DCE-MRI在颈动脉粥样硬化中的应用进展
摘要
动脉粥样硬化(AS)病变的炎症反应是斑块失稳的重要因素,而新生血管形成是AS炎症的组织学标志之一。动态对比增强磁共振(DCE-MRI)技术能够对活体组织的新生血管程度进行量化评估。近年来DCE-MRI逐渐应用于颈动脉AS病变的研究中。本文就AS与新生血管的关系、DCE-MRI基本原理及其在颈动脉AS中的应用现状进行综述。
引文
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[28] Skeoch S,Cristinacce PL,Williams H,et al.Imaging atherosclerosis in rheumatoid arthritis:evidence for increased prevalence,altered phenotype and a link between systemic and localised plaque inflammation[J].Sci Rep,2017,7(1):827.
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[33] Zollner FG,Daab M,Sourbron SP,et al.An open source software for analysis of dynamic contrast enhanced magnetic resonance images:UMMPerfusion revisited[J].BMC Med Imaging,2016,16:7.
[2] Calcagno C,Mani V,Ramachandran S,et al.Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) of atherosclerotic plaque angiogenesis[J].Angiogenesis,2010,13(2):87-99.
[3] 俞顺,石清磊,苏家威,等.DCE-MRI定量参数在不同病理类型腮腺肿瘤鉴别诊断中的初步研究[J].磁共振成像,2017,8(9):654-661.
[4] 金兴兴,岳巍,韩东明,等.薄层小视野高分辨MRI结合DCE-MRI对卵巢肿瘤的诊断价值[J].放射学实践,2016,31(4):369-372.
[5] Yuan C,Kerwin WS,Ferguson MS,et al.Contrast-enhanced high resolution MRI for atherosclerotic carotid artery tissue characterization[J].J Magn Reson Imaging,2002,15(1):62-67.
[6] Portanova A,Hakakian N,Mikulis DJ,et al.Intracranial vasa vasorum:insights and implications for imaging[J].Radiology,2013,267(3):667-679.
[7] Leclercq A,Houard X,Philippe M,et al.Involvement of intraplaque hemorrhage in atherothrombosis evolution via neutrophil protease enrichment[J].J Leukoc Biol,2007,82(6):1420-1429.
[8] Taruya A,Tanaka A,Nishiguchi T,et al.Vasa vasorum restructuring in human atherosclerotic plaque vulnerability:a clinical optical coherence tomography study[J].J Am Coll Cardiol,2015,65(23):2469-2477.
[9] Ribatti D,Levi-Schaffer F,Kovanen PT.Inflammatory angiogenesis in atherogenesis——a double-edged sword[J].Ann Med,2008,40(8):606-621.
[10] Virmani R,Kolodgie FD,Burke AP,et al.Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage[J].Arterioscler Thromb Vasc Biol,2005,25(10):2054-2061.
[11] Sun Z.Atherosclerosis and atheroma plaque rupture:imaging modalities in the visualization of vasa vasorum and atherosclerotic plaques[J].Scientific World J,2014,2014:312764.
[12] Port Ruediger E,Knopp Michael V,Hoffmann Ulf,et al.Multicompartment analysis of gadolinium chelate kinetics:blood-tissue exchange in mammary tumors as monitored by dynamic MR imaging[J].J Magn Reson Imaging,1999,10(3):233-241.
[13] Gaens ME,Backes WH,Rozel S,et al.Dynamic contrast-enhanced MR imaging of carotid atherosclerotic plaque:model selection,reproducibility,and validation[J].Radiology,2013,266(1):271-279.
[14] Tofts PS,Brix G,Buckley DL,et al.Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer:standardized quantities and symbols[J].J Magn Reson Imaging,1999,10(3):223-232.
[15] Patlak CS,Blasberg RG.Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data.Generalizations[J].J Cereb Blood Flow Metab,1985,5(4):584-590.
