益气泄浊和络方联合中药灌肠改善气虚湿瘀型CKD3-4期患者肾性贫血的临床研究
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摘要
目的:观察益气泄浊和络方联合中药灌肠治疗气虚湿瘀型CKD3-4期患者肾性贫血的临床疗效。方法:将56例患者随机分为治疗组28例和对照组28例,对照组予基础治疗,治疗组在对照组基础上采用益气泄浊和络方联合中药灌肠治疗,疗程12周。比较两组治疗前后RBC、HB、HCT、e GFR、RET%、SF、BUN、Scr的变化。结果:治疗组和对照组总有效率分别为92.9%和89.3%,差异无统计学意义(P>0.05);两组治疗后RBC、HB、HCT、RET%、SF、TS与治疗前比较,差异均有统计学意义(P<0.05);治疗后两组组间比较,RBC、HB、HCT、RET%、SF、TS差异均有统计学意义(P<0.05);TS比较差异无统计学意义(P>0.05)。治疗后两组e GFR、Scr、BUN、Cys C均有变化(P<0.05)。结论:益气泄浊和络方联合中药灌肠可早期干预肾脏代谢及内分泌功能,减少并发症,提高生活质量,延缓进入终末期肾脏的风险。
Objective: To observe the effect of Yiqi Xiezhuo Huoluo Prescription( 益 气 泄 浊 和 络 方,YQXZHLP) oral and enema with traditional Chinese medicine on CKD3-4 patients with renal anemia of Qi deficiency and dampness and blood Stasis. Methods: The 56 patients were randomly divided into treatment group(28 cases) and control group(28 cases), control group received basic treatment; on the basis of the control group, the treatment group received YQXZHLP oral and enema with traditional Chinese medicine for 12 weeks. The changes of RBC, HB, HCT, e GFR, RET%, SF, BUN, and Scr before and after treatment in two groups were compared. Results: The total effective rate of treatment group and the control group respectively was 92.9% and 89.3%, the difference was not statistically significant(P >0.05); the two groups after treatment RBC, HB, HCT, RET%, SF, TS compared with before treatment, the differences were statistically significant(P<0.05); after treatment between the two groups, RBC HB, HCT, RET%, SF and TS had significant difference(P<0.05); there was no significant difference between TS(P>0.05). After treatment, the e GFR, Scr, BUN, Cys C of the two groups were all changed(P<0.05). Conclusion: Yiqi Xiezhuo Huoluo prescription combined with Chinese herbal enema can improve kidney metabolism and endocrine function, early intervention to reduce complications and improve the quality of life, and delay into the end stage renal the risk.
Objective: To observe the effect of Yiqi Xiezhuo Huoluo Prescription( 益 气 泄 浊 和 络 方,YQXZHLP) oral and enema with traditional Chinese medicine on CKD3-4 patients with renal anemia of Qi deficiency and dampness and blood Stasis. Methods: The 56 patients were randomly divided into treatment group(28 cases) and control group(28 cases), control group received basic treatment; on the basis of the control group, the treatment group received YQXZHLP oral and enema with traditional Chinese medicine for 12 weeks. The changes of RBC, HB, HCT, e GFR, RET%, SF, BUN, and Scr before and after treatment in two groups were compared. Results: The total effective rate of treatment group and the control group respectively was 92.9% and 89.3%, the difference was not statistically significant(P >0.05); the two groups after treatment RBC, HB, HCT, RET%, SF, TS compared with before treatment, the differences were statistically significant(P<0.05); after treatment between the two groups, RBC HB, HCT, RET%, SF and TS had significant difference(P<0.05); there was no significant difference between TS(P>0.05). After treatment, the e GFR, Scr, BUN, Cys C of the two groups were all changed(P<0.05). Conclusion: Yiqi Xiezhuo Huoluo prescription combined with Chinese herbal enema can improve kidney metabolism and endocrine function, early intervention to reduce complications and improve the quality of life, and delay into the end stage renal the risk.
引文
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[11]白剑峰,林培贤.中药灌肠治疗慢性肾衰竭[J].中医临床研究,2011,3(3):86-87.
[12]李静,任东升,陶雅非.中药灌肠在慢性肾衰保守治疗中的疗效观察[J].中国实用医药,2013,8(13):205-206.
[13]黄永辉.中药保留灌肠联合护理干预治疗老年慢性肾衰157例临床观察[J].实用中医内科杂志,2014,28(10):157-159.
[14]钱晓平,徐芳,杨金亮,等.中药口服、灌肠、熏蒸治疗慢性肾衰氮质血症期临床研究[J].光明中医,2010,25(1):25-28.
[15]李焦枝.中药口服加灌肠佐治慢性肾衰26例疗效观察[J].国医论坛,2015,30(6):54-55.
[2]肾性贫血诊断和治疗共识中国专家组.肾性贫血诊断与治疗中国专家共识[J].中华肾脏病杂志,2013,29(5):389-392.
[3]赵先锋.中医药治疗慢性肾衰竭研究进展[J].现代中西医结合杂志,2014,23(2):217-220.
[4]National Kidney Foundation.Kidney disease outcomes quality in-itiative[J].Am J Kidney Dis,2002(39):51-226.
[5]Inker L A,Astor B C,Fox C H,et al.KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for the Evaluation and Management of CKD[J].American Journal of Kidney Diseases,2014,63(5):713-735.
[6]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:163-164.
[7]马鸿杰,李康康.肾性贫血的中医药研究进展[J].云南中医中药杂志,2014,35(3):58-59.
[8]张蕾,杨霓芝,刘旭生,等.中医药治疗肾性贫血及肾性营养不良的专家咨询结果分析[J].时珍国医国药,2010,21(11):2996-2997.
[9]赵平,张法荣.肾性贫血方剂组方规律中医文献分析[J].山东中医药大学学报,2016,40(2):119-123.
[10]黄青青.中西医结合治疗尿毒症早期肾性贫血20例疗效观察[J].临床合理用药,2014,4(6c):77-78.
[11]白剑峰,林培贤.中药灌肠治疗慢性肾衰竭[J].中医临床研究,2011,3(3):86-87.
[12]李静,任东升,陶雅非.中药灌肠在慢性肾衰保守治疗中的疗效观察[J].中国实用医药,2013,8(13):205-206.
[13]黄永辉.中药保留灌肠联合护理干预治疗老年慢性肾衰157例临床观察[J].实用中医内科杂志,2014,28(10):157-159.
[14]钱晓平,徐芳,杨金亮,等.中药口服、灌肠、熏蒸治疗慢性肾衰氮质血症期临床研究[J].光明中医,2010,25(1):25-28.
[15]李焦枝.中药口服加灌肠佐治慢性肾衰26例疗效观察[J].国医论坛,2015,30(6):54-55.