三黄健齿汤治疗慢性牙周炎合并动脉粥样硬化疗效及对患者IL-1β、IL-6水平的影响研究
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摘要
目的:探讨三黄健齿汤治疗慢性牙周炎合并动脉粥样硬化的疗效及炎症状况的影响。方法:选取200例慢性牙周炎合并动脉粥样硬化患者进行研究,根据患者入院ID号尾号进行随机分组,将其均分为对照组和观察组。对照组采取龈下洁治、根面平整等治疗,观察组在对照组的基础上采取三黄健齿汤治疗。对两组患者治疗后的临床疗效、治疗前后的中医症候评分、炎症状况、牙周探诊深度(PD)和牙龈出血指数(BI)、血脂水平进行比较分析。结果:观察组患者总有效率98.00%明显高于对照组90.00%,两组比较差异有统计学意义(P<0.05)。治疗后观察组的次症候群评分(1.62±0.54)分,明显低于对照组(6.45±0.63)分,IL-1β、IL-6水平(4.23±0.21pg/ml、6.27±0.22pg/ml)明显低于对照组(5.08±0.52pg/ml、6.55±0.09pg/ml),TG、TC、LDL-C水平(1.56±0.41mmol/L、4.35±0.96mmol/L、2.40±0.52mmol/L)明显低于对照组(1.89±0.53mmol/L、4.86±1.23mmol/L、2.92±0.68 mmol/L),HDL-C(1.51±0.43)mmol/L明显高于对照组(1.36±0.35)mmol/L,两组比较差异有统计学意义(P<0.05)。结论:采取三黄健齿汤对慢性牙周炎合并动脉粥样硬化患者进行治疗,能够提高临床治疗效果,改善患者的炎症状况、中医症候评分以及血脂水平。
Objective:To investigate the curative effect and inflammatory conditions of tooth Sanhuang Jianchi decoction in the treatment of chronic periodontitis and atherosclerosis.Methods:200 cases of chronic periodontitis with atherosclerosis were studied.According to the number of the patients' entrance number ID,the patients were randomly divided into the control group and the observation group.The control group was taken the subgingival scaling and root planing treatment,and the observation group was taken Sanhuang Jianchi decoction in the treatment of tooth on the basic of the control group.The clinical efficacy of two groups of patients after treatment,TCM syndrome score before and after treatment,inflammatory condition,periodontal detection depth(PD),gingival bleeding index(BI)and blood lipid level were compared and analyzed.Results:The total effective rate of the patients in the observation group 98% was significantly higher than that of the control group 90%,and the difference between the two groups was statistically significant(P<0.05).After treatment,the observation group of syndrome score(1.62±0.54)was significantly lower than the control group(6.45±0.63),and IL-1β,IL-6 level(4.23±0.21 pg/ml,6.27±0.22 pg/ml)were significantly lower than that of control group(5.08±0.52 pg/ml,6.55±0.09 pg/ml),TG,TC and LDL-C levels(1.56±0.41 mmol/L,4.35±0.96 mmol/L,2.40±0.52 mmol/L)were significantly lower than the control group(1.89±0.53 mmol/L,4.86±1.23 mmol/L,2.92±0.68 mmol/L),HDL-C(1.51±0.43 mmol/L)was significantly higher than the control group(1.36±0.35)mmol/L,there was significant difference between two groups(P<0.05).Conclusions:Take on patients with chronic periodontitis and atherosclerosis were treated with Sanhuang Jianchi decoction tooth,can improve the clinical treatment effect,and improve the score of TCM symptoms and inflammatory conditions,and it is worthy of clinical promotion and application.
