生物活性肽调节免疫功能的研究现状
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摘要
生物活性肽是一类源于生物且具有不同生物活性的产物。一般由几个到几十个氨基酸组成,氨基酸排列顺序各异、结构多样。这些肽生物活性多样,包括抗菌、抗病毒、抗肿瘤、抗氧化、心血管保护作用(抗高血压、抗动脉粥样化和抗凝血)、免疫调节、镇痛、抗焦虑、抗糖尿病、抑制食欲和神经活性等作用,一些生物活性肽具有一定的营养价值和药用价值,因此也吸引了保健品和制药行业对活性肽的关注。一些生物活性肽或其衍生物具有很高的商业价值,部分已经进入制药行业或营养食品的市场。其中的大部分如今已处于不同的临床试验阶段或临床前试验阶段。本文主要介绍了生物活性肽调节免疫功能目前的研究状况以及对未来发展前景进行展望,并着重介绍这些生物活性肽的营养价值。
the biologically active peptide is a kind of biological product with different biological activity. Dozens of amino acids in peptides vary from sequence to structure. Their bioactivities include anti-bacterium,anti-virus,anti-tumor,anti-oxidation,cardiovascular protection( anti-hypertension,anti-atheroma and anti-coagulant),immune regulation,analgesia,antianxiety,anti-diabetes,and suppressing appetite and neural activity. Some bioactive peptides contribute to the nutritional and medicinal value,so they attract the attention of the dietary supplements and pharmaceutical industry. Because of the high values in commerce of some bioactive peptides or its derivatives,some have been adopted in the pharmaceutical industry or nutrition food markets. Most of them are in different stages of clinical trials or in preclinical trials now. This paper mainly introduces the current research status and the development prospects about the regulating immune function of bioactive peptides,and emphatically introduces the nutritional value of them.
the biologically active peptide is a kind of biological product with different biological activity. Dozens of amino acids in peptides vary from sequence to structure. Their bioactivities include anti-bacterium,anti-virus,anti-tumor,anti-oxidation,cardiovascular protection( anti-hypertension,anti-atheroma and anti-coagulant),immune regulation,analgesia,antianxiety,anti-diabetes,and suppressing appetite and neural activity. Some bioactive peptides contribute to the nutritional and medicinal value,so they attract the attention of the dietary supplements and pharmaceutical industry. Because of the high values in commerce of some bioactive peptides or its derivatives,some have been adopted in the pharmaceutical industry or nutrition food markets. Most of them are in different stages of clinical trials or in preclinical trials now. This paper mainly introduces the current research status and the development prospects about the regulating immune function of bioactive peptides,and emphatically introduces the nutritional value of them.
引文
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[25]Yang R,Zhang Z,Pei X,et al.Immunomodulatory effects of Marine oligopeptide preparation from chum salmon(Oncorhynchus Keta)in mice[J].Food Chemistry,2009,113(2):464–470.
[26]Bagni M,Archetti L,Amadori M,et al.Effect of long-term oral administration of an immunostimulant diet on innate immunity in sea bass(Dicentrarchus labrax)[J].Journal of veterinary medicine.B,Infectious diseases and veterinary public health,2000,47(10):745-751.
[27]Ahn CB,Cho YS,Je JY.Purification and anti-inflammatory action of tripeptide from salmon pectoral fin byproduct protein hydrolysate[J].Food Chemistry,2015,168(10):151-156.
[28]Wickramaarachchi WD,De Zoysa M,Whang I,et al.Kazal-type proteinase inhibitor from disk abalone(Haliotis discus discus):molecular characterization and transcriptional response upon immune stimulation[J].Fish&Shellfish Immunology,2013,35(3):1039-1043.
[29]Zambrowicz A,Pokora M,Setner B,et al.Multifunctional peptides derived from an egg yolk protein hydrolysate:isolation and characterization[J].Amino Acids,2015,47(2):369-380.
