1-(2,6-二异丙基苯基)-2-苯基-1H-咪唑的合成
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摘要
以2,6-二异丙基苯胺为原料,与苯甲酰氯成酰胺,再经三氯氧磷氯代,氨基乙醛缩二乙醇亲核取代后,在磷酸作用下环合得到1-(2,6-二异丙基苯基)-2-苯基-1H-咪唑,4步反应的总收率为47.7%。目标化合物结构经ESI-MS、1H NMR确证。
The target compound 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole was prepared in overall yield of 47.69% starting from 2,6-diisopropyl aniline via acylation by benzoyl chloride, chlorination by phosphorus oxychloride, nucleophilic substitution by aminoacetaldehyde diethyl acetal, and cyclization by phosphate. The structure of target compound was characterized by1 H NMR and ESI-MS.
The target compound 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole was prepared in overall yield of 47.69% starting from 2,6-diisopropyl aniline via acylation by benzoyl chloride, chlorination by phosphorus oxychloride, nucleophilic substitution by aminoacetaldehyde diethyl acetal, and cyclization by phosphate. The structure of target compound was characterized by1 H NMR and ESI-MS.
引文
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