耳净散治疗急性化脓性中耳炎疗效研究
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摘要
目的:探讨中药耳净散治疗急性化脓性中耳炎的疗效及安全性。方法:选取我院收治的100例急性化脓性中耳炎患者,按照入院时间,随机数字表法分为两组,对照组予常规西药盐酸左氧氟沙星滴耳液抗感染治疗,观察组在对照组治疗基础上加用中药耳净散,并在此基础上辨证论治,随证加减。系统观察疗效、安全性指标。结果:观察组痊愈19例,显效16例,有效12例,无效3例,总有效率94%;对照组痊愈11例,显效15例,有效13例,无效11例,总有效率78%,观察组总有效率显著高于对照组(P<0.05)。观察组各临床症状观察指标恢复时间均显著低于对照组(P<0.05)。治疗后观察组纯音气导听阈、气导骨差分别为(23.43±7.45)dB HL、(3.52±1.05)dB HL均显著低于对照组(37.52±5.95)dB HL、(6.52±1.18)dB HL(P<0.05)。观察组分泌物病原菌清除率88.75%显著高于对照组76.54%(P<0.05)。治疗期间两组肝肾功能、血常规均未见显著异常,观察组有1例出现恶心呕吐,1例出现皮疹;对照组有2例出现恶心呕吐,3例出现皮疹;不影响继续治疗,也无统计学差异(P>0.05)。结论:耳净散联合常规西药治疗急性化脓性中耳炎疗效较好,可显著缓解耳痛、消退鼓膜红肿,改善其听力学指标,且不良反应较少,安全较高。
Objective: To explore the curative effect and safety of the treatment of acute purulent otitis media with Erjing San. Methods:100 cases of acute suppurative otitis media treated by the admission department of our hospital were selected and divided into two groups according to the admission time and the random number table method. The control group was treated with conventional levofloxacin hydrochloride ear drops for anti-infection treatment.The observation group was treated with Erjing San on the basis of the treatment of the control group. Systematic observation: efficacy and safety index. Results :In the observation group, there were 19 cases of recovery, 16 cases of obvious effect, 12 cases of effective effect, and 3 cases of ineffective effect, with a total effective rate of 94%. In the control group, there were 11 cases of recovery, 15 cases of obvious effect, 13 cases of effective effect, and 11 cases of ineffective effect, with a total effective rate of 78%. The total effective rate of the observation group was significantly higher than that of the control group(P< 0.05). The recovery time of clinical symptoms in the observation group was significantly lower than that in the control group(P< 0.05).After treatment, the difference of pure tone and bone conduction in the observation group was(23.43± 7.45)dB HL,(3.52±1.05)dB HL, significantly lower than the control group(37.52±5.95)dB HL and(6.52±1.18)dB HL(P< 0.05).The clearance rate of pathogenic bacteria in secretions of the observation group was 88.75% significantly higher than that of the control group 76.54%(P< 0.05).During the treatment, there was no significant abnormality in liver and kidney function or blood routine of the two groups. In the observation group, there was 1 case of nausea and vomiting, 1 case of skin rash, 2 cases of nausea and vomiting in the control group, and 3 cases of skin rash(P>0.05).Conclusion: The treatment of acute suppurative otitis media with Erjing San combined with conventional western medicine has good curative effect, which can significantly alleviate earache, alleviate tympanic membrane redness and improve its audiology index, and has less adverse reactions, high safety and worthy of clinical promotion.
Objective: To explore the curative effect and safety of the treatment of acute purulent otitis media with Erjing San. Methods:100 cases of acute suppurative otitis media treated by the admission department of our hospital were selected and divided into two groups according to the admission time and the random number table method. The control group was treated with conventional levofloxacin hydrochloride ear drops for anti-infection treatment.The observation group was treated with Erjing San on the basis of the treatment of the control group. Systematic observation: efficacy and safety index. Results :In the observation group, there were 19 cases of recovery, 16 cases of obvious effect, 12 cases of effective effect, and 3 cases of ineffective effect, with a total effective rate of 94%. In the control group, there were 11 cases of recovery, 15 cases of obvious effect, 13 cases of effective effect, and 11 cases of ineffective effect, with a total effective rate of 78%. The total effective rate of the observation group was significantly higher than that of the control group(P< 0.05). The recovery time of clinical symptoms in the observation group was significantly lower than that in the control group(P< 0.05).After treatment, the difference of pure tone and bone conduction in the observation group was(23.43± 7.45)dB HL,(3.52±1.05)dB HL, significantly lower than the control group(37.52±5.95)dB HL and(6.52±1.18)dB HL(P< 0.05).The clearance rate of pathogenic bacteria in secretions of the observation group was 88.75% significantly higher than that of the control group 76.54%(P< 0.05).During the treatment, there was no significant abnormality in liver and kidney function or blood routine of the two groups. In the observation group, there was 1 case of nausea and vomiting, 1 case of skin rash, 2 cases of nausea and vomiting in the control group, and 3 cases of skin rash(P>0.05).Conclusion: The treatment of acute suppurative otitis media with Erjing San combined with conventional western medicine has good curative effect, which can significantly alleviate earache, alleviate tympanic membrane redness and improve its audiology index, and has less adverse reactions, high safety and worthy of clinical promotion.
引文
[1] 王力福,沈美勤,赵金花.肿节风分散片联合洛美沙星治疗急性化脓性中耳炎的疗效观察[J].现代药物与临床,2016,14(8):1260-1263.
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[17] 熊剑丁,夏良勇,杨剑锋.氧氟沙星耳镜下冲洗治疗化脓性中耳炎的临床疗效观察[J]. 现代诊断与治疗,2016,27(18):3370-3371.