Objective:To investigate the curative effect and inflammatory conditions of tooth Sanhuang Jianchi decoction in the treatment of chronic periodontitis and atherosclerosis.Methods:200 cases of chronic periodontitis with atherosclerosis were studied.According to the number of the patients' entrance number ID,the patients were randomly divided into the control group and the observation group.The control group was taken the subgingival scaling and root planing treatment,and the observation group was taken Sanhuang Jianchi decoction in the treatment of tooth on the basic of the control group.The clinical efficacy of two groups of patients after treatment,TCM syndrome score before and after treatment,inflammatory condition,periodontal detection depth(PD),gingival bleeding index(BI)and blood lipid level were compared and analyzed.Results:The total effective rate of the patients in the observation group 98% was significantly higher than that of the control group 90%,and the difference between the two groups was statistically significant(P<0.05).After treatment,the observation group of syndrome score(1.62±0.54)was significantly lower than the control group(6.45±0.63),and IL-1β,IL-6 level(4.23±0.21 pg/ml,6.27±0.22 pg/ml)were significantly lower than that of control group(5.08±0.52 pg/ml,6.55±0.09 pg/ml),TG,TC and LDL-C levels(1.56±0.41 mmol/L,4.35±0.96 mmol/L,2.40±0.52 mmol/L)were significantly lower than the control group(1.89±0.53 mmol/L,4.86±1.23 mmol/L,2.92±0.68 mmol/L),HDL-C(1.51±0.43 mmol/L)was significantly higher than the control group(1.36±0.35)mmol/L,there was significant difference between two groups(P<0.05).Conclusions:Take on patients with chronic periodontitis and atherosclerosis were treated with Sanhuang Jianchi decoction tooth,can improve the clinical treatment effect,and improve the score of TCM symptoms and inflammatory conditions,and it is worthy of clinical promotion and application.
引文
[1]孟焕新.牙周病学[M].北京:人民卫生出版社,2013:22-24.
[2]Goyal L,Goyal T,Gupta ND.Osteoporosis and Periodontitis in Postmenopausal Women:A Systematic Review[J].J Midlife Health.2017,8(4):151-158.
[3]李文娟,彭伟,王丹.葛根芩连汤对慢性牙周炎合并动脉粥样硬化大鼠血清TNF-α水平的影响[J].实用口腔医学杂志,2015,31(1):23-26.
[4]刘俊田.动脉粥样硬化发病的炎症机制的研究进展[J].西安交通大学学报:医学版,2015,36(2):141-152.
[5]Shahidi M,Vaziri F,Haerian A,et al.Proliferative and Anti-Inflammatory Effects of Resveratrol and Silymarin on Human Gingival Fibroblasts:A View to the Future[J].J Dent(Tehran).2017,14(4):203-211.
[6]马超.米诺环素辅助治疗慢性牙周炎临床疗效及安全性评价[J].中国临床药理学杂志,2015,31(14):1405-1406.
[7]袁杰,王少果,周建业,等.慢性牙周炎唾液牙龈卟啉单胞菌的定量PCR检测[J].口腔医学研究,2015,31(2):133-136.
[8]陈英,张文玲,黄涛,等.炎症因子TNF-α、IL-6、IL-17与类风湿关节炎并发动脉粥样硬化的关系[J].免疫学杂志,2017,33(3):268-272.
[9]李爽,易根云,李志强,等.牙周炎与冠心病之间联系机制的研究进展[J].口腔医学研究,2017,33(4):455-458.
[10]李靓,谢巍,姜志胜,等.我国动脉粥样硬化基础研究近三年进展[J].中国动脉硬化杂志,2015,23(11):1182-1188.
[11]Makino-Oi A,Ishii Y,Makino K,et al.Treatment of Severe Chronic Periodontitis with Surgical and Prosthetic Intervention:A 9-year Follow-up Case Report[J].Bull Tokyo Dent Coll.2017,58(4):237-246.
[12]张芳,陈燕,蔡哲,等.补肾养阴清火法治疗慢性牙周炎的临床疗效和对龈沟液中IL-1β、IL-6的影响[J].中华中医药杂志,2015,30(12):4324-4327.
[13]林梅,张冬雪,刘志强,等.慢性牙周炎患者血清IL-33、TNF-α、IL-6的检测及意义[J].首都医科大学学报,2016,37(3):255-259.
