单纯性肥胖学龄前儿童血清瘦素、胰岛素抵抗、内分泌激素及血脂与生长发育的关系研究
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摘要
目的分析与研究单纯性肥胖学龄前儿童血清瘦素、胰岛素抵抗、内分泌激素及血脂与生长发育的关系。方法本次研究的对象为2015年6月～2017年12月期间在我院接受治疗的120例单纯性肥胖学龄前儿童以及同时期到我院进行体检的120例正常体重的学龄前儿童,单纯性肥胖学龄前儿童作为观察组,正常体重学龄前儿童作为对照组,比较两组儿童的瘦素、生长激素、皮质醇、甲状腺激素水平,血糖、糖化血红蛋白、胰岛素、胰岛素抵抗指数水平以及血脂水平。结果观察组儿童的瘦素、皮质醇、甲状腺激素水平高于对照组,生长激素水平显著低于对照组,数据差异有统计学意义(P <0.05);观察组儿童的血糖水平低于对照组,差异无统计学意义(P> 0.05),观察组儿童的糖化血红蛋白、胰岛素以及胰岛素抵抗指数水平均高于对照组,差异有统计学意义(P <0.05);观察组儿童的总胆固醇、甘油三脂、低密度脂蛋水平高于对照组,高密度脂蛋白水平低于对照组,差异有统计学意义(P <0.05)。结论单纯性肥胖学龄前儿童存在瘦素抵抗、生长激素分泌减少及内分泌和血脂代谢紊乱等,且严重影响儿童的正常生长发育。
Objective To analyze and study the relationship between serum leptin,insulin resistance,endocrine hormones,blood lipids and growth and development in preschool children with simple obesity. Methods One hundred and twenty preschool children with simple obesity who were treated in our hospital and 120 preschool children with normal weight who underwent physical examination in our hospital from June 2015 to December 2017 were selected as research objects.Preschool children with simple obesity were set as the observation group and preschool children with normal weight were set as the control group.Leptin,growth hormone,cortisol,thyroid hormone level,blood glucose,glycosylated hemoglobin,insulin,insulin resistance index and blood lipid level of children in the two groups were compared. Results The leptin,cortisol,and thyroid hormone level in the observation group were higher than those in the control group,and the growth hormone level was significantly lower than that in the control group,the difference was statistically significant(P < 0.05).The blood glucose level in the observation group was lower than that in the control group.There was no statistically significant difference between the two groups(P > 0.05).Glycosylated hemoglobin,insulin and insulin resistance index in the observation group were significantly higher than those in the control group,the difference was statistically significant(P < 0.05).The total cholesterol,triglycerides and LDL levels of the children in the observation group were higher than those in the control group,and the HDL levels were lower than those in the control group,the difference was statistically significant(P < 0.05). Conclusion Preschool children with simple obesity suffer from leptin resistance,decreased growth hormone secretion,endocrine disorder and lipid metabolism disorder.Simple obesity seriously affects children's normal growth and development.
Objective To analyze and study the relationship between serum leptin,insulin resistance,endocrine hormones,blood lipids and growth and development in preschool children with simple obesity. Methods One hundred and twenty preschool children with simple obesity who were treated in our hospital and 120 preschool children with normal weight who underwent physical examination in our hospital from June 2015 to December 2017 were selected as research objects.Preschool children with simple obesity were set as the observation group and preschool children with normal weight were set as the control group.Leptin,growth hormone,cortisol,thyroid hormone level,blood glucose,glycosylated hemoglobin,insulin,insulin resistance index and blood lipid level of children in the two groups were compared. Results The leptin,cortisol,and thyroid hormone level in the observation group were higher than those in the control group,and the growth hormone level was significantly lower than that in the control group,the difference was statistically significant(P < 0.05).The blood glucose level in the observation group was lower than that in the control group.There was no statistically significant difference between the two groups(P > 0.05).Glycosylated hemoglobin,insulin and insulin resistance index in the observation group were significantly higher than those in the control group,the difference was statistically significant(P < 0.05).The total cholesterol,triglycerides and LDL levels of the children in the observation group were higher than those in the control group,and the HDL levels were lower than those in the control group,the difference was statistically significant(P < 0.05). Conclusion Preschool children with simple obesity suffer from leptin resistance,decreased growth hormone secretion,endocrine disorder and lipid metabolism disorder.Simple obesity seriously affects children's normal growth and development.