[30]Mallet JF,Duarte J,Vinderola G,et al.The immunopotentiating effects of shark-derived protein hydrolysate[J].Nutrition(Burbank,Los Angeles County,Calif.),2014,30(6):706-712.
[31]Martínez-Augustin O,Rivero-Gutiérrez B,Mascaraque C,et al.Food derived bioactive peptides and intestinal barrier function[J].International Journal of Molecular Sciences,2014,15(12):22857-22873.
[32]Karthik L,Kumar G,Keswani T,et al.Protease inhibitors from Marine actinobacteria as a potential source for antimalarial compound[J].PLOS One,2014,9(3):e90972.
[33]Sun Y,Takada K,Nogi Y,et al.Lower homologues of ahpatinin,aspartic protease inhibitors,from a Marine Streptomyces sp[J].Journal of Natural Products,2014,77(7):1749-1752.
[2]Hayes M,Tiwari BK.Bioactive carbohydrates and peptides in foods:an overview of sources,downstream processing steps and associated bioactivities[J].International Journal of Molecular Sciences,2015,16(9):22485-22508.
[3]Park YW,Nam MS.Bioactive peptides in milk and dairy products:a review[J].Korean Journal for Food Science of Animal Resources,2015,35(6):831-840.
[4]Baer B,Millar AH.Proteomics in evolutionary ecology[J].Journal of Proteomics,2016,135(10):4-11.
[5]Flsch G,Strid L,Mellander O.Hydrolysis of phosphopeptides.II.Leucine aminopeptidase hydrolysis of free and O-phosphorylated serine peptides[J].Acta?Chemica?Scandinavica,1965,19(7):1566-1574.
[6]汤卡罗.人工合成胰岛素的精神代代相传——纪念我国人工合成结晶牛胰岛素50周年[J].大学化学,2015,30(2):1-5.
[7]Coscueta ER,Amorim MM,Voss GB,et al.Bioactive properties of peptides obtained from Argentinian defatted soy flour protein by Corolase PP hydrolysis[J].Food Chemistry,2016,198(16):36-44.
[8]Christodoulou E,Kadoglou NP,Kostomitsopoulos N,et al.Saffron:a natural product with potential pharmaceutical applications[J].The Journal of pharmacy and pharmacology,2015,67(12):1634-1649.
[9]Mogendi JB,De Steur H,Gellynck X,et al.Consumer evaluation of food with nutritional benefits:a systematic review and narrative synthesis[J].International Journal of Food Sciences and Nutrition,2016,67(4):355-371.
[10]Medina KL.Overview of the immune system[J].Handbook of clinical neurology,2016,133(35):61-76.
[11]Guerrero-García NB,Gómez-LomelíZM,Leal-Mora D,et al.Frailty in the elderly and nutritional status according to the Mini Nutritional Assessment[J].Revista medica del Instituto Mexicano del Seguro Social,2016,54(3):312-317.
[12]庞广昌,陈庆森,胡志和,等.蛋白质的消化吸收及其功能评述[J].食品科学,2013,34(9):375-391.
[13]程媛,曹慧,徐斐,等.食源性蛋白中免疫活性肽的研究进展[J].食品科学,2015,36(17):296-299.
[14]Mousavinezhad-Moghaddam M,Amin AA,Rafatpanah H,et al.A new insight into viral proteins as Immunomodulatory therapeutic agents:KSHV v OX2 a homolog of human CD200 as a potent antiinflammatory protein[J].Iranian Journal of Basic Medical Sciences,2016,19(1):2-13.
[15]Marcinkiewicz M,Majewski S.The role of antimicrobial peptides in chronic inflammatory skin diseases[J].Postepy dermatology i alergology,2016,33(1):6-12.
[16]Mansour SC,Pena OM,Hancock RE.Host defense peptides:frontline immunomodulators[J].Trends in Immunology,2014,35(9):443-450.
