汽化过氧化氢消毒效果空间差异性分析与消毒风险评估
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摘要
目的观察汽化过氧化氢对室内环境物体消毒效果的空间差异性,为评估室内环境消毒风险提供依据。方法采用载体熏蒸杀菌实验方法,观察汽化过氧化氢消毒设备对某实验室内环境物品消毒效果空间差异。结果该汽化过氧化氢消毒设备在某140 m3实验室空间内以低、中、高3种流量运行程序向空间扩散过氧化氢汽体,过氧化氢浓度平均峰值依次为189 mg/L、342 mg/L和553 mg/L,且浓度的上升速率和峰值与设定流量和持续时间均呈正相关性关系。3种运行程序中,只有高流量消毒程序可以使室内各采样点不锈钢载体上嗜热脂肪杆菌芽孢被完全杀灭;低和中流量运行程序不能完全杀灭地面和房间入口处载体上细菌芽孢。结论本研究汽化过氧化氢消毒设备在室内空间过氧化氢浓度达到553 mg/L的高流量运行程序可以使室内所有采样点载体上细菌芽孢被完全杀灭,结果提示汽化过氧化氢在室内环境物体消毒效果存在空间差异性,地面和房间入口处为最难消毒点。
Objective To observe the spatial difference of disinfection effect of vaporized hydrogen peroxide on the surfaces of objects,and provide evidence for evaluating the risk of disinfection in indoor environment. Methods Carrier fumigation germicidal method was used to observe the spatial difference of disinfection effect of vaporized hydrogen peroxide equipment. Results The average peak of vaporized hydrogen peroxide concentration in 140 cubic meters laboratory was 189 mg/L,342 mg/L and 553 mg/L respectively when the low,medium and high flow programs were running,and the rising rate and peak of hydrogen peroxide vapor concentration were positively correlated with the program. The Bacillus stearothermophilus spores at each monitoring point were completely killed only under the high flow program,and the spores at ground and indoor entrances were not completely killed under the medium flow or low flow programs. Conclusion The high flow program of vaporized hydrogen peroxide equipment in indoor space with the concentration of 553 mg/L kill spores completely at each monitoring point. The disinfection effect of vaporized hydrogen peroxide has obvious spatial difference. The most difficult space to disinfection of vaporized hydrogen peroxide is the ground and indoor entrances.
Objective To observe the spatial difference of disinfection effect of vaporized hydrogen peroxide on the surfaces of objects,and provide evidence for evaluating the risk of disinfection in indoor environment. Methods Carrier fumigation germicidal method was used to observe the spatial difference of disinfection effect of vaporized hydrogen peroxide equipment. Results The average peak of vaporized hydrogen peroxide concentration in 140 cubic meters laboratory was 189 mg/L,342 mg/L and 553 mg/L respectively when the low,medium and high flow programs were running,and the rising rate and peak of hydrogen peroxide vapor concentration were positively correlated with the program. The Bacillus stearothermophilus spores at each monitoring point were completely killed only under the high flow program,and the spores at ground and indoor entrances were not completely killed under the medium flow or low flow programs. Conclusion The high flow program of vaporized hydrogen peroxide equipment in indoor space with the concentration of 553 mg/L kill spores completely at each monitoring point. The disinfection effect of vaporized hydrogen peroxide has obvious spatial difference. The most difficult space to disinfection of vaporized hydrogen peroxide is the ground and indoor entrances.
引文
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[2]陆烨,陆龙喜,李晔,等.汽化过氧化氢对不同空间消毒效果观察[J].中华医院感染学杂志,2015,25(11):2628.
[3]帖金凤,王长德,陈金龙,等.过氧化氢蒸汽对生物安全实验室灭菌效果观察[J].中国消毒学杂志,2012,29(6):463-465.
[4]蔡冉,陆烨,李晔,等.汽化过氧化氢对不同材料表面的消毒效果比较[J].中国消毒学杂志,2016,33(7):616-618.
[5]孙志平,韩文东,丁悦娜,等.过氧化氢干雾对生物安全柜微环境表面消毒效果的研究[J].微生物与感染,2013,8(4):220-226.
[6]宋大海.过氧化氢干雾灭菌新技术探讨[J].中国制药装备,2013,12(35):33-34,50.
[7]郝丽梅,衣颖,吴金辉,等.汽化过氧化氢在消毒领域中的应用研究[J].医疗卫生装备,2018,39(2):94.
[8]张文福.汽化过氧化氢消毒技术及其在生物安全领域的应用[J].中国消毒学杂志,2017,34(10):962.
[9]付丽娟,刘万忠.过氧化氢消毒灭菌技术及设备的研究新进展[J].中国药师,2017,20(2):341.