抽动障碍患儿的执行功能缺陷
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摘要
抽动障碍(TD)患儿执行功能的多种成分存在缺陷,表现在工作记忆能力下降,持续性注意和反应抑制、认知灵活性、思维组织性、计划性等方面存在障碍,非语言能力和社交功能损害等。TD患儿如果伴有注意缺陷多动障碍(ADHD)、强迫障碍(OCD)以及孤独症谱系障碍(ASD)等共患病,其执行功能缺陷常常更严重。TD患儿执行功能的某些缺陷与其抽动症状的严重性相关,完整的执行功能发展与抽动症状的缓解过程有关,通过改善TD患儿的执行功能缺陷可以间接地减少TD患儿的抽动症状。
Many components of executive functions are impaired in children suffering from tic disorders(TD),including working memory ability declines,difficulty in sustained attention,response inhibition,cognitive flexibility,thought organization,planning ability,social ability,comprehension of nonliteral language.Comorbid conditions of TD such as attention-deficit/hyperactivity disorder(ADHD),obsessive-compulsive disorder(OCD),autism spectrum disorder(ASD) will worsen executive functions deficits.There are significant correlations between tic severity and some executive functions deficits.Intact executive function development is related to remission processes of tic symptoms.Improvement of executive function may reduce severity of tic symptoms.
Many components of executive functions are impaired in children suffering from tic disorders(TD),including working memory ability declines,difficulty in sustained attention,response inhibition,cognitive flexibility,thought organization,planning ability,social ability,comprehension of nonliteral language.Comorbid conditions of TD such as attention-deficit/hyperactivity disorder(ADHD),obsessive-compulsive disorder(OCD),autism spectrum disorder(ASD) will worsen executive functions deficits.There are significant correlations between tic severity and some executive functions deficits.Intact executive function development is related to remission processes of tic symptoms.Improvement of executive function may reduce severity of tic symptoms.
引文
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[16] 季卫东,周家秀,杨闯,等.抽动秽语综合征汉族患者的执行功能及与多巴胺D4受体第3外显子48bp可重复序列多态性[J].中国心理卫生杂志,2010,24(8):568-573.
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[18] Channon S,Pratt P,Robertson MM.Executive function,memory,and learning in Tourette′s syndrome [J].Neuropsychology,2003,17(2):247-254.
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[20] Thibeault M,Lemay M,Chouinard S,et al.Response inhibition in tic disorders:waiting to respond is harder when ADHD is present[J].J Atten Disord,2016,20(3):251-259.
[21] Hovik KT,Plessen KJ,Skogli EW,et al.Dissociable response inhibition in children with Tourette′s syndrome compared with children with ADHD[J].J Atten Disord,2016,20(10):825-835.
[22] Hovik KT,Egeland J,Isquith PK,et al.Distinct patterns of everyday executive function problems distinguish children with Tourette syndrome from children with ADHD or autism spectrum disorders[J].J Atten Disord,2017,21(10):811-823.
[23] Messerotti Benvenuti S,Buodo G,Leone V,et al.Neurofeedback training for tourette syndrome:an uncontrolled single case study[J].Appl Psychophysiol Biofeedback,2011,36(4):281-288.
[24] Eddy CM,Cavanna AE.Triangles,tricks and tics:hyper-mentalizing in response to animated shapes in Tourette syndrome[J].Cortex,2015,71:68-75.
[25] Yaniv A,Benaroya-Milshtein N,Steinberg T,et al.Executive control development in Tourette syndrome and its role in tic reduction[J].Psychiatry Res,2018,262:527-535.
[2] Yaniv A,Benaroya-Milshtein N,Steinberg T,et al.Specific executive control impairments in Tourette syndrome:The role of response inhibition[J].Res Dev Disabil,2017,61:1-10.
[3] 吴思,郑东明.执行功能测评技术的临床应用现状与展望[J].国际神经病学神经外科学杂志,2018,45(2):169-172.
[4] Hughes AJ,Denney DR,Owens EM,et al.Procedural variations in the stroop and the symbol digit modalities test:impact on patients with multiple sclerosis[J].Arch Clin Neuropsychol,2013,28(5):452-462.