[18] 韩鹏.耳鼻喉不同治疗方法在急性化脓性中耳炎治疗中的临床效果比较分析[J].中西医结合心血管病电子杂志,2018,21(18):124-126.
[19] 王新莉.中西医结合治疗急性非化脓性中耳炎(风寒袭耳证)患者疗效观察[J].中国中医急症, 2017,16(4):740-741.
[20] 盛国强,张伟.补阳还五汤治疗慢性化脓性中耳炎45例[J].陕西中医,2017, 38(9):1258-1259.
[21] 邝萍兰,唐东华,梁文辉,等.中西医结合治疗急性化脓性中耳炎的疗效观察[J].世界中医药,2018,16(4) :180-184.
[22] 赵志强.围手术期清热利湿法预防肛肠病术后尿潴留临床研究[J].世界中医药,2014,32(1):44-45.
[23] 吴硕文,邹本革,唐丽华,等.氟苯尼考与天然冰片联用体外抑菌效果研究[J].黑龙江畜牧兽医,2017,30(8):166-167.
[24] 崔国静,贺蔷,江肖肖.收湿敛疮的儿茶[J].首都食品与医药,2016,23(19):59-59.
[25] 盛迎涛,孟繁杰,王平.激素内镜下咽鼓管注入和鼓膜穿刺注入对慢性分泌性中耳炎患者近期疗效、气导听阈及复发率的影响[J].中华全科医学,2017,15(5):799-801.
[2] 邓欣欣,梁耕田,卢岭, 等.成人与儿童分泌性中耳炎中耳积液中耳炎差异球菌对比分析[J].听力学及言语疾病杂志,2018,26(3):280-283.
[3] 刘祥群,张春霞,候素珍.对化脓性中耳炎患者的治疗及护理[J].医药前沿, 2016,8(3):235-235.
[4] 邹树勇.盐酸左氧氟沙星滴耳液用于急性化脓性中耳炎患者治疗中的疗效[J].临床医药文献电子杂志,2016,43(3):8654-8654..
[5] 赵德渊,沈晓玲,张宁国,等.左氧氟沙星注射液联合地塞米松治疗化脓性中耳炎的疗效观察[J].青海医药杂志,2017,13(7):17-18.
[6] 孙青红,梁俊薇.分泌性中耳炎的研究进展[J].中国民族民间医药,2016, 25(21):46-50.
[7] 陈奕辉.中医药治疗120例急性化脓性中耳炎的临床效果分析[J].时珍国医国药, 2014,30(12):2970-2971.
[8] 盖建青,孙宝霞,艾建伟,等.中药耳净散治疗慢性化脓性中耳炎活动期的应用研究[J]. 中华耳科学杂志,2017,15(2):191-194.
[9] 中华医学会耳鼻咽喉头颈外科学分会耳科学组.中耳炎临床分类和手术分型指南[J].中华耳鼻咽喉头颈外科杂志,2013, 48(1):39-41.
[10] 国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社, 2002.
[11] 王进东,孙静涛,张再兴,等.外耳道高负压吸引、正压给药联合鼻腔雾化吸入治疗小儿急性化脓性中耳炎[J].山东医药,2015,15(11):104-105.
[12] 姚赞原,吴燕玲.中耳炎延误治疗后果严重[J].家庭科学(新健康), 2017, 16(10):82-85.
[13] 陶振峰,肖淑芬,陈坤,等.儿童分泌性中耳炎76例误漏诊原因分析及治疗观察[J]. 临床误诊误治,2018,7(1):51-53.
[14] 郭子文.左氧氟沙星滴耳液治疗急性化脓性中耳炎的疗效探究[J].当代医药论丛, 2018,16(8):157-160.
[15] 莫晓蓉.盐酸左氧氟沙星滴耳液治疗急性化脓性中耳炎的疗效观察[J].医药卫生:全文版, 2016,18(4):149-152.
[16] 白晶,谢瑞玲, 熊观霞.左氧氟沙星联合布地奈德混悬液在治疗豚鼠急性化脓性中耳炎模型中的疗效与安全性分析[J].中华临床医师杂志:电子版,2016:10(18):2729-2735.
[17] 熊剑丁,夏良勇,杨剑锋.氧氟沙星耳镜下冲洗治疗化脓性中耳炎的临床疗效观察[J]. 现代诊断与治疗,2016,27(18):3370-3371.
[18] 韩鹏.耳鼻喉不同治疗方法在急性化脓性中耳炎治疗中的临床效果比较分析[J].中西医结合心血管病电子杂志,2018,21(18):124-126.
[19] 王新莉.中西医结合治疗急性非化脓性中耳炎(风寒袭耳证)患者疗效观察[J].中国中医急症, 2017,16(4):740-741.
[20] 盛国强,张伟.补阳还五汤治疗慢性化脓性中耳炎45例[J].陕西中医,2017, 38(9):1258-1259.
[21] 邝萍兰,唐东华,梁文辉,等.中西医结合治疗急性化脓性中耳炎的疗效观察[J].世界中医药,2018,16(4) :180-184.
[22] 赵志强.围手术期清热利湿法预防肛肠病术后尿潴留临床研究[J].世界中医药,2014,32(1):44-45.
[23] 吴硕文,邹本革,唐丽华,等.氟苯尼考与天然冰片联用体外抑菌效果研究[J].黑龙江畜牧兽医,2017,30(8):166-167.
[24] 崔国静,贺蔷,江肖肖.收湿敛疮的儿茶[J].首都食品与医药,2016,23(19):59-59.
[25] 盛迎涛,孟繁杰,王平.激素内镜下咽鼓管注入和鼓膜穿刺注入对慢性分泌性中耳炎患者近期疗效、气导听阈及复发率的影响[J].中华全科医学,2017,15(5):799-801.