羊膜炎45例,占64.29%;研究组共发生早产儿并发症26例,发生率为37.14%,其中确诊绒毛羊膜炎的45例患者中25例发生并发症,并发症发生率为55.55%。结论 CRP和FFN与PROM孕妇亚临床绒毛膜羊膜炎密切相关,联合检测CRP和FFN可以提高诊断绒毛羊膜炎和预测早产儿预后的敏感性和特异性。
OBJECTIVE To investigate the relation of combined detection of fetal protein fiber connection(FFN)and C-reactive protein(CRP)to diagnosis and prognosis of intra-amniotic infection,so as to provide reference for diagnosis and prognosis of intra-amniotic infection.METHODS During Jun.2010 to Jun.2012,a total of 70 cases of PROM as study group and 50 cases of normal pregnant women as control group were detected by FFN qualitative detection,CRP testing and placental membranes pathological examination.SPSS16.0software was used for statistical analysis.RESULTS CRP>10mg/L,FFN positive and combined detection positive rates were2.00%,4.00%and 0in control group,while were 60.00%,71.43%and 47.14%in study group,which were significantly higher than control group(P<0.05).There were 45cases(64.29%)of chorioamnionitis in 70 PROM patients.There were 26cases(37.14%)of complications in study group.There were 25cases(55.55%)in 45 cases of patients with chorioamnionitis.CONCLUSION CRP and FFN are closely related to PROM pregnant women with subclinical chorioamnionitis.The combined detection of CRP and FFN can improve sensitivity and specificity of diagnosis of chorioamnionitis and prediction of the prognosis of premature infants.
OBJECTIVE To investigate the relation of combined detection of fetal protein fiber connection(FFN)and C-reactive protein(CRP)to diagnosis and prognosis of intra-amniotic infection,so as to provide reference for diagnosis and prognosis of intra-amniotic infection.METHODS During Jun.2010 to Jun.2012,a total of 70 cases of PROM as study group and 50 cases of normal pregnant women as control group were detected by FFN qualitative detection,CRP testing and placental membranes pathological examination.SPSS16.0software was used for statistical analysis.RESULTS CRP>10mg/L,FFN positive and combined detection positive rates were2.00%,4.00%and 0in control group,while were 60.00%,71.43%and 47.14%in study group,which were significantly higher than control group(P<0.05).There were 45cases(64.29%)of chorioamnionitis in 70 PROM patients.There were 26cases(37.14%)of complications in study group.There were 25cases(55.55%)in 45 cases of patients with chorioamnionitis.CONCLUSION CRP and FFN are closely related to PROM pregnant women with subclinical chorioamnionitis.The combined detection of CRP and FFN can improve sensitivity and specificity of diagnosis of chorioamnionitis and prediction of the prognosis of premature infants.
引文
[1]赵映华,何洁云,郑燕彩,等.妊娠晚期不同状况羊膜腔内细菌学临床研究[J].中国综合临床,2011,27(1):100-103.
[2]谢爱兰,狄小丹,陈小鸣,等.未足月胎膜早破患者发生组织学绒毛膜羊膜炎的影响因素及新生儿结局[J].中华妇产科杂志,2012,47(2):105-109.
[3]徐澈.绒毛膜羊膜炎发病机制及研究进展[J].实用妇产科杂志,2011,27(8):584-586.
[4]张玲玲,曹耀辉.足月妊娠胎膜早破并发绒毛膜羊膜炎对新生儿的影响[J].山东医药,2011,51(6):58-59.
[5]秦宝玲,张文颖,党艳丽,等.北京部分郊区279例孕产妇早产相关因素分析[J].中华医学杂志,2011,91(33):2340-2342.
[6]Abdelazim IA.Fetal fibronectin(Quick Check fFN test)for detection of premature rupture of fetal membranes[J].Arch Gynecol Obstet,2013,287(2):205-210.
[7]蔡蓓珺,蒋洪波.胎儿纤维连接蛋白联合解脲支原体检测用于预测早产的临床价值[J].河北医学,2012,18(7):899-901.
[8]金雪静,周云香,虞冬霜,等.胎膜早破亚临床绒毛膜羊膜炎与妊娠结局的关系[J].中华医院感染学杂志,2012,22(6):1203-1204.
[9]张文瑛,朱梅英.绒毛膜羊膜炎与早产儿并发症的关系探讨[J].中国新生儿科杂志,2012,27(6):390-393.
[10]Lee SM,Romero R,Park JW,et al.The clinical significance of a positive Amnisure test in women with preterm labor and intact membranes[J].Matern Fetal Neonatal Med,2012,25(9):1690-1698.
[11]杨亚静,张砺,张蕾,等.2010年度卫生部全国细菌耐药监测报告:0~14岁儿童细菌耐药监测分析[J].中华医院感染学杂志,2012,22(1):50-55.
[2]谢爱兰,狄小丹,陈小鸣,等.未足月胎膜早破患者发生组织学绒毛膜羊膜炎的影响因素及新生儿结局[J].中华妇产科杂志,2012,47(2):105-109.
[3]徐澈.绒毛膜羊膜炎发病机制及研究进展[J].实用妇产科杂志,2011,27(8):584-586.
[4]张玲玲,曹耀辉.足月妊娠胎膜早破并发绒毛膜羊膜炎对新生儿的影响[J].山东医药,2011,51(6):58-59.
[5]秦宝玲,张文颖,党艳丽,等.北京部分郊区279例孕产妇早产相关因素分析[J].中华医学杂志,2011,91(33):2340-2342.
[6]Abdelazim IA.Fetal fibronectin(Quick Check fFN test)for detection of premature rupture of fetal membranes[J].Arch Gynecol Obstet,2013,287(2):205-210.
[7]蔡蓓珺,蒋洪波.胎儿纤维连接蛋白联合解脲支原体检测用于预测早产的临床价值[J].河北医学,2012,18(7):899-901.
[8]金雪静,周云香,虞冬霜,等.胎膜早破亚临床绒毛膜羊膜炎与妊娠结局的关系[J].中华医院感染学杂志,2012,22(6):1203-1204.
[9]张文瑛,朱梅英.绒毛膜羊膜炎与早产儿并发症的关系探讨[J].中国新生儿科杂志,2012,27(6):390-393.
[10]Lee SM,Romero R,Park JW,et al.The clinical significance of a positive Amnisure test in women with preterm labor and intact membranes[J].Matern Fetal Neonatal Med,2012,25(9):1690-1698.
[11]杨亚静,张砺,张蕾,等.2010年度卫生部全国细菌耐药监测报告:0~14岁儿童细菌耐药监测分析[J].中华医院感染学杂志,2012,22(1):50-55.