[17]Pikuta M,Zieliński M,Specjalski K,et al.In vitro evaluation of the allergic potential of antibacterial peptides:camel and citropin[J].Chemical Biology&Drug Design,2016,87(4):562-568.
[18]Nawrot R,Barylski J,Nowicki G,et al.Plant antimicrobial peptides[J].Folia Microbiologica,2014,59(3):181-196.
[19]Salas CE,Badillo-Corona JA,Ramírez-Sotelo G,et al.Biologically active and antimicrobial peptides from plants[J].Bio Med research international,2015(2015):102129.
[20]Shaala LA,Youssef DT,Ibrahim SR,et al.Callyptide A,a new cytotoxic peptide from the Red Sea Marine sponge callyspongia species[J].Natural product research,2016,7(9):1-8.
[21]Lule VK,Garg S,Pophaly SD,et al.Potential health benefits of lunasin:a multifaceted soy-derived bioactive peptide[J].Journal of Food Science,2015,80(3):485-494.
[22]Gurrola GB,Hernández-López RA,Rodríguez De La Vega RC,et al.Structure,function,and chemical synthesis of Vaejovis mexicanus peptide 24:a novel potent blocker of Kv1.3 Potassium channels of human T lymphocytes[J].Biochemistry,2012,51(19):4049-4061.
[23]Varga Z,Gurrola-Briones G,Papp F,et al.Vm24,a natural immunosuppressive peptide,potently and selectively blocks Kv1.3Potassium channels of human T cells[J].Molecular Pharmacology,2012,82(3):372-382.
[24]Sabeena Farvin KH,Andersen LL,Otte J,et al.Antioxidant activity of cod(Gadus morhua)protein hydrolysates:Fractionation and characterisation of peptide fractions[J].Food Chemistry,2016,204(11):409-419.
[25]Yang R,Zhang Z,Pei X,et al.Immunomodulatory effects of Marine oligopeptide preparation from chum salmon(Oncorhynchus Keta)in mice[J].Food Chemistry,2009,113(2):464–470.
[26]Bagni M,Archetti L,Amadori M,et al.Effect of long-term oral administration of an immunostimulant diet on innate immunity in sea bass(Dicentrarchus labrax)[J].Journal of veterinary medicine.B,Infectious diseases and veterinary public health,2000,47(10):745-751.
[27]Ahn CB,Cho YS,Je JY.Purification and anti-inflammatory action of tripeptide from salmon pectoral fin byproduct protein hydrolysate[J].Food Chemistry,2015,168(10):151-156.
[28]Wickramaarachchi WD,De Zoysa M,Whang I,et al.Kazal-type proteinase inhibitor from disk abalone(Haliotis discus discus):molecular characterization and transcriptional response upon immune stimulation[J].Fish&Shellfish Immunology,2013,35(3):1039-1043.
[29]Zambrowicz A,Pokora M,Setner B,et al.Multifunctional peptides derived from an egg yolk protein hydrolysate:isolation and characterization[J].Amino Acids,2015,47(2):369-380.
[30]Mallet JF,Duarte J,Vinderola G,et al.The immunopotentiating effects of shark-derived protein hydrolysate[J].Nutrition(Burbank,Los Angeles County,Calif.),2014,30(6):706-712.
[31]Martínez-Augustin O,Rivero-Gutiérrez B,Mascaraque C,et al.Food derived bioactive peptides and intestinal barrier function[J].International Journal of Molecular Sciences,2014,15(12):22857-22873.
[32]Karthik L,Kumar G,Keswani T,et al.Protease inhibitors from Marine actinobacteria as a potential source for antimalarial compound[J].PLOS One,2014,9(3):e90972.
[33]Sun Y,Takada K,Nogi Y,et al.Lower homologues of ahpatinin,aspartic protease inhibitors,from a Marine Streptomyces sp[J].Journal of Natural Products,2014,77(7):1749-1752.