[16] Chen H,Li F,Zhao X,et al.Extended graphical model for analysis of dynamic contrast-enhanced MRI[J].Magn Reson Med,2011,66(3):868-878.
[17] Larsson HB,Stubgaard M,Frederiksen JL,et al.Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors[J].Magn Reson Med,1990,16(1):117-131.
[18] Weinmann HJ,Laniado M,Mutzel W.Pharmacokinetics of Gd-DTPA/dimeglumine after intravenous injection into healthy volunteers[J].Physiol Chem Phys Med NMR,1984,16(2):167-172.
[19] Fritz-Hansen T,Rostrup E,Larsson HB,et al.Measurement of the arterial concentration of Gd-DTPA using MRI:A step toward quantitative perfusion imaging[J].Magn Reson Med,1996,36(2):225-231.
[20] Yang C,Karczmar GS,Medved M,et al.Reproducibility assessment of a multiple reference tissue method for quantitative dynamic contrast enhanced-MRI analysis[J].Magn Reson Med,2009,61(4):851-859.
[21] Kovar DA,Lewis M,Karczmar GS.A new method for imaging perfusion and contrast extraction fraction:input functions derived from reference tissues[J].J Magn Reson Imaging,1998,8(5):1126-1134.
[22] Wang J,Chen H,Sun J,et al.Dynamic contrast-enhanced MR imaging of carotid vasa vasorum in relation to coronary and cerebrovascular events[J].Atherosclerosis,2017,263:420-426.
[23] Dong L,Kerwin WS,Chen HJ,et al.Carotid artery atherosclerosis:effect of intensive lipid therapy on the vasa vasorum-evaluation by using dynamic contrast-enhanced MR imaging[J].Radiology,2011,260(1):224-231.
[24] Kerwin WS,Oikawa M,Yuan C,et al.MR imaging of adventitial vasa vasorum in carotid atherosclerosis[J].Magn Reson Med,2008,59(3):507-514.
[25] Kerwin W.Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque[J].Circulation,2003,107(6):851-856.
[26] van Hoof RHM,Schreuder Fhbm,Nelemans P,et al.Ischemic stroke patients demonstrate increased carotid plaque microvasculature compared to (ocular) transient Ischemic attack patients[J].Cerebrovasc Dis,2017,44(5-6):297-303.
[27] Yuan J,Makris G,Patterson A,et al.Relationship between carotid plaque surface morphology and perfusion:a 3D DCE-MRI study[J].MAGMA,2018,31(1):191-199.
[28] Skeoch S,Cristinacce PL,Williams H,et al.Imaging atherosclerosis in rheumatoid arthritis:evidence for increased prevalence,altered phenotype and a link between systemic and localised plaque inflammation[J].Sci Rep,2017,7(1):827.
[29] Chen H,Ricks J,Rosenfeld M,et al.Progression of experimental lesions of atherosclerosis:assessment by kinetic modeling of black-blood dynamic contrast-enhanced MRI[J].Magn Reson Med,2013,69(6):1712-1720.
[30] Wu T,Wang J,Song Y,et al.Homologous homologous black-bright-blood and flexible interleaved imaging sequence (HOBBI) for dynamic contrast-enhanced MRI of the vessel wall[J].Magn Reson Med,2015,73(5):1754-1763.
[31] Kerwin WS,O'Brien KD,Ferguson MS,et al.Inflammation in carotid atherosclerotic plaque:a dynamic contrast-enhanced MR imaging study[J].Radiology,2006,241(2):459-468.
[32] Chen HJ,Sun J,Kerwin WS,et al.Scan-rescan reproducibility of quantitative assessment of inflammatory carotid atherosclerotic plaque using dynamic contrast-enhanced 3T CMR in amulti-center study[J].J Cardiovasc Magn Reson,2014,16:51.
[33] Zollner FG,Daab M,Sourbron SP,et al.An open source software for analysis of dynamic contrast enhanced magnetic resonance images:UMMPerfusion revisited[J].BMC Med Imaging,2016,16:7.