[14]孙俊毅,汪明敏,朱春晖,等.牙周炎患者牙根纵裂51例临床分析[J].陕西医学杂志,2016,45(2):210-211,214.
[15]Costa LC,Fonseca MAD,Pinheiro ADR,et al.Chronic Periodontitis and RANKL/OPG Ratio in Peri-Implant Mucosae Inflammation[J].Braz Dent J.2018,29(1):14-22.
[16]童钰鑫,陈悦,黄若文,等.黄芩类制剂辅助牙周基础治疗对慢性牙周炎的疗效分析[J].陕西中医,2016,37(12):1619-1622.
[17]罗东玲.黄芩酒制、炒炭炮制前后6种黄酮类成分含量变化及炮制机理[J].医药前沿,2016,12(20):377-378.
[2]Goyal L,Goyal T,Gupta ND.Osteoporosis and Periodontitis in Postmenopausal Women:A Systematic Review[J].J Midlife Health.2017,8(4):151-158.
[3]李文娟,彭伟,王丹.葛根芩连汤对慢性牙周炎合并动脉粥样硬化大鼠血清TNF-α水平的影响[J].实用口腔医学杂志,2015,31(1):23-26.
[4]刘俊田.动脉粥样硬化发病的炎症机制的研究进展[J].西安交通大学学报:医学版,2015,36(2):141-152.
[5]Shahidi M,Vaziri F,Haerian A,et al.Proliferative and Anti-Inflammatory Effects of Resveratrol and Silymarin on Human Gingival Fibroblasts:A View to the Future[J].J Dent(Tehran).2017,14(4):203-211.
[6]马超.米诺环素辅助治疗慢性牙周炎临床疗效及安全性评价[J].中国临床药理学杂志,2015,31(14):1405-1406.
[7]袁杰,王少果,周建业,等.慢性牙周炎唾液牙龈卟啉单胞菌的定量PCR检测[J].口腔医学研究,2015,31(2):133-136.
[8]陈英,张文玲,黄涛,等.炎症因子TNF-α、IL-6、IL-17与类风湿关节炎并发动脉粥样硬化的关系[J].免疫学杂志,2017,33(3):268-272.
[9]李爽,易根云,李志强,等.牙周炎与冠心病之间联系机制的研究进展[J].口腔医学研究,2017,33(4):455-458.
[10]李靓,谢巍,姜志胜,等.我国动脉粥样硬化基础研究近三年进展[J].中国动脉硬化杂志,2015,23(11):1182-1188.
[11]Makino-Oi A,Ishii Y,Makino K,et al.Treatment of Severe Chronic Periodontitis with Surgical and Prosthetic Intervention:A 9-year Follow-up Case Report[J].Bull Tokyo Dent Coll.2017,58(4):237-246.
[12]张芳,陈燕,蔡哲,等.补肾养阴清火法治疗慢性牙周炎的临床疗效和对龈沟液中IL-1β、IL-6的影响[J].中华中医药杂志,2015,30(12):4324-4327.
[13]林梅,张冬雪,刘志强,等.慢性牙周炎患者血清IL-33、TNF-α、IL-6的检测及意义[J].首都医科大学学报,2016,37(3):255-259.
[14]孙俊毅,汪明敏,朱春晖,等.牙周炎患者牙根纵裂51例临床分析[J].陕西医学杂志,2016,45(2):210-211,214.
[15]Costa LC,Fonseca MAD,Pinheiro ADR,et al.Chronic Periodontitis and RANKL/OPG Ratio in Peri-Implant Mucosae Inflammation[J].Braz Dent J.2018,29(1):14-22.
[16]童钰鑫,陈悦,黄若文,等.黄芩类制剂辅助牙周基础治疗对慢性牙周炎的疗效分析[J].陕西中医,2016,37(12):1619-1622.
[17]罗东玲.黄芩酒制、炒炭炮制前后6种黄酮类成分含量变化及炮制机理[J].医药前沿,2016,12(20):377-378.