亮氨酸类离子液体的合成及其气相色谱分离性能研究
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摘要
研究亮氨酸类离子液体作为气相色谱固定相的分离性能及其应用.合成了L-亮氨酸乙酯四氟硼酸盐和L-亮氨酸乙酯双(三氟甲基磺酰)亚胺盐离子液体,将其作为固定相制备毛细管气相色谱柱,建立了50,80和110℃时的Abraham溶剂化参数模型,选用Grob试剂和正构烷烃混合物对固定相的气相色谱分离能力和选择性进行了考察.结果表明,亮氨酸类离子液体固定相具有良好的涂渍性能,对化合物进行保留所产生的多种相互作用力中,偶极相互作用力和氢键相互作用力占主导地位,具备较好的色谱分离能力和应用价值.
A study on the leucine-based ionic liquids as stationary phases in gas chromatography was presented.L-Leucine ethyl ester tetrafluoroborate and L-leucine ethyl ester bis[(trifluoromethyl)sulfonyl]imide were synthesized and used as stationary phases in gas chromatography.Meanwhile,Abraham solvation parameter models at 50,80 and 110 ℃ were used to evaluate the solvation characteristics.Furthermore,the chromatographic separation performance was evaluated by a Grob test mixture and n-alkanes mixture.The present results demonstrate that the leucine-based ionic liquids stationary phases have good film-forming ability.The system constants indicated that the dipolarity/polarizability and the hydrogen-bond interaction play a major role among five molecular interactions between stationary phases and solute molecules. Leucine-based ionic liquids stationary phases possess excellent chromatographic separation performance, and may be applicable as valuable gas chromatography stationary phases.
A study on the leucine-based ionic liquids as stationary phases in gas chromatography was presented.L-Leucine ethyl ester tetrafluoroborate and L-leucine ethyl ester bis[(trifluoromethyl)sulfonyl]imide were synthesized and used as stationary phases in gas chromatography.Meanwhile,Abraham solvation parameter models at 50,80 and 110 ℃ were used to evaluate the solvation characteristics.Furthermore,the chromatographic separation performance was evaluated by a Grob test mixture and n-alkanes mixture.The present results demonstrate that the leucine-based ionic liquids stationary phases have good film-forming ability.The system constants indicated that the dipolarity/polarizability and the hydrogen-bond interaction play a major role among five molecular interactions between stationary phases and solute molecules. Leucine-based ionic liquids stationary phases possess excellent chromatographic separation performance, and may be applicable as valuable gas chromatography stationary phases.
引文
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[10]刘国湘,张新信,胡德荣,等.氨基酸酯化方法的比较及其红外光谱研究[J].氨基酸和生物资源,1995,17(3):36-39.Liu Guoxiang,Zhang Xinxin,Hu Derong,et al.Esterification of amino acids and their infrared spectroscopy[J].Amino Acids&Biotic Resources,1995,17(3):36-39.(in Chinese)
[11]Abraham M H.Scales of solute hydrogen-bonding:their construction and application to physicochemical and biochemical processes[J].Chemical Society Reviews,1993,22(2):73-83.
[2]Yu H,Ho T D,Anderson J L.Ionic liquid and polymeric ionic liquid coatings in solid-phase microextraction[J].Trends in Analytical Chemistry,2013,45:219-232.
[3]Twu P,Zhao Q,Pitner W R,et al.Evaluating the solvation properties of functionalized ionic liquids with varied cation/anion composition using the solvation parameter model[J].Journal of Chromatography A,2011,1218(31):5311-5318.
[4]Poole C F,Lenca N.Gas chromatography on wallcoated open-tubular columns with ionic liquid stationary phases[J].Journal of Chromatography A,2014,1357:87-109.
[5]Roeleveld K,David F,Lynen F.Comparison between polymerized ionic liquids synthesized using chain-growth and step-growth mechanisms used as stationary phase in gas chromatography[J].Journal of Chromatography A,2016,1451:135-144.
[6]Ragonese C,Sciarrone D,Grasso E,et al.Enhanced resolution of Mentha piperita volatile fraction using a novel medium-polarity ionic liquid gas chromatography stationary phase[J].Journal of Separation Science,2016,39(3):537-544.
[7]Wu D,Zhou Y,Cai P,et al.Specific cooperative effect for the enantiomeric separation of amino acids using aqueous two-phase systems with task-specific ionic liquids[J].Journal of Chromatography A,2015,1395:65-72.
[8]Sistla Y S,Khanna A.CO2absorption studies in amino acid-anion based ionic liquids[J].Chemical Engineering Journal,2015,273:268-276.
[9]Jordan A,Gathergood N.Biodegradation of ionic liquids-a critical review[J].Chemical Society Reviews,2015,44(22):8200-8237.
[10]刘国湘,张新信,胡德荣,等.氨基酸酯化方法的比较及其红外光谱研究[J].氨基酸和生物资源,1995,17(3):36-39.Liu Guoxiang,Zhang Xinxin,Hu Derong,et al.Esterification of amino acids and their infrared spectroscopy[J].Amino Acids&Biotic Resources,1995,17(3):36-39.(in Chinese)
[11]Abraham M H.Scales of solute hydrogen-bonding:their construction and application to physicochemical and biochemical processes[J].Chemical Society Reviews,1993,22(2):73-83.