引文
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[4]潘佳秋,王萌,郭晓闻,等.肥胖对初诊2型糖尿病患者血清β抑制素2及胰岛素抵抗的影响[J].中国全科医学,2014,17(11):1238-1240.
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[6]吕瑞利,卢小蕴.儿童单纯性肥胖与血脂、血糖及内分泌激素水平的相关性分析[J].中国妇幼保健,2018,33(2):347-349.
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[8]宋媛,朱庆庆,汪宪平,等.学龄前单纯性肥胖儿童血清瘦素、胰岛素及性激素水平[J].中国妇幼保健,2010,25(6):765-767.
[9]沙海滨,贺圣文,王燕琳,等.学龄前儿童单纯性肥胖影响因素的Logistic回归分析[J].中国妇幼保健,2011,26(6):891-893.
[10]吴旭龙,赵雯,李晶晶,等.北京市学龄前儿童单纯性肥胖影响因素研究[J].中国儿童保健杂志,2015,23(4):340-343.
[11]王彦平,韩二芳,钱志伟.营养配餐在中小学膳食中的必要性[J].河南农业,2017,1(3):63-64.
[12]冯益.中医药健康管理服务在儿童保健中的应用效果评价[J].中国妇幼保健,2017,32(14):3105-3107.
[13]赵青,刘苹,黄汉明.托幼园所儿童1558人体检结果分析[J].现代医药卫生,2015,31(16):2435-2437.
[14]伊媛媛,沈理笑.儿童肥胖的影响因素[J].中国妇幼保健,2016,31(2):448-450.
[15]张韬,薛雅静,计瑛,等.单纯性肥胖对上海市惠南地区儿童性激素水平及性腺发育的影响研究[J].中国初级卫生保健,2015,29(8):35-36,39.
[2]王晓瑜,刘小芸,徐开渝.单纯性肥胖儿童血清瘦素、胰岛素抵抗、内分泌激素及血脂与生长发育的关系研究[J].海南医学院学报,2015,21(10):1355-1357.
[3]邢笑杰.单纯性肥胖对少年儿童健康的影响[J].智慧健康,2017,3(14):123-124.
[4]潘佳秋,王萌,郭晓闻,等.肥胖对初诊2型糖尿病患者血清β抑制素2及胰岛素抵抗的影响[J].中国全科医学,2014,17(11):1238-1240.
[5]王萌.肥胖对初诊2型糖尿病患者血清β抑制素2及胰岛素抵抗的影响[D].佳木斯:佳木斯大学,2014.
[6]吕瑞利,卢小蕴.儿童单纯性肥胖与血脂、血糖及内分泌激素水平的相关性分析[J].中国妇幼保健,2018,33(2):347-349.
[7]陈惠东.莆田市学龄前幼儿单纯性肥胖与出生体重关系调查[J].内江科技,2017,38(2):133-134.
[8]宋媛,朱庆庆,汪宪平,等.学龄前单纯性肥胖儿童血清瘦素、胰岛素及性激素水平[J].中国妇幼保健,2010,25(6):765-767.
[9]沙海滨,贺圣文,王燕琳,等.学龄前儿童单纯性肥胖影响因素的Logistic回归分析[J].中国妇幼保健,2011,26(6):891-893.
[10]吴旭龙,赵雯,李晶晶,等.北京市学龄前儿童单纯性肥胖影响因素研究[J].中国儿童保健杂志,2015,23(4):340-343.
[11]王彦平,韩二芳,钱志伟.营养配餐在中小学膳食中的必要性[J].河南农业,2017,1(3):63-64.
[12]冯益.中医药健康管理服务在儿童保健中的应用效果评价[J].中国妇幼保健,2017,32(14):3105-3107.
[13]赵青,刘苹,黄汉明.托幼园所儿童1558人体检结果分析[J].现代医药卫生,2015,31(16):2435-2437.
[14]伊媛媛,沈理笑.儿童肥胖的影响因素[J].中国妇幼保健,2016,31(2):448-450.
[15]张韬,薛雅静,计瑛,等.单纯性肥胖对上海市惠南地区儿童性激素水平及性腺发育的影响研究[J].中国初级卫生保健,2015,29(8):35-36,39.