祛湿汤治疗痰湿壅盛型单纯舒张期高血压随机平行对照研究
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摘要
[目的]观察祛湿汤治疗痰湿壅盛型单纯舒张期高血压疗效。[方法]使用随机平行对照方法,将108例住院及门诊患者按抛硬币法简单随机分为两组。对照组54例氢氯噻嗪,25mg/次,1次/d。治疗组54例祛湿汤(竹茹、枳实、半夏、黄芩、陈皮、三七各10g,丹皮、茯神、白术、天麻各15g,生地、山楂各20g,酒芍30g),1剂/d,水煎400m L,早晚口服,200m L/次。连续治疗21d为1疗程。观测临床症状、血压、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效31例,有效20例,无效3例,总有效率94.44%。对照组显效22例,有效20例,无效12例,总有效率77.78%。治疗组疗效优于对照组(P<0.05)。血压指标两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]祛湿汤治疗痰湿壅盛型单纯舒张期高血压疗效满意,无严重不良反应,值得推广。
[Objective]To observe the dampness heat Treated Type IDH effect.[Methods]Randomized parallel controlled method,108 inpatients and outpatients law simply by flipping a coin randomly divided into two groups.The control group 54 cases hydrochlorothiazide,25mg/times,1 times/d.The treatment group 54 cases dampness soup(Zhuru,Zh ishi,Banxaia,Huangqin,Chenpi,Sanqi 10 g,Danpi,Fushen,Baizhu,Tianma 15 g,Shengdi,Shanzha 20 g,Jiushao 30g),1 agent/d,decoction 400 m L,sooner or later,oral,200 m L/times.21 d for a course of continuous treatment.Observation of clinical symptoms,blood pressure and adverse reactions.One course of treatment,to determine efficacy.[Results]The treatment group 31 cases,effective 20 cases,3 cases,the total efficiency of 94.44%.The control group 22 cases markedly effective in 20 cases,12 cases,the total efficiency of 77.78%.Treatment group than the control group(P<0.05).Blood pressure indicators improved in both groups(P<0.01),the treatment group than the control group improved(P<0.01).[Conclusion]Heat dampness Decoction type IDH results were satisfactory,no serious adverse reactions,is worth promoting.
[Objective]To observe the dampness heat Treated Type IDH effect.[Methods]Randomized parallel controlled method,108 inpatients and outpatients law simply by flipping a coin randomly divided into two groups.The control group 54 cases hydrochlorothiazide,25mg/times,1 times/d.The treatment group 54 cases dampness soup(Zhuru,Zh ishi,Banxaia,Huangqin,Chenpi,Sanqi 10 g,Danpi,Fushen,Baizhu,Tianma 15 g,Shengdi,Shanzha 20 g,Jiushao 30g),1 agent/d,decoction 400 m L,sooner or later,oral,200 m L/times.21 d for a course of continuous treatment.Observation of clinical symptoms,blood pressure and adverse reactions.One course of treatment,to determine efficacy.[Results]The treatment group 31 cases,effective 20 cases,3 cases,the total efficiency of 94.44%.The control group 22 cases markedly effective in 20 cases,12 cases,the total efficiency of 77.78%.Treatment group than the control group(P<0.05).Blood pressure indicators improved in both groups(P<0.01),the treatment group than the control group improved(P<0.01).[Conclusion]Heat dampness Decoction type IDH results were satisfactory,no serious adverse reactions,is worth promoting.
引文
[1]中国高血压联盟,中华医学会,国家卫生部疾病控制司和国家心血管病中心.中国高血压防治指南[M].北京:人民卫生出版社,2011.
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[5]陆永勇,裘春晖.苯磺酸氨氯地平联合缬沙坦治疗单纯舒张期高血压疗效观察[J].中国基层医药,2012,19(11):1715-1716.
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[7]张福利,宋博,马伯艳,等.清热化浊祛瘀降逆法治疗单纯舒张期高血压56例临床观察[J].中国中医药科技,2009,16(6):3.
[8]国家药典委员会.中华人民共和国药典[M].北京:中国中医药科技出版社,2010:114-115.
[2]中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行)[S].(2007-03-26)[2015-01-11].http://www.moh.gov.cn/qjjys/s3581/200804/b9f1bfee4ab344ec892e68097296e2a8.shtml.
[3]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002.
[4]肖倩倩,张福利.基于湿热论治单纯舒张期高血压67例[J].黑龙江医学,2014,38(9):1014-1015.
[5]陆永勇,裘春晖.苯磺酸氨氯地平联合缬沙坦治疗单纯舒张期高血压疗效观察[J].中国基层医药,2012,19(11):1715-1716.
[6]叶天士.临证指南医案[M].北京:中国医药科技出版社,2011:39-40.
[7]张福利,宋博,马伯艳,等.清热化浊祛瘀降逆法治疗单纯舒张期高血压56例临床观察[J].中国中医药科技,2009,16(6):3.
[8]国家药典委员会.中华人民共和国药典[M].北京:中国中医药科技出版社,2010:114-115.