原发性高血压病人紧张状态与免疫相关指标的相关性研究
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摘要
目的探讨原发性高血压病人紧张状态对免疫相关指标的影响。方法选取原发性高血压病人146例,根据是否存在紧张状态分为紧张状态组(32例)与非紧张状态组(114例)。检测并比较其免疫相关指标。结果原发性高血压紧张状态病人血清球蛋白(GLB)、免疫球蛋白G(IgG)均低于非紧张状态病人,差异有统计学意义(P<0.05),且GLB、IgG均与紧张状态呈负相关(r=-0.189,P=0.023;r=-0.223,P=0.007)。结论原发性高血压病人紧张状态易导致免疫功能下降。
Objective To investigate the effect of stress on immune-related indexes in patients with essential hypertension(EH).Methods One hundred and forty-six patients with EH,of wich 32 patients in tension and114 patients in non-tension state,were selected.The immune-related indicators were detected.Results The levels of serum globulin(GLB)and immunoglobulin G(IgG)in hypertensive patients with tension were significantly lower than those in patients with non-tension state(P <0.05).There was a significant negative correlation between GLB,IgG and tension(r=-0.189,P =0.023;r=-0.223,P =0.007).Conclusion Tension in patients with EH can lead to the decline of immune function.
Objective To investigate the effect of stress on immune-related indexes in patients with essential hypertension(EH).Methods One hundred and forty-six patients with EH,of wich 32 patients in tension and114 patients in non-tension state,were selected.The immune-related indicators were detected.Results The levels of serum globulin(GLB)and immunoglobulin G(IgG)in hypertensive patients with tension were significantly lower than those in patients with non-tension state(P <0.05).There was a significant negative correlation between GLB,IgG and tension(r=-0.189,P =0.023;r=-0.223,P =0.007).Conclusion Tension in patients with EH can lead to the decline of immune function.
引文
[1]古丽仙·吾麦尔.职业性紧张因素与高血压发病的关系[J].世界最新医学信息文摘,2016,16(69):125-129.
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[6]Danese A,Lewis SJ.Psychoneuroimmunology of early-life stress:the hidden wounds of childhood trauma?[J].Neuropsychopharmacology,2016,42(1):99-114.
[7]Wong ML,Inserra A,Lewis MD,et al.Inflammasome signaling affects anxiety-and depressive-like behavior and gut microbiome composition[J].Molecular Psychiatry,2016,21(6):797-805.
[8]Schlaich MP,Esler MD,Fink GD,et al.Targeting the sympathetic nervous system:critical issues in patient selection,efficacy,and safety of renal denervation[J].Hypertension,2014,63(3):426-432.
[9]BajkóZ,Szekeres CC,Kovács KR,et al.Anxiety,depression and autonomic nervous system dysfunction in hypertension[J].Journal of the Neurological Sciences,2012,317(1/2):112-116.
[10]Torpy DJ,Mullen N,Ilias I,et al.Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion:a series of 58 cases[J].Annals of the New York Academy of Sciences,2002,970(1):134-144.
[11]Baek JH,Kim HJ,Fava M,et al.Reduced venous blood basophil count and anxious depression in patients with major depressive disorder[J].Psychiatry Investigation,2016,13(3):321-326.
[2]刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[3]刘粹,于雅琴,康岚,等.北京市和吉林省高血压共病抑郁及焦虑障碍患病率和心理社会因素分析[J].中华精神科杂志,2015,48(2):86-91.
[4]理查德·格里格.心理学与生活[M].16版.北京:人民邮电出版社,2006:1-5.
[5]Lamb AL,Hess DE,Edenborn S,et al.Elevated salivary IgA,decreased anxiety,and an altered oral microbiota are associated with active participation on an undergraduate athletic team[J].Physiol Behav,2016,5(169):169-177.
[6]Danese A,Lewis SJ.Psychoneuroimmunology of early-life stress:the hidden wounds of childhood trauma?[J].Neuropsychopharmacology,2016,42(1):99-114.
[7]Wong ML,Inserra A,Lewis MD,et al.Inflammasome signaling affects anxiety-and depressive-like behavior and gut microbiome composition[J].Molecular Psychiatry,2016,21(6):797-805.
[8]Schlaich MP,Esler MD,Fink GD,et al.Targeting the sympathetic nervous system:critical issues in patient selection,efficacy,and safety of renal denervation[J].Hypertension,2014,63(3):426-432.
[9]BajkóZ,Szekeres CC,Kovács KR,et al.Anxiety,depression and autonomic nervous system dysfunction in hypertension[J].Journal of the Neurological Sciences,2012,317(1/2):112-116.
[10]Torpy DJ,Mullen N,Ilias I,et al.Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion:a series of 58 cases[J].Annals of the New York Academy of Sciences,2002,970(1):134-144.
[11]Baek JH,Kim HJ,Fava M,et al.Reduced venous blood basophil count and anxious depression in patients with major depressive disorder[J].Psychiatry Investigation,2016,13(3):321-326.