板蓝根颗粒中有效成分的测定及药理作用研究进展
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摘要
板蓝根颗粒由板蓝根和大青叶两种中药材组成,主要含生物碱、有机酸、苷类、氨基酸、硫代葡萄糖苷及其代谢产物、金属等成分,具有抗病原微生物、抗内毒素、增强免疫功能、抗肿瘤、抗衰老、保护和预防金属中毒等作用。通过测定板蓝根颗粒中的有效成分,提升板蓝根药材品质,确保该药临床使用的安全性。本文从板蓝根颗粒的有效成分、测定方法及药理作用、实际临床应用等方面进行综述,为板蓝根颗粒今后的研究提供一定的借鉴。
Banlangen Granules are composed of two kinds of Chinese medicinal materials, which are Radix Isatidis and Folium Isatidis. They mainly contain alkaloids, organic acids, glycosides, amino acids, glucosinolates and their metabolites, metals and other ingredients. It has the effects of anti-pathogenic microorganisms, anti-endotoxin, improving immune function, anti-tumor, anti-aging, protection and prevention of metal poisoning, and so on. By measuring the effective components in Banlangen Granules, the quality of Radix Isatidis is improved to ensure the safety of this drug in clinical use. This paper reviews the effective components, determination methods, pharmacological effects and practical clinical application of Banlangen Granules, and provides some reference for the future research of Banlangen Granules.
Banlangen Granules are composed of two kinds of Chinese medicinal materials, which are Radix Isatidis and Folium Isatidis. They mainly contain alkaloids, organic acids, glycosides, amino acids, glucosinolates and their metabolites, metals and other ingredients. It has the effects of anti-pathogenic microorganisms, anti-endotoxin, improving immune function, anti-tumor, anti-aging, protection and prevention of metal poisoning, and so on. By measuring the effective components in Banlangen Granules, the quality of Radix Isatidis is improved to ensure the safety of this drug in clinical use. This paper reviews the effective components, determination methods, pharmacological effects and practical clinical application of Banlangen Granules, and provides some reference for the future research of Banlangen Granules.
引文
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[20]樊永恒,陈慧,邬静,等.板蓝根多糖对染铅雄性小鼠生长性能的影响[J].中兽医医药杂志,2018,37(3):60-62.
[21]刘洋,蒋忠秀,潘凤琪,等.板蓝根联合阿奇霉素对小儿支原体肺炎血清炎症因子影响[J].现代生物医学进展,2016,16(4):730-733.
[22]石家贵.应用野菊花、板蓝根、半枝莲超声雾化治疗慢性咽炎的用药效果探讨[J].中国处方药,2015,13(3):14-15.
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[24]王小红.板蓝根颗粒联合利巴韦林注射液治疗儿童流行性腮腺炎的临床分析[J].北方医学,2018,15(1):101.
[25]吴辉,袁晓玲.板蓝根免煎颗粒灌肠联合美沙拉嗪治疗溃疡性结肠炎的临床研究与应用[J].中国现代药物应用,2018,12(17):206-207.
[26]张军.板蓝根注射液联合聚肌胞注射液治疗单疱病毒性角膜炎临床观察[J].吉林医学,2013,34(6):1062.
[27]张琼丽.乳头瘤病毒感染患者应用外用壳聚糖抗菌膜联合内服板蓝根颗粒治疗的临床效果[J].中国医药科学,2016,6(1):94-95.
[28]许卫华.复方板蓝根冲剂与治疣胶囊治疗扁平疣疗效观察[J].陕西中医,2014,35(12):1642-1643.
[2]崔伟亮,李慧芬,刘江亭.大青叶抗病毒抑菌作用研究进展[J].山东中医杂志,2014,33(5):410-411.
[3] Yang QF,Yang KL,Yao J,et al. Effects of three kinds of Chinese medicine polysaccharides on the immune effect of new-castle disease vaccine[J]. Agr Sci Tech,2015,16(10):2283-2285.
[4]曹波,谷静逸,尹海波,等.不同产地及干燥方式板蓝根中4种活性成分含量比较分析[J].辽宁中医杂志,2015,42(10):1955-1958.
[5]闫峻,赵春芳,李伯平,等.板蓝根化学成分及抗氧化活性的研究[J].质谱学报,2017,38(2):249-255.
