血清半乳糖凝集素-3及炎症因子与冠脉病变程度和主要心脏不良事件的相关性
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摘要
目的观察冠心病患者血清半乳糖凝集素-3(Gal-3)及炎症因子超敏C反应蛋白(Hs-CRP)、白介素(IL)-6、肿瘤坏死因子(TNF)-α水平变化,探讨其与冠状动脉病变程度及30 d内主要心脏不良事件(MACE)的相关性。方法检测126例冠心病和54例非冠心病患者血清Gal-3、Hs-CRP、IL-6、TNF-α的水平,分析其与冠状动脉病变程度及MACE之间的相关性。结果冠心病组血清Gal-3和炎症因子水平显著高于对照组(P<0.01),其中多支病变、重度狭窄的患者高于双支、单支病变及轻度狭窄的患者,差异有统计学意义(P<0.01);冠心病组血清Gal-3和炎症因子水平与冠状动脉Gensini评分呈显著正相关性(P<0.01);发生MACE患者血清Gal-3和炎症因子水平显著高于未发生MACE患者(P<0.05)。结论冠心病患者血清Gal-3及Hs-CRP、IL-6、TNF-α水平明显升高,并与冠脉病变程度及MACE密切相关,提示Gal-3可作为评估冠状动脉病变程度及近期预后新的观察指标。
Objective To observe the serum levels of Gal-3,Hs-CRP,IL-6 and TNF-α,and discuss the correlation between those indicators and the severity of coronary lesion and major adverse cardiac events(MACE). Methods Serum levels of Gal-3,Hs-CRP,IL-6 and TNF-α were detected in 126 patients with coronary heart disease and 54 patients with non-coronary heart disease. To analyze the correlation between those indicators and the severity of coronary lesion and MACE. Results Serum levels of Gal-3 and inflammatory factors of in the coronary heart disease group were significantly increased compared with the control group(P < 0. 01),and serum levels of Gal-3 and inflammatory factors in the multi-vessel disease group and the severe coronary disease stenosis group higer than that of the double-vessel disease group,the single-vessel disease group and the mild coronary disease stenosis group(P <0. 05). Serum levels of Gal-3,inflammatory factors and Gensini scores were positively correlated(P < 0. 01). Serum levels of Gal-3,inflammatory factors were significantly higher with MACE compared to without MACE(P <0. 05). Conclusion The serum levels of Gal-3 and Hs-CRP,IL-6,TNF-α,Gensini scores in patients with coronary heart disease are positively correlated,serum Gal-3 has great potential to become effective clinical indicators,which could be used to preliminary predict the severity of coronary artery disease and evaluate the short-term prognosis of patients with coronary heart disease.
Objective To observe the serum levels of Gal-3,Hs-CRP,IL-6 and TNF-α,and discuss the correlation between those indicators and the severity of coronary lesion and major adverse cardiac events(MACE). Methods Serum levels of Gal-3,Hs-CRP,IL-6 and TNF-α were detected in 126 patients with coronary heart disease and 54 patients with non-coronary heart disease. To analyze the correlation between those indicators and the severity of coronary lesion and MACE. Results Serum levels of Gal-3 and inflammatory factors of in the coronary heart disease group were significantly increased compared with the control group(P < 0. 01),and serum levels of Gal-3 and inflammatory factors in the multi-vessel disease group and the severe coronary disease stenosis group higer than that of the double-vessel disease group,the single-vessel disease group and the mild coronary disease stenosis group(P <0. 05). Serum levels of Gal-3,inflammatory factors and Gensini scores were positively correlated(P < 0. 01). Serum levels of Gal-3,inflammatory factors were significantly higher with MACE compared to without MACE(P <0. 05). Conclusion The serum levels of Gal-3 and Hs-CRP,IL-6,TNF-α,Gensini scores in patients with coronary heart disease are positively correlated,serum Gal-3 has great potential to become effective clinical indicators,which could be used to preliminary predict the severity of coronary artery disease and evaluate the short-term prognosis of patients with coronary heart disease.
引文
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[12]秦月,仲琳,杨军.冠心病患者冠状动脉病变程度与半乳糖凝集素-3水平的相关性分析[J].中国循环杂志,2015,30(5):442-5.
[13]孙利强,陈杰,李恩.急性冠脉综合症患者血清半乳糖凝集素-3和C反应蛋白水平的变化[J].郑州大学学报(医学版),2014,49(3):397-400.
[14]张育民,李庆宽,全勇,等.急性心肌梗死患者血清半乳糖凝集素-3水平与冠状动脉病变的相关性[J].中国动脉硬化杂志,2014,22(6):591-4.
[2]Lyu Y,Jiang X,Dai W.The roles of a novel inflammatory neopterin in subjects with coronary atherosclerotic heart disease[J].Int Immunopharmacol,2015,24(2):169-72.
[3]Mishra B B,Li Q,Steichen A L,et al.Galectin-3 functions as an alarmin:pathogenic role for sepsis development in murine respiratory tularemia[J].PLo S One,2013,8(3):e59616.
[4]Gensini G G.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606.
[5]Dumic J,Dabelic S,Flgel M.Galectin-3:an open-ended story[J].Biochim Biophys Acta,2006,1760(4):616-35.
[6]Rudolf J,Lewandrowski K B.Cholestrol,lipoproteins,high-sensitivity c-reactive protein,and other risk factors for atherosclerosis[J].Clin Lab Med,2014,34(1):113-27.
[7]Lacobini C,Menni S,Ricci C,et al.Accelerated lipid-induced atherogenesis in galectin-3-deficient mice:role of lipoxidation via receptor-mediated mechanisms[J].Arterioscler Thromb Vasc Biol,2009,29(6):831-6.
[8]Al-Ansari S,Zeebregts C J,Slart R H,et al.Galectins in atherosclerotic disease[J].Trends Cardiovasc Med,2009,19(5):164-9.
[9]Lee Y J,Koh Y S,Park H E,et al.Spatial and temporal expression,and stain responsivenesss of galectin-1 and galectin-3 in murine atherosclerosis[J].Korean Circ J,2013,43(4):223-30.
[10]Mackinnon A C,Liu X,Hadoke P W,et al.Inhibition of galectin-3reduces atherosclerosis in apolipoprotein E-deficient mice[J].Glycobiology,2013,23(6):654-63.
[11]Falcone C,Lucibello S,Mazzucchelli I,et al.Galectin-3 plasma levels and coronary artery disease:a new possible biomarker of acute coronary syndrome[J].Int J Immunopathol Pharmacol,2011,24(4):905-13.
[12]秦月,仲琳,杨军.冠心病患者冠状动脉病变程度与半乳糖凝集素-3水平的相关性分析[J].中国循环杂志,2015,30(5):442-5.
[13]孙利强,陈杰,李恩.急性冠脉综合症患者血清半乳糖凝集素-3和C反应蛋白水平的变化[J].郑州大学学报(医学版),2014,49(3):397-400.
[14]张育民,李庆宽,全勇,等.急性心肌梗死患者血清半乳糖凝集素-3水平与冠状动脉病变的相关性[J].中国动脉硬化杂志,2014,22(6):591-4.