[5] 杜亚松.儿童心理执行功能的检查和评估[J].上海精神医学,2008,20(1):44-48.
[6] 赵建华,陈佐明,李彤,等.儿童Tourette综合征患者执行功能的研究[J].临床神经病学杂志,2007,20(4):265-267.
[7] 李惠琳,杜亚松,孙锦华,等.抽动障碍患儿执行功能损害特征的研究[J].临床精神医学杂志,2011,21(5):295-298.
[8] Eddy CM,Mitchell IJ,Beck SR,et al.Impaired comprehension of nonliteral language in Tourette syndrome [J].Cogn Behav Neurol,2010,23(3):178-184.
[9] Eichele H,Eichele T,Hammar A,et al.Go/NoGo performance in boys with Tourette syndrome [J].Child Neuropsychol,2010,16(2):162-168.
[10] Jeter CB,Patel SS,Morris JS,et al.Oculomotor executive function abnormalities with increased tic severity in Tourette syndrome[J].J Child Psychol Psychiatry,2015,56(2):193-202.
[11] Eddy CM,Rizzo R,Cavanna AE.Neuropsychological aspects of Tourette syndrome:a review [J].J Psychosom Res,2009,67(6):503-513.
[12] Eddy CM,Cavanna AE.Set-shifting deficits:a possible neurocognitive endophenotype for Tourette syndrome without ADHD [J].J Atten Disord,2017,21(10):824-834.
[13] 廖怡,曲海波,蔡晓唐,等.儿童抽动秽语综合征脑皮层厚度改变的磁共振研究[J].影像诊断与介入放射学,2018,27(1):33-39.
[14] Plessen KJ,Bansal R,Peterson BS.Imaging evidence for anatomical disturbances and neuroplastic compensation in persons with Tourette syndrome[J].J Psychosom Res,2009,67(6):559-573.
[15] 季卫东,杨闯,周家秀,等.抽动秽语综合征儿童的IL-1Ra基因多态性与执行功能[J].中国心理卫生杂志,2013,27(8):629-633.
[16] 季卫东,周家秀,杨闯,等.抽动秽语综合征汉族患者的执行功能及与多巴胺D4受体第3外显子48bp可重复序列多态性[J].中国心理卫生杂志,2010,24(8):568-573.
[17] Schuerholz LJ,Baumgardner TL,Singer HS,et al.Neuropsychological status of children with Tourette′s syndrome with and without attention deficit hyperactivity disorder[J].Neurology,1996,46(4):958-965.
[18] Channon S,Pratt P,Robertson MM.Executive function,memory,and learning in Tourette′s syndrome [J].Neuropsychology,2003,17(2):247-254.
[19] Termine C,Luoni C,Fontolan S,et al.Impact of co-morbid attention-deficit and hyperactivity disorder on cognitive function in male children with Tourette syndrome:a controlled study [J].Psychiatry Res,2016,243:263-267.
[20] Thibeault M,Lemay M,Chouinard S,et al.Response inhibition in tic disorders:waiting to respond is harder when ADHD is present[J].J Atten Disord,2016,20(3):251-259.
[21] Hovik KT,Plessen KJ,Skogli EW,et al.Dissociable response inhibition in children with Tourette′s syndrome compared with children with ADHD[J].J Atten Disord,2016,20(10):825-835.
[22] Hovik KT,Egeland J,Isquith PK,et al.Distinct patterns of everyday executive function problems distinguish children with Tourette syndrome from children with ADHD or autism spectrum disorders[J].J Atten Disord,2017,21(10):811-823.
[23] Messerotti Benvenuti S,Buodo G,Leone V,et al.Neurofeedback training for tourette syndrome:an uncontrolled single case study[J].Appl Psychophysiol Biofeedback,2011,36(4):281-288.
[24] Eddy CM,Cavanna AE.Triangles,tricks and tics:hyper-mentalizing in response to animated shapes in Tourette syndrome[J].Cortex,2015,71:68-75.
[25] Yaniv A,Benaroya-Milshtein N,Steinberg T,et al.Executive control development in Tourette syndrome and its role in tic reduction[J].Psychiatry Res,2018,262:527-535.