[6]周燕萍,范平,刘瑜,等.UPLC-MS/MS法同时测定十味板蓝根颗粒中4种成分的含量[J].中医药导报,2016,22(20):40-41.
[7]李培启.高效毛细管电泳法测定板蓝根颗粒中的4种有机酸[J].华西药学杂志,2014,29(4):425-427.
[8]庄会荣,王爱香.离子色谱法测定板蓝根颗粒中的有机酸[J].临沂大学学报,2016,38(1):139-141.
[9] Kiyohara H,Matsumoto T,Yamada H. Intestinal immune system modulating polysaccharides in a Japanese herbal(kampo)medicine,Juzen-Taiho-To[J]. Phytomedicine,2002,9(7):614-625.
[10] David SN,Guillermo MR,Ardythe LM. Human milk glycans protect infants against enteric pathogens[J]. Ann Rev Nutr,2005,25:37-58.
[11]张利沙,孙玮玮,徐自慧,等.复方南板蓝根颗粒中多糖的含量测定及单糖组成分析[J].药物分析杂志,2016,2017,37(10):1845-1850.
[12]任国萍,田璐,李铮,等.板蓝根药材中氨基酸含量测定研究[J].中国新药杂志,2014,23(1):99-104.
[13]毛丰,金艺,袁波,等.尿苷和表告依春在大鼠体内的药物动力学[J].沈阳药科大学学报,2014,31(4):301-307.
[14]程淼,曹鸿云,王成祥,等.板蓝根对流感病毒FM1所致肺炎小鼠病理损伤修复作用的研究[J].中华中医药杂志,2017,32(8):3684-3687.
[15]常晓波.板蓝根与抗内毒素药效作用及化学基础研究[J].吉林医学,2013,34(27):5539.
[16]周蓉蓉,高鹏飞,张文意,等.槐耳板蓝根双向发酵提取物抑制乳腺癌MCF-7细胞迁移/侵袭及相关因子的研究[J].中国中医药信息杂志,2016,23(5):64-68.
[17]李吉萍,朱冠华,袁野,等.板蓝根多糖体内抗肿瘤作用与免疫功能调节实验研究[J].天然产物研究与开发,2017,29:2010-2016.
[18]田冰,刘璟.板蓝根多糖在结核小鼠模型中的免疫干预研究[J].检验医学与临床,2017,14(19):2842-2844.
[19]农石生,龚子龙,周金花,等.板蓝根抗氧化成分及抗氧化性能研究[J].中国野生植物资源,2017,36(3):18-22.
[20]樊永恒,陈慧,邬静,等.板蓝根多糖对染铅雄性小鼠生长性能的影响[J].中兽医医药杂志,2018,37(3):60-62.
[21]刘洋,蒋忠秀,潘凤琪,等.板蓝根联合阿奇霉素对小儿支原体肺炎血清炎症因子影响[J].现代生物医学进展,2016,16(4):730-733.
[22]石家贵.应用野菊花、板蓝根、半枝莲超声雾化治疗慢性咽炎的用药效果探讨[J].中国处方药,2015,13(3):14-15.
[23]储开东.磷酸奥司他韦颗粒联合复方板蓝根治疗流感样患儿疗效观察[J].现代中西医结合杂志,2015,24(32):3592-3593.
[24]王小红.板蓝根颗粒联合利巴韦林注射液治疗儿童流行性腮腺炎的临床分析[J].北方医学,2018,15(1):101.
[25]吴辉,袁晓玲.板蓝根免煎颗粒灌肠联合美沙拉嗪治疗溃疡性结肠炎的临床研究与应用[J].中国现代药物应用,2018,12(17):206-207.
[26]张军.板蓝根注射液联合聚肌胞注射液治疗单疱病毒性角膜炎临床观察[J].吉林医学,2013,34(6):1062.
[27]张琼丽.乳头瘤病毒感染患者应用外用壳聚糖抗菌膜联合内服板蓝根颗粒治疗的临床效果[J].中国医药科学,2016,6(1):94-95.
[28]许卫华.复方板蓝根冲剂与治疣胶囊治疗扁平疣疗效观察[J].陕西中医,2014,35(12):